Tissue specific hormonal regulation of the rat angiotensinogen gene expression.
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Kunapuli SP, Benedict CR, Kumar A
Tissue specific hormonal regulation of the rat angiotensinogen gene expression.
Arch Biochem Biophys. 1987 May 1;254(2):642-6.
- PubMed ID
- 3579322 [ View in PubMed]
- Abstract
Angiotensinogen is the precursor of the most potent pressor substance, angiotensin. Angiotensinogen levels are increased in some forms of human hypertension. Its levels are modulated by various factors including glucocorticoids, estrogens, and prostaglandins. We have recently reported the isolation of a human angiotensinogen cDNA clone and provided evidence for the presence of its mRNA in rat liver, brain, and heart. In this communication we report the effect of dexamethasone and estradiol on angiotensinogen mRNA levels in rat liver, brain, and heart. Our results indicate that angiotensinogen levels are increased to different extents in these three tissues as a result of glucocorticoid or estrogen administration.