Angiotensinogen

Details

Name
Angiotensinogen
Synonyms
  • Serpin A8
  • SERPINA8
Gene Name
AGT
Organism
Humans
Amino acid sequence
>lcl|BSEQ0021841|Angiotensinogen
MRKRAPQSEMAPAGVSLRATILCLLAWAGLAAGDRVYIHPFHLVIHNESTCEQLAKANAG
KPKDPTFIPAPIQAKTSPVDEKALQDQLVLVAAKLDTEDKLRAAMVGMLANFLGFRIYGM
HSELWGVVHGATVLSPTAVFGTLASLYLGALDHTADRLQAILGVPWKDKNCTSRLDAHKV
LSALQAVQGLLVAQGRADSQAQLLLSTVVGVFTAPGLHLKQPFVQGLALYTPVVLPRSLD
FTELDVAAEKIDRFMQAVTGWKTGCSLMGASVDSTLAFNTYVHFQGKMKGFSLLAEPQEF
WVDNSTSVSVPMLSGMGTFQHWSDIQDNFSVTQVPFTESACLLLIQPHYASDLDKVEGLT
FQQNSLNWMKKLSPRTIHLTMPQLVLQGSYDLQDLLAQAELPAILHTELNLQKLSNDRIR
VGEVLNSIFFELEADEREPTESTQQLNKPEVLEVTLNRPFLFAVYDQSATALHFLGRVAN
PLSTA
Number of residues
485
Molecular Weight
53153.73
Theoretical pI
6.27
GO Classification
Functions
growth factor activity / hormone activity / serine-type endopeptidase inhibitor activity / sodium channel regulator activity / superoxide-generating NADPH oxidase activator activity / type 1 angiotensin receptor binding / type 2 angiotensin receptor binding
Processes
activation of NF-kappaB-inducing kinase activity / activation of phospholipase C activity / aging / angiotensin maturation / angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure / angiotensin-mediated drinking behavior / artery smooth muscle contraction / astrocyte activation / blood vessel development / blood vessel remodeling / branching involved in ureteric bud morphogenesis / catenin import into nucleus / cell growth involved in cardiac muscle cell development / cell surface receptor signaling pathway / cell-cell signaling / cell-matrix adhesion / cellular lipid metabolic process / cellular protein metabolic process / cellular response to mechanical stimulus / cellular sodium ion homeostasis / cytokine secretion / ERK1 and ERK2 cascade / establishment of blood-nerve barrier / excretion / extracellular matrix organization / female pregnancy / fibroblast proliferation / G-protein coupled receptor signaling pathway / G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger / kidney development / low-density lipoprotein particle remodeling / negative regulation of angiogenesis / negative regulation of cell growth / negative regulation of cell proliferation / negative regulation of endopeptidase activity / negative regulation of neuron apoptotic process / negative regulation of neurotrophin TRK receptor signaling pathway / negative regulation of sodium ion transmembrane transporter activity / negative regulation of tissue remodeling / nitric oxide mediated signal transduction / ovarian follicle rupture / peristalsis / phospholipase C-activating G-protein coupled receptor signaling pathway / positive regulation of activation of JAK2 kinase activity / positive regulation of branching involved in ureteric bud morphogenesis / positive regulation of cardiac muscle hypertrophy / positive regulation of cellular protein metabolic process / positive regulation of cholesterol esterification / positive regulation of cytokine production / positive regulation of endothelial cell migration / positive regulation of epidermal growth factor receptor signaling pathway / positive regulation of extracellular matrix constituent secretion / positive regulation of extrinsic apoptotic signaling pathway / positive regulation of fatty acid biosynthetic process / positive regulation of fibroblast proliferation / positive regulation of gap junction assembly / positive regulation of inflammatory response / positive regulation of macrophage derived foam cell differentiation / positive regulation of MAPK cascade / positive regulation of membrane hyperpolarization / positive regulation of multicellular organism growth / positive regulation of NAD(P)H oxidase activity / positive regulation of NF-kappaB transcription factor activity / positive regulation of nitric oxide biosynthetic process / positive regulation of organ growth / positive regulation of peptidyl-serine phosphorylation / positive regulation of peptidyl-tyrosine phosphorylation / positive regulation of phosphatidylinositol 3-kinase signaling / positive regulation of protein kinase C activity / positive regulation of protein tyrosine kinase activity / positive regulation of reactive oxygen species metabolic process / positive regulation of renal sodium excretion / positive regulation of superoxide anion generation / positive regulation of transcription, DNA-templated / positive regulation of vasodilation / regulation of blood pressure / regulation of blood vessel size by renin-angiotensin / regulation of blood volume by renin-angiotensin / regulation of calcium ion transport / regulation of cardiac conduction / regulation of cell growth / regulation of cell proliferation / regulation of extracellular matrix assembly / regulation of heart rate / regulation of long-term neuronal synaptic plasticity / regulation of norepinephrine secretion / regulation of renal output by angiotensin / regulation of renal sodium excretion / regulation of transmission of nerve impulse / regulation of vasoconstriction / renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure / renal system process / renin-angiotensin regulation of aldosterone production / response to cold / response to muscle activity involved in regulation of muscle adaptation / response to salt stress / small molecule metabolic process / smooth muscle cell differentiation / smooth muscle cell proliferation / stress-activated MAPK cascade / uterine smooth muscle contraction / vasodilation
Components
blood microparticle / cytoplasm / extracellular exosome / extracellular region / extracellular space
General Function
Type 2 angiotensin receptor binding
Specific Function
Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.Angiotensin-3: stimulates aldosterone release.Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
>lcl|BSEQ0021842|Angiotensinogen (AGT)
ATGCGGAAGCGAGCACCCCAGTCTGAGATGGCTCCTGCCGGTGTGAGCCTGAGGGCCACC
ATCCTCTGCCTCCTGGCCTGGGCTGGCCTGGCTGCAGGTGACCGGGTGTACATACACCCC
TTCCACCTCGTCATCCACAATGAGAGTACCTGTGAGCAGCTGGCAAAGGCCAATGCCGGG
AAGCCCAAAGACCCCACCTTCATACCTGCTCCAATTCAGGCCAAGACATCCCCTGTGGAT
GAAAAGGCCCTACAGGACCAGCTGGTGCTAGTCGCTGCAAAACTTGACACCGAAGACAAG
TTGAGGGCCGCAATGGTCGGGATGCTGGCCAACTTCTTGGGCTTCCGTATATATGGCATG
CACAGTGAGCTATGGGGCGTGGTCCATGGGGCCACCGTCCTCTCCCCAACGGCTGTCTTT
GGCACCCTGGCCTCTCTCTATCTGGGAGCCTTGGACCACACAGCTGACAGGCTACAGGCA
ATCCTGGGTGTTCCTTGGAAGGACAAGAACTGCACCTCCCGGCTGGATGCGCACAAGGTC
CTGTCTGCCCTGCAGGCTGTACAGGGCCTGCTAGTGGCCCAGGGCAGGGCTGATAGCCAG
GCCCAGCTGCTGCTGTCCACGGTGGTGGGCGTGTTCACAGCCCCAGGCCTGCACCTGAAG
CAGCCGTTTGTGCAGGGCCTGGCTCTCTATACCCCTGTGGTCCTCCCACGCTCTCTGGAC
TTCACAGAACTGGATGTTGCTGCTGAGAAGATTGACAGGTTCATGCAGGCTGTGACAGGA
TGGAAGACTGGCTGCTCCCTGATGGGAGCCAGTGTGGACAGCACCCTGGCTTTCAACACC
TACGTCCACTTCCAAGGGAAGATGAAGGGCTTCTCCCTGCTGGCCGAGCCCCAGGAGTTC
TGGGTGGACAACAGCACCTCAGTGTCTGTTCCCATGCTCTCTGGCATGGGCACCTTCCAG
CACTGGAGTGACATCCAGGACAACTTCTCGGTGACTCAAGTGCCCTTCACTGAGAGCGCC
TGCCTGCTGCTGATCCAGCCTCACTATGCCTCTGACCTGGACAAGGTGGAGGGTCTCACT
TTCCAGCAAAACTCCCTCAACTGGATGAAGAAACTATCTCCCCGGACCATCCACCTGACC
ATGCCCCAACTGGTGCTGCAAGGATCTTATGACCTGCAGGACCTGCTCGCCCAGGCTGAG
CTGCCCGCCATTCTGCACACCGAGCTGAACCTGCAAAAATTGAGCAATGACCGCATCAGG
GTGGGGGAGGTGCTGAACAGCATTTTTTTTGAGCTTGAAGCGGATGAGAGAGAGCCCACA
GAGTCTACCCAACAGCTTAACAAGCCTGAGGTCTTGGAGGTGACCCTGAACCGCCCATTC
CTGTTTGCTGTGTATGATCAAAGCGCCACTGCCCTGCACTTCCTGGGCCGCGTGGCCAAC
CCGCTGAGCACAGCATGA
Chromosome Location
1
Locus
1q42-q43
External Identifiers
ResourceLink
UniProtKB IDP01019
UniProtKB Entry NameANGT_HUMAN
GenBank Protein ID178640
GenBank Gene IDK02215
GenAtlas IDAGT
HGNC IDHGNC:333
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB12548SparsentaninvestigationalunknownDetails
DB09130Copperapproved, investigationalunknownDetails
DB01593Zincapproved, investigationalunknownDetails
DB14487Zinc acetateapproved, investigationalunknownDetails
DB14533Zinc chlorideapproved, investigationalunknownDetails