Alternative RNA processing events in human calcitonin/calcitonin gene-related peptide gene expression.
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Jonas V, Lin CR, Kawashima E, Semon D, Swanson LW, Mermod JJ, Evans RM, Rosenfeld MG
Alternative RNA processing events in human calcitonin/calcitonin gene-related peptide gene expression.
Proc Natl Acad Sci U S A. 1985 Apr;82(7):1994-8.
- PubMed ID
- 3872459 [ View in PubMed]
- Abstract
Two mRNAs generated as a consequence of alternative RNA processing events in expression of the human calcitonin gene encode the protein precursors of either calcitonin or calcitonin gene-related peptide (CGRP). Both calcitonin and CGRP RNAs and their encoded peptide products are expressed in the human pituitary and in medullary thyroid tumors. On the basis of sequence comparison, it is suggested that both the calcitonin and CGRP exons arose from a common primordial sequence, suggesting that duplication and rearrangement events are responsible for the generation of this complex transcription unit.