Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line.
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Drivas GT, Shih A, Coutavas E, Rush MG, D'Eustachio P
Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line.
Mol Cell Biol. 1990 Apr;10(4):1793-8.
- PubMed ID
- 2108320 [ View in PubMed]
- Abstract
A mixed-oligonucleotide probe was used to identify four ras-like coding sequences in a human teratocarcinoma cDNA library. Two of these sequences resembled the rho genes, one was closely related to H-, K-, and N-ras, and one shared only the four sequence domains that define the ras gene superfamily. Homologs of the four genes were found in genomic DNA from a variety of mammals and from chicken. The genes were transcriptionally active in a range of human cell types.