Rational design of new bifunctional inhibitors of type II dehydroquinase.
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Toscano MD, Stewart KA, Coggins JR, Lapthorn AJ, Abell C
Rational design of new bifunctional inhibitors of type II dehydroquinase.
Org Biomol Chem. 2005 Sep 7;3(17):3102-4. Epub 2005 Aug 1.
- PubMed ID
- 16106291 [ View in PubMed]
- Abstract
Selective inhibitors of type II dehydroquinase were rationally designed to explore a second binding-pocket in the active-site. The molecular modelling, synthesis, inhibition studies and crystal structure determination are described.