A role for scavenger receptor B-I in selective transfer of rhodamine-PE from liposomes to cells.

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Yan X, Poelstra K, Scherphof GL, Kamps JA

A role for scavenger receptor B-I in selective transfer of rhodamine-PE from liposomes to cells.

Biochem Biophys Res Commun. 2004 Dec 17;325(3):908-14.

PubMed ID

15541376 [ View in PubMed

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Abstract

We investigated the potential role of scavenger receptor B-I (SR-BI) in the selective removal of liposomal markers from blood by hepatocytes. Liposomes were labeled with [(3)H]cholesteryloleyl-ether ([(3)H]COE), 1,2-di[1-(14)C]palmitoyl-phosphatidylcholine ([(14)C]PC), and N-(lissamine rhodamine-B sulfonyl)-phosphatidylethanolamine (N-Rh-PE). The radiolabels were eliminated at identical rates from plasma, while N-Rh-PE was cleared twice as fast. Involvement of SR-BI in the selective removal of N-Rh-PE from liposomes was studied in transfected Chinese hamster ovary cells over-expressing SR-BI. Uptake of N-Rh-PE from liposomes containing phosphatidylserine was higher than [(3)H]COE, and was further enhanced by apolipoprotein A-I, confirming involvement of SR-BI in the selective uptake of liposomal N-Rh-PE by cells.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Phosphatidyl serine	Scavenger receptor class B member 1	Protein	Humans	Unknown	Not Available	Details