Oxytocin receptor

Details

Name
Oxytocin receptor
Synonyms
  • OT-R
Gene Name
OXTR
Organism
Humans
Amino acid sequence
>lcl|BSEQ0010596|Oxytocin receptor
MEGALAANWSAEAANASAAPPGAEGNRTAGPPRRNEALARVEVAVLCLILLLALSGNACV
LLALRTTRQKHSRLFFFMKHLSIADLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQV
VGMFASTYLLLLMSLDRCLAICQPLRSLRRRTDRLAVLATWLGCLVASAPQVHIFSLREV
ADGVFDCWAVFIQPWGPKAYITWITLAVYIVPVIVLAACYGLISFKIWQNLRLKTAAAAA
AEAPEGAAAGDGGRVALARVSSVKLISKAKIRTVKMTFIIVLAFIVCWTPFFFVQMWSVW
DANAPKEASAFIIVMLLASLNSCCNPWIYMLFTGHLFHELVQRFLCCSASYLKGRRLGET
SASKKSNSSSFVLSHRSSSQRSCSQPSTA
Number of residues
389
Molecular Weight
42770.99
Theoretical pI
9.88
GO Classification
Functions
oxytocin receptor activity / peptide binding / peptide hormone binding / vasopressin receptor activity
Processes
cell surface receptor signaling pathway / cellular response to hormone stimulus / digestive tract development / eating behavior / ERK1 and ERK2 cascade / estrous cycle / female pregnancy / G-protein coupled receptor signaling pathway / heart development / lactation / maternal behavior / maternal process involved in parturition / memory / muscle contraction / negative regulation of gastric acid secretion / positive regulation of blood pressure / positive regulation of cytosolic calcium ion concentration / positive regulation of norepinephrine secretion / positive regulation of penile erection / positive regulation of synapse assembly / positive regulation of synaptic transmission, GABAergic / positive regulation of synaptic transmission, glutamatergic / positive regulation of uterine smooth muscle contraction / positive regulation of vasoconstriction / regulation of systemic arterial blood pressure by vasopressin / response to amphetamine / response to anoxia / response to cocaine / response to cytokine / response to drug / response to estradiol / response to peptide / response to peptide hormone / response to progesterone / sleep / social behavior / sperm ejaculation / suckling behavior / telencephalon development
Components
apical plasma membrane / cell-cell adherens junction / cytosol / integral component of plasma membrane / microvillus / plasma membrane
General Function
Vasopressin receptor activity
Specific Function
Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
Pfam Domain Function
Transmembrane Regions
39-63 75-97 114-135 155-175 203-225 276-294 310-332
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0010597|Oxytocin receptor (OXTR)
ATGGAGGGCGCGCTCGCAGCCAACTGGAGCGCCGAGGCAGCCAACGCCAGCGCCGCGCCG
CCGGGGGCCGAGGGCAACCGCACCGCCGGACCCCCGCGGCGCAACGAGGCCCTGGCGCGC
GTGGAGGTGGCGGTGCTGTGTCTCATCCTGCTCCTGGCGCTGAGCGGGAACGCGTGTGTG
CTGCTGGCGCTGCGCACCACACGCCAGAAGCACTCGCGCCTCTTCTTCTTCATGAAGCAC
CTAAGCATCGCCGACCTGGTGGTGGCAGTGTTTCAGGTGCTGCCGCAGTTGCTGTGGGAC
ATCACCTTCCGCTTCTACGGGCCCGACCTGCTGTGCCGCCTGGTCAAGTACTTGCAGGTG
GTGGGCATGTTCGCCTCCACCTACCTGCTGCTGCTCATGTCCCTGGACCGCTGCCTGGCC
ATCTGCCAGCCGCTGCGCTCGCTGCGCCGCCGCACCGACCGCCTGGCAGTGCTCGCCACG
TGGCTCGGCTGCCTGGTGGCCAGCGCGCCGCAGGTGCACATCTTCTCTCTGCGCGAGGTG
GCTGACGGCGTCTTCGACTGCTGGGCCGTCTTCATCCAGCCCTGGGGACCCAAGGCCTAC
ATCACATGGATCACGCTAGCTGTCTACATCGTGCCGGTCATCGTGCTCGCTGCCTGCTAC
GGCCTTATCAGCTTCAAGATCTGGCAGAACTTGCGGCTCAAGACCGCTGCAGCGGCGGCG
GCCGAGGCGCCAGAGGGCGCGGCGGCTGGCGATGGGGGGCGCGTGGCCCTGGCGCGTGTC
AGCAGCGTCAAGCTCATCTCCAAGGCCAAGATCCGCACGGTCAAGATGACTTTCATCATC
GTGCTGGCCTTCATCGTGTGCTGGACGCCTTTCTTCTTCGTGCAGATGTGGAGCGTCTGG
GATGCCAACGCGCCCAAGGAAGCCTCGGCCTTCATCATCGTCATGCTCCTGGCCAGCCTC
AACAGCTGCTGCAACCCCTGGATCTACATGCTGTTCACGGGCCACCTCTTCCACGAACTC
GTGCAGCGCTTCCTGTGCTGCTCCGCCAGCTACCTGAAGGGCAGACGCCTGGGAGAGACG
AGTGCCAGCAAAAAGAGCAACTCGTCCTCCTTTGTCCTGAGCCATCGCAGCTCCAGCCAG
AGGAGCTGCTCCCAGCCATCCACGGCGTGA
Chromosome Location
3
Locus
3p25
External Identifiers
ResourceLink
UniProtKB IDP30559
UniProtKB Entry NameOXYR_HUMAN
GenBank Protein ID34765
GenBank Gene IDX64878
GenAtlas IDOXTR
HGNC IDHGNC:8529
General References
  1. Kimura T, Tanizawa O, Mori K, Brownstein MJ, Okayama H: Structure and expression of a human oxytocin receptor. Nature. 1992 Apr 9;356(6369):526-9. [Article]
  2. Inoue T, Kimura T, Azuma C, Inazawa J, Takemura M, Kikuchi T, Kubota Y, Ogita K, Saji F: Structural organization of the human oxytocin receptor gene. J Biol Chem. 1994 Dec 23;269(51):32451-6. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01282Carbetocinapproved, investigationalyesagonistDetails
DB00107Oxytocinapproved, vet_approvedyesagonistDetails
DB13929RelcovaptaninvestigationalunknownantagonistDetails
DB09059Atosibanapproved, investigationalyesantagonistDetails
DB00067VasopressinapprovedyesagonistDetails