Identification
NameOxytocin
Accession NumberDB00107  (BTD00016, BIOD00016)
TypeBiotech
GroupsApproved, Vet Approved
Description

Synthetic 9 residue cyclic peptide. The hormone is prepared synthetically to avoid possible contamination with vasopressin (ADH) and other small polypeptides with biologic activity.

Protein structureDb00107
Related Articles
Protein chemical formulaC43H66N12O12S2
Protein average weight1007.187 Da
Sequences
>DB00107 sequence
CYIQNCPLG
Download FASTA Format
Synonyms
Pitocin
Syntocinon
External IDs Not Available
Product Ingredients Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
OxytocinInjection10 [USP'U]/mLIntramuscular; IntravenousBaxter Laboratories2009-06-262015-12-29Us
OxytocinInjection, solution10 [USP'U]/mLIntramuscular; IntravenousCardinal Health2000-08-10Not applicableUs
OxytocinInjection10 [USP'U]/mLIntramuscular; IntravenousWest Ward Pharmaceutical1980-04-29Not applicableUs
OxytocinInjection, solution10 [USP'U]/mLIntramuscular; IntravenousCardinal Health2000-08-10Not applicableUs
OxytocinInjection10 [USP'U]/mLIntramuscular; IntravenousWest Ward Pharmaceutical1980-04-29Not applicableUs
OxytocinInjection10 [iU]/mLIntravenousJHP Pharmaceuticals, LLC.2012-06-012017-05-02Us
OxytocinInjection, solution10 [USP'U]/mLIntramuscular; IntravenousFresenius Kabi2000-08-10Not applicableUs
OxytocinInjection10 [iU]/mLIntravenousJHP Pharmaceuticals, LLC.2012-06-012017-05-02Us
Oxytocin Inj 10unit/ml USPLiquid10 unitIntramuscular; IntravenousLyphomed, Division Of Fujisawa Canada Inc.1988-12-311996-09-10Canada
Oxytocin InjectionSolution10 unitIntramuscular; IntravenousFresenius Kabi1996-08-14Not applicableCanada
Oxytocin Injection 10unit/mlSolution10 unitIntramuscular; IntravenousHospira, Inc.1981-12-31Not applicableCanada
PitocinInjection10 [iU]/mLIntravenousJHP Pharmaceuticals, LLC.2012-09-052017-04-29Us
PitocinInjection10 [iU]/mLIntravenousPar Pharmaceutical2007-10-01Not applicableUs
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
OxytocinInjection10 [USP'U]/mLIntramuscular; IntravenousWest Ward Pharmaceutical2013-02-13Not applicableUs
OxytocinInjection10 [USP'U]/mLIntramuscular; IntravenousWest Ward Pharmaceutical2013-02-13Not applicableUs
OxytocinInjection, solution10 [USP'U]/mLIntramuscular; IntravenousSagent Pharmaceuticals2016-04-012016-10-13Us
Approved Over the Counter ProductsNot Available
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
OxytocinInjection, solution20 [USP'U]/500mLIntravenousCantrell Drug Company2016-03-18Not applicableUs
OxytocinInjection, solution10 [USP'U]/1000mLIntravenousCantrell Drug Company2012-07-30Not applicableUs
OxytocinInjection, solution30 [USP'U]/500mLIntravenousCantrell Drug Company2011-10-20Not applicableUs
OxytocinInjection, solution2 [USP'U]/100mLIntravenousCantrell Drug Company2012-11-12Not applicableUs
OxytocinInjection, solution30 [USP'U]/1000mLIntravenousCantrell Drug Company2016-03-18Not applicableUs
OxytocinInjection, solution2 [USP'U]/100mLIntravenousCantrell Drug Company2011-10-20Not applicableUs
OxytocinInjection, solution30 [USP'U]/500mLIntravenousCantrell Drug Company2011-10-20Not applicableUs
OxytocinInjection, solution30 [USP'U]/500mLIntravenousCantrell Drug Company2011-07-01Not applicableUs
OxytocinInjection, solution2 [USP'U]/100mLIntravenousCantrell Drug Company2011-10-20Not applicableUs
OxytocinInjection, solution30 [USP'U]/500mLIntravenousCantrell Drug Company2011-10-20Not applicableUs
International Brands
NameCompany
SyntocinonSandoz
Brand mixturesNot Available
Categories
UNII1JQS135EYN
CAS number50-56-6
Pharmacology
Indication

Used for labor induction, augmentation of labor, postpartum abbreviation of third stage of labor, postpartum control of uterine bleeding, termination of pregnancy and for the evaluation of fetal respiratory capability. Oxytocin cannot be used for elective induction of labor, there must be a clear medical requirement.

Structured Indications
Pharmacodynamics

Indirectly stimulates contraction of uterine smooth muscle by increasing the sodium permeability of uterine myofibrils. Increases contraction amplitude and frequency, which tends to decrease cervical activity, produce dilation and effacement of the cervix, and transiently impede uterine blood flow; contractions produced by oxytocin at term are similar to those occurring during spontaneous labor. High estrogen concentrations lower the threshold for uterine response to oxytocin. Uterine response increases with the duration of pregnancy and is greater in labor than when not in labor; only very large doses elicit contractions in early pregnancy. Contracts myoepithelial cells surrounding the alveoli of the breasts, forcing milk from the alveoli into the larger ducts and facilitating milk ejection. Minimal antidiuretic activity relative to vasopressin; water intoxication possible at high doses and/or excessive electrolyte-free fluid.

Mechanism of action

Uterine motility depends on the formation of the contractile protein actomyosin under the influence of the Ca2+-dependent phosphorylating enzyme myosin light-chain kinase. Oxytocin promotes contractions by increasing the intracellular Ca2+, which in turn activates myosin's light chain kinase.. Oxytocin has specific receptors in the muscle lining of the uterus and the receptor concentration increases greatly during pregnancy, reaching a maximum in early labor at term.

TargetKindPharmacological actionActionsOrganismUniProt ID
Oxytocin receptorProteinyes
agonist
HumanP30559 details
Oxytocin-neurophysin 1Proteinunknown
binder
HumanP01178 details
Related Articles
Absorption

Uterine response after IV administration is immediate and subsides after 1 hour. Uterine contractions occur 3-5mins after IM administration and decreases within 2-3 hours. When 100-200milliunits is administered IV, contractions of the myoepithelial tissue surrounding the alveoli of the breasts occur within minutes and last for about 20 mins.

Volume of distribution

Distributes throughout the extracellular fluid and crosses the placenta. It is probable that it also distributes into milk in small amounts.

Protein binding

30%

Metabolism

Oxytocin is rapidly metabolized in the liver and also in the plasma by oxytocinases. It is also metabolized to a smaller degree by the mammary glands.

Route of elimination

Biliary and renal (excreted unchanged in the urine)

Half life

1-6 min, this is decreased in late pregnancy and during lactation.

ClearanceNot Available
Toxicity

Oxytocin can produce a severe water intoxication due to its antidiuretic effect. Prolonged IV infusions of more 40milliunits/min are usually the cause. Severe water intoxication with convulsions, coma, and death can occur. Some neonatal seizures have also been reported. Consider potential for water intoxication, particularly when administered by IV infusion and patient is receiving oral fluids. Uterine effects: High doses or hypersensitivity to oxytocin may cause uterine hypertonicity, spasm, tetanic contraction, or rupture of the uterus. There have also been reported allergic and anaphylactic reactions to oxytocin but they were rarely fatal.

Affected organisms
  • Humans and other mammals
PathwaysNot Available
Pharmacogenomic Effects/ADRs Not Available
Interactions
Drug Interactions
DrugInteractionDrug group
AmiodaroneOxytocin may increase the QTc-prolonging activities of Amiodarone.Approved, Investigational
AnagrelideOxytocin may increase the QTc-prolonging activities of Anagrelide.Approved
Arsenic trioxideOxytocin may increase the QTc-prolonging activities of Arsenic trioxide.Approved, Investigational
ArtemetherOxytocin may increase the QTc-prolonging activities of Artemether.Approved
AsenapineOxytocin may increase the QTc-prolonging activities of Asenapine.Approved
AzithromycinOxytocin may increase the QTc-prolonging activities of Azithromycin.Approved
BedaquilineOxytocin may increase the QTc-prolonging activities of Bedaquiline.Approved
Carboprost TromethamineThe risk or severity of adverse effects can be increased when Carboprost Tromethamine is combined with Oxytocin.Approved
CeritinibOxytocin may increase the QTc-prolonging activities of Ceritinib.Approved
ChloroquineOxytocin may increase the QTc-prolonging activities of Chloroquine.Approved, Vet Approved
ChlorpromazineOxytocin may increase the QTc-prolonging activities of Chlorpromazine.Approved, Vet Approved
CiprofloxacinOxytocin may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
CisaprideOxytocin may increase the QTc-prolonging activities of Cisapride.Approved, Investigational, Withdrawn
CitalopramOxytocin may increase the QTc-prolonging activities of Citalopram.Approved
ClarithromycinOxytocin may increase the QTc-prolonging activities of Clarithromycin.Approved
ClozapineOxytocin may increase the QTc-prolonging activities of Clozapine.Approved
CrizotinibOxytocin may increase the QTc-prolonging activities of Crizotinib.Approved
DinoprostoneThe risk or severity of adverse effects can be increased when Dinoprostone is combined with Oxytocin.Approved
DisopyramideOxytocin may increase the QTc-prolonging activities of Disopyramide.Approved
DofetilideOxytocin may increase the QTc-prolonging activities of Dofetilide.Approved
DolasetronOxytocin may increase the QTc-prolonging activities of Dolasetron.Approved
DomperidoneOxytocin may increase the QTc-prolonging activities of Domperidone.Approved, Investigational, Vet Approved
DronedaroneOxytocin may increase the QTc-prolonging activities of Dronedarone.Approved
DroperidolOxytocin may increase the QTc-prolonging activities of Droperidol.Approved, Vet Approved
EliglustatOxytocin may increase the QTc-prolonging activities of Eliglustat.Approved
ErythromycinOxytocin may increase the QTc-prolonging activities of Erythromycin.Approved, Vet Approved
EscitalopramOxytocin may increase the QTc-prolonging activities of Escitalopram.Approved, Investigational
FlecainideOxytocin may increase the QTc-prolonging activities of Flecainide.Approved, Withdrawn
FluoxetineOxytocin may increase the QTc-prolonging activities of Fluoxetine.Approved, Vet Approved
FlupentixolOxytocin may increase the QTc-prolonging activities of Flupentixol.Approved, Withdrawn
Gadobenic acidOxytocin may increase the QTc-prolonging activities of Gadobenic acid.Approved
GemifloxacinOxytocin may increase the QTc-prolonging activities of Gemifloxacin.Approved, Investigational
GoserelinOxytocin may increase the QTc-prolonging activities of Goserelin.Approved
GranisetronOxytocin may increase the QTc-prolonging activities of Granisetron.Approved, Investigational
HaloperidolOxytocin may increase the QTc-prolonging activities of Haloperidol.Approved
IbutilideOxytocin may increase the QTc-prolonging activities of Ibutilide.Approved
IloperidoneOxytocin may increase the QTc-prolonging activities of Iloperidone.Approved
LenvatinibOxytocin may increase the QTc-prolonging activities of Lenvatinib.Approved
LeuprolideOxytocin may increase the QTc-prolonging activities of Leuprolide.Approved, Investigational
LevofloxacinOxytocin may increase the QTc-prolonging activities of Levofloxacin.Approved, Investigational
LopinavirOxytocin may increase the QTc-prolonging activities of Lopinavir.Approved
LumefantrineOxytocin may increase the QTc-prolonging activities of Lumefantrine.Approved
MethadoneOxytocin may increase the QTc-prolonging activities of Methadone.Approved
MifepristoneMifepristone may increase the QTc-prolonging activities of Oxytocin.Approved, Investigational
MisoprostolThe risk or severity of adverse effects can be increased when Misoprostol is combined with Oxytocin.Approved
MoxifloxacinOxytocin may increase the QTc-prolonging activities of Moxifloxacin.Approved, Investigational
NilotinibOxytocin may increase the QTc-prolonging activities of Nilotinib.Approved, Investigational
OfloxacinOxytocin may increase the QTc-prolonging activities of Ofloxacin.Approved
OndansetronOxytocin may increase the QTc-prolonging activities of Ondansetron.Approved
PaliperidoneOxytocin may increase the QTc-prolonging activities of Paliperidone.Approved
PanobinostatOxytocin may increase the QTc-prolonging activities of Panobinostat.Approved, Investigational
PazopanibOxytocin may increase the QTc-prolonging activities of Pazopanib.Approved
PentamidineOxytocin may increase the QTc-prolonging activities of Pentamidine.Approved
PerflutrenOxytocin may increase the QTc-prolonging activities of Perflutren.Approved
PimozideOxytocin may increase the QTc-prolonging activities of Pimozide.Approved
PrimaquineOxytocin may increase the QTc-prolonging activities of Primaquine.Approved
ProcainamideOxytocin may increase the QTc-prolonging activities of Procainamide.Approved
PromazineOxytocin may increase the QTc-prolonging activities of Promazine.Approved, Vet Approved
PropafenoneOxytocin may increase the QTc-prolonging activities of Propafenone.Approved
QuetiapineOxytocin may increase the QTc-prolonging activities of Quetiapine.Approved
QuinidineOxytocin may increase the QTc-prolonging activities of Quinidine.Approved
QuinineOxytocin may increase the QTc-prolonging activities of Quinine.Approved
SaquinavirOxytocin may increase the QTc-prolonging activities of Saquinavir.Approved, Investigational
SotalolOxytocin may increase the QTc-prolonging activities of Sotalol.Approved
SulfisoxazoleOxytocin may increase the QTc-prolonging activities of Sulfisoxazole.Approved, Vet Approved
TelavancinOxytocin may increase the QTc-prolonging activities of Telavancin.Approved
TelithromycinOxytocin may increase the QTc-prolonging activities of Telithromycin.Approved
TetrabenazineOxytocin may increase the QTc-prolonging activities of Tetrabenazine.Approved
ThioridazineOxytocin may increase the QTc-prolonging activities of Thioridazine.Withdrawn
ToremifeneOxytocin may increase the QTc-prolonging activities of Toremifene.Approved, Investigational
VandetanibOxytocin may increase the QTc-prolonging activities of Vandetanib.Approved
VemurafenibOxytocin may increase the QTc-prolonging activities of Vemurafenib.Approved
ZiprasidoneOxytocin may increase the QTc-prolonging activities of Ziprasidone.Approved
ZuclopenthixolOxytocin may increase the QTc-prolonging activities of Zuclopenthixol.Approved, Investigational
Food InteractionsNot Available
References
Synthesis Reference

Kerstin Uvnas-Moberg, Thomas Lundeberg, "Use of substances having oxytocin activity for preparation of medicaments for wound healing." U.S. Patent US6262021, issued August, 1988.

US6262021
General References
  1. Kosfeld M, Heinrichs M, Zak PJ, Fischbacher U, Fehr E: Oxytocin increases trust in humans. Nature. 2005 Jun 2;435(7042):673-6. [PubMed:15931222 ]
  2. Takayanagi Y, Yoshida M, Bielsky IF, Ross HE, Kawamata M, Onaka T, Yanagisawa T, Kimura T, Matzuk MM, Young LJ, Nishimori K: Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice. Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):16096-101. Epub 2005 Oct 25. [PubMed:16249339 ]
  3. Carmichael MS, Humbert R, Dixen J, Palmisano G, Greenleaf W, Davidson JM: Plasma oxytocin increases in the human sexual response. J Clin Endocrinol Metab. 1987 Jan;64(1):27-31. [PubMed:3782434 ]
  4. Paquin J, Danalache BA, Jankowski M, McCann SM, Gutkowska J: Oxytocin induces differentiation of P19 embryonic stem cells to cardiomyocytes. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9550-5. Epub 2002 Jul 1. [PubMed:12093924 ]
  5. Jankowski M, Danalache B, Wang D, Bhat P, Hajjar F, Marcinkiewicz M, Paquin J, McCann SM, Gutkowska J: Oxytocin in cardiac ontogeny. Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):13074-9. Epub 2004 Aug 17. [PubMed:15316117 ]
  6. Link [Link]
External Links
ATC CodesH01BB02 — OxytocinG02AC01 — Methylergometrine and oxytocin
AHFS Codes
  • 76:00.00
PDB Entries
FDA labelNot Available
MSDSNot Available
Clinical Trials
Clinical Trials
PhaseStatusPurposeConditionsCount
0Active Not RecruitingOtherEating Behavior1
0Active Not RecruitingTreatmentMagnetoencephalography (MEG) / Oxytocin / Schizophrenic Disorders / Social Cognition1
0Active Not RecruitingTreatmentOxytocin / Schizophrenic Disorders / Social Cognition1
0CompletedBasic ScienceFacial Expressions1
0CompletedBasic ScienceHealthy Volunteers3
0CompletedBasic SciencePsychology, Social1
0CompletedBasic ScienceSocial Activity1
0CompletedBasic ScienceSocial Perception1
0CompletedOtherOverweight and Obesity1
0CompletedTreatmentCardiac Dysrhythmia1
0CompletedTreatmentMethadone Treatment / Opioid Dependence / Substance Abuse1
0CompletedTreatmentPostprocedural Delayed Gastric Emptying1
0RecruitingBasic ScienceCancer, Breast / Ductal Carcinoma In Situ1
0RecruitingBasic ScienceHealthy Volunteers2
0RecruitingBasic SciencePosttraumatic Stress Disorders1
0RecruitingBasic SciencePsychology, Social2
0RecruitingPreventionHealthy Volunteers2
0RecruitingTreatmentAlcoholism / Stress Disorders, Post-Traumatic1
0RecruitingTreatmentFunctional Magnetic Resonance Imaging (fMRI) / Oxytocin / Schizophrenic Disorders / Social Cognition1
0RecruitingTreatmentOxytocin / Schizophrenic Disorders / Social Cognition1
0RecruitingTreatmentPreEclampsia1
0SuspendedBasic ScienceCongenital Prosopagnosia / Healthy Volunteers1
0Unknown StatusBasic ScienceExpressed Emotion / Social Cognition1
0WithdrawnBasic ScienceDyssocial Behavior1
1Active Not RecruitingBasic ScienceOxytocin Effect on Memory Performance During Phase 1 / Oxytocin Effect on Memory Performance During Phase 2 / Oxytocin Effect on Memory Performance During Phase 31
1CompletedNot AvailableCocaine Use Disorders / Opioid Use Disorders1
1CompletedBasic ScienceHealthy Male Adults1
1CompletedBasic ScienceHealthy Male Volunteers3
1CompletedBasic ScienceHealthy Volunteers1
1CompletedBasic ScienceSustained Positive Behavior Change / Sustained Positive Emotions1
1CompletedDiagnosticAutism Spectrum Disorder (ASD)1
1CompletedPreventionPost Partum Hemorrhage1
1CompletedTreatmentAutism, Early Infantile1
1CompletedTreatmentFrontotemporal Dementia1
1CompletedTreatmentHealthy Males1
1CompletedTreatmentPostpartum Hemorrhage1
1CompletedTreatmentPrader Willi Syndrome1
1CompletedTreatmentSchizophrenic Disorders1
1Not Yet RecruitingNot AvailableHealthy Women of Child Bearing Potential1
1Not Yet RecruitingOtherAlcoholism1
1Not Yet RecruitingPreventionPost Partum Haemorrhage1
1RecruitingNot AvailableAutism Spectrum Disorder (ASD)1
1RecruitingNot AvailableAutism Spectrum Disorder (ASD) / Schizophrenic Disorders1
1RecruitingNot AvailableUnit Cohesion1
1RecruitingBasic ScienceAlcohol Related Disorders / Alcoholism1
1RecruitingBasic ScienceBorderline Personality Disorder (BPD) / BPD / Schizotypal Personality Disorder / SPD1
1RecruitingBasic ScienceEmotion Regulation / Emotions / Parent-Child Relations1
1RecruitingBasic SciencePain1
1RecruitingBasic SciencePregnancy / Substance Abuse Problem1
1RecruitingHealth Services ResearchPostpartum Hemorrhage1
1RecruitingOtherAmphetamine Use Disorders1
1RecruitingTreatmentAlcohol Use Disorders (AUD)1
1RecruitingTreatmentPostpartum Hemorrhage1
1TerminatedTreatmentEmbryo Transfer1
1Unknown StatusNot AvailableOpiate Dependence1
1Unknown StatusTreatmentDepressive State / Major Depressive Disorder (MDD)1
1WithdrawnBasic ScienceAutism Disorder1
1, 2CompletedBasic ScienceAutism Spectrum Disorder (ASD)1
1, 2CompletedBasic ScienceSocial Anxiety Disorder (SAD)1
1, 2CompletedPreventionPost Partum Haemorrhage1
1, 2CompletedTreatmentPrader Willi Syndrome1
1, 2CompletedTreatmentPrader-Willi Syndrome1
1, 2Enrolling by InvitationTreatmentOpiate withdrawal symptoms / Opioid Dependence1
1, 2TerminatedTreatmentChildhood Onset Psychotic Disorders / Schizophrenic Disorders1
2Active Not RecruitingOtherSchizophrenic Disorders1
2Active Not RecruitingTreatmentAutism Spectrum Disorder (ASD)4
2Active Not RecruitingTreatmentHyperphagia / Prader-Willi Syndrome1
2CompletedNot AvailableDependence, Cocaine1
2CompletedNot AvailablePTSD1
2CompletedBasic ScienceFocus of Study: Neural Correlates of Oxytocin Administration1
2CompletedOtherAutism Spectrum Disorder (ASD)1
2CompletedOtherInterpersonal Conflict / Neuroendocrine Reactivity / Substance Misuse1
2CompletedPreventionPostpartum Hemorrhage1
2CompletedScreeningPostpartum Hemorrhage1
2CompletedTreatmentAtrophy1
2CompletedTreatmentAutism Spectrum Disorder (ASD)2
2CompletedTreatmentAutism, Early Infantile2
2CompletedTreatmentChronic Migraine / High Frequency Episodic Migraine and Chronic Migraine1
2CompletedTreatmentEmotional Intelligence / Social Anxiety / Social Cognition1
2CompletedTreatmentFemale Sexual Dysfunction (FSD)1
2CompletedTreatmentFragile X Syndrome (FXS)1
2CompletedTreatmentInduction of Labour1
2CompletedTreatmentPrader Willi Syndrome1
2CompletedTreatmentSchizophrenic Disorders2
2CompletedTreatmentVulvovaginal Atrophy2
2CompletedTreatmentOne to five years postmenopausal / Vulvovaginal Atrophy1
2Not Yet RecruitingPreventionPost Anaesthetic Shivering1
2Not Yet RecruitingTreatmentAlcohol Use1
2Not Yet RecruitingTreatmentBMI >30 kg/m21
2Not Yet RecruitingTreatmentHyperphagia / Prader-Willi Syndrome1
2Not Yet RecruitingTreatmentStimulant Use Disorder1
2RecruitingNot AvailableBody Dysmorphic Disorders / Obsessive-Compulsive Disorder (OCD)1
2RecruitingBasic ScienceAlcohol Use Disorder (AUD) / Healthy Controls / Non-social Motivation / Social Motivation1
2RecruitingBasic ScienceHealthy Volunteer Study1
2RecruitingBasic SciencePain, Neuropathic1
2RecruitingPreventionPostpartum Depression / Posttraumatic Stress Disorders1
2RecruitingPreventionPostpartum Hemorrhage1
2RecruitingTreatmentAlcohol Dependence / Alcohol Withdrawal Syndrome(AWS)1
2RecruitingTreatmentAttachement Style1
2RecruitingTreatmentAutism Spectrum Disorder (ASD)2
2RecruitingTreatmentAutism Spectrum Disorder (ASD) / Autism, Early Infantile1
2RecruitingTreatmentCocaine Use Disorders1
2RecruitingTreatmentDepressive Disorders1
2RecruitingTreatmentFrontotemporal Dementia1
2RecruitingTreatmentHypothalamic Obesity / Postsurgical craniopharyngioma1
2RecruitingTreatmentIntemittant, Continue, Oxytocin1
2RecruitingTreatmentMoods Disorders / Oppositional Defiant Disorder1
2RecruitingTreatmentObstetric Labor1
2RecruitingTreatmentPhelan-McDermid Syndrome1
2RecruitingTreatmentPostoperative pain1
2TerminatedTreatmentFetal Membranes, Premature Rupture / Induction of Labour1
2Unknown StatusBasic ScienceThe Impact of Oxytocin on Social Cognition1
2Unknown StatusTreatmentOxytocin + Non Specific Counselling / Oxytocin + Social Skills Training / Placebo + Non Specific Counselling / Placebo + Social Skills Training1
2Unknown StatusTreatmentProlonged Labour1
2Unknown StatusTreatmentSchizophrenic Disorders1
2, 3Active Not RecruitingTreatmentDependence, Cocaine1
2, 3Active Not RecruitingTreatmentPremenstrual Dysphoric Disorder1
2, 3CompletedPreventionCesarean Section1
2, 3Not Yet RecruitingTreatmentMyocardial Infarction (MI)1
2, 3Not Yet RecruitingTreatmentPain, Chronic / Pelvic Pain1
2, 3RecruitingTreatmentPrader-Willi Syndrome1
2, 3SuspendedTreatmentAutism Spectrum Disorder (ASD)1
3Active Not RecruitingTreatmentFetus or Newborn or Maternal; Effects of Induction of Labor1
3Active Not RecruitingTreatmentPost Partum Haemorrhage1
3CompletedNot AvailableInduction / Labour / PROM (Pregnancy)1
3CompletedBasic ScienceHealthy Volunteers1
3CompletedPreventionComplications; Cesarean Section1
3CompletedPreventionDelivery1
3CompletedPreventionLabour1
3CompletedPreventionPostpartum Hemorrhage2
3CompletedTreatmentObstetrics1
3CompletedTreatmentPostpartum Hemorrhage1
3Not Yet RecruitingPreventionPost Partum Hemorrhage1
3Not Yet RecruitingPreventionUterine Hemorrhage1
3Not Yet RecruitingTreatmentASD / Autism Spectrum Disorder (ASD) / PDD / Pervasive Developmental Disorder NOS1
3Not Yet RecruitingTreatmentInduction of Labour1
3Not Yet RecruitingTreatmentPost-Partum Hemorrhage1
3Not Yet RecruitingTreatmentPostpartum Hemorrhage1
3RecruitingPreventionCesarean Section During Labor1
3RecruitingPreventionPost Partum Haemorrhage2
3RecruitingTreatmentAlcoholism / Substance-Related Disorders1
3RecruitingTreatmentCervical Ripening / Induction of Labour / Multiparity1
3RecruitingTreatmentPoor; Labor1
3RecruitingTreatmentPost Partum Hemorrhage1
3SuspendedTreatmentPostpartum Hemorrhage1
3TerminatedTreatmentLabour Dystocia1
3Unknown StatusPreventionPostpartum Hemorrhage / Severe Preeclampsia1
3Unknown StatusTreatmentSchizophrenic Disorders1
3WithdrawnPreventionPostpartum Hemorrhage1
4Active Not RecruitingDiagnosticNeonatal Hyperbilirubinemia1
4Active Not RecruitingTreatmentHealthy Volunteers1
4Active Not RecruitingTreatmentPosttraumatic Stress Disorder (PTSD)1
4CompletedNot AvailableAnxiety Disorder / Posttraumatic Stress Disorders / Reconsolidation1
4CompletedBasic ScienceHealth1
4CompletedBasic ScienceSocial Behavior1
4CompletedPreventionPostpartum Hemorrhage1
4CompletedPreventionPostpartum Hemorrhage / Uterine Atony1
4CompletedPreventionUterine Atony1
4CompletedTreatmentAOD Use, Abuse, and Dependence1
4CompletedTreatmentAnemias / Haemorrhage1
4CompletedTreatmentArterial Hypotension / Bloodloss / Myocardial Ischemia1
4CompletedTreatmentArterial Hypotension / Uterine Atony1
4CompletedTreatmentEffects of; Anesthesia, in Pregnancy1
4CompletedTreatmentInduction of Labour1
4CompletedTreatmentLabor Augmentation1
4CompletedTreatmentLabor; Forced or Induced, Affecting Fetus or Newborn1
4CompletedTreatmentMaternal Care for Late Fetal Death / Pregnancy, Cornual1
4CompletedTreatmentMissed Abortion1
4CompletedTreatmentPostpartum Hemorrhage / Uterine Atony1
4CompletedTreatmentSchizophrenic Disorders1
4CompletedTreatmentThird Stage of Labour1
4CompletedTreatmentTrust1
4Enrolling by InvitationTreatmentAutism Spectrum Disorder (ASD)1
4Not Yet RecruitingTreatmentPremature Rupture of Fetal Membranes1
4RecruitingBasic ScienceNicotine Dependence / Tobacco Smoking1
4RecruitingOtherBMI >30 kg/m2 / Induction of Labour / Oxytocin1
4RecruitingPreventionAdverse Reaction to Oxytocin1
4RecruitingTreatmentDystocia1
4RecruitingTreatmentFailed Induction (of Labor) by Oxytocin1
4RecruitingTreatmentLabor Stage, Third/Drug Effects / Oxytocin/Administration & Dosage / Pregnancy Termination / Pregnancy Trimester, Second1
4RecruitingTreatmentPregnancy1
4TerminatedTreatmentCesarean Section / Vaginal Delivery1
4TerminatedTreatmentDrug Dependence1
4Unknown StatusPreventionCARBETOCIN FOR PREVENTION OF PLACENTAL RETAINED1
4Unknown StatusTreatmentLabour1
4WithdrawnPreventionPostpartum Hemorrhage / Uterine Atony1
Not AvailableActive Not RecruitingTreatmentDystocia1
Not AvailableCompletedNot AvailableBonding / Breastfeeding / Newborns / Oxytocin / Perinatal1
Not AvailableCompletedNot AvailableCoping Skills / Oxytocin / Stress1
Not AvailableCompletedNot AvailableOxytocin / Pregnancy1
Not AvailableCompletedNot AvailablePreEclampsia1
Not AvailableCompletedNot AvailableScarred Uterus1
Not AvailableCompletedNot AvailableSepsis1
Not AvailableCompletedBasic ScienceDrug Dependence1
Not AvailableCompletedBasic ScienceHealthy Volunteers4
Not AvailableCompletedBasic ScienceMechanisms and Modulators of Placebo Analgesia in Healthy Volunteers1
Not AvailableCompletedBasic ScienceOxytocin / Placebo1
Not AvailableCompletedBasic SciencePosttraumatic Stress Disorders1
Not AvailableCompletedBasic ScienceSocial Behavior2
Not AvailableCompletedBasic ScienceSocial Intelligence1
Not AvailableCompletedDiagnosticImpact of Oxytocin on Social Learning1
Not AvailableCompletedPreventionBlood Loss,Surgical1
Not AvailableCompletedPreventionComplications; Cesarean Section1
Not AvailableCompletedPreventionPlacenta, Retained / Postpartum Hemorrhage1
Not AvailableCompletedPreventionPostpartum Hemorrhage4
Not AvailableCompletedPreventionProlonged First Stage Labor - Prevention1
Not AvailableCompletedTreatmentAdverse Effect of Oxytocic Drugs / Inappropriate Dose of Drug Administered / Uterine Hemorrhage1
Not AvailableCompletedTreatmentAdverse Reaction to Oxytocin / Complications; Cesarean Section1
Not AvailableCompletedTreatmentAnaesthesia / Pregnancy Related1
Not AvailableCompletedTreatmentAutism Spectrum Disorder (ASD)1
Not AvailableCompletedTreatmentBirth; Delayed1
Not AvailableCompletedTreatmentCervical Ripening / Induction of Labour / Pregnancy1
Not AvailableCompletedTreatmentCervical Ripening / Premature Rupture of Membranes1
Not AvailableCompletedTreatmentCesarean Delivery / Induction of Uterine contractions1
Not AvailableCompletedTreatmentChronic Daily Headache1
Not AvailableCompletedTreatmentChronic Tinnitus1
Not AvailableCompletedTreatmentFrontotemporal Dementia / Pick's Disease1
Not AvailableCompletedTreatmentHeart; Disease,Complicating Pregnancy, Pre-existing1
Not AvailableCompletedTreatmentIdiopathic Infertility1
Not AvailableCompletedTreatmentIndigestion / Lack of Satiety1
Not AvailableCompletedTreatmentInduction of Labour1
Not AvailableCompletedTreatmentInterstitial Cystitis1
Not AvailableCompletedTreatmentMarijuana Dependence2
Not AvailableCompletedTreatmentPostpartum Hemorrhage8
Not AvailableCompletedTreatmentPregnancy Termination1
Not AvailableCompletedTreatmentSchizoaffective Disorders / Schizophrenic Disorders1
Not AvailableCompletedTreatmentSchizophrenic Disorders1
Not AvailableEnrolling by InvitationPreventionBlood Loss / Dysfunctional Labor / Uterine Atony1
Not AvailableNot Yet RecruitingNot AvailableCervical Ripening1
Not AvailableNot Yet RecruitingNot AvailableSchizophrenia Spectrum1
Not AvailableNot Yet RecruitingBasic ScienceAlcohol Abuse / Anxiety Disorder / Stress Disorders, Post-Traumatic1
Not AvailableNot Yet RecruitingBasic ScienceHealthy Volunteers2
Not AvailableNot Yet RecruitingTreatmentPremature Rupture of Membranes / Unfavorable Cervix1
Not AvailableRecruitingNot AvailableBorderline Personality Disorder (BPD)1
Not AvailableRecruitingNot AvailableDependence, Cocaine1
Not AvailableRecruitingBasic ScienceEmotions / Mental Health Wellness 1 / Social Behavior1
Not AvailableRecruitingBasic ScienceHealthy Volunteers2
Not AvailableRecruitingBasic ScienceInteroception1
Not AvailableRecruitingBasic ScienceIntrusive Memories1
Not AvailableRecruitingBasic ScienceMaternal Behavior2
Not AvailableRecruitingOtherSleep Apnea and Cardiovascular Diseases / Sleep Apnea Syndrome1
Not AvailableRecruitingPreventionDelayed Umbilical Cord Clamping Benefits / Intraventricular Hemorrhage / Postpartum Hemorrhage1
Not AvailableRecruitingPreventionMaternal Infection During Pregnancy (Diagnosis) / Neonatal Infections1
Not AvailableRecruitingPreventionPostpartum Bleeding1
Not AvailableRecruitingPreventionPregnancy / Premature Rupture of Membranes / Preterm Premature Rupture of Membranes1
Not AvailableRecruitingTreatmentASD / Autism Spectrum Disorder (ASD) / PDD / Pervasive Developmental Disorder NOS1
Not AvailableRecruitingTreatmentBlood Loss / Dilation and Evacuation / Hemorrhage / Pregnancy termination therapy1
Not AvailableRecruitingTreatmentFailed Induction of Labor2
Not AvailableRecruitingTreatmentInduction of Labour1
Not AvailableRecruitingTreatmentLabor; Forced or Induced, Affecting Fetus or Newborn / Pregnancy1
Not AvailableRecruitingTreatmentLabour Pain / Pregnancy1
Not AvailableRecruitingTreatmentMedical Induction of Labor Affecting Newborn1
Not AvailableRecruitingTreatmentNicotine Dependence1
Not AvailableRecruitingTreatmentPostpartum Hemorrhage4
Not AvailableRecruitingTreatmentPrader-Willi Syndrome2
Not AvailableRecruitingTreatmentPremature Rupture of Fetal Membranes1
Not AvailableRecruitingTreatmentSchizophrenic Disorders1
Not AvailableSuspendedTreatmentAnxiety Disorder1
Not AvailableSuspendedTreatmentSchizophrenic Disorders2
Not AvailableTerminatedTreatmentDysthymia Disorder / Major Depressive Disorder (MDD)1
Not AvailableUnknown StatusBasic ScienceASD / Autism, Early Infantile1
Not AvailableUnknown StatusBasic ScienceEffects of Oxytocin on Borderline Personality Disorder1
Not AvailableUnknown StatusBasic ScienceHealthy Volunteers1
Not AvailableUnknown StatusBasic SciencePsychiatric Disorders1
Not AvailableUnknown StatusDiagnosticPostpartum Depression1
Not AvailableUnknown StatusPreventionPrevention of Post Partum Haemorrhage1
Not AvailableUnknown StatusPreventionStress Disorders, Post-Traumatic1
Not AvailableUnknown StatusTreatmentCervix; Insufficient Dilatation in Labor1
Not AvailableUnknown StatusTreatmentInduction of Labor in Multiparous Women1
Not AvailableUnknown StatusTreatmentInduction of Labour / Pregnancy1
Not AvailableUnknown StatusTreatmentParanoia / Schizophrenic Disorders / Social Cognition Deficits / Social Dysfunction1
Not AvailableUnknown StatusTreatmentPostpartum Hemorrhage1
Not AvailableUnknown StatusTreatmentInduction of Uterine contractions1
Not AvailableWithdrawnBasic ScienceCoagulation Changes With Oxytocin1
Not AvailableWithdrawnBasic SciencePain1
Not AvailableWithdrawnBasic ScienceSchizophrenic Disorders1
Pharmacoeconomics
Manufacturers
  • App pharmaceuticals llc
  • Baxter healthcare corp anesthesia critical care
  • Teva parenteral medicines inc
  • Abbott laboratories pharmaceutical products div
  • Jhp pharmaceuticals llc
  • Novartis pharmaceuticals corp
Packagers
Dosage forms
FormRouteStrength
InjectionIntramuscular; Intravenous10 [USP'U]/mL
Injection, solutionIntramuscular; Intravenous10 [USP'U]/mL
Injection, solutionIntravenous10 [USP'U]/1000mL
Injection, solutionIntravenous2 [USP'U]/100mL
Injection, solutionIntravenous20 [USP'U]/500mL
Injection, solutionIntravenous30 [USP'U]/1000mL
Injection, solutionIntravenous30 [USP'U]/500mL
LiquidIntramuscular; Intravenous10 unit
SolutionIntramuscular; Intravenous10 unit
InjectionIntravenous10 [iU]/mL
Prices
Unit descriptionCostUnit
Oxytocin powder1762.25USD g
Oxytocin 10 unit/ml vial9.84USD vial
Pitocin 10 unit/ml vial1.6USD ml
Oxytocin-lr 40 unit/500 ml0.09USD ml
Oxytocin-d5w-lr 40 unit/500 ml0.07USD ml
Oxytocin-d5lr 30 unit/500 ml0.06USD ml
Oxytocin-lr 20 unit/500 ml0.06USD ml
Oxytocin-d5w-lr 15 unit/500 ml0.05USD ml
Oxytocin-d5w-lr 20 unit/500 ml0.05USD ml
Oxytocin-lr 10 unit/500 ml0.05USD ml
Oxytocin-d5-1/4ns 15 unit/2500.04USD ml
Oxytocin-d5w 40 unit/1000 ml0.04USD ml
Oxytocin-d5w-lr 10 unit/500 ml0.04USD ml
Oxytocin-d5w 20 unit/1000 ml0.03USD ml
Oxytocin-d5w 30 unit/1000 ml0.03USD ml
Oxytocin-lr 30 unit/500 ml0.03USD ml
Oxytocin-ns 30 unit/1000 ml0.03USD ml
Oxytocin-d5w 10 unit/1000 ml0.02USD ml
Oxytocin-lr 5 unit/500 ml0.02USD ml
Oxytocin-ns 40 unit/1000 ml0.02USD ml
Oxytocin-d5-1/2ns 10 unit/10000.01USD ml
Oxytocin-d5-1/2ns 20 unit/10000.01USD ml
Oxytocin-d5-1/2ns 30 unit/10000.01USD ml
Oxytocin-d5-ns 20 unit/1000 ml0.01USD ml
Oxytocin-ns 10 unit/1000 ml0.01USD ml
Oxytocin-ns 20 unit/1000 ml0.01USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateLiquid
Experimental Properties
PropertyValueSource
hydrophobicity-2.7Not Available
isoelectric point5.51Not Available
Taxonomy
DescriptionNot Available
KingdomOrganic Compounds
Super ClassOrganic Acids
ClassCarboxylic Acids and Derivatives
Sub ClassAmino Acids, Peptides, and Analogues
Direct ParentPeptides
Alternative ParentsNot Available
SubstituentsNot Available
Molecular FrameworkNot Available
External DescriptorsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Vasopressin receptor activity
Specific Function:
Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
Gene Name:
OXTR
Uniprot ID:
P30559
Molecular Weight:
42770.99 Da
References
  1. Spyranti Z, Fragiadaki M, Magafa V, Borovickova L, Spyroulias GA, Cordopatis P, Slaninova J: In position 7 L- and D-Tic-substituted oxytocin and deamino oxytocin: NMR study and conformational insights. Amino Acids. 2010 Jul;39(2):539-48. doi: 10.1007/s00726-009-0470-1. Epub 2010 Jan 27. [PubMed:20108008 ]
  2. Frantz MC, Rodrigo J, Boudier L, Durroux T, Mouillac B, Hibert M: Subtlety of the structure-affinity and structure-efficacy relationships around a nonpeptide oxytocin receptor agonist. J Med Chem. 2010 Feb 25;53(4):1546-62. doi: 10.1021/jm901084f. [PubMed:20104850 ]
  3. Gimpl G, Reitz J, Brauer S, Trossen C: Oxytocin receptors: ligand binding, signalling and cholesterol dependence. Prog Brain Res. 2008;170:193-204. doi: 10.1016/S0079-6123(08)00417-2. [PubMed:18655883 ]
  4. Ahn TG, Han SJ, Cho YS, An TH, Pak SC, Flouret G: In vivo activity of the potent oxytocin antagonist on uterine activity in the rat. In Vivo. 2004 Nov-Dec;18(6):763-6. [PubMed:15646817 ]
  5. Furman DJ, Chen MC, Gotlib IH: Variant in oxytocin receptor gene is associated with amygdala volume. Psychoneuroendocrinology. 2011 Jul;36(6):891-7. doi: 10.1016/j.psyneuen.2010.12.004. Epub 2011 Jan 3. [PubMed:21208749 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
binder
General Function:
Not Available
Specific Function:
Neurophysin 1 specifically binds oxytocin.Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland.
Gene Name:
OXT
Uniprot ID:
P01178
Molecular Weight:
12721.51 Da
References
  1. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  2. Land H, Grez M, Ruppert S, Schmale H, Rehbein M, Richter D, Schutz G: Deduced amino acid sequence from the bovine oxytocin-neurophysin I precursor cDNA. Nature. 1983 Mar 24-30;302(5906):342-4. [PubMed:6687626 ]
  3. Rao VV, Loffler C, Battey J, Hansmann I: The human gene for oxytocin-neurophysin I (OXT) is physically mapped to chromosome 20p13 by in situ hybridization. Cytogenet Cell Genet. 1992;61(4):271-3. [PubMed:1486803 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Serine-type peptidase activity
Specific Function:
Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.
Gene Name:
PREP
Uniprot ID:
P48147
Molecular Weight:
80698.945 Da
References
  1. Irazusta J, Silveira PF, Gil J, Varona A, Casis L: Effects of hydrosaline treatments on prolyl endopeptidase activity in rat tissues. Regul Pept. 2001 Sep 15;101(1-3):141-7. [PubMed:11495689 ]
  2. Bausback HH, Ward PE: Vascular, post proline cleaving enzyme: metabolism of vasoactive peptides. Adv Exp Med Biol. 1986;198 Pt A:397-404. [PubMed:3544718 ]
  3. Yoshimoto T, Nishimura T, Kita T, Tsuru D: Post-proline cleaving enzyme (prolyl endopeptidase) from bovine brain. J Biochem. 1983 Oct;94(4):1179-90. [PubMed:6361010 ]
Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23