tRNA (cytidine(34)-2'-O)-methyltransferase
Details
- Name
- tRNA (cytidine(34)-2'-O)-methyltransferase
- Synonyms
- 2.1.1.207
- tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmL
- Gene Name
- trmL
- Organism
- Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
- Amino acid sequence
>lcl|BSEQ0011796|tRNA (cytidine(34)-2'-O)-methyltransferase MLDIVLYEPEIPQNTGNIIRLCANTGFRLHLIEPLGFTWDDKRLRRSGLDYHEFAEIKRH KTFEAFLESEKPKRLFALTTKGCPAHSQVKFKLGDYLMFGPETRGIPMSILNEMPMEQKI RIPMTANSRSMNLSNSVAVTVYEAWRQLGYKGAVNLPEVK
- Number of residues
- 160
- Molecular Weight
- 18401.245
- Theoretical pI
- 9.43
- GO Classification
- FunctionsRNA binding / S-adenosylmethionine-dependent methyltransferase activity / tRNA methyltransferase activityComponentscytoplasm
- General Function
- Trna methyltransferase activity
- Specific Function
- Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide.
- Pfam Domain Function
- SpoU_methylase (PF00588)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0011797|tRNA (cytidine(34)-2'-O)-methyltransferase (trmL) ATGTTAGATATCGTTTTATATGAACCAGAAATCCCACAAAATACTGGTAACATTATTCGA CTTTGTGCCAACACAGGATTTCGCTTGCACTTAATTGAACCACTAGGTTTCACTTGGGAT GATAAACGCTTACGCCGCTCAGGTTTGGATTATCACGAATTTGCGGAAATCAAACGCCAC AAAACCTTTGAAGCCTTTTTAGAAAGCGAAAAACCCAAACGCCTTTTTGCACTTACAACA AAAGGCTGTCCAGCACATAGCCAAGTGAAATTTAAACTTGGGGATTATTTAATGTTTGGC CCAGAAACTCGTGGCATTCCGATGTCAATTTTAAATGAAATGCCGATGGAACAAAAAATC CGCATTCCAATGACTGCCAATAGCCGCAGTATGAACTTGTCTAATTCTGTTGCAGTAACG GTTTATGAAGCGTGGCGACAATTAGGCTATAAAGGTGCGGTAAATTTACCAGAAGTAAAA TAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P44868 UniProtKB Entry Name TRML_HAEIN GenBank Gene ID L42023 - General References
- Fleischmann RD, Adams MD, White O, Clayton RA, Kirkness EF, Kerlavage AR, Bult CJ, Tomb JF, Dougherty BA, Merrick JM, et al.: Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science. 1995 Jul 28;269(5223):496-512. [Article]
- Lim K, Zhang H, Tempczyk A, Krajewski W, Bonander N, Toedt J, Howard A, Eisenstein E, Herzberg O: Structure of the YibK methyltransferase from Haemophilus influenzae (HI0766): a cofactor bound at a site formed by a knot. Proteins. 2003 Apr 1;51(1):56-67. [Article]