Purine nucleotide phosphorylase, putative
Details
- Name
- Purine nucleotide phosphorylase, putative
- Synonyms
- EC 2.4.2.3
- Gene Name
- Not Available
- Organism
- Plasmodium falciparum (isolate 3D7)
- Amino acid sequence
>lcl|BSEQ0022444|Purine nucleotide phosphorylase, putative MDNLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFL CVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHL LIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAV VEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKL ATKYA
- Number of residues
- 245
- Molecular Weight
- 26857.88
- Theoretical pI
- 6.49
- GO Classification
- Functionsuridine phosphorylase activityProcessesnucleoside metabolic process
- General Function
- Uridine phosphorylase activity
- Specific Function
- Not Available
- Pfam Domain Function
- PNP_UDP_1 (PF01048)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0022445|Purine nucleotide phosphorylase, putative ATGGATAATCTTTTACGCCATTTAAAAATAAGCAAGGAACAAATAACACCAGTTGTTTTA GTTGTAGGAGATCCAGGAAGAGTCGACAAGATAAAAGTGGTATGTGATTCATATGTTGAT TTAGCATACAACAGAGAATACAAAAGTGTAGAATGTCATTATAAGGGTCAGAAATTTTTA TGTGTTAGTCACGGTGTAGGTTCAGCAGGATGTGCTGTATGTTTTGAAGAATTATGTCAA AATGGAGCTAAAGTAATTATTCGTGCAGGTTCATGTGGATCTCTTCAACCAGATTTAATA AAAAGAGGTGACATATGTATATGTAATGCAGCTGTTAGGGAAGATAGAGTATCTCATTTA TTAATTCATGGAGATTTCCCAGCTGTTGGTGATTTTGATGTTTATGATACTTTAAATAAA TGTGCACAAGAATTGAATGTGCCAGTTTTTAATGGTATCAGTGTTTCATCAGATATGTAT TATCCCAATAAAATTATTCCTTCAAGATTAGAAGATTATTCTAAAGCTAATGCTGCTGTT GTTGAAATGGAACTAGCCACTCTTATGGTTATTGGAACCTTAAGAAAAGTTAAAACAGGT GGTATTCTTATTGTTGATGGATGTCCATTCAAATGGGACGAAGGGGATTTCGACAACAAT TTAGTTCCTCACCAATTAGAAAATATGATTAAAATAGCCTTAGGAGCATGTGCAAAATTA GCAACCAAATATGCCTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q8I3X4 UniProtKB Entry Name Q8I3X4_PLAF7 GenBank Gene ID AL929352 - General References
- Shi W, Ting LM, Kicska GA, Lewandowicz A, Tyler PC, Evans GB, Furneaux RH, Kim K, Almo SC, Schramm VL: Plasmodium falciparum purine nucleoside phosphorylase: crystal structures, immucillin inhibitors, and dual catalytic function. J Biol Chem. 2004 Apr 30;279(18):18103-6. Epub 2004 Feb 23. [Article]
- Schnick C, Robien MA, Brzozowski AM, Dodson EJ, Murshudov GN, Anderson L, Luft JR, Mehlin C, Hol WG, Brannigan JA, Wilkinson AJ: Structures of Plasmodium falciparum purine nucleoside phosphorylase complexed with sulfate and its natural substrate inosine. Acta Crystallogr D Biol Crystallogr. 2005 Sep;61(Pt 9):1245-54. Epub 2005 Aug 16. [Article]
- Chaikuad A, Brady RL: Conservation of structure and activity in Plasmodium purine nucleoside phosphorylases. BMC Struct Biol. 2009 Jul 3;9:42. doi: 10.1186/1472-6807-9-42. [Article]
- Donaldson TM, Ting LM, Zhan C, Shi W, Zheng R, Almo SC, Kim K: Structural determinants of the 5'-methylthioinosine specificity of Plasmodium purine nucleoside phosphorylase. PLoS One. 2014 Jan 8;9(1):e84384. doi: 10.1371/journal.pone.0084384. eCollection 2014. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB03881 (2S,3R,4S,5S)-3,4-Dihydroxy-2-[(methylsulfanyl)methyl]-5-(4-oxo-4,5-dihydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl)pyrrolidinium experimental unknown Details DB11638 Artenimol approved, experimental, investigational unknown ligand Details