Glycoside Hydrolases

Name
Glycoside Hydrolases
Accession Number
DBCAT000166
Description
Not Available
Drugs
DrugDrug Description
Hyaluronidase (ovine)A purified form of sheep hyaluronidase enzyme used as an adjunct in subcutaneous rehydration therapy and to increase absorption of other drugs and radiopaque imaging agents.
ImigluceraseA form of recombinant human beta-glucocerebrosidase enzyme used to replace the deficient endogenous enzyme in the treatment of Gaucher disease.
AlgluceraseA form of recombinant beta-glucocerebrosidase enzyme used to replace the deficient endogenous enzyme in the treatment of Gaucher disease.
Agalsidase betaA form of recombinant human alpha-galactosidase A enzyme used to treat Fabry disease, a genetic deficiency in the enzyme leading to buildup of globotriaosylceramide.
Alglucosidase alfaAn acid alpha- glucosidase (GAA) derivative used as an enzyme replacement therapy for the treatment of Pompe disease in infants and pediatric patients caused by GAA deficiency.
ALTU-135Investigated for use/treatment in cystic fibrosis and pancreatic disorders.
SacrosidaseAn enzyme replacement therapy used for the treatment of congenital sucrase-isomaltase deficiency (CSID).
Taliglucerase alfaA hydrolytic lysosomal glucocerebroside specific enzyme, used for long term enzyme replacement therapy in patients with Type 1 Gaucher disease.
Pancrelipase amylaseA lipase used to treat pancreatic exocrine insufficiency.
AviscumineCy 503 is under investigation in clinical trial NCT00658437 (Aviscumine for the Treatment of Malignant Melanoma Stage IV After Failure of Prior Therapy).
LysozymeNot Annotated
TilactaseA beta-D-galactosidase use to treat lactose intolerance.
Vorhyaluronidase alfaIndicated as an adjuvant to increase the absorption and dispersion of other injected drugs; for hypodermoclysis; and as an adjunct in subcutaneous urography for improving resorption of radiopaque agents.
HyaluronidaseAn enzyme used to improve the absorption and dispersion of parenterally administered fluids, drugs, and contrast agents.
Valanafusp alfaValanafusp alfa is under investigation in clinical trial NCT03071341 (Extension Study Evaluating Long Term Safety and Activity of AGT-181 in Children With MPS I).
Drugs & Drug Targets
DrugTargetType
Hyaluronidase (ovine)Transforming growth factor beta-1target
Hyaluronidase (ovine)Serum albumincarrier
Hyaluronidase (ovine)Hyaluronantarget
ImigluceraseGlucocerebrosidetarget
AlgluceraseGlucocerebrosidetarget
Agalsidase betaGlobotriaosylceramidetarget
Alglucosidase alfaCation-dependent mannose-6-phosphate receptortarget
Alglucosidase alfaGlycogentarget
Taliglucerase alfaGlucocerebrosidetarget
Pancrelipase amylaseDietary starchtarget
TilactaseLactosetarget
Vorhyaluronidase alfaHyaluronantarget
Vorhyaluronidase alfaTransforming growth factor beta-1target
Vorhyaluronidase alfaSerum albumincarrier
HyaluronidaseHyaluronic acidtarget