Hydroxylamines

Organic compounds that contain the (-NH2OH) radical.
DrugDrug NameDrug Description
DB00176FluvoxamineA selective serotonin-reuptake inhibitor used to treat obsessive-compulsive disorder.
DB00551Acetohydroxamic acidA synthetic urea derivative used to treat urea splitting bacterial infections of the urinary tract.
DB00733PralidoximeA cholinesterase reactivator used to treat organophosphate poisoning.
DB00746DeferoxamineA chelating agent used to treat iron or aluminum toxicity and some blood transfusion dependent anemias.
DB00786MarimastatFor the treatment of various cancers
DB01630SC-74020Not Available
DB01747CoprogenNot Available
DB01924Benzhydroxamic AcidNot Available
DB02052Indirubin-3'-monoximeNot Available
DB02071WAY-151693Not Available
DB02079Aminooxyacetic acidA compound that inhibits aminobutyrate aminotransferase activity in vivo, thereby raising the level of gamma-aminobutyric acid in tissues. [PubChem]
DB02546VorinostatA histone deacetylase (HDAC) inhibitor used for the treatment of cutaneous manifestations in patients with progressive, persistent, or recurrent cutaneous T- cell lymphoma (CTCL) following prior systemic therapies.
DB02660FilaminastFilaminast is a phosphodiesterase 4 inhibitor (PDE4 inhibitor). As such, has potential in the treatment of asthma and chronic obstructive pulmonary disease (COPD).
DB03436GallichromeNot Available
DB03734XylarohydroxamateNot Available
DB04368Bb-3497Not Available
DB044964-Phospho-D-Erythronohydroxamic AcidNot Available
DB04857BrasofensineFor the treatment of Parkinson's Disease.
DB05015BelinostatA histone deacetylase (HDAC) inhibitor used for the treatment of patients with relapsed or refractory peripheral T-cell lymphoma (PTCL).
DB06297LX-2931Investigated for use/treatment in rheumatoid arthritis, inflammatory disorders (unspecified), and autoimmune diseases.
DB06311DarapladibInvestigated for use/treatment in atherosclerosis.
DB06603PanobinostatA non-selective histone deacetylase inhibitor used to treat multiple myeloma in combination with other antineoplastic agents.
DB06680AsoprisnilInvestigated for use/treatment in uterine fibroids.
DB06713NorelgestrominA progestin used for the prevention of pregnancy in women who elect to use a transdermal patch as a method of contraception.
DB08912DabrafenibA kinase inhibitor used to treat patients with specific types of melanoma, non-small cell lung cancer, and thyroid cancer.
DB08925AdrafinilUsed to relieve excessive sleepiness and inattention in elderly patients.
DB08955IbuproxamIbuproxam is a non steroidal anti-inflammatory drug (NSAID).
DB09163Technetium Tc-99m exametazimeA radiopharmaceutical diagnostic agent used as an adjunct for scintigraphy in the detection of altered regional cerebral perfusion in stroke.
DB11781TosedostatTosedostat has been used in trials studying the treatment and supportive care of AML, Leukemia, Pancreas Cancer, Multiple Myeloma, and Pancreatic Cancer, among others. Tosedostat is an inhibitor of the...
DB11912LanopepdenLanopepden has been used in trials studying the treatment of Pneumonia, Infections, Bacterial, Skin Diseases, Infectious, and Skin Infections, Bacterial.
DB12174CUDC-101CUDC-101 has been used in trials studying the treatment of Cancer, Tumors, Liver Cancer, Breast Cancer, and Gastric Cancer, among others.
DB12259CG-200745Cg200745 has been used in trials studying the treatment of Solid Tumour.
DB12376RicolinostatRicolinostat is under investigation for the treatment of Breast Carcinoma and Metastatic Breast Cancer.
DB12382R-306465R306465 has been used in trials studying the treatment of Neoplasms.
DB12392ResminostatResminostat has been used in trials studying the treatment of Sezary Syndrome, Mycosis fungoides, Hodgkin's Lymphoma, Hepatocellular Carcinoma, and Lymphoma, T-Cell, Cutaneous, among others.
DB12565AbexinostatAbexinostat has been used in trials studying the treatment of Sarcoma, Lymphoma, Leukemia, Lymphocytic, and Hodgkin Disease, among others. It is a novel, broad-spectrum hydroxamic acid-based inhibitor of histone deacetylase...
DB12847PyroxamidePyroxamide has been used in trials studying the treatment of Leukemia, Lymphoma, Small Intestine Cancer, Precancerous Condition, and Myelodysplastic Syndromes, among others.
DB12948DidoxDidox has been used in trials studying the supportive care of Gastric Cancer.
DB12985QuisinostatQuisinostat has been used in trials studying the treatment of Lymphoma, Neoplasms, Myelodysplastic Syndromes, and Advanced or Refractory Leukemia.
DB13346BufexamacAn NSAID used to treat skin conditions like atopic eczema and inflammatory dermatoses.
DB13750ObidoximeNot Annotated
DB08490CTS-1027CTS-1027 has been used in trials studying the treatment of Hepatitis C and Chronic Hepatitis C Virus Infection.
DB02446Glutamine hydroxamateNot Available
DB14979MartinostatMartinostat is under investigation in clinical trial NCT03721211 (Imaging With [11C]Martinostat in Breast Cancer).
DB15321TefinostatTefinostat is under investigation in clinical trial NCT02759601 (Dose Escalation Trial of Tefinostat for Cancer Associated Inflamation in Hepatocellular Carcinoma (HCC)).
DB11717EpacadostatEpacadostat has been used in trials studying the treatment of HL, Melanoma, Glioblastoma, Mucosal Melanoma, and Ovarian Carcinoma, among others.
DB13805ReposalReposal is a barbiturate derivative invented in the 1960s in Denmark that has sedative, hypnotic and anticonvulsant properties. It was used primarily in the treatment of insomnia.
DrugDrug NameTargetType
DB00176FluvoxamineSodium-dependent serotonin transportertarget
DB00176FluvoxamineCytochrome P450 1A2enzyme
DB00176FluvoxamineCytochrome P450 2D6enzyme
DB00176FluvoxamineCytochrome P450 2C9enzyme
DB00176FluvoxamineCytochrome P450 2C19enzyme
DB00176FluvoxamineCytochrome P450 1A1enzyme
DB00176FluvoxamineCytochrome P450 3A4enzyme
DB00176FluvoxamineCytochrome P450 3A Subfamilyenzyme
DB00176FluvoxamineP-glycoprotein 1transporter
DB00176FluvoxamineCytochrome P450 2B6enzyme
DB00176FluvoxaminePotassium voltage-gated channel subfamily H member 2target
DB00176FluvoxamineBile salt export pumptransporter
DB00551Acetohydroxamic acidUrease subunit alphatarget
DB00551Acetohydroxamic acidMacrophage metalloelastasetarget
DB00733PralidoximeAcetylcholinesterasetarget
DB00733PralidoximeCholinesterasetarget
DB00746DeferoxamineXanthine dehydrogenase/oxidaseenzyme
DB00746DeferoxamineIrontarget
DB00746DeferoxamineAluminumtarget
DB00746DeferoxamineAmyloid beta A4 proteintarget
DB00786Marimastat72 kDa type IV collagenasetarget
DB00786MarimastatMatrix metalloproteinase-9target
DB00786MarimastatStromelysin-1target
DB00786MarimastatInterstitial collagenasetarget
DB00786MarimastatStromelysin-2target
DB00786MarimastatMatrilysintarget
DB00786MarimastatNeutrophil collagenasetarget
DB00786MarimastatStromelysin-3target
DB00786MarimastatMacrophage metalloelastasetarget
DB00786MarimastatCollagenase 3target
DB00786MarimastatMatrix metalloproteinase-14target
DB00786MarimastatMatrix metalloproteinase-15target
DB00786MarimastatMatrix metalloproteinase-16target
DB00786MarimastatMatrix metalloproteinase-17target
DB00786MarimastatMatrix metalloproteinase-19target
DB00786MarimastatMatrix metalloproteinase-20target
DB00786MarimastatMatrix metalloproteinase-21target
DB00786MarimastatMatrix metalloproteinase-23target
DB00786MarimastatMatrix metalloproteinase-24target
DB00786MarimastatMatrix metalloproteinase-25target
DB00786MarimastatMatrix metalloproteinase-26target
DB00786MarimastatMatrix metalloproteinase-27target
DB00786MarimastatMatrix metalloproteinase-28target
DB01630SC-7402072 kDa type IV collagenasetarget
DB01747CoprogenIron(3+)-hydroxamate-binding protein FhuDtarget
DB02052Indirubin-3'-monoximeGlycogen synthase kinase-3 betatarget
DB02052Indirubin-3'-monoximeCyclin-dependent kinase 5target
DB02052Indirubin-3'-monoximeCyclin-dependent kinase 1target
DB02052Indirubin-3'-monoximeCyclin-dependent kinase 5 activator 1target
DB02052Indirubin-3'-monoximeCyclin-dependent kinase 2target
DB02052Indirubin-3'-monoximeAryl hydrocarbon receptortarget
DB02071WAY-151693Collagenase 3target
DB02079Aminooxyacetic acidSerine--pyruvate aminotransferasetarget
DB02546VorinostatHistone deacetylase 1target
DB02546VorinostatHistone deacetylase 2target
DB02546VorinostatHistone deacetylase 3target
DB02546VorinostatHistone deacetylase 6target
DB02546VorinostatHistone deacetylase 8target
DB02546VorinostatAcetoin utilization proteintarget
DB02660FilaminastcAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
DB03436GallichromeIron(3+)-hydroxamate-binding protein FhuDtarget
DB03734XylarohydroxamateGlucarate dehydratasetarget
DB04368Bb-3497Peptide deformylasetarget
DB04368Bb-3497Peptide deformylase, mitochondrialtarget
DB044964-Phospho-D-Erythronohydroxamic AcidRibose-5-phosphate isomerase Btarget
DB04857BrasofensineDopamine D2 receptortarget
DB05015BelinostatHistone deacetylasetarget
DB05015BelinostatCytochrome P450 1A2enzyme
DB05015BelinostatUDP-glucuronosyltransferase 1-4enzyme
DB05015BelinostatCytochrome P450 2C8enzyme
DB05015BelinostatCytochrome P450 2C9enzyme
DB05015BelinostatP-glycoprotein 1transporter
DB06311DarapladibCytosolic phospholipase A2target
DB06603PanobinostatCytochrome P450 2D6enzyme
DB06603PanobinostatCytochrome P450 3A4enzyme
DB06603PanobinostatP-glycoprotein 1transporter
DB06603PanobinostatHistone deacetylasetarget
DB06680AsoprisnilProgesterone receptortarget
DB06713NorelgestrominSteryl-sulfataseenzyme
DB06713NorelgestrominProgesterone receptortarget
DB06713NorelgestrominSerum albumintarget
DB06713NorelgestrominAndrogen receptortarget
DB06713NorelgestrominCytochrome P450 3A4enzyme
DB08912DabrafenibCytochrome P450 3A4enzyme
DB08912DabrafenibCytochrome P450 2C8enzyme
DB08912DabrafenibP-glycoprotein 1transporter
DB08912DabrafenibATP-binding cassette sub-family G member 2transporter
DB08912DabrafenibSolute carrier organic anion transporter family member 1B1transporter
DB08912DabrafenibSolute carrier organic anion transporter family member 1B3transporter
DB08912DabrafenibSolute carrier family 22 member 6transporter
DB08912DabrafenibSolute carrier family 22 member 8transporter
DB08912DabrafenibSerine/threonine-protein kinase B-raftarget
DB08912DabrafenibRAF proto-oncogene serine/threonine-protein kinasetarget
DB08912DabrafenibSerine/threonine-protein kinase SIK1target
DB08912DabrafenibSerine/threonine-protein kinase Nek11target
DB08912DabrafenibLIM domain kinase 1target
DB08912DabrafenibCytochrome P450 2B6enzyme
DB08912DabrafenibCytochrome P450 2C9enzyme
DB11781TosedostatPuromycin-sensitive aminopeptidasetarget
DB11781TosedostatLeukotriene A-4 hydrolasetarget
DB12565AbexinostatHistone deacetylase 1target
DB13346BufexamacProstaglandin G/H synthase 1target
DB13346BufexamacProstaglandin G/H synthase 2target
DB13346BufexamacHistone deacetylase 6target
DB13346BufexamacHistone deacetylase 10target
DB08490CTS-1027Collagenase 3target
DB02446Glutamine hydroxamateGlutamine--fructose-6-phosphate aminotransferase [isomerizing]target