Appetite Depressants

Agents that are used to suppress appetite.
DrugDrug NameDrug Description
DB00191PhentermineA sympathomimetic anorectic agent used as a short-term adjunct therapy that is included in a regimen of weight reduction in cases of exogenous obesity.
DB00397PhenylpropanolamineA sympathomimetic that was previously used in nasal decongestants and weight loss products, but has been withdrawn by the FDA due to safety risks and lack of efficacy.
DB00830PhenmetrazineUsed as an anorectic in the treatment of obesity.
DB00937DiethylpropionAn appetite suppressant used for the short term treatment of exogenous obesity in addition to calorie restriction.
DB01105SibutramineA norepinephrine, serotonin and dopamine reuptake inhibitor indicated to assist with weight loss in obesity.
DB01486CathineUsed to decrease appetite.
DB06230NalmefeneAn opioid antagonist used in conjunction with psychosocial support to help adults with alcohol dependence reduce alcohol consumption.
DB06554GaboxadolInvestigated for use/treatment in sleep disorders and insomnia.
DB09022BenfluorexBenfluorex is an anorectic and hypolipidemic agent that is structurally related to fenfluramine. It was patented and manufactured by a French pharmaceutical company Servier. The European Medicines Agency (EMA) recommended...
DrugDrug NameTargetType
DB00191PhentermineSodium-dependent noradrenaline transportertarget
DB00191PhentermineSodium-dependent dopamine transportertarget
DB00191PhentermineAmine oxidase [flavin-containing] Atarget
DB00191PhentermineAmine oxidase [flavin-containing] Btarget
DB00191PhentermineSodium-dependent serotonin transportertarget
DB00191PhenterminePro-neuropeptide Ytarget
DB00191PhentermineCytochrome P450 3A4enzyme
DB00397PhenylpropanolamineAmine oxidase [flavin-containing] Aenzyme
DB00397PhenylpropanolamineDopamine D1 receptortarget
DB00397PhenylpropanolamineBeta-1 adrenergic receptortarget
DB00397PhenylpropanolamineBeta-2 adrenergic receptortarget
DB00397PhenylpropanolamineAlpha-2 adrenergic receptorstarget
DB00830PhenmetrazineSodium-dependent noradrenaline transportertarget
DB00830PhenmetrazineSodium-dependent dopamine transportertarget
DB00937DiethylpropionSodium-dependent noradrenaline transportertarget
DB00937DiethylpropionSodium-dependent dopamine transportertarget
DB01105SibutramineSodium-dependent serotonin transportertarget
DB01105SibutramineSodium-dependent noradrenaline transportertarget
DB01105SibutramineCytochrome P450 3A4enzyme
DB01105SibutramineSodium-dependent dopamine transportertarget
DB06230NalmefeneMu-type opioid receptortarget
DB06230NalmefeneKappa-type opioid receptortarget
DB06230NalmefeneDelta-type opioid receptortarget
DB06230NalmefeneUDP-glucuronosyltransferase 2B7enzyme
DB06230NalmefeneUDP-glucuronosyltransferase 1-3enzyme
DB06230NalmefeneUDP-glucuronosyltransferase 1-8enzyme
DB06554GaboxadolProton-coupled amino acid transporter 1transporter