Purinergic P1 Receptor Antagonists

Compounds that bind to and block the stimulation of PURINERGIC P1 RECEPTORS.
DrugDrug NameDrug Description
DB00201CaffeineA stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness.
DB00277TheophyllineA xanthine used to manage the symptoms of asthma, COPD, and other lung conditions caused by reversible airflow obstruction.
DB00824EnprofyllineUsed in the management of symptoms of asthma. Also used in the treatment of peripheral vascular diseases and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy.
DB01223AminophyllineA bronchodilator consisting of theophylline that is used for the treatment of bronchospasm due to asthma, emphysema and chronic bronchitis.
DB06471NaxifyllineInvestigated for use/treatment in congestive heart failure.
DB06625VipadenantInvestigated for use/treatment in parkinson's disease.
DB11757IstradefyllineA selective adenoside A2A receptor antagonist indicated in adjunct to levodopa and carbidopa for the treatment of Parkinson's Disease.
DB129468-cyclopentyl-1,3-dipropylxanthineCPX has been used in trials studying the treatment of Cystic Fibrosis.
DrugDrug NameTargetType
DB00201CaffeineAdenosine receptor A1target
DB00201CaffeinecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
DB00201CaffeineAdenosine receptor A2atarget
DB00201CaffeineCytochrome P450 1A2enzyme
DB00201CaffeineRyanodine receptor 1target
DB00201CaffeineCytochrome P450 3A4enzyme
DB00201CaffeineCytochrome P450 3A5enzyme
DB00201CaffeineCytochrome P450 3A7enzyme
DB00201CaffeineCytochrome P450 2E1enzyme
DB00201CaffeineCytochrome P450 2C8enzyme
DB00201CaffeineCytochrome P450 2C9enzyme
DB00201CaffeineCytochrome P450 1A1enzyme
DB00201CaffeineCytochrome P450 1B1enzyme
DB00201CaffeineCytochrome P450 2D6enzyme
DB00201CaffeineCyclic nucleotide phosphodiesterasetarget
DB00201CaffeineDNA-dependent protein kinase catalytic subunittarget
DB00201CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformtarget
DB00201CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformtarget
DB00201CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformtarget
DB00201CaffeineInositol 1,4,5-trisphosphate receptortarget
DB00201CaffeineSerine-protein kinase ATMtarget
DB00201CaffeineATP-binding cassette sub-family G member 2transporter
DB00277TheophyllinecGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
DB00277TheophyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
DB00277TheophyllineAdenosine receptor A2btarget
DB00277TheophyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
DB00277TheophyllinecGMP-specific 3',5'-cyclic phosphodiesterasetarget
DB00277TheophyllineAdenosine receptor A1target
DB00277TheophyllineAdenosine receptor A2atarget
DB00277TheophyllineCytochrome P450 1A2enzyme
DB00277TheophyllineAdenosine deaminaseenzyme
DB00277TheophyllineCytochrome P450 2E1enzyme
DB00277TheophyllineCytochrome P450 3A4enzyme
DB00277TheophyllineSolute carrier family 22 member 7transporter
DB00277TheophyllineCytochrome P450 1A1enzyme
DB00277TheophyllineCytochrome P450 1B1enzyme
DB00277TheophyllineCytochrome P450 2D6enzyme
DB00277TheophyllineHistone deacetylase 2target
DB00277TheophyllineCopine-1target
DB00277TheophyllineMinor histocompatibility antigen H13target
DB00277TheophyllineNodal modulator 1target
DB00277TheophyllinePoly [ADP-ribose] polymerase 1target
DB00277TheophyllineProtein RIC-3target
DB00277TheophyllineTubulin monoglycylase TTLL3target
DB00824EnprofyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
DB00824EnprofyllineAdenosine receptor A2btarget
DB00824EnprofyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
DB00824EnprofyllineAdenosine receptor A1target
DB00824EnprofyllineAdenosine receptor A2atarget
DB00824EnprofyllineAdenosine receptor A3target
DB01223AminophyllinecGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
DB01223AminophyllineAdenosine receptor A3target
DB01223AminophyllineAdenosine receptor A1target
DB01223AminophyllineCytochrome P450 1A2enzyme
DB01223AminophyllineCytochrome P450 2E1enzyme
DB01223AminophyllineCytochrome P450 3A4enzyme
DB01223AminophyllineHistone deacetylase 2target
DB06471NaxifyllineAdenosine receptor A1target
DB11757IstradefyllineCytochrome P450 1A1enzyme
DB11757IstradefyllineCytochrome P450 3A4enzyme
DB11757IstradefyllineCytochrome P450 3A5enzyme
DB11757IstradefyllineCytochrome P450 1A2enzyme
DB11757IstradefyllineCytochrome P450 2B6enzyme
DB11757IstradefyllineCytochrome P450 2C8enzyme
DB11757IstradefyllineCytochrome P450 2C9enzyme
DB11757IstradefyllineCytochrome P450 2C18enzyme
DB11757IstradefyllineCytochrome P450 2D6enzyme
DB11757IstradefyllineCYP3Aenzyme
DB11757IstradefyllineP-glycoprotein 1transporter
DB11757IstradefyllineAdenosine receptor A2atarget
DB11757IstradefyllineAdenosine receptor A1target
DB11757IstradefyllineSerum albumincarrier
DB11757Istradefyllinealpha1-acid glycoproteincarrier
DB11757IstradefyllineATP-binding cassette sub-family G member 2transporter
DB11757IstradefyllineSolute carrier organic anion transporter family member 1B1transporter
DB11757IstradefyllineSolute carrier organic anion transporter family member 1B3transporter
DB11757IstradefyllineSolute carrier family 22 member 6transporter
DB11757IstradefyllinePOU domain, class 2, transcription factor 2transporter
DB11757IstradefyllineMultidrug and toxin extrusion protein 1transporter
DB11757IstradefyllineMultidrug and toxin extrusion protein 2transporter