Deoxyribonucleosides

A purine or pyrimidine base bonded to DEOXYRIBOSE.
DrugDrug NameDrug Indication
DB00242CladribineFor the treatment of active hairy cell leukemia (leukemic reticuloendotheliosis) as defined by clinically significant anemia, neutropenia, thrombocytopenia, or disease-related symptoms. Also used as an alternative agent for the treatment of chronic lymphocytic leukemia (CLL), low-grade non-Hodgkin's lymphoma, and cutaneous T-cell lymphoma.
DB00249IdoxuridineFor use in keratoconjunctivitis and keratitis caused by herpes simplex virus.
DB00322FloxuridineFor palliative management of gastrointestinal adenocarcinoma metastatic to the liver, when given by continuous regional intra-arterial infusion in carefully selected patients who are considered incurable by surgery or other means. Also for the palliative management of liver cancer (usually administered by hepatic intra-arterial infusion).
DB00432TrifluridineTrifluridine is used for the treatment of primay keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex virus, types 1 and 2 in ophthalmic solutions. Trifluridine, in combination with tipiracil as oral tablets, is indicated for the treatment of adult patients with metastatic colorectal cancer who have been previously treated with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, an anti-VEGF biological therapy, and if RAS wild-type, an anti-EGFR therapy [FDA Label].
DB00441GemcitabineGemcitabine is indicated for the treatment of advanced ovarian cancer that has relapsed at least 6 months after completion of platinum-based therapy; metastatic ovarian cancer; inoperable, locally advanced (Stage IIIA or IIIB), or metastatic (Stage IV) non-small cell lung cancer; and locally advanced (nonresectable Stage II or Stage III) or metastatic (Stage IV) adenocarcinoma of the pancreas.
DB00495ZidovudineUsed in combination with other antiretroviral agents for the treatment of human immunovirus (HIV) infections.
DB00552PentostatinFor the treatment of hairy cell leukaemia refractory to alpha interferon.
DB00649StavudineFor the treatment of human immunovirus (HIV) infections.
DB00709LamivudineFor the treatment of HIV infection and chronic hepatitis B (HBV).
DB00879EmtricitabineIndicated, in combination with other antiretroviral agents, for the treatment of HIV-1 infection in adults and for postexposure prophylaxis of HIV infection in health care workers and others exposed occupationally or nonoccupationally via percutaneous injury or mucous membrane or nonintact skin contact with blood, tissues, or other body fluids associated with risk for transmission of the virus.
DB00900DidanosineFor use, in combination with other antiretroviral agents, in the treatment of HIV-1 infection in adults.
DB00943ZalcitabineFor the treatment of Human immunovirus (HIV) infections in conjunction with other antivirals.
DB01048AbacavirFor the treatment of HIV-1 infection, in combination with other antiretroviral agents.
DB01101CapecitabineFor the treatment of patients with metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen. May also be used in combination with docetaxel for the treatment of metastatic breast cancer in patients who have failed to respond to, or recurred or relasped during or following anthracycline-containing chemotherapy. Capecitabine is used alone as an adjuvant therapy following the complete resection of primary tumor in patients with stage III colon cancer when monotherapy with fluroprymidine is preferred. The use or capecitabine in combination regimens for advanced gastric cancer is currently being investigated.
DB01265TelbivudineFor the treatment of chronic hepatitis B in adult and adolescent patients ≥16 years of age with evidence of viral replication and either evidence of persistent elevations in serum aminotransferases (ALT or AST) or histologically active disease.
DB022825'-Deoxy-5'-MethylthioadenosineNot Available
DB025028-Hydroxy-2'-DeoxyguanosineNot Available
DB036093-DeoxyguanosineNot Available
DB037165'-Fluoro-5'-DeoxyadenosineNot Available
DB04485ThymidineNot Available
DB05116ThymectacinInvestigated for use/treatment in colorectal cancer.
DB06198AlovudineInvestigated for use/treatment in HIV infection.
DB06236ElvucitabineInvestigated for use/treatment in hepatitis (viral, B) and HIV infection.
DB06433TezacitabineInvestigated for use/treatment in colorectal cancer, lung cancer, leukemia (unspecified), and gastric cancer.
DB08937TAS-102Not Available
DB12028BroxuridineNot Available
DB12045MericitabineNot Available
DB12074CensavudineNot Available
DB12156CordycepinNot Available
DB12423Fozivudine TidoxilNot Available
DB12470DexelvucitabineNot Available
DB12564Gemcitabine elaidateNot Available
DB12753RacivirNot Available
DB12855ApricitabineNot Available
DB12894RaluridineNot Available
DB12906LY-2334737Not Available
DB12947DoxifluridineNot Available
DB129575-fluoro-2'-deoxycytidineNot Available
DB13421EdoxudineEdoxudine was used in Europe, in the form of a topical antiviral, for the treatment of human herpes keratitis.[A32643] Human herpes keratitis is an inflammation of the cornea in the eye caused by herpes simplex virus infection. This infection is a cause of significant morbidity whose incidence is significantly increased in the presence of recurrent infection and it can even produce corneal blindness.[A32645] Edoxudine 3% cream was also indicated for the treatment of dermal herpes simplex virus.[A32643] This virus can produce an infection ubiquitously and it is highly contagious. There are two types of herpes virus, type 1 that is mainly transmitted by oral-to-oral contact and type 2 that is sexually transmitted.[L2411]
DB139212'-C-methylcytidineNot Available
DB03312BrivudineNot Available
DrugDrug NameTargetType
DB00242CladribinePurine nucleoside phosphorylasetarget
DB00242CladribineDNAtarget
DB00242CladribineDeoxycytidine kinaseenzyme
DB00242CladribineRibonucleoside-diphosphate reductase large subunittarget
DB00242CladribineRibonucleoside-diphosphate reductase subunit M2target
DB00242CladribineRibonucleoside-diphosphate reductase subunit M2 Btarget
DB00242CladribineDNA polymerase alpha catalytic subunittarget
DB00242CladribineDNA polymerase epsilon catalytic subunit Atarget
DB00242CladribineDNA polymerase epsilon subunit 2target
DB00242CladribineDNA polymerase epsilon subunit 3target
DB00242CladribineDNA polymerase epsilon subunit 4target
DB00242CladribineATP-binding cassette sub-family G member 2transporter
DB00242CladribineSolute carrier family 28 member 3transporter
DB00249IdoxuridineThymidine kinasetarget
DB00249IdoxuridineDNAtarget
DB00322FloxuridineThymidylate synthasetarget
DB00322FloxuridineThymidine phosphorylaseenzyme
DB00322FloxuridineCytochrome P450 2C9enzyme
DB00322FloxuridineThyroxine-binding globulincarrier
DB00432TrifluridineThymidylate synthasetarget
DB00432TrifluridineDNAtarget
DB00432TrifluridineThymidine kinase, cytosolicenzyme
DB00432TrifluridineThymidine phosphorylaseenzyme
DB00432TrifluridineSolute carrier family 22 member 6transporter
DB00432TrifluridineSodium/nucleoside cotransporter 1transporter
DB00432TrifluridineEquilibrative nucleoside transporter 1transporter
DB00432TrifluridineEquilibrative nucleoside transporter 2transporter
DB00432TrifluridineSerum albumincarrier
DB00441GemcitabineRibonucleoside-diphosphate reductase large subunittarget
DB00441GemcitabineUMP-CMP kinasetarget
DB00441GemcitabineThymidylate synthasetarget
DB00441GemcitabineCytidine deaminaseenzyme
DB00441GemcitabineDeoxycytidine kinaseenzyme
DB00441GemcitabineMultidrug resistance protein 1transporter
DB00441GemcitabineMultidrug resistance-associated protein 7transporter
DB00441GemcitabineEquilibrative nucleoside transporter 1transporter
DB00441GemcitabineDNAtarget
DB00441GemcitabineSodium/nucleoside cotransporter 1transporter
DB00441GemcitabineEquilibrative nucleoside transporter 2transporter
DB00441GemcitabineSolute carrier family 28 member 3transporter
DB00495ZidovudineSerum albumincarrier
DB00495ZidovudineCytochrome P450 2A6enzyme
DB00495ZidovudineCytochrome P450 2C8enzyme
DB00495ZidovudineCytochrome P450 2C9enzyme
DB00495ZidovudineCytochrome P450 3A4enzyme
DB00495ZidovudineReverse transcriptase/RNaseHtarget
DB00495ZidovudineSolute carrier family 22 member 2transporter
DB00495ZidovudineSolute carrier family 22 member 6transporter
DB00495ZidovudineSolute carrier family 22 member 7transporter
DB00495ZidovudineSolute carrier family 22 member 8transporter
DB00495ZidovudineSolute carrier family 22 member 11transporter
DB00495ZidovudineSodium/nucleoside cotransporter 1transporter
DB00495ZidovudineEquilibrative nucleoside transporter 2transporter
DB00495ZidovudineMultidrug resistance protein 1transporter
DB00495ZidovudineMultidrug resistance-associated protein 4transporter
DB00495ZidovudineMultidrug resistance-associated protein 5transporter
DB00495ZidovudineATP-binding cassette sub-family G member 2transporter
DB00495ZidovudineTelomerase reverse transcriptasetarget
DB00495ZidovudineThymidine kinase, cytosolicenzyme
DB00495ZidovudineUDP-glucuronosyltransferase 2B7enzyme
DB00495ZidovudineUDP-glucuronosyltransferase 1-1enzyme
DB00552PentostatinAdenosine deaminasetarget
DB00649StavudineSolute carrier family 22 member 6transporter
DB00649StavudineReverse transcriptase/RNaseHtarget
DB00649StavudineSodium/nucleoside cotransporter 1transporter
DB00649StavudineSerum albumincarrier
DB00709LamivudineDNAtarget
DB00709LamivudineProtein Ptarget
DB00709LamivudineMultidrug resistance-associated protein 1transporter
DB00709LamivudineSolute carrier family 22 member 6transporter
DB00709LamivudineATP-binding cassette sub-family G member 2transporter
DB00709LamivudineReverse transcriptase/RNaseHtarget
DB00709LamivudineSolute carrier family 22 member 1transporter
DB00709LamivudineSolute carrier family 22 member 2transporter
DB00709LamivudineSolute carrier family 22 member 3transporter
DB00709LamivudineDeoxycytidine kinaseenzyme
DB00709LamivudineUMP-CMP kinaseenzyme
DB00709LamivudinePhosphoglycerate kinase 1enzyme
DB00709LamivudineNucleoside diphosphate kinase Aenzyme
DB00709LamivudineNucleoside diphosphate kinase Benzyme
DB00709LamivudineCholine-phosphate cytidylyltransferase Aenzyme
DB00709LamivudineEthanolamine-phosphate cytidylyltransferaseenzyme
DB00709LamivudineMultidrug resistance protein 1transporter
DB00709LamivudineMultidrug resistance-associated protein 4transporter
DB00709LamivudineCanalicular multispecific organic anion transporter 2transporter
DB00709LamivudineCanalicular multispecific organic anion transporter 1transporter
DB00709Lamivudine5'(3')-deoxyribonucleotidase, cytosolic typeenzyme
DB00709LamivudineSerum albumincarrier
DB00879EmtricitabineReverse transcriptase/RNaseHtarget
DB00879EmtricitabineDeoxycytidine kinaseenzyme
DB00879EmtricitabineSerum albumincarrier
DB00900DidanosineSolute carrier family 22 member 6transporter
DB00900DidanosinePurine nucleoside phosphorylasetarget
DB00900DidanosineReverse transcriptase/RNaseHtarget
DB00900DidanosineEquilibrative nucleoside transporter 1transporter
DB00900DidanosineEquilibrative nucleoside transporter 2transporter
DB00900DidanosineSerum albumincarrier
DB00943ZalcitabineDeoxycytidine kinaseenzyme
DB00943ZalcitabineSolute carrier family 22 member 6transporter
DB00943ZalcitabineSolute carrier family 22 member 7transporter
DB00943ZalcitabineReverse transcriptase/RNaseHtarget
DB00943ZalcitabineEquilibrative nucleoside transporter 1transporter
DB00943ZalcitabineEquilibrative nucleoside transporter 2transporter
DB00943ZalcitabineSerum albumincarrier
DB01048AbacavirAlcohol dehydrogenase 6enzyme
DB01048AbacavirUDP-glucuronosyltransferase 1-1enzyme
DB01048AbacavirReverse transcriptase/RNaseHtarget
DB01048AbacavirAdenosine kinaseenzyme
DB01048AbacavirHLA class I histocompatibility antigen, B-57 alpha chaintarget
DB01101CapecitabineThymidylate synthasetarget
DB01101CapecitabineThymidine phosphorylaseenzyme
DB01101CapecitabineCytidine deaminaseenzyme
DB01101CapecitabineLiver carboxylesterase 1enzyme
DB01101CapecitabineDihydropyrimidine dehydrogenase [NADP(+)]enzyme
DB01101CapecitabineCytochrome P450 2C9enzyme
DB01101CapecitabineDNAtarget
DB01101CapecitabineRNAtarget
DB01265TelbivudineProtein Ptarget
DB01265TelbivudineDNAtarget
DB022825'-Deoxy-5'-MethylthioadenosineModification methylase RsrItarget
DB022825'-Deoxy-5'-MethylthioadenosineS-methyl-5'-thioadenosine phosphorylasetarget
DB036093-DeoxyguanosinePurine nucleoside phosphorylasetarget
DB037165'-Fluoro-5'-Deoxyadenosine5'-fluoro-5'-deoxy-adenosine synthasetarget
DB04485ThymidineThymidylate kinasetarget
DB04485ThymidineThymidine kinasetarget
DB04485ThymidineUridine phosphorylasetarget
DB04485ThymidineThymidine kinasetarget
DB04485ThymidineThymidine kinase 2, mitochondrialtarget
DB04485ThymidineNucleoside-specific channel-forming protein tsxtarget
DB04485ThymidineGlucose-1-phosphate thymidylyltransferasetarget
DB04485ThymidineSolute carrier family 28 member 3transporter
DB05116ThymectacinThymidylate synthasetarget
DB06433TezacitabineRibonucleoside-diphosphate reductase large subunittarget
DB06433TezacitabineThymidine phosphorylaseenzyme
DB12855ApricitabineReverse transcriptase/RNaseHtarget
DB13421EdoxudineSerum albumincarrier
DB13421EdoxudineDNA polymerasetarget
DB03312BrivudineThymidine kinasetarget