Deoxyribonucleosides

Name
Deoxyribonucleosides
Accession Number
DBCAT000597
Description

A purine or pyrimidine base bonded to DEOXYRIBOSE.

Drugs
DrugDrug Description
CladribineA purine antimetabolite used for the management of relapsing forms of Multiple Sclerosis (MS), used in patients who have not responded to or who were unable to tolerate alternative MS drugs.
IdoxuridineA pyrimidine analog antiviral used for the treatment of viral eye infections, including herpes simplex keratitis.
FloxuridineAn antimetabolite used as palliative management for liver metastases of gastrointestinal malignancy.
TrifluridineA nucleoside metabolic inhibitor used to treat keratoconjunctivitis and epithelial keratitis caused by simplex virus, and as a part of chemotherapy for certain types of metastatic gastrointestinal cancers.
GemcitabineA nucleoside metabolic inhibitor used as adjunct therapy in the treatment of certain types of ovarian cancer, non-small cell lung carcinoma, metastatic breast cancer, and as a single agent for pancreatic cancer.
ZidovudineA dideoxynucleoside used in the treatment of HIV infection.
PentostatinAn adenosine deaminase inhibitor used to treat hairy cell leukemia.
StavudineA dideoxynucleoside used in the treatment of HIV infection.
LamivudineA reverse transcriptase inhibitor used to treat HIV and hepatitis B infections.
EmtricitabineA nucleoside reverse transcriptase inhibitor used for the treatment and prophylaxis of HIV.
DidanosineA reverse transcriptase inhibitor used to treat HIV.
ZalcitabineA dideoxynucleoside used to treat HIV.
AbacavirAn antiviral nucleoside reverse transcriptase inhibitor used in combination with other antiretrovirals for the treatment of HIV.
CapecitabineA nucleoside metabolic inhibitor indicated to treat colon, colorectal and breast cancer.
TelbivudineA thymidine nucleoside analog used for the treatment of chronic hepatitis B with clinical evidence of viral replication or persistent elevations in serum aminotransferases (ALT or AST).
5'-S-methyl-5'-thioadenosineNot Available
8-hydroxy-2'-deoxyguanosineNot Available
5'-Fluoro-5'-DeoxyadenosineNot Available
ThymidineThymidine is a pyrimidine deoxynucleoside. Thymidine is the DNA nucleoside T, which pairs with deoxyadenosine (A) in double-stranded DNA. In cell biology it is used to synchronize the cells in...
ThymectacinInvestigated for use/treatment in colorectal cancer.
AlovudineInvestigated for use/treatment in HIV infection.
ElvucitabineInvestigated for use/treatment in hepatitis (viral, B) and HIV infection.
TezacitabineInvestigated for use/treatment in colorectal cancer, lung cancer, leukemia (unspecified), and gastric cancer.
TAS-102TAS-102 (Taiho Pharma USA, Inc.) is an anti-cancer drug under development and in stage 3 clinical trials for the treatment of colorectal cancer. It is composed of the thymidine phosphorylase...
BroxuridineBroxuridine has been used in trials studying the treatment of Leukemia, Stage I Prostate Cancer, Stage IIB Prostate Cancer, and Stage IIA Prostate Cancer.
MericitabineMericitabine has been investigated for the treatment of Hepatitis C, Chronic. Mericitabine is a polymerase inhibitor being developed for the treatment of chronic hepatitis C. Mericitabine is a prodrug of...
CensavudineCensavudine has been used in trials studying the treatment of HIV-1 Infection.
CordycepinCordycepin has been used in trials studying the treatment of Leukemia.
Fozivudine TidoxilFozivudine Tidoxil has been used in trials studying the treatment of HIV Infections.
DexelvucitabineDexelvucitabine has been used in trials studying the treatment of HIV Infections and Human Immunodeficiency Virus.
Gemcitabine elaidateGemcitabine elaidate has been used in trials studying the treatment of Solid Tumor, Lung Cancer, Non-small-cell Lung Cancer, and Metastatic Pancreatic Adenocarcinoma.
RacivirRacivir, also known as RCV, is an oxothiolane nucleoside reverse transcriptase inhibitor similar to emtricitabine and lamivudine. Racivir is a 50:50 mixture of emtricitabine DB00879 and its positive enantiomer. Racivir...
ApricitabineApricitabine has been used in trials studying the treatment of HIV Infections.
RaluridineRaluridine has been used in trials studying the treatment of HIV Infections.
LY-2334737LY2334737 has been used in trials studying the treatment of Solid Tumor, Metastatic Tumor, and Malignant Solid Tumor.
DoxifluridineDoxifluridine has been investigated for the treatment of Stomach Cancer.
5-fluoro-2'-deoxycytidine5-fluoro-2'-deoxycytidine has been used in trials studying the treatment of Neoplasms, Lung Neoplasms, Breast Neoplasms, Head and Neck Neoplasms, and Urinary Bladder Neoplasms, among others.
EdoxudineA deoxythymidine analog used to treat herpetic keratitis.
2'-C-methylcytidineA nucleoside analog with anti-hepatitis C virus (HCV) activity. Upon phosphorylation into its 5-triphosphate form, this metabolite inhibits viral RNA chain elongation and viral RNA-dependent RNA polymerase activity. This blocks...
BrivudineBrivudine is used in the treatment of herpes zoster. Although not approved in the U.S. or Canada, it is approved in several European countries.
LumicitabineLumicitabine is under investigation in clinical trial NCT03010059 (A Study to Assess the Relative Bioavailability of JNJ64041575 Administered as 2 Different New Concept Formulations (Oral Suspension and Tablet) Compared to...
Alovudine F-18Alovudine F-18 is under investigation in clinical trial NCT02819024 (Dexamethasone Effects in Patients With Refractory Non-Small Cell Lung Cancer Using FLT Positron Emission Tomography).
Zidovudine monophosphateNot Available
Zidovudine diphosphateNot Available
IslatravirIslatravir is under investigation in clinical trial NCT04233216 (Doravirine/islatravir (DOR/ISL) in Heavily Treatment-experienced (HTE) Participants for Human Immunodeficiency Virus Type 1 (HIV-1) Infection (MK-8591A-019)).
Drugs & Drug Targets
DrugTargetType
CladribinePurine nucleoside phosphorylasetarget
CladribineDNAtarget
CladribineDeoxycytidine kinaseenzyme
CladribineRibonucleoside-diphosphate reductase large subunittarget
CladribineRibonucleoside-diphosphate reductase subunit M2target
CladribineRibonucleoside-diphosphate reductase subunit M2 Btarget
CladribineDNA polymerase alpha catalytic subunittarget
CladribineDNA polymerase epsilon catalytic subunit Atarget
CladribineDNA polymerase epsilon subunit 2target
CladribineDNA polymerase epsilon subunit 3target
CladribineDNA polymerase epsilon subunit 4target
CladribineATP-binding cassette sub-family G member 2transporter
CladribineSolute carrier family 28 member 3transporter
IdoxuridineThymidine kinasetarget
IdoxuridineDNAtarget
FloxuridineThymidylate synthasetarget
FloxuridineThymidine phosphorylaseenzyme
FloxuridineCytochrome P450 2C9enzyme
FloxuridineThyroxine-binding globulincarrier
TrifluridineThymidylate synthasetarget
TrifluridineDNAtarget
TrifluridineThymidine kinase, cytosolicenzyme
TrifluridineThymidine phosphorylaseenzyme
TrifluridineSolute carrier family 22 member 6transporter
TrifluridineSodium/nucleoside cotransporter 1transporter
TrifluridineEquilibrative nucleoside transporter 1transporter
TrifluridineEquilibrative nucleoside transporter 2transporter
TrifluridineSerum albumincarrier
GemcitabineRibonucleoside-diphosphate reductase large subunittarget
GemcitabineUMP-CMP kinasetarget
GemcitabineThymidylate synthasetarget
GemcitabineCytidine deaminaseenzyme
GemcitabineDeoxycytidine kinaseenzyme
GemcitabineP-glycoprotein 1transporter
GemcitabineMultidrug resistance-associated protein 7transporter
GemcitabineEquilibrative nucleoside transporter 1transporter
GemcitabineDNAtarget
GemcitabineSodium/nucleoside cotransporter 1transporter
GemcitabineEquilibrative nucleoside transporter 2transporter
GemcitabineSolute carrier family 28 member 3transporter
ZidovudineSerum albumincarrier
ZidovudineCytochrome P450 2A6enzyme
ZidovudineCytochrome P450 2C9enzyme
ZidovudineCytochrome P450 3A4enzyme
ZidovudineReverse transcriptase/RNaseHtarget
ZidovudineSolute carrier family 22 member 2transporter
ZidovudineSolute carrier family 22 member 6transporter
ZidovudineSolute carrier family 22 member 7transporter
ZidovudineSolute carrier family 22 member 8transporter
ZidovudineSolute carrier family 22 member 11transporter
ZidovudineSodium/nucleoside cotransporter 1transporter
ZidovudineEquilibrative nucleoside transporter 2transporter
ZidovudineP-glycoprotein 1transporter
ZidovudineMultidrug resistance-associated protein 4transporter
ZidovudineMultidrug resistance-associated protein 5transporter
ZidovudineATP-binding cassette sub-family G member 2transporter
ZidovudineTelomerase reverse transcriptasetarget
ZidovudineThymidine kinase, cytosolicenzyme
ZidovudineUDP-glucuronosyltransferase 2B7enzyme
ZidovudineUDP-glucuronosyltransferase 1-1enzyme
PentostatinAdenosine deaminasetarget
StavudineSolute carrier family 22 member 6transporter
StavudineReverse transcriptase/RNaseHtarget
StavudineSodium/nucleoside cotransporter 1transporter
StavudineSerum albumincarrier
LamivudineDNAtarget
LamivudineProtein Ptarget
LamivudineMultidrug resistance-associated protein 1transporter
LamivudineSolute carrier family 22 member 6transporter
LamivudineATP-binding cassette sub-family G member 2transporter
LamivudineReverse transcriptase/RNaseHtarget
LamivudineSolute carrier family 22 member 1transporter
LamivudineSolute carrier family 22 member 2transporter
LamivudineSolute carrier family 22 member 3transporter
LamivudineDeoxycytidine kinaseenzyme
LamivudineUMP-CMP kinaseenzyme
LamivudinePhosphoglycerate kinase 1enzyme
LamivudineNucleoside diphosphate kinase Aenzyme
LamivudineNucleoside diphosphate kinase Benzyme
LamivudineCholine-phosphate cytidylyltransferase Aenzyme
LamivudineEthanolamine-phosphate cytidylyltransferaseenzyme
LamivudineP-glycoprotein 1transporter
LamivudineMultidrug resistance-associated protein 4transporter
LamivudineCanalicular multispecific organic anion transporter 2transporter
LamivudineCanalicular multispecific organic anion transporter 1transporter
Lamivudine5'(3')-deoxyribonucleotidase, cytosolic typeenzyme
LamivudineSerum albumincarrier
EmtricitabineReverse transcriptase/RNaseHtarget
EmtricitabineDeoxycytidine kinaseenzyme
EmtricitabineSerum albumincarrier
EmtricitabineMultidrug and toxin extrusion protein 1transporter
DidanosineSolute carrier family 22 member 6transporter
DidanosinePurine nucleoside phosphorylasetarget
DidanosineReverse transcriptase/RNaseHtarget
DidanosineEquilibrative nucleoside transporter 1transporter
DidanosineEquilibrative nucleoside transporter 2transporter
DidanosineSerum albumincarrier
ZalcitabineDeoxycytidine kinaseenzyme
ZalcitabineSolute carrier family 22 member 6transporter
ZalcitabineSolute carrier family 22 member 7transporter
ZalcitabineReverse transcriptase/RNaseHtarget
ZalcitabineEquilibrative nucleoside transporter 1transporter
ZalcitabineEquilibrative nucleoside transporter 2transporter
ZalcitabineSerum albumincarrier
AbacavirAlcohol dehydrogenase 6enzyme
AbacavirUDP-glucuronosyltransferase 1-1enzyme
AbacavirReverse transcriptase/RNaseHtarget
AbacavirAdenosine kinaseenzyme
AbacavirHLA class I histocompatibility antigen, B-57 alpha chaintarget
CapecitabineThymidylate synthasetarget
CapecitabineThymidine phosphorylaseenzyme
CapecitabineCytidine deaminaseenzyme
CapecitabineLiver carboxylesterase 1enzyme
CapecitabineDihydropyrimidine dehydrogenase [NADP(+)]enzyme
CapecitabineCytochrome P450 2C9enzyme
CapecitabineDNAtarget
CapecitabineRNAtarget
TelbivudineProtein Ptarget
TelbivudineDNAtarget
5'-S-methyl-5'-thioadenosineModification methylase RsrItarget
5'-S-methyl-5'-thioadenosineS-methyl-5'-thioadenosine phosphorylasetarget
5'-Fluoro-5'-Deoxyadenosine5'-fluoro-5'-deoxy-adenosine synthasetarget
ThymidineThymidylate kinasetarget
ThymidineThymidine kinasetarget
ThymidineUridine phosphorylasetarget
ThymidineThymidine kinasetarget
ThymidineThymidine kinase 2, mitochondrialtarget
ThymidineNucleoside-specific channel-forming protein tsxtarget
ThymidineGlucose-1-phosphate thymidylyltransferasetarget
ThymidineSolute carrier family 28 member 3transporter
ThymectacinThymidylate synthasetarget
TezacitabineRibonucleoside-diphosphate reductase large subunittarget
TezacitabineThymidine phosphorylaseenzyme
ApricitabineReverse transcriptase/RNaseHtarget
EdoxudineSerum albumincarrier
EdoxudineDNA polymerasetarget
BrivudineThymidine kinase 2, mitochondrialtarget
BrivudineDNA polymerasetarget
BrivudineThymidine kinasetarget
Zidovudine monophosphateThymidylate kinasetarget
Zidovudine monophosphateThymidylate kinasetarget
Zidovudine diphosphateNucleoside diphosphate kinase Atarget