Deoxyribonucleosides

A purine or pyrimidine base bonded to DEOXYRIBOSE.
DrugDrug NameDrug Description
DB00242CladribineA purine antimetabolite used for the management of relapsing forms of Multiple Sclerosis (MS), used in patients who have not responded to or who were unable to tolerate alternative MS drugs.
DB00249IdoxuridineA pyrimidine analog antiviral used for the treatment of viral eye infections, including herpes simplex keratitis.
DB00322FloxuridineAn antimetabolite used as palliative management for liver metastases of gastrointestinal malignancy.
DB00432TrifluridineA nucleoside metabolic inhibitor used to treat keratoconjunctivitis and epithelial keratitis caused by simplex virus, and as a part of chemotherapy for certain types of metastatic gastrointestinal cancers.
DB00441GemcitabineA nucleoside metabolic inhibitor used as adjunct therapy in the treatment of certain types of ovarian cancer, non-small cell lung carcinoma, metastatic breast cancer, and as a single agent for pancreatic cancer.
DB00495ZidovudineA dideoxynucleoside used in the treatment of HIV infection.
DB00552PentostatinAn adenosine deaminase inhibitor used to treat hairy cell leukemia.
DB00649StavudineA dideoxynucleoside used in the treatment of HIV infection.
DB00709LamivudineA reverse transcriptase inhibitor used to treat HIV and hepatitis B infections.
DB00879EmtricitabineA nucleoside reverse transcriptase inhibitor used for the treatment and prophylaxis of HIV.
DB00900DidanosineA reverse transcriptase inhibitor used to treat HIV.
DB00943ZalcitabineA dideoxynucleoside used to treat HIV.
DB01048AbacavirAn antiviral nucleoside reverse transcriptase inhibitor used in combination with other antiretrovirals for the treatment of HIV.
DB01101CapecitabineA nucleoside metabolic inhibitor indicated to treat colon, colorectal and breast cancer.
DB01265TelbivudineA thymidine nucleoside analog used for the treatment of chronic hepatitis B with clinical evidence of viral replication or persistent elevations in serum aminotransferases (ALT or AST).
DB022825'-Deoxy-5'-MethylthioadenosineNot Available
DB025028-Hydroxy-2'-DeoxyguanosineNot Available
DB036093-Deoxyguanosine3-deoxyguanosine is a solid. This compound belongs to the purine nucleosides and analogues. These are compounds comprising a purine base attached to a sugar. This medication targets the protein purine...
DB037165'-Fluoro-5'-DeoxyadenosineNot Available
DB04485ThymidineThymidine is a pyrimidine deoxynucleoside. Thymidine is the DNA nucleoside T, which pairs with deoxyadenosine (A) in double-stranded DNA. In cell biology it is used to synchronize the cells in...
DB05116ThymectacinInvestigated for use/treatment in colorectal cancer.
DB06198AlovudineInvestigated for use/treatment in HIV infection.
DB06236ElvucitabineInvestigated for use/treatment in hepatitis (viral, B) and HIV infection.
DB06433TezacitabineInvestigated for use/treatment in colorectal cancer, lung cancer, leukemia (unspecified), and gastric cancer.
DB08937TAS-102TAS-102 (Taiho Pharma USA, Inc.) is an anti-cancer drug under development and in stage 3 clinical trials for the treatment of colorectal cancer. It is composed of the thymidine phosphorylase...
DB12028BroxuridineBroxuridine has been used in trials studying the treatment of Leukemia, Stage I Prostate Cancer, Stage IIB Prostate Cancer, and Stage IIA Prostate Cancer.
DB12045MericitabineMericitabine has been investigated for the treatment of Hepatitis C, Chronic. Mericitabine is a polymerase inhibitor being developed for the treatment of chronic hepatitis C. Mericitabine is a prodrug of...
DB12074CensavudineCensavudine has been used in trials studying the treatment of HIV-1 Infection.
DB12156CordycepinCordycepin has been used in trials studying the treatment of Leukemia.
DB12423Fozivudine TidoxilFozivudine Tidoxil has been used in trials studying the treatment of HIV Infections.
DB12470DexelvucitabineDexelvucitabine has been used in trials studying the treatment of HIV Infections and Human Immunodeficiency Virus.
DB12564Gemcitabine elaidateGemcitabine elaidate has been used in trials studying the treatment of Solid Tumor, Lung Cancer, Non-small-cell Lung Cancer, and Metastatic Pancreatic Adenocarcinoma.
DB12753RacivirRacivir, also known as RCV, is an oxothiolane nucleoside reverse transcriptase inhibitor similar to emtricitabine and lamivudine. Racivir is a 50:50 mixture of emtricitabine DB00879 and its positive enantiomer. Racivir...
DB12855ApricitabineApricitabine has been used in trials studying the treatment of HIV Infections.
DB12894RaluridineRaluridine has been used in trials studying the treatment of HIV Infections.
DB12906LY-2334737LY2334737 has been used in trials studying the treatment of Solid Tumor, Metastatic Tumor, and Malignant Solid Tumor.
DB12947DoxifluridineDoxifluridine has been investigated for the treatment of Stomach Cancer.
DB129575-fluoro-2'-deoxycytidine5-fluoro-2'-deoxycytidine has been used in trials studying the treatment of Neoplasms, Lung Neoplasms, Breast Neoplasms, Head and Neck Neoplasms, and Urinary Bladder Neoplasms, among others.
DB13421EdoxudineA deoxythymidine analog used to treat herpetic keratitis.
DB139212'-C-methylcytidineA nucleoside analog with anti-hepatitis C virus (HCV) activity. Upon phosphorylation into its 5-triphosphate form, this metabolite inhibits viral RNA chain elongation and viral RNA-dependent RNA polymerase activity. This blocks...
DB03312BrivudineBrivudine is used in the treatment of herpes zoster. Although not approved in the U.S. or Canada, it is approved in several European countries.
DB14808LumicitabineLumicitabine is under investigation in clinical trial NCT03010059 (A Study to Assess the Relative Bioavailability of JNJ64041575 Administered as 2 Different New Concept Formulations (Oral Suspension and Tablet) Compared to...
DB14930Alovudine F-18Alovudine F-18 is under investigation in clinical trial NCT02819024 (Dexamethasone Effects in Patients With Refractory Non-Small Cell Lung Cancer Using FLT Positron Emission Tomography).
DrugDrug NameTargetType
DB00242CladribinePurine nucleoside phosphorylasetarget
DB00242CladribineDNAtarget
DB00242CladribineDeoxycytidine kinaseenzyme
DB00242CladribineRibonucleoside-diphosphate reductase large subunittarget
DB00242CladribineRibonucleoside-diphosphate reductase subunit M2target
DB00242CladribineRibonucleoside-diphosphate reductase subunit M2 Btarget
DB00242CladribineDNA polymerase alpha catalytic subunittarget
DB00242CladribineDNA polymerase epsilon catalytic subunit Atarget
DB00242CladribineDNA polymerase epsilon subunit 2target
DB00242CladribineDNA polymerase epsilon subunit 3target
DB00242CladribineDNA polymerase epsilon subunit 4target
DB00242CladribineATP-binding cassette sub-family G member 2transporter
DB00242CladribineSolute carrier family 28 member 3transporter
DB00249IdoxuridineThymidine kinasetarget
DB00249IdoxuridineDNAtarget
DB00322FloxuridineThymidylate synthasetarget
DB00322FloxuridineThymidine phosphorylaseenzyme
DB00322FloxuridineCytochrome P450 2C9enzyme
DB00322FloxuridineThyroxine-binding globulincarrier
DB00432TrifluridineThymidylate synthasetarget
DB00432TrifluridineDNAtarget
DB00432TrifluridineThymidine kinase, cytosolicenzyme
DB00432TrifluridineThymidine phosphorylaseenzyme
DB00432TrifluridineSolute carrier family 22 member 6transporter
DB00432TrifluridineSodium/nucleoside cotransporter 1transporter
DB00432TrifluridineEquilibrative nucleoside transporter 1transporter
DB00432TrifluridineEquilibrative nucleoside transporter 2transporter
DB00432TrifluridineSerum albumincarrier
DB00441GemcitabineRibonucleoside-diphosphate reductase large subunittarget
DB00441GemcitabineUMP-CMP kinasetarget
DB00441GemcitabineThymidylate synthasetarget
DB00441GemcitabineCytidine deaminaseenzyme
DB00441GemcitabineDeoxycytidine kinaseenzyme
DB00441GemcitabineP-glycoprotein 1transporter
DB00441GemcitabineMultidrug resistance-associated protein 7transporter
DB00441GemcitabineEquilibrative nucleoside transporter 1transporter
DB00441GemcitabineDNAtarget
DB00441GemcitabineSodium/nucleoside cotransporter 1transporter
DB00441GemcitabineEquilibrative nucleoside transporter 2transporter
DB00441GemcitabineSolute carrier family 28 member 3transporter
DB00495ZidovudineSerum albumincarrier
DB00495ZidovudineCytochrome P450 2A6enzyme
DB00495ZidovudineCytochrome P450 2C9enzyme
DB00495ZidovudineCytochrome P450 3A4enzyme
DB00495ZidovudineReverse transcriptase/RNaseHtarget
DB00495ZidovudineSolute carrier family 22 member 2transporter
DB00495ZidovudineSolute carrier family 22 member 6transporter
DB00495ZidovudineSolute carrier family 22 member 7transporter
DB00495ZidovudineSolute carrier family 22 member 8transporter
DB00495ZidovudineSolute carrier family 22 member 11transporter
DB00495ZidovudineSodium/nucleoside cotransporter 1transporter
DB00495ZidovudineEquilibrative nucleoside transporter 2transporter
DB00495ZidovudineP-glycoprotein 1transporter
DB00495ZidovudineMultidrug resistance-associated protein 4transporter
DB00495ZidovudineMultidrug resistance-associated protein 5transporter
DB00495ZidovudineATP-binding cassette sub-family G member 2transporter
DB00495ZidovudineTelomerase reverse transcriptasetarget
DB00495ZidovudineThymidine kinase, cytosolicenzyme
DB00495ZidovudineUDP-glucuronosyltransferase 2B7enzyme
DB00495ZidovudineUDP-glucuronosyltransferase 1-1enzyme
DB00552PentostatinAdenosine deaminasetarget
DB00649StavudineSolute carrier family 22 member 6transporter
DB00649StavudineReverse transcriptase/RNaseHtarget
DB00649StavudineSodium/nucleoside cotransporter 1transporter
DB00649StavudineSerum albumincarrier
DB00709LamivudineDNAtarget
DB00709LamivudineProtein Ptarget
DB00709LamivudineMultidrug resistance-associated protein 1transporter
DB00709LamivudineSolute carrier family 22 member 6transporter
DB00709LamivudineATP-binding cassette sub-family G member 2transporter
DB00709LamivudineReverse transcriptase/RNaseHtarget
DB00709LamivudineSolute carrier family 22 member 1transporter
DB00709LamivudineSolute carrier family 22 member 2transporter
DB00709LamivudineSolute carrier family 22 member 3transporter
DB00709LamivudineDeoxycytidine kinaseenzyme
DB00709LamivudineUMP-CMP kinaseenzyme
DB00709LamivudinePhosphoglycerate kinase 1enzyme
DB00709LamivudineNucleoside diphosphate kinase Aenzyme
DB00709LamivudineNucleoside diphosphate kinase Benzyme
DB00709LamivudineCholine-phosphate cytidylyltransferase Aenzyme
DB00709LamivudineEthanolamine-phosphate cytidylyltransferaseenzyme
DB00709LamivudineP-glycoprotein 1transporter
DB00709LamivudineMultidrug resistance-associated protein 4transporter
DB00709LamivudineCanalicular multispecific organic anion transporter 2transporter
DB00709LamivudineCanalicular multispecific organic anion transporter 1transporter
DB00709Lamivudine5'(3')-deoxyribonucleotidase, cytosolic typeenzyme
DB00709LamivudineSerum albumincarrier
DB00879EmtricitabineReverse transcriptase/RNaseHtarget
DB00879EmtricitabineDeoxycytidine kinaseenzyme
DB00879EmtricitabineSerum albumincarrier
DB00879EmtricitabineMultidrug and toxin extrusion protein 1transporter
DB00900DidanosineSolute carrier family 22 member 6transporter
DB00900DidanosinePurine nucleoside phosphorylasetarget
DB00900DidanosineReverse transcriptase/RNaseHtarget
DB00900DidanosineEquilibrative nucleoside transporter 1transporter
DB00900DidanosineEquilibrative nucleoside transporter 2transporter
DB00900DidanosineSerum albumincarrier
DB00943ZalcitabineDeoxycytidine kinaseenzyme
DB00943ZalcitabineSolute carrier family 22 member 6transporter
DB00943ZalcitabineSolute carrier family 22 member 7transporter
DB00943ZalcitabineReverse transcriptase/RNaseHtarget
DB00943ZalcitabineEquilibrative nucleoside transporter 1transporter
DB00943ZalcitabineEquilibrative nucleoside transporter 2transporter
DB00943ZalcitabineSerum albumincarrier
DB01048AbacavirAlcohol dehydrogenase 6enzyme
DB01048AbacavirUDP-glucuronosyltransferase 1-1enzyme
DB01048AbacavirReverse transcriptase/RNaseHtarget
DB01048AbacavirAdenosine kinaseenzyme
DB01048AbacavirHLA class I histocompatibility antigen, B-57 alpha chaintarget
DB01101CapecitabineThymidylate synthasetarget
DB01101CapecitabineThymidine phosphorylaseenzyme
DB01101CapecitabineCytidine deaminaseenzyme
DB01101CapecitabineLiver carboxylesterase 1enzyme
DB01101CapecitabineDihydropyrimidine dehydrogenase [NADP(+)]enzyme
DB01101CapecitabineCytochrome P450 2C9enzyme
DB01101CapecitabineDNAtarget
DB01101CapecitabineRNAtarget
DB01265TelbivudineProtein Ptarget
DB01265TelbivudineDNAtarget
DB022825'-Deoxy-5'-MethylthioadenosineModification methylase RsrItarget
DB022825'-Deoxy-5'-MethylthioadenosineS-methyl-5'-thioadenosine phosphorylasetarget
DB036093-DeoxyguanosinePurine nucleoside phosphorylasetarget
DB037165'-Fluoro-5'-Deoxyadenosine5'-fluoro-5'-deoxy-adenosine synthasetarget
DB04485ThymidineThymidylate kinasetarget
DB04485ThymidineThymidine kinasetarget
DB04485ThymidineUridine phosphorylasetarget
DB04485ThymidineThymidine kinasetarget
DB04485ThymidineThymidine kinase 2, mitochondrialtarget
DB04485ThymidineNucleoside-specific channel-forming protein tsxtarget
DB04485ThymidineGlucose-1-phosphate thymidylyltransferasetarget
DB04485ThymidineSolute carrier family 28 member 3transporter
DB05116ThymectacinThymidylate synthasetarget
DB06433TezacitabineRibonucleoside-diphosphate reductase large subunittarget
DB06433TezacitabineThymidine phosphorylaseenzyme
DB12855ApricitabineReverse transcriptase/RNaseHtarget
DB13421EdoxudineSerum albumincarrier
DB13421EdoxudineDNA polymerasetarget
DB03312BrivudineThymidine kinasetarget