Piperidones

Name
Piperidones
Accession Number
DBCAT000785
Description

Cyclic compounds that include atoms other than carbon in their ring structure.

Drugs
DrugDrug Description
AminoglutethimideAn adrenocortical steroid synthesis inhibitor used in the treatment of Cushing's syndrome.
LenalidomideA thalidomide derivative used to treat multiple myeloma and anemia in low to intermediate risk myelodysplastic syndrome.
GlutethimideFor the treatment of insomnia.
PomalidomideA thalidomide analogue used in combination with dexamethasone to treat patients with multiple myeloma.
DexetimideA muscarinic antagonist that has been used to treat neuroleptic-induced parkinsonism. Benzetimide is the (-)-enantimorph of dexetimide.
PhenglutarimideNot Annotated
S-3APGS-3APG (S-3-[3-amino-phthalimido]-glutarimide) is a derivative of thalidomide with dual activity against B-cell neoplasias.
Drugs & Drug Targets
DrugTargetType
AminoglutethimideCytochrome P450 19A1target
AminoglutethimideCytochrome P450 2C19enzyme
AminoglutethimideCytochrome P450 3A4enzyme
AminoglutethimideCholesterol side-chain cleavage enzyme, mitochondrialtarget
LenalidomideProstaglandin G/H synthase 2target
LenalidomideTumor necrosis factor ligand superfamily member 11target
LenalidomideCadherin-5target
LenalidomideProtein cereblontarget
LenalidomideP-glycoprotein 1transporter
GlutethimideCholesterol side-chain cleavage enzyme, mitochondrialenzyme
GlutethimideGamma-aminobutyric acid receptor subunit alpha-1target
GlutethimideGABA(A) Receptortarget
PomalidomideCytochrome P450 1A2enzyme
PomalidomideCytochrome P450 3A4enzyme
PomalidomideP-glycoprotein 1transporter
PomalidomideProtein cereblontarget
PomalidomideTumor necrosis factortarget
PomalidomideProstaglandin G/H synthase 2target