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Identification
NameGlutethimide
Accession NumberDB01437
TypeSmall Molecule
GroupsApproved, Illicit
DescriptionA hypnotic and sedative. Its use has been largely superseded by other drugs. [PubChem]
Structure
Thumb
Synonyms
2-Ethyl-2-phenylglutarimide
Doriden
External Identifiers Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
DoridenU.S.V .
ElrodormNot Available
GlimidPolfa Pabianice
GlutethimidBalkanpharma
NoxyronNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNIIC8I4BVN78E
CAS number77-21-4
WeightAverage: 217.2637
Monoisotopic: 217.110278729
Chemical FormulaC13H15NO2
InChI KeyJMBQKKAJIKAWKF-UHFFFAOYSA-N
InChI
InChI=1S/C13H15NO2/c1-2-13(10-6-4-3-5-7-10)9-8-11(15)14-12(13)16/h3-7H,2,8-9H2,1H3,(H,14,15,16)
IUPAC Name
3-ethyl-3-phenylpiperidine-2,6-dione
SMILES
CCC1(CCC(=O)NC1=O)C1=CC=CC=C1
Pharmacology
IndicationFor the treatment of insomnia.
Structured Indications Not Available
PharmacodynamicsGlutethimide is a hypnotic sedative that was introduced in 1954 as a safe alternative to barbiturates to treat insomnia. Before long, however, it had become clear that glutethimide was just as likely to cause addiction and caused similarly severe withdrawal symptoms.
Mechanism of actionGlutethimide seems to be a GABA agonist which helps induced sedation. It also induces CYP 2D6. When taken with codeine, it enables the body to convert higher amounts of the codeine (higher than the average 5 - 10%) to morphine. The general sedative effect also adds to the power of the combination.
TargetKindPharmacological actionActionsOrganismUniProt ID
Gamma-aminobutyric acid receptor subunit alpha-1Proteinyes
agonist
HumanP14867 details
GABA-A receptor (anion channel)Protein groupyes
positive allosteric modulator
Humannot applicabledetails
Related Articles
AbsorptionVariable
Volume of distributionNot Available
Protein bindingNot Available
Metabolism

Hepatic. Glutethimide is almost completely metabolized.

Route of eliminationglutethimide is inactivated by conjugation and the metabolites are excreted in urine, only 2% of the parent substance is excreted in urine, up to 2% of the dose has been reported to be found in the faeces.
Half life10-12 hours
ClearanceNot Available
ToxicityIn adults, death has been reported after 5 g. The usual lethal dose is 10 to 20g, although survival after a dose of 28 g has been reported.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
1,1,1,2 TetrafluoroethaneThe risk or severity of adverse effects can be increased when Glutethimide is combined with 1,1,1,2 Tetrafluoroethane.Investigational
7-NitroindazoleThe risk or severity of adverse effects can be increased when Glutethimide is combined with 7-Nitroindazole.Experimental
AcenocoumarolThe metabolism of Acenocoumarol can be increased when combined with Glutethimide.Approved
AcepromazineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Acepromazine.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Aceprometazine.Approved
adipiplonThe risk or severity of adverse effects can be increased when Glutethimide is combined with adipiplon.Investigational
AgomelatineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Agomelatine.Approved, Investigational
AlfaxaloneThe risk or severity of adverse effects can be increased when Glutethimide is combined with Alfaxalone.Vet Approved
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Glutethimide.Approved, Illicit
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Glutethimide is combined with Alphacetylmethadol.Experimental, Illicit
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Glutethimide.Approved, Illicit, Investigational
AmisulprideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Amisulpride.Approved, Investigational
AmitriptylineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Amitriptyline.Approved
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Glutethimide.Approved, Illicit
AmoxapineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Amoxapine.Approved
AmperozideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Amperozide.Experimental
AripiprazoleThe risk or severity of adverse effects can be increased when Aripiprazole is combined with Glutethimide.Approved, Investigational
ArticaineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Articaine.Approved
AsenapineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Asenapine.Approved
AzaperoneThe risk or severity of adverse effects can be increased when Glutethimide is combined with Azaperone.Vet Approved
AzelastineGlutethimide may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
AzelastineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Azelastine.Approved
BaclofenThe risk or severity of adverse effects can be increased when Glutethimide is combined with Baclofen.Approved
BarbitalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Barbital.Illicit
BenperidolThe risk or severity of adverse effects can be increased when Glutethimide is combined with Benperidol.Investigational
BenzocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Glutethimide.Approved
Benzyl alcoholThe risk or severity of adverse effects can be increased when Glutethimide is combined with Benzyl alcohol.Approved
BrexpiprazoleThe risk or severity of adverse effects can be increased when Glutethimide is combined with Brexpiprazole.Approved
BrimonidineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Brimonidine.Approved
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.Approved
BromazepamThe risk or severity of adverse effects can be increased when Glutethimide is combined with Bromazepam.Approved, Illicit
BrompheniramineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Brompheniramine.Approved
BrotizolamThe risk or severity of adverse effects can be increased when Glutethimide is combined with Brotizolam.Approved, Withdrawn
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Glutethimide.Approved, Investigational
BuprenorphineGlutethimide may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Glutethimide.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Glutethimide.Approved, Illicit
ButacaineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Butacaine.Vet Approved
ButalbitalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Butalbital.Approved, Illicit
ButambenThe risk or severity of adverse effects can be increased when Glutethimide is combined with Butamben.Approved
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Glutethimide.Approved, Illicit
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Glutethimide.Approved, Illicit, Vet Approved
CarbamazepineThe risk or severity of adverse effects can be increased when Carbamazepine is combined with Glutethimide.Approved, Investigational
CarbinoxamineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Carbinoxamine.Approved
CarfentanilThe risk or severity of adverse effects can be increased when Glutethimide is combined with Carfentanil.Illicit, Vet Approved
CarisoprodolThe risk or severity of adverse effects can be increased when Glutethimide is combined with Carisoprodol.Approved
CetirizineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Cetirizine.Approved
Chloral hydrateThe risk or severity of adverse effects can be increased when Glutethimide is combined with Chloral hydrate.Approved, Illicit, Vet Approved
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Glutethimide.Approved, Illicit
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Glutethimide.Approved, Withdrawn
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Glutethimide.Approved
ChlorphenamineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Chlorphenamine.Approved
ChlorpromazineThe risk or severity of adverse effects can be increased when Chlorpromazine is combined with Glutethimide.Approved, Vet Approved
ChlorprothixeneThe risk or severity of adverse effects can be increased when Chlorprothixene is combined with Glutethimide.Approved, Withdrawn
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Glutethimide is combined with Chlorzoxazone.Approved
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Glutethimide.Approved, Vet Approved
CitalopramThe risk or severity of adverse effects can be increased when Glutethimide is combined with Citalopram.Approved
ClemastineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Clemastine.Approved
ClidiniumThe risk or severity of adverse effects can be increased when Glutethimide is combined with Clidinium.Approved
ClobazamThe risk or severity of adverse effects can be increased when Glutethimide is combined with Clobazam.Approved, Illicit
clomethiazoleThe risk or severity of adverse effects can be increased when Glutethimide is combined with clomethiazole.Investigational
ClomipramineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Clomipramine.Approved, Vet Approved
ClonazepamThe risk or severity of adverse effects can be increased when Glutethimide is combined with Clonazepam.Approved, Illicit
ClonidineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Clonidine.Approved
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Glutethimide.Approved, Illicit
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Glutethimide.Approved
CocaineThe risk or severity of adverse effects can be increased when Cocaine is combined with Glutethimide.Approved, Illicit
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Glutethimide.Approved, Illicit
CyclizineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Cyclizine.Approved
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Glutethimide.Approved
CyproheptadineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Cyproheptadine.Approved
DantroleneThe risk or severity of adverse effects can be increased when Glutethimide is combined with Dantrolene.Approved
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Glutethimide.Approved
DapoxetineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Dapoxetine.Investigational
deramciclaneThe risk or severity of adverse effects can be increased when Glutethimide is combined with deramciclane.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Glutethimide.Approved
DesipramineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Desipramine.Approved
DesloratadineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Desloratadine.Approved, Investigational
DesvenlafaxineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Desvenlafaxine.Approved
DetomidineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Detomidine.Vet Approved
DexbrompheniramineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Dexbrompheniramine.Approved
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Glutethimide.Approved, Vet Approved
DextromoramideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Dextromoramide.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Glutethimide.Approved, Illicit, Withdrawn
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Glutethimide.Approved
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Glutethimide.Approved, Illicit, Vet Approved
DicoumarolThe metabolism of Dicoumarol can be increased when combined with Glutethimide.Approved
DifenoxinThe risk or severity of adverse effects can be increased when Glutethimide is combined with Difenoxin.Approved, Illicit
DihydrocodeineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Dihydrocodeine.Approved, Illicit
DihydroetorphineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Dihydroetorphine.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Dihydromorphine.Experimental, Illicit
DimenhydrinateThe risk or severity of adverse effects can be increased when Glutethimide is combined with Dimenhydrinate.Approved
DiphenhydramineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Glutethimide.Approved
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Glutethimide.Approved, Illicit
DoramectinThe risk or severity of adverse effects can be increased when Glutethimide is combined with Doramectin.Vet Approved
DoxepinThe risk or severity of adverse effects can be increased when Glutethimide is combined with Doxepin.Approved
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.Approved, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when Glutethimide is combined with DPDPE.Investigational
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.Approved, Illicit
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.Approved, Vet Approved
DrotebanolThe risk or severity of adverse effects can be increased when Glutethimide is combined with Drotebanol.Experimental, Illicit
DuloxetineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Duloxetine.Approved
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Glutethimide.Approved
EcgonineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Ecgonine.Experimental, Illicit
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when Glutethimide is combined with ECGONINE METHYL ESTER.Experimental
EcopipamThe risk or severity of adverse effects can be increased when Glutethimide is combined with Ecopipam.Investigational
EfavirenzThe risk or severity of adverse effects can be increased when Glutethimide is combined with Efavirenz.Approved, Investigational
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Glutethimide.Approved, Vet Approved
EntacaponeThe risk or severity of adverse effects can be increased when Glutethimide is combined with Entacapone.Approved, Investigational
EscitalopramThe risk or severity of adverse effects can be increased when Glutethimide is combined with Escitalopram.Approved, Investigational
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Glutethimide.Approved, Illicit
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Glutethimide.Approved
EthanolGlutethimide may increase the central nervous system depressant (CNS depressant) activities of Ethanol.Approved
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Glutethimide.Approved, Illicit, Withdrawn
EthosuximideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Ethosuximide.Approved
EthotoinThe risk or severity of adverse effects can be increased when Glutethimide is combined with Ethotoin.Approved
Ethyl biscoumacetateThe metabolism of Ethyl biscoumacetate can be increased when combined with Glutethimide.Withdrawn
Ethyl carbamateThe risk or severity of adverse effects can be increased when Glutethimide is combined with Ethyl carbamate.Withdrawn
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Glutethimide is combined with Ethyl loflazepate.Approved, Illicit
EthylmorphineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Ethylmorphine.Approved, Illicit
EtidocaineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Etidocaine.Approved
EtifoxineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Etifoxine.Withdrawn
EtizolamThe risk or severity of adverse effects can be increased when Glutethimide is combined with Etizolam.Approved
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Glutethimide.Approved
EtoperidoneThe risk or severity of adverse effects can be increased when Glutethimide is combined with Etoperidone.Approved
EtorphineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Etorphine.Illicit, Vet Approved
EzogabineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Ezogabine.Approved
FelbamateThe risk or severity of adverse effects can be increased when Glutethimide is combined with Felbamate.Approved
FencamfamineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Fencamfamine.Approved, Illicit, Withdrawn
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Glutethimide.Approved, Illicit, Investigational, Vet Approved
FexofenadineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Fexofenadine.Approved
FlibanserinThe risk or severity of adverse effects can be increased when Glutethimide is combined with Flibanserin.Approved
FludiazepamThe risk or severity of adverse effects can be increased when Glutethimide is combined with Fludiazepam.Approved, Illicit
FluindioneThe metabolism of Fluindione can be increased when combined with Glutethimide.Investigational
FlunarizineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Flunarizine.Approved
FlunitrazepamThe risk or severity of adverse effects can be increased when Glutethimide is combined with Flunitrazepam.Approved, Illicit
FluoxetineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Fluoxetine.Approved, Vet Approved
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Glutethimide.Approved, Withdrawn
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Glutethimide.Approved
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Glutethimide.Approved, Illicit
FluspirileneThe risk or severity of adverse effects can be increased when Glutethimide is combined with Fluspirilene.Approved
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Glutethimide is combined with Fluticasone Propionate.Approved
FluvoxamineThe risk or severity of adverse effects can be increased when Fluvoxamine is combined with Glutethimide.Approved, Investigational
FosphenytoinThe risk or severity of adverse effects can be increased when Glutethimide is combined with Fosphenytoin.Approved
FospropofolThe risk or severity of adverse effects can be increased when Glutethimide is combined with Fospropofol.Approved, Illicit
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Glutethimide.Approved, Investigational
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Glutethimide is combined with gabapentin enacarbil.Approved
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Glutethimide is combined with Gamma Hydroxybutyric Acid.Approved, Illicit
GepironeThe risk or severity of adverse effects can be increased when Glutethimide is combined with Gepirone.Investigational
GuanfacineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Guanfacine.Approved, Investigational
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Glutethimide.Approved, Illicit, Withdrawn
HaloperidolThe risk or severity of adverse effects can be increased when Haloperidol is combined with Glutethimide.Approved
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Glutethimide.Approved, Vet Approved
HeroinThe risk or severity of adverse effects can be increased when Glutethimide is combined with Heroin.Approved, Illicit
HexobarbitalThe risk or severity of adverse effects can be increased when Hexobarbital is combined with Glutethimide.Approved
HydrocodoneGlutethimide may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Glutethimide.Approved, Illicit
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.Approved
IloperidoneThe risk or severity of adverse effects can be increased when Glutethimide is combined with Iloperidone.Approved
ImipramineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Imipramine.Approved
IndalpineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Indalpine.Investigational, Withdrawn
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Glutethimide.Approved, Vet Approved
KetamineThe risk or severity of adverse effects can be increased when Ketamine is combined with Glutethimide.Approved, Vet Approved
KetazolamThe risk or severity of adverse effects can be increased when Glutethimide is combined with Ketazolam.Approved
KetobemidoneThe risk or severity of adverse effects can be increased when Glutethimide is combined with Ketobemidone.Approved
LamotrigineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Lamotrigine.Approved, Investigational
LevetiracetamThe risk or severity of adverse effects can be increased when Glutethimide is combined with Levetiracetam.Approved, Investigational
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Glutethimide.Approved
LevocabastineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Levocabastine.Approved
LevocetirizineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Levocetirizine.Approved
LevodopaThe risk or severity of adverse effects can be increased when Glutethimide is combined with Levodopa.Approved
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Glutethimide.Approved
LevomilnacipranThe risk or severity of adverse effects can be increased when Glutethimide is combined with Levomilnacipran.Approved
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Glutethimide.Approved
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Glutethimide.Approved, Vet Approved
LithiumThe risk or severity of adverse effects can be increased when Lithium is combined with Glutethimide.Approved
LofentanilThe risk or severity of adverse effects can be increased when Glutethimide is combined with Lofentanil.Illicit
LoratadineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Loratadine.Approved
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Glutethimide.Approved
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Glutethimide.Approved
Lu AA21004The risk or severity of adverse effects can be increased when Glutethimide is combined with Lu AA21004.Investigational
LurasidoneThe risk or severity of adverse effects can be increased when Glutethimide is combined with Lurasidone.Approved
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.Approved, Vet Approved
MaprotilineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Maprotiline.Approved
MeclizineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Meclizine.Approved
MedetomidineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Medetomidine.Vet Approved
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Glutethimide.Approved, Nutraceutical, Vet Approved
MelperoneThe risk or severity of adverse effects can be increased when Glutethimide is combined with Melperone.Approved
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Glutethimide.Approved, Vet Approved
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Glutethimide.Approved, Illicit
MesoridazineThe risk or severity of adverse effects can be increased when Mesoridazine is combined with Glutethimide.Approved
MetaxaloneThe risk or severity of adverse effects can be increased when Glutethimide is combined with Metaxalone.Approved
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Glutethimide.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Glutethimide.Approved, Illicit
MethapyrileneThe risk or severity of adverse effects can be increased when Glutethimide is combined with Methapyrilene.Withdrawn
MethaqualoneThe risk or severity of adverse effects can be increased when Glutethimide is combined with Methaqualone.Illicit, Withdrawn
MethocarbamolThe risk or severity of adverse effects can be increased when Glutethimide is combined with Methocarbamol.Approved, Vet Approved
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Glutethimide.Approved
MethotrimeprazineGlutethimide may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Glutethimide.Approved, Vet Approved
MethsuximideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Methsuximide.Approved
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Glutethimide.Approved
MetyrosineGlutethimide may increase the sedative activities of Metyrosine.Approved
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Glutethimide.Approved, Illicit
MilnacipranThe risk or severity of adverse effects can be increased when Glutethimide is combined with Milnacipran.Approved
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.Approved, Investigational
MirtazapineGlutethimide may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MolindoneThe risk or severity of adverse effects can be increased when Glutethimide is combined with Molindone.Approved
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Glutethimide.Approved, Investigational
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.Approved, Investigational
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Glutethimide.Approved
NefazodoneThe risk or severity of adverse effects can be increased when Glutethimide is combined with Nefazodone.Approved, Withdrawn
NitrazepamThe risk or severity of adverse effects can be increased when Glutethimide is combined with Nitrazepam.Approved
Nitrous oxideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Nitrous oxide.Approved, Vet Approved
NormethadoneThe risk or severity of adverse effects can be increased when Glutethimide is combined with Normethadone.Approved, Illicit
NortriptylineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Nortriptyline.Approved
OlanzapineThe risk or severity of adverse effects can be increased when Olanzapine is combined with Glutethimide.Approved, Investigational
OlopatadineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Olopatadine.Approved
OndansetronThe risk or severity of adverse effects can be increased when Ondansetron is combined with Glutethimide.Approved
OpiumThe risk or severity of adverse effects can be increased when Glutethimide is combined with Opium.Approved, Illicit
OrphenadrineGlutethimide may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantThe risk or severity of adverse effects can be increased when Glutethimide is combined with Osanetant.Investigational
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Glutethimide.Approved
OxetacaineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Oxetacaine.Investigational
OxprenololThe risk or severity of adverse effects can be increased when Glutethimide is combined with Oxprenolol.Approved
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Glutethimide.Approved
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Glutethimide.Approved, Illicit, Investigational
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Glutethimide.Approved, Investigational, Vet Approved
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Glutethimide.Approved
ParaldehydeGlutethimide may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
ParoxetineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Paroxetine.Approved, Investigational
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Glutethimide.Approved, Vet Approved
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Glutethimide.Approved, Vet Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.Approved
PerazineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Perazine.Investigational
PerospironeThe risk or severity of adverse effects can be increased when Glutethimide is combined with Perospirone.Approved
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Glutethimide.Approved
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Glutethimide.Approved
PhenindioneThe metabolism of Phenindione can be increased when combined with Glutethimide.Approved
PhenobarbitalThe risk or severity of adverse effects can be increased when Phenobarbital is combined with Glutethimide.Approved
PhenoxyethanolThe risk or severity of adverse effects can be increased when Glutethimide is combined with Phenoxyethanol.Approved
PhenprocoumonThe metabolism of Phenprocoumon can be increased when combined with Glutethimide.Approved
PhenytoinThe risk or severity of adverse effects can be increased when Glutethimide is combined with Phenytoin.Approved, Vet Approved
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Glutethimide.Approved
PipamperoneThe risk or severity of adverse effects can be increased when Glutethimide is combined with Pipamperone.Approved
PipotiazineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Pipotiazine.Approved
PiritramideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Piritramide.Investigational
PizotifenThe risk or severity of adverse effects can be increased when Glutethimide is combined with Pizotifen.Approved
PomalidomideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Pomalidomide.Approved
PramipexoleGlutethimide may increase the sedative activities of Pramipexole.Approved, Investigational
PramocaineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Pramocaine.Approved
PrazepamThe risk or severity of adverse effects can be increased when Glutethimide is combined with Prazepam.Approved, Illicit
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Glutethimide.Approved, Illicit, Investigational
PregnanoloneThe risk or severity of adverse effects can be increased when Glutethimide is combined with Pregnanolone.Investigational
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Glutethimide.Approved
PrimidoneThe risk or severity of adverse effects can be increased when Glutethimide is combined with Primidone.Approved, Vet Approved
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Glutethimide.Approved, Investigational, Vet Approved
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Glutethimide.Approved, Vet Approved
PromazineThe risk or severity of adverse effects can be increased when Promazine is combined with Glutethimide.Approved, Vet Approved
PromethazineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Promethazine.Approved
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Glutethimide.Approved, Vet Approved
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Glutethimide.Approved, Investigational, Vet Approved
PropoxycaineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Propoxycaine.Approved
ProtriptylineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Protriptyline.Approved
PSD502The risk or severity of adverse effects can be increased when Glutethimide is combined with PSD502.Investigational
QuazepamThe risk or severity of adverse effects can be increased when Glutethimide is combined with Quazepam.Approved, Illicit
QuetiapineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Glutethimide.Approved
RacloprideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Raclopride.Investigational
RamelteonThe risk or severity of adverse effects can be increased when Glutethimide is combined with Ramelteon.Approved, Investigational
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Glutethimide.Approved
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Glutethimide.Approved, Withdrawn
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Glutethimide.Approved
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Glutethimide.Approved, Investigational
RitanserinThe risk or severity of adverse effects can be increased when Glutethimide is combined with Ritanserin.Investigational
RomifidineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Romifidine.Vet Approved
RopiniroleGlutethimide may increase the sedative activities of Ropinirole.Approved, Investigational
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Glutethimide.Approved
RotigotineGlutethimide may increase the sedative activities of Rotigotine.Approved
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Glutethimide.Approved
S-EthylisothioureaThe risk or severity of adverse effects can be increased when Glutethimide is combined with S-Ethylisothiourea.Experimental
Sage 547The risk or severity of adverse effects can be increased when Glutethimide is combined with Sage 547.Investigational
ScopolamineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Scopolamine.Approved
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Glutethimide.Approved, Vet Approved
SertindoleThe risk or severity of adverse effects can be increased when Glutethimide is combined with Sertindole.Approved, Withdrawn
SertralineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Sertraline.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Glutethimide.Approved, Vet Approved
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.Approved
StiripentolThe risk or severity of adverse effects can be increased when Glutethimide is combined with Stiripentol.Approved
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Glutethimide.Approved, Investigational
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Glutethimide.Approved
SuvorexantGlutethimide may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved
TandospironeThe risk or severity of adverse effects can be increased when Glutethimide is combined with Tandospirone.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.Approved
TasimelteonThe risk or severity of adverse effects can be increased when Glutethimide is combined with Tasimelteon.Approved
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Glutethimide.Approved
TetrabenazineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Tetrabenazine.Approved
TetracaineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Tetracaine.Approved, Vet Approved
TetrodotoxinThe risk or severity of adverse effects can be increased when Glutethimide is combined with Tetrodotoxin.Investigational
ThalidomideGlutethimide may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Glutethimide.Approved, Vet Approved
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Glutethimide.Approved, Vet Approved
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with Glutethimide.Approved
ThiothixeneThe risk or severity of adverse effects can be increased when Glutethimide is combined with Thiothixene.Approved
TiagabineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Tiagabine.Approved
TiaprideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Tiapride.Investigational
TiletamineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Tiletamine.Vet Approved
TizanidineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Tizanidine.Approved
TolcaponeThe risk or severity of adverse effects can be increased when Glutethimide is combined with Tolcapone.Approved, Withdrawn
TopiramateThe risk or severity of adverse effects can be increased when Glutethimide is combined with Topiramate.Approved
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Glutethimide.Approved, Investigational
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Trans-2-Phenylcyclopropylamine.Experimental
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Glutethimide.Approved
TrazodoneThe risk or severity of adverse effects can be increased when Trazodone is combined with Glutethimide.Approved, Investigational
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Glutethimide.Approved
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Glutethimide.Approved
TriflupromazineThe risk or severity of adverse effects can be increased when Triflupromazine is combined with Glutethimide.Approved, Vet Approved
TrimipramineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Trimipramine.Approved
TriprolidineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Triprolidine.Approved
Uc1010The risk or severity of adverse effects can be increased when Glutethimide is combined with Uc1010.Investigational
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Glutethimide.Approved, Investigational
VenlafaxineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Venlafaxine.Approved
VigabatrinThe risk or severity of adverse effects can be increased when Glutethimide is combined with Vigabatrin.Approved
VortioxetineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Vortioxetine.Approved
WarfarinThe metabolism of Warfarin can be increased when combined with Glutethimide.Approved
XylazineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Xylazine.Vet Approved
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Glutethimide.Approved, Illicit, Investigational
ZiconotideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Ziconotide.Approved
ZimelidineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Zimelidine.Withdrawn
ZiprasidoneThe risk or severity of adverse effects can be increased when Ziprasidone is combined with Glutethimide.Approved
ZolazepamThe risk or severity of adverse effects can be increased when Glutethimide is combined with Zolazepam.Vet Approved
ZolpidemGlutethimide may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZonisamideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Zonisamide.Approved, Investigational
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Glutethimide.Approved
ZotepineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Zotepine.Approved
ZuclopenthixolThe risk or severity of adverse effects can be increased when Glutethimide is combined with Zuclopenthixol.Approved, Investigational
Food Interactions
  • Avoid alcohol.
  • Take without regard to meals.
References
Synthesis Reference

Hoffmann, K. and Tagmann, E.; U.S. Patent 2,673,205; March 23, 1954; assigned to Ciba Pharmaceutical Products, Inc.

General ReferencesNot Available
External Links
ATC CodesN05CE01
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9973
Blood Brain Barrier+0.996
Caco-2 permeable+0.5931
P-glycoprotein substrateSubstrate0.6677
P-glycoprotein inhibitor INon-inhibitor0.5334
P-glycoprotein inhibitor IINon-inhibitor0.9611
Renal organic cation transporterNon-inhibitor0.7747
CYP450 2C9 substrateNon-substrate0.7785
CYP450 2D6 substrateNon-substrate0.894
CYP450 3A4 substrateSubstrate0.5173
CYP450 1A2 substrateNon-inhibitor0.8856
CYP450 2C9 inhibitorNon-inhibitor0.9101
CYP450 2D6 inhibitorNon-inhibitor0.8664
CYP450 2C19 inhibitorNon-inhibitor0.8671
CYP450 3A4 inhibitorNon-inhibitor0.863
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8527
Ames testNon AMES toxic0.8254
CarcinogenicityNon-carcinogens0.8911
BiodegradationNot ready biodegradable0.9927
Rat acute toxicity2.5276 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9778
hERG inhibition (predictor II)Non-inhibitor0.7311
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage formsNot Available
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point78-81Hoffmann, K. and Tagmann, E.; U.S. Patent 2,673,205; March 23, 1954; assigned to Ciba Pharmaceutical Products, Inc.
water solubility999 mg/L (at 30 °C)YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP1.90HANSCH,C ET AL. (1995)
logS-2.34ADME Research, USCD
pKa9.2SANGSTER (1994)
Predicted Properties
PropertyValueSource
Water Solubility0.327 mg/mLALOGPS
logP1.89ALOGPS
logP2.13ChemAxon
logS-2.8ALOGPS
pKa (Strongest Acidic)11.69ChemAxon
pKa (Strongest Basic)-6.7ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area46.17 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity60.65 m3·mol-1ChemAxon
Polarizability23.15 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (9.43 KB)
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as phenylpiperidines. These are compounds containing a phenylpiperidine skeleton, which consists of a piperidine bound to a phenyl group.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassPiperidines
Sub ClassPhenylpiperidines
Direct ParentPhenylpiperidines
Alternative Parents
Substituents
  • Phenylpiperidine
  • Piperidinedione
  • Piperidinone
  • Dicarboximide
  • Delta-lactam
  • Benzenoid
  • Monocyclic benzene moiety
  • Carboxylic acid imide, n-unsubstituted
  • Carboxylic acid imide
  • Lactam
  • Carboxamide group
  • Azacycle
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External DescriptorsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Inhibitory extracellular ligand-gated ion channel activity
Specific Function:
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By si...
Gene Name:
GABRA1
Uniprot ID:
P14867
Molecular Weight:
51801.395 Da
References
  1. Skerritt JH, Johnston GA: Interactions of some anaesthetic, convulsant, and anticonvulsant drugs at GABA-benzodiazepine receptor-ionophore complexes in rat brain synaptosomal membranes. Neurochem Res. 1983 Oct;8(10):1351-62. [PubMed:6318143 ]
Kind
Protein group
Organism
Human
Pharmacological action
yes
Actions
positive allosteric modulator
General Function:
Inhibitory extracellular ligand-gated ion channel activity
Specific Function:
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By similarity).
Components:
NameUniProt IDDetails
Gamma-aminobutyric acid receptor subunit alpha-1P14867 Details
Gamma-aminobutyric acid receptor subunit alpha-2P47869 Details
Gamma-aminobutyric acid receptor subunit alpha-3P34903 Details
Gamma-aminobutyric acid receptor subunit alpha-4P48169 Details
Gamma-aminobutyric acid receptor subunit alpha-5P31644 Details
Gamma-aminobutyric acid receptor subunit alpha-6Q16445 Details
Gamma-aminobutyric acid receptor subunit beta-1P18505 Details
Gamma-aminobutyric acid receptor subunit beta-2P47870 Details
Gamma-aminobutyric acid receptor subunit beta-3P28472 Details
Gamma-aminobutyric acid receptor subunit deltaO14764 Details
Gamma-aminobutyric acid receptor subunit epsilonP78334 Details
Gamma-aminobutyric acid receptor subunit gamma-1Q8N1C3 Details
Gamma-aminobutyric acid receptor subunit gamma-2P18507 Details
Gamma-aminobutyric acid receptor subunit gamma-3Q99928 Details
Gamma-aminobutyric acid receptor subunit piO00591 Details
Gamma-aminobutyric acid receptor subunit thetaQ9UN88 Details
References
  1. ChEMBL Compound Report Card [Link]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, nad(p)h as one donor, and incorporation of one atom of oxygen
Specific Function:
Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.
Gene Name:
CYP11A1
Uniprot ID:
P05108
Molecular Weight:
60101.87 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Pearson MW, Roberts CJ: Drug induction of hepatic enzymes in the elderly. Age Ageing. 1984 Sep;13(5):313-6. [PubMed:6496244 ]
  2. Petik D, Acs N, Banhidy F, Czeizel AE: A study of the effects of large doses of glutethimide that were used for self-poisoning during pregnancy on human fetuses. Toxicol Ind Health. 2008 Feb-Mar;24(1-2):69-78. doi: 10.1177/0748233708089014. [PubMed:18818183 ]
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Drug created on July 26, 2007 13:33 / Updated on August 17, 2016 12:23