Name
Indenes
Accession Number
DBCAT000931
Description

A family of fused-ring hydrocarbons isolated from coal tar that act as intermediates in various chemical reactions and are used in the production of coumarone-indene resins.

Drugs
DrugDrug Description
PhenindioneFor the treatment of pulmonary embolism, cardiomyopathy, atrial fibrillation and flutter, cerebral embolism, mural thrombosis, and thrombophili. Also used for anticoagulant prophylaxis.
SulindacAn NSAID used to treat osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute subacromial bursitis or supraspinatus tendinitis, and acute gouty arthritis.
CandoxatrilCandoxatril is the orally-active prodrug of candoxatrilat (UK-73967), a potent neutral endopeptidase (NEP) inhibitor.
DonepezilAn acetylcholinesterase inhibitor used to treat the behavioral and cognitive effects of Alzheimer's Disease and other types of dementia.
AnisindioneFor the prophylaxis and treatment of venous thrombosis and its extension, the treatment of atrial fibrillation with embolization, the prophylaxis and treatment of pulmonary embolism, and as an adjunct in...
RasagilineAn irreversible inhibitor of monoamine oxidase used for the symptomatic management of idiopathic Parkinson's disease as initial monotherapy and as adjunct therapy to levodopa.
AprindineAprindine is a cardiac depressant used in arrhythmias.
L-756423Not Available
IndacaterolAn inhaled long-acting beta-2 adrenergic agonist used to relax bronchial smooth muscle and improve symptoms and airflow obstruction caused by Chronic Obstructive Pulmonary Disease (COPD) and moderate to severe asthma.
RonacaleretPost-menopausal women with osteoporosis
OSI-461Investigated for use/treatment in crohn's disease, inflammatory bowel disease, kidney cancer, leukemia (lymphoid), and prostate cancer.
ExisulindInvestigated for use/treatment in adenomatous polyposis coli, lung cancer, prostate cancer, colon polyps, Barrett's esophagus disease, and pediatric indications.
EnrasentanInvestigated for use/treatment in congestive heart failure, chronic obstructive pulmonary disease (COPD), and benign prostatic hyperplasia.
FipamezoleInvestigated for use/treatment in parkinson's disease and neurologic disorders.
DimetindeneIndicated as symptomatic treatment of allergic reactions: urticaria, allergies of the upper respiratory tract such as hey fever and perennial rhinitis, food and drug allergies; pruritus of various origins, except...
OzanimodA sphingosine 1-phosphate receptor modulator being studied to treat Multiple Sclerosis (MS) and inflammatory bowel disease (IBD).
ST-101ST101 has been used in trials studying the treatment of Essential Tremor and Alzheimer's Disease.
GSK-1521498GSK1521498 has been used in trials studying the treatment of Obesity and Alcoholism.
AQX-1125AQX-1125 has been used in trials studying the treatment of COPD, Atopic Dermatitis, Interstitial Cystitis, and Bladder Pain Syndrome.
FluindioneFluindione is under investigation for the treatment of Venous Thrombosis, Pulmonary Embolism, Permanent Atrial Fibrillation, and Anticoagulating Treatment on a Duration at Least 12-month-old Superior. Fluindione has been investigated for...
ClorindioneClorindione is a vitamin K antagonist, which may be useful to decrease prothrombin levels in humans.
DelaprilNot Annotated
DiphenadioneNot Annotated
IndantadolIndantadol has been used in trials studying the treatment of Cough and Diabetic Peripheral Neuropathic Pain.
Drugs & Drug Targets
DrugTargetType
PhenindioneVitamin K epoxide reductase complex subunit 1target
SulindacProstaglandin G/H synthase 2target
SulindacAldose reductasetarget
SulindacProstaglandin G/H synthase 1target
SulindacMitogen-activated protein kinase 3target
SulindacPeroxisome proliferator-activated receptor deltatarget
SulindacProstaglandin D2 receptor 2target
SulindacSerum albumincarrier
SulindacSolute carrier family 22 member 6transporter
SulindacCytochrome P450 1A1enzyme
SulindacAldo-keto reductase family 1 member B10target
CandoxatrilNeprilysintarget
CandoxatrilAngiotensin-converting enzymetarget
DonepezilAcetylcholinesterasetarget
Donepezil5-hydroxytryptamine receptor 2Atarget
DonepezilCytochrome P450 3A4enzyme
DonepezilCytochrome P450 2D6enzyme
DonepezilCytochrome P450 2C9enzyme
DonepezilCholinesterasetarget
DonepezilNitric oxide synthase, braintarget
DonepezilTumor necrosis factor-inducible gene 6 proteintarget
DonepezilInterleukin-1 betatarget
DonepezilNuclear factor NF-kappa-Btarget
DonepezilATP-binding cassette sub-family G member 2transporter
DonepezilNMDA receptortarget
AnisindioneVitamin K-dependent gamma-carboxylasetarget
RasagilineApoptosis regulator Bcl-2target
RasagilineAmine oxidase [flavin-containing] Btarget
RasagilineCytochrome P450 1A2enzyme
AprindineAlpha-1-acid glycoprotein 1carrier
AprindineCalmodulintarget
AprindineSodium channel protein type 5 subunit alphatarget
AprindineCytochrome P450 2D6enzyme
L-756423Gag-Pol polyproteintarget
IndacaterolBeta-2 adrenergic receptortarget
IndacaterolCytochrome P450 3A4enzyme
IndacaterolUDP-glucuronosyltransferase 1-1enzyme
IndacaterolP-glycoprotein 1transporter
RonacaleretExtracellular calcium-sensing receptortarget
RonacaleretProbable G-protein coupled receptor 110target
OSI-461cGMP-specific 3',5'-cyclic phosphodiesterasetarget
ExisulindcAMP-specific 3',5'-cyclic phosphodiesterase 4Dtarget
ExisulindcAMP-specific 3',5'-cyclic phosphodiesterase 4Ctarget
ExisulindcGMP-specific 3',5'-cyclic phosphodiesterasetarget
ExisulindcGMP-dependent 3',5'-cyclic phosphodiesterasetarget
ExisulindGlutathione S-transferase Ptarget
ExisulindAldose reductasetarget
ExisulindAldo-keto reductase family 1 member B10target
EnrasentanEndothelin-1 receptortarget
EnrasentanEndothelin B receptortarget
DimetindeneMuscarinic acetylcholine receptor M2target
DimetindeneHistamine H1 receptortarget
OzanimodSphingosine 1-phosphate receptor 1target
OzanimodSphingosine 1-phosphate receptor 5target
OzanimodAmine oxidase [flavin-containing] Btransporter
OzanimodATP-binding cassette sub-family G member 2transporter
OzanimodP-glycoprotein 1transporter
OzanimodFatty aldehyde dehydrogenaseenzyme
OzanimodAlcohol dehydrogenase class-3enzyme
OzanimodArylamine N-acetyltransferase 2enzyme
OzanimodCytochrome P450 2C8enzyme
OzanimodAmine oxidase [flavin-containing] Benzyme
OzanimodAldo-keto reductase family 1 member C1enzyme
OzanimodAldo-keto reductase family 1 member C2enzyme
OzanimodCytochrome P450 3A4enzyme
FluindioneCytochrome P450 2C9enzyme
FluindioneCytochrome P450 3A4enzyme
ClorindioneCytochrome P450 3A4enzyme
DiphenadioneCytochrome P450 3A4enzyme