Fluindione is under investigation for the treatment of Venous Thrombosis, Pulmonary Embolism, Permanent Atrial Fibrillation, and Anticoagulating Treatment on a Duration at Least 12-month-old Superior. Fluindione has been investigated for the treatment of Blood Coagulation Disorders.

Structure

Similar Structures

Synonyms

Not Available

Categories

UNII

EQ35YMS20Q

CAS number

957-56-2

Weight

Average: 240.233
Monoisotopic: 240.058657693

Chemical Formula

C₁₅H₉FO₂

InChI Key

NASXCEITKQITLD-UHFFFAOYSA-N

InChI

InChI=1S/C15H9FO2/c16-10-7-5-9(6-8-10)13-14(17)11-3-1-2-4-12(11)15(13)18/h1-8,13H

IUPAC Name

2-(4-fluorophenyl)-2,3-dihydro-1H-indene-1,3-dione

SMILES

FC1=CC=C(C=C1)C1C(=O)C2=CC=CC=C2C1=O

Pharmacology

Indication: Not Available
Pharmacodynamics: Not Available
Mechanism of action: Not Available
Absorption: Not Available
Volume of distribution: Not Available
Protein binding: Not Available
Metabolism: Not Available
Route of elimination: Not Available
Half life: Not Available
Clearance: Not Available
Toxicity: Not Available
Affected organisms: Not Available
Pathways: Not Available
Pharmacogenomic Effects/ADRs: Not Available

Interactions

Drug Interactions

Drug	Interaction	Drug group
(4R)-limonene	(4R)-limonene may increase the anticoagulant activities of Fluindione.	Investigational
Abciximab	Abciximab may increase the anticoagulant activities of Fluindione.	Approved
Aceclofenac	Aceclofenac may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Acemetacin	The risk or severity of bleeding can be increased when Fluindione is combined with Acemetacin.	Approved, Experimental, Investigational
Acenocoumarol	Acenocoumarol may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Acetaminophen	Acetaminophen may increase the anticoagulant activities of Fluindione.	Approved
Acetohexamide	Acetohexamide may increase the anticoagulant activities of Fluindione.	Approved, Investigational, Withdrawn
Acetylsalicylic acid	Acetylsalicylic acid may increase the anticoagulant activities of Fluindione.	Approved, Vet Approved
Adapalene	Adapalene may increase the anticoagulant activities of Fluindione.	Approved
Alaproclate	Alaproclate may increase the anticoagulant activities of Fluindione.	Experimental
Alclofenac	Alclofenac may increase the anticoagulant activities of Fluindione.	Approved, Withdrawn
Allopurinol	Allopurinol may increase the anticoagulant activities of Fluindione.	Approved
Allylestrenol	The therapeutic efficacy of Fluindione can be decreased when used in combination with Allylestrenol.	Approved
Alminoprofen	Alminoprofen may increase the anticoagulant activities of Fluindione.	Experimental
Aloxiprin	Aloxiprin may increase the anticoagulant activities of Fluindione.	Experimental
Alprostadil	Alprostadil may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Alteplase	Alteplase may increase the anticoagulant activities of Fluindione.	Approved
Altrenogest	The therapeutic efficacy of Fluindione can be decreased when used in combination with Altrenogest.	Vet Approved
Aluminium clofibrate	Aluminium clofibrate may increase the anticoagulant activities of Fluindione.	Experimental
Amdinocillin	Amdinocillin may increase the anticoagulant activities of Fluindione.	Investigational, Withdrawn
Amineptine	Amineptine may increase the anticoagulant activities of Fluindione.	Illicit, Withdrawn
Aminosalicylic Acid	Aminosalicylic Acid may increase the anticoagulant activities of Fluindione.	Approved
Amiodarone	The therapeutic efficacy of Fluindione can be increased when used in combination with Amiodarone.	Approved, Investigational
Amitriptyline	Amitriptyline may increase the anticoagulant activities of Fluindione.	Approved
Amitriptylinoxide	Amitriptylinoxide may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Amobarbital	The metabolism of Fluindione can be increased when combined with Amobarbital.	Approved, Illicit
Amoxapine	Amoxapine may increase the anticoagulant activities of Fluindione.	Approved
Amoxicillin	Amoxicillin may increase the anticoagulant activities of Fluindione.	Approved, Vet Approved
Ampicillin	Ampicillin may increase the anticoagulant activities of Fluindione.	Approved, Vet Approved
Anagrelide	Anagrelide may increase the anticoagulant activities of Fluindione.	Approved
Ancrod	Ancrod may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Andrographolide	Andrographolide may increase the anticoagulant activities of Fluindione.	Investigational
Anisodamine	Anisodamine may increase the anticoagulant activities of Fluindione.	Investigational
Anistreplase	Anistreplase may increase the anticoagulant activities of Fluindione.	Approved
Antipyrine	Antipyrine may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Antithrombin III human	Antithrombin III human may increase the anticoagulant activities of Fluindione.	Approved
Antrafenine	Antrafenine may increase the anticoagulant activities of Fluindione.	Approved
Apixaban	Apixaban may increase the anticoagulant activities of Fluindione.	Approved
Apocynin	Apocynin may increase the anticoagulant activities of Fluindione.	Investigational
Apremilast	Apremilast may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Aprotinin	The therapeutic efficacy of Fluindione can be decreased when used in combination with Aprotinin.	Approved, Investigational, Withdrawn
Ardeparin	Ardeparin may increase the anticoagulant activities of Fluindione.	Approved, Investigational, Withdrawn
Argatroban	Argatroban may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Aspoxicillin	Aspoxicillin may increase the anticoagulant activities of Fluindione.	Experimental
Astaxanthin	Astaxanthin may increase the anticoagulant activities of Fluindione.	Investigational
Azapropazone	Azapropazone may increase the anticoagulant activities of Fluindione.	Withdrawn
Azathioprine	Azathioprine may decrease the anticoagulant activities of Fluindione.	Approved
Azelastine	Azelastine may increase the anticoagulant activities of Fluindione.	Approved
Azficel-T	The risk or severity of adverse effects can be increased when Fluindione is combined with Azficel-T.	Approved, Investigational
Azidocillin	Azidocillin may increase the anticoagulant activities of Fluindione.	Approved
Azithromycin	The serum concentration of Fluindione can be increased when it is combined with Azithromycin.	Approved
Azlocillin	Azlocillin may increase the anticoagulant activities of Fluindione.	Approved
Bacampicillin	Bacampicillin may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Balsalazide	Balsalazide may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Barbexaclone	The metabolism of Fluindione can be increased when combined with Barbexaclone.	Experimental
Barbital	The metabolism of Fluindione can be increased when combined with Barbital.	Illicit
Batroxobin	Batroxobin may increase the anticoagulant activities of Fluindione.	Experimental
Bazedoxifene	Bazedoxifene may decrease the anticoagulant activities of Fluindione.	Approved, Investigational
Becaplermin	Becaplermin may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Bemiparin	Bemiparin may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Bendazac	Bendazac may increase the anticoagulant activities of Fluindione.	Experimental
Benorilate	Benorilate may increase the anticoagulant activities of Fluindione.	Experimental
Benoxaprofen	Benoxaprofen may increase the anticoagulant activities of Fluindione.	Withdrawn
Benzydamine	Benzydamine may increase the anticoagulant activities of Fluindione.	Approved
Benzylpenicillin	Benzylpenicillin may increase the anticoagulant activities of Fluindione.	Approved, Vet Approved
Benzylpenicilloyl Polylysine	Benzylpenicilloyl Polylysine may increase the anticoagulant activities of Fluindione.	Approved
Beraprost	Beraprost may increase the anticoagulant activities of Fluindione.	Investigational
Bevonium	Bevonium may increase the anticoagulant activities of Fluindione.	Experimental
Bezafibrate	Bezafibrate may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Bicalutamide	The serum concentration of Fluindione can be increased when it is combined with Bicalutamide.	Approved
Bivalirudin	Bivalirudin may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Bosentan	The metabolism of Fluindione can be increased when combined with Bosentan.	Approved, Investigational
Brinase	Brinase may increase the anticoagulant activities of Fluindione.	Experimental
Bromfenac	Bromfenac may increase the anticoagulant activities of Fluindione.	Approved
Bucillamine	Bucillamine may increase the anticoagulant activities of Fluindione.	Investigational
Bufexamac	Bufexamac may increase the anticoagulant activities of Fluindione.	Approved, Experimental
Buflomedil	Buflomedil may increase the anticoagulant activities of Fluindione.	Experimental
Bumadizone	Bumadizone may increase the anticoagulant activities of Fluindione.	Experimental
Butriptyline	Butriptyline may increase the anticoagulant activities of Fluindione.	Approved
Butylphthalide	Butylphthalide may increase the anticoagulant activities of Fluindione.	Investigational
Cangrelor	Cangrelor may increase the anticoagulant activities of Fluindione.	Approved
Capecitabine	The serum concentration of Fluindione can be increased when it is combined with Capecitabine.	Approved, Investigational
Caplacizumab	Caplacizumab may increase the anticoagulant activities of Fluindione.	Investigational
Capsaicin	Capsaicin may increase the anticoagulant activities of Fluindione.	Approved
Carbamazepine	The serum concentration of Fluindione can be decreased when it is combined with Carbamazepine.	Approved, Investigational
Carbaspirin calcium	Carbaspirin calcium may increase the anticoagulant activities of Fluindione.	Experimental, Investigational
Carbenicillin	Carbenicillin may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Carbenicillin indanyl	Carbenicillin indanyl may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Carbimazole	Carbimazole may decrease the anticoagulant activities of Fluindione.	Approved, Investigational
Carbomycin	The serum concentration of Fluindione can be increased when it is combined with Carbomycin.	Vet Approved
Carbutamide	Carbutamide may increase the anticoagulant activities of Fluindione.	Experimental
Carfecillin	Carfecillin may increase the anticoagulant activities of Fluindione.	Experimental
Carprofen	Carprofen may increase the anticoagulant activities of Fluindione.	Approved, Vet Approved, Withdrawn
Castanospermine	Castanospermine may increase the anticoagulant activities of Fluindione.	Experimental
Cefacetrile	Cefacetrile may increase the anticoagulant activities of Fluindione.	Approved
Cefaclor	Cefaclor may increase the anticoagulant activities of Fluindione.	Approved
Cefadroxil	Cefadroxil may increase the anticoagulant activities of Fluindione.	Approved, Vet Approved, Withdrawn
Cefalotin	Cefalotin may increase the anticoagulant activities of Fluindione.	Approved, Investigational, Vet Approved
Cefamandole	Cefamandole may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Cefapirin	Cefapirin may increase the anticoagulant activities of Fluindione.	Approved, Vet Approved
Cefatrizine	Cefatrizine may increase the anticoagulant activities of Fluindione.	Experimental
Cefazedone	Cefazedone may increase the anticoagulant activities of Fluindione.	Experimental
Cefazolin	Cefazolin may increase the anticoagulant activities of Fluindione.	Approved
Cefbuperazone	Cefbuperazone may increase the anticoagulant activities of Fluindione.	Experimental
Cefcapene	Cefcapene may increase the anticoagulant activities of Fluindione.	Experimental
Cefdinir	Cefdinir may increase the anticoagulant activities of Fluindione.	Approved
Cefditoren	Cefditoren may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Cefepime	Cefepime may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Cefetamet	Cefetamet may increase the anticoagulant activities of Fluindione.	Experimental
Cefixime	Cefixime may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Cefmenoxime	Cefmenoxime may increase the anticoagulant activities of Fluindione.	Approved
Cefmetazole	Cefmetazole may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Cefminox	Cefminox may increase the anticoagulant activities of Fluindione.	Approved
Cefodizime	Cefodizime may increase the anticoagulant activities of Fluindione.	Experimental
Cefonicid	Cefonicid may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Cefoperazone	Cefoperazone may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Ceforanide	Ceforanide may increase the anticoagulant activities of Fluindione.	Approved
Cefotaxime	Cefotaxime may increase the anticoagulant activities of Fluindione.	Approved
Cefotetan	Cefotetan may increase the anticoagulant activities of Fluindione.	Approved
Cefotiam	Cefotiam may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Cefoxitin	Cefoxitin may increase the anticoagulant activities of Fluindione.	Approved
Cefozopran	Cefozopran may increase the anticoagulant activities of Fluindione.	Experimental
Cefpirome	Cefpirome may increase the anticoagulant activities of Fluindione.	Approved
Cefpodoxime	Cefpodoxime may increase the anticoagulant activities of Fluindione.	Approved, Vet Approved
Cefprozil	Cefprozil may increase the anticoagulant activities of Fluindione.	Approved
Cefradine	Cefradine may increase the anticoagulant activities of Fluindione.	Approved
Cefroxadine	Cefroxadine may increase the anticoagulant activities of Fluindione.	Withdrawn
Cefsulodin	Cefsulodin may increase the anticoagulant activities of Fluindione.	Experimental
Ceftaroline fosamil	Ceftaroline fosamil may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Ceftazidime	Ceftazidime may increase the anticoagulant activities of Fluindione.	Approved
Ceftezole	Ceftezole may increase the anticoagulant activities of Fluindione.	Experimental
Ceftibuten	Ceftibuten may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Ceftizoxime	Ceftizoxime may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Ceftobiprole	Ceftobiprole may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Ceftriaxone	Ceftriaxone may increase the anticoagulant activities of Fluindione.	Approved
Cefuroxime	Cefuroxime may increase the anticoagulant activities of Fluindione.	Approved
Celecoxib	Celecoxib may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Cephalexin	Cephalexin may increase the anticoagulant activities of Fluindione.	Approved, Investigational, Vet Approved
Cephaloglycin	Cephaloglycin may increase the anticoagulant activities of Fluindione.	Approved
Cephaloridine	Cephaloridine may increase the anticoagulant activities of Fluindione.	Approved, Withdrawn
Certoparin	Certoparin may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Chloral hydrate	The serum concentration of Fluindione can be increased when it is combined with Chloral hydrate.	Approved, Illicit, Investigational, Vet Approved
Chloramphenicol	Chloramphenicol may increase the anticoagulant activities of Fluindione.	Approved, Vet Approved
Chlormadinone	Chlormadinone may decrease the anticoagulant activities of Fluindione.	Experimental
Chloroquine	Chloroquine may increase the anticoagulant activities of Fluindione.	Approved, Investigational, Vet Approved
Chlorotrianisene	Chlorotrianisene may decrease the anticoagulant activities of Fluindione.	Investigational, Withdrawn
Chlorphenesin	Chlorphenesin may increase the anticoagulant activities of Fluindione.	Approved, Vet Approved, Withdrawn
Chlorpropamide	Chlorpropamide may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Chlortetracycline	Chlortetracycline may increase the anticoagulant activities of Fluindione.	Approved, Investigational, Vet Approved
Cholestyramine	Cholestyramine can cause a decrease in the absorption of Fluindione resulting in a reduced serum concentration and potentially a decrease in efficacy.	Approved, Investigational
Choline magnesium trisalicylate	Choline magnesium trisalicylate may increase the anticoagulant activities of Fluindione.	Approved
Cilostazol	Cilostazol may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Cimetidine	Cimetidine may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Cimicoxib	Cimicoxib may increase the anticoagulant activities of Fluindione.	Investigational
Cinoxacin	Cinoxacin may increase the anticoagulant activities of Fluindione.	Approved, Investigational, Withdrawn
Ciprofibrate	Ciprofibrate may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Ciprofloxacin	Ciprofloxacin may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Cisplatin	Cisplatin may increase the anticoagulant activities of Fluindione.	Approved
Citalopram	Citalopram may increase the anticoagulant activities of Fluindione.	Approved
Citric Acid	Citric Acid may increase the anticoagulant activities of Fluindione.	Approved, Nutraceutical, Vet Approved
Clarithromycin	The serum concentration of Fluindione can be increased when it is combined with Clarithromycin.	Approved
Clodronic Acid	Clodronic Acid may increase the anticoagulant activities of Fluindione.	Approved, Investigational, Vet Approved
Clofibrate	Clofibrate may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Clofibride	Clofibride may increase the anticoagulant activities of Fluindione.	Experimental
Clomipramine	Clomipramine may increase the anticoagulant activities of Fluindione.	Approved, Investigational, Vet Approved
Clonixin	Clonixin may increase the anticoagulant activities of Fluindione.	Approved
Clopidogrel	Clopidogrel may increase the anticoagulant activities of Fluindione.	Approved
Cloricromen	Cloricromen may increase the anticoagulant activities of Fluindione.	Experimental
Clorindione	Clorindione may increase the anticoagulant activities of Fluindione.	Experimental
Cloxacillin	Cloxacillin may decrease the anticoagulant activities of Fluindione.	Approved, Investigational, Vet Approved
Colesevelam	Colesevelam can cause a decrease in the absorption of Fluindione resulting in a reduced serum concentration and potentially a decrease in efficacy.	Approved
Colestipol	Colestipol can cause a decrease in the absorption of Fluindione resulting in a reduced serum concentration and potentially a decrease in efficacy.	Approved
Collagenase clostridium histolyticum	The risk or severity of adverse effects can be increased when Fluindione is combined with Collagenase clostridium histolyticum.	Approved, Investigational
Conjugated estrogens	Conjugated estrogens may decrease the anticoagulant activities of Fluindione.	Approved
Cranberry	Cranberry may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Curcumin	Curcumin may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Cyclacillin	Cyclacillin may increase the anticoagulant activities of Fluindione.	Approved
Cyproterone acetate	Cyproterone acetate may decrease the anticoagulant activities of Fluindione.	Approved, Investigational
Dabigatran etexilate	Dabigatran etexilate may increase the anticoagulant activities of Fluindione.	Approved
Daidzein	Daidzein may decrease the anticoagulant activities of Fluindione.	Experimental
Dalteparin	Dalteparin may increase the anticoagulant activities of Fluindione.	Approved
Danaparoid	Danaparoid may increase the anticoagulant activities of Fluindione.	Approved, Withdrawn
Danazol	Danazol may increase the anticoagulant activities of Fluindione.	Approved
Dapoxetine	Dapoxetine may increase the anticoagulant activities of Fluindione.	Investigational
Darexaban	Darexaban may increase the anticoagulant activities of Fluindione.	Investigational
Dasatinib	Dasatinib may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Deferasirox	The risk or severity of adverse effects can be increased when Fluindione is combined with Deferasirox.	Approved, Investigational
Defibrotide	Defibrotide may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Demeclocycline	Demeclocycline may increase the anticoagulant activities of Fluindione.	Approved
Demegestone	The therapeutic efficacy of Fluindione can be decreased when used in combination with Demegestone.	Approved
Deoxycholic Acid	The risk or severity of adverse effects can be increased when Fluindione is combined with Deoxycholic Acid.	Approved
Dersalazine	Dersalazine may increase the anticoagulant activities of Fluindione.	Investigational
Desipramine	Desipramine may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Desirudin	Desirudin may increase the anticoagulant activities of Fluindione.	Approved
Desmoteplase	Desmoteplase may increase the anticoagulant activities of Fluindione.	Investigational
Desogestrel	Desogestrel may decrease the anticoagulant activities of Fluindione.	Approved
Desvenlafaxine	The risk or severity of adverse effects can be increased when Desvenlafaxine is combined with Fluindione.	Approved, Investigational
Dexibuprofen	Dexibuprofen may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Dexketoprofen	Dexketoprofen may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Dexmethylphenidate	The serum concentration of Fluindione can be increased when it is combined with Dexmethylphenidate.	Approved, Investigational
Dextran	Dextran may increase the anticoagulant activities of Fluindione.	Approved, Investigational, Vet Approved
Dibenzepin	Dibenzepin may increase the anticoagulant activities of Fluindione.	Experimental
Diclofenac	Diclofenac may increase the anticoagulant activities of Fluindione.	Approved, Vet Approved
Dicloxacillin	Dicloxacillin may decrease the anticoagulant activities of Fluindione.	Approved, Investigational, Vet Approved
Dicoumarol	Dicoumarol may increase the anticoagulant activities of Fluindione.	Approved
Dienestrol	Dienestrol may decrease the anticoagulant activities of Fluindione.	Approved, Investigational
Dienogest	Dienogest may decrease the anticoagulant activities of Fluindione.	Approved
Diethylstilbestrol	Diethylstilbestrol may decrease the anticoagulant activities of Fluindione.	Approved, Investigational
Difenpiramide	Difenpiramide may increase the anticoagulant activities of Fluindione.	Experimental
Diflunisal	Diflunisal may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Dimetacrine	Dimetacrine may increase the anticoagulant activities of Fluindione.	Approved, Withdrawn
Diphenadione	Diphenadione may increase the anticoagulant activities of Fluindione.	Experimental
Dipyridamole	Dipyridamole may increase the anticoagulant activities of Fluindione.	Approved
Disulfiram	The serum concentration of Fluindione can be increased when it is combined with Disulfiram.	Approved
Ditazole	Ditazole may increase the anticoagulant activities of Fluindione.	Approved, Withdrawn
Dosulepin	Dosulepin may increase the anticoagulant activities of Fluindione.	Approved
Doxepin	Doxepin may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Doxycycline	Doxycycline may increase the anticoagulant activities of Fluindione.	Approved, Investigational, Vet Approved
Dronedarone	The serum concentration of Fluindione can be increased when it is combined with Dronedarone.	Approved
Drospirenone	Drospirenone may decrease the anticoagulant activities of Fluindione.	Approved
Drotrecogin alfa	Drotrecogin alfa may increase the anticoagulant activities of Fluindione.	Approved, Investigational, Withdrawn
Droxicam	Droxicam may increase the anticoagulant activities of Fluindione.	Withdrawn
Duloxetine	Duloxetine may increase the anticoagulant activities of Fluindione.	Approved
Duvelisib	Duvelisib may increase the anticoagulant activities of Fluindione.	Investigational
Dydrogesterone	The therapeutic efficacy of Fluindione can be decreased when used in combination with Dydrogesterone.	Approved, Investigational, Withdrawn
E-6201	E-6201 may increase the anticoagulant activities of Fluindione.	Investigational
Econazole	The serum concentration of Fluindione can be increased when it is combined with Econazole.	Approved
Edetic Acid	Edetic Acid may increase the anticoagulant activities of Fluindione.	Approved, Vet Approved
Edoxaban	Edoxaban may increase the anticoagulant activities of Fluindione.	Approved
Efavirenz	The serum concentration of Fluindione can be decreased when it is combined with Efavirenz.	Approved, Investigational
Enoxacin	Enoxacin may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Enoxaparin	Enoxaparin may increase the anticoagulant activities of Fluindione.	Approved
Epicillin	Epicillin may increase the anticoagulant activities of Fluindione.	Experimental
Epimestrol	Epimestrol may decrease the anticoagulant activities of Fluindione.	Experimental
Epinastine	Epinastine may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Epirizole	Epirizole may increase the anticoagulant activities of Fluindione.	Approved
Eplivanserin	Eplivanserin may increase the anticoagulant activities of Fluindione.	Investigational
eplivanserine	eplivanserine may increase the anticoagulant activities of Fluindione.	Investigational
Epoprostenol	Epoprostenol may increase the anticoagulant activities of Fluindione.	Approved
Eptifibatide	Eptifibatide may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Equol	Equol may decrease the anticoagulant activities of Fluindione.	Investigational
Erythromycin	The serum concentration of Fluindione can be increased when it is combined with Erythromycin.	Approved, Investigational, Vet Approved
Escitalopram	Escitalopram may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Esomeprazole	The serum concentration of Fluindione can be increased when it is combined with Esomeprazole.	Approved, Investigational
Estradiol	Estradiol may decrease the anticoagulant activities of Fluindione.	Approved, Investigational, Vet Approved
Estradiol acetate	Estradiol acetate may decrease the anticoagulant activities of Fluindione.	Approved, Investigational, Vet Approved
Estradiol cypionate	Estradiol cypionate may decrease the anticoagulant activities of Fluindione.	Approved, Investigational, Vet Approved
Estradiol valerate	Estradiol valerate may decrease the anticoagulant activities of Fluindione.	Approved, Investigational, Vet Approved
Estriol	Estriol may decrease the anticoagulant activities of Fluindione.	Approved, Investigational, Vet Approved
Estrogens, esterified	Estrogens, esterified may decrease the anticoagulant activities of Fluindione.	Approved
Estrone	Estrone may decrease the anticoagulant activities of Fluindione.	Approved
Etacrynic acid	The serum concentration of Fluindione can be increased when it is combined with Etacrynic acid.	Approved, Investigational
Etanercept	Etanercept may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Ethanol	The serum concentration of Fluindione can be decreased when it is combined with Ethanol.	Approved
Ethenzamide	Ethenzamide may increase the anticoagulant activities of Fluindione.	Experimental
Ethinyl Estradiol	Ethinyl Estradiol may decrease the anticoagulant activities of Fluindione.	Approved
Ethotoin	Ethotoin may increase the anticoagulant activities of Fluindione.	Approved
Ethyl biscoumacetate	Ethyl biscoumacetate may increase the anticoagulant activities of Fluindione.	Withdrawn
Ethynodiol	The therapeutic efficacy of Fluindione can be decreased when used in combination with Ethynodiol.	Experimental
Ethynodiol diacetate	Ethynodiol diacetate may decrease the anticoagulant activities of Fluindione.	Approved
Etodolac	Etodolac may increase the anticoagulant activities of Fluindione.	Approved, Investigational, Vet Approved
Etofenamate	Etofenamate may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Etofibrate	Etofibrate may increase the anticoagulant activities of Fluindione.	Approved
Etonogestrel	Etonogestrel may decrease the anticoagulant activities of Fluindione.	Approved, Investigational
Etoperidone	Etoperidone may increase the anticoagulant activities of Fluindione.	Withdrawn
Etoposide	Etoposide may increase the anticoagulant activities of Fluindione.	Approved
Etoricoxib	Etoricoxib may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Evening primrose oil	Evening primrose oil may increase the anticoagulant activities of Fluindione.	Investigational, Nutraceutical
Exenatide	Exenatide may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Exisulind	Exisulind may increase the anticoagulant activities of Fluindione.	Investigational
Felbinac	Felbinac may increase the anticoagulant activities of Fluindione.	Experimental
Fenbufen	Fenbufen may increase the anticoagulant activities of Fluindione.	Approved
Fenofibrate	Fenofibrate may increase the anticoagulant activities of Fluindione.	Approved
Fenofibric acid	Fenofibric acid may increase the anticoagulant activities of Fluindione.	Approved
Fenoprofen	Fenoprofen may increase the anticoagulant activities of Fluindione.	Approved
Fentiazac	Fentiazac may increase the anticoagulant activities of Fluindione.	Experimental
Feprazone	Feprazone may increase the anticoagulant activities of Fluindione.	Experimental
Ferulic acid	Ferulic acid may increase the anticoagulant activities of Fluindione.	Experimental
Fibrinolysin	Fibrinolysin may increase the anticoagulant activities of Fluindione.	Investigational
Fish oil	Fish oil may increase the anticoagulant activities of Fluindione.	Approved, Nutraceutical
Fleroxacin	Fleroxacin may increase the anticoagulant activities of Fluindione.	Approved
Floctafenine	Floctafenine may increase the anticoagulant activities of Fluindione.	Approved, Withdrawn
Flucloxacillin	Flucloxacillin may decrease the anticoagulant activities of Fluindione.	Approved, Investigational
Fluconazole	The serum concentration of Fluindione can be increased when it is combined with Fluconazole.	Approved, Investigational
Flumequine	Flumequine may increase the anticoagulant activities of Fluindione.	Withdrawn
Flunixin	Flunixin may increase the anticoagulant activities of Fluindione.	Vet Approved
Flunoxaprofen	Flunoxaprofen may increase the anticoagulant activities of Fluindione.	Experimental
Fluorouracil	The serum concentration of Fluindione can be increased when it is combined with Fluorouracil.	Approved
Fluoxetine	Fluoxetine may increase the anticoagulant activities of Fluindione.	Approved, Vet Approved
Fluoxymesterone	Fluoxymesterone may increase the anticoagulant activities of Fluindione.	Approved, Illicit
Flurbiprofen	Flurbiprofen may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Fluvoxamine	Fluvoxamine may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Fondaparinux	Fondaparinux sodium may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Fosphenytoin	Fosphenytoin may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Fusidic Acid	The serum concentration of Fluindione can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Gabexate	Gabexate may increase the anticoagulant activities of Fluindione.	Investigational
Garenoxacin	Garenoxacin may increase the anticoagulant activities of Fluindione.	Investigational
Gatifloxacin	Gatifloxacin may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Gefitinib	Gefitinib may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Gemfibrozil	Gemfibrozil may increase the anticoagulant activities of Fluindione.	Approved
Gemifloxacin	Gemifloxacin may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Genistein	Genistein may decrease the anticoagulant activities of Fluindione.	Investigational
Gestodene	Gestodene may decrease the anticoagulant activities of Fluindione.	Approved, Investigational
Gestonorone	The therapeutic efficacy of Fluindione can be decreased when used in combination with Gestonorone.	Experimental
Gestrinone	The therapeutic efficacy of Fluindione can be decreased when used in combination with Gestrinone.	Approved
Ginkgo biloba	The risk or severity of adverse effects can be increased when Ginkgo biloba is combined with Fluindione.	Approved, Investigational, Nutraceutical
Ginseng	Ginseng may increase the anticoagulant activities of Fluindione.	Approved, Investigational, Nutraceutical
Glibornuride	Glibornuride may increase the anticoagulant activities of Fluindione.	Investigational, Withdrawn
Gliclazide	Gliclazide may increase the anticoagulant activities of Fluindione.	Approved
Glimepiride	Glimepiride may increase the anticoagulant activities of Fluindione.	Approved
Glipizide	Glipizide may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Gliquidone	Gliquidone may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Glisoxepide	Glisoxepide may increase the anticoagulant activities of Fluindione.	Investigational
GLPG-0492	GLPG-0492 may increase the anticoagulant activities of Fluindione.	Investigational
Glucagon recombinant	Glucagon recombinant may increase the anticoagulant activities of Fluindione.	Approved
Glutethimide	The metabolism of Fluindione can be increased when combined with Glutethimide.	Approved, Illicit
Glyburide	Glyburide may increase the anticoagulant activities of Fluindione.	Approved
Grepafloxacin	Grepafloxacin may increase the anticoagulant activities of Fluindione.	Approved, Investigational, Withdrawn
Griseofulvin	The serum concentration of Fluindione can be decreased when it is combined with Griseofulvin.	Approved, Investigational, Vet Approved
Guacetisal	Guacetisal may increase the anticoagulant activities of Fluindione.	Experimental
Hemin	Hemin may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Hemoglobin crosfumaril	Hemoglobin crosfumaril may increase the anticoagulant activities of Fluindione.	Experimental
Heparin	Heparin may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Hexestrol	Hexestrol may decrease the anticoagulant activities of Fluindione.	Withdrawn
Hexobarbital	The metabolism of Fluindione can be increased when combined with Hexobarbital.	Approved
Higenamine	Higenamine may increase the anticoagulant activities of Fluindione.	Investigational
Hydroxyprogesterone caproate	The therapeutic efficacy of Fluindione can be decreased when used in combination with Hydroxyprogesterone caproate.	Approved, Investigational
Hydroxytyrosol	Hydroxytyrosol may increase the anticoagulant activities of Fluindione.	Investigational
Ibritumomab tiuxetan	The risk or severity of adverse effects can be increased when Fluindione is combined with Ibritumomab tiuxetan.	Approved, Investigational
Ibrutinib	The risk or severity of adverse effects can be increased when Ibrutinib is combined with Fluindione.	Approved
Ibudilast	Ibudilast may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Ibuprofen	Ibuprofen may increase the anticoagulant activities of Fluindione.	Approved
Ibuproxam	Ibuproxam may increase the anticoagulant activities of Fluindione.	Withdrawn
Icatibant	Icatibant may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Icosapent	Icosapent may increase the anticoagulant activities of Fluindione.	Approved, Nutraceutical
Icosapent ethyl	Icosapent ethyl may increase the anticoagulant activities of Fluindione.	Approved, Investigational, Nutraceutical
Idraparinux	Idraparinux may increase the anticoagulant activities of Fluindione.	Investigational
Ifenprodil	Ifenprodil may increase the anticoagulant activities of Fluindione.	Approved, Investigational, Withdrawn
Ifetroban	Ifetroban may increase the anticoagulant activities of Fluindione.	Investigational
Ifosfamide	Ifosfamide may increase the anticoagulant activities of Fluindione.	Approved
Iloprost	Iloprost may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Imidazole salicylate	Imidazole salicylate may increase the anticoagulant activities of Fluindione.	Experimental
Imipramine	Imipramine may increase the anticoagulant activities of Fluindione.	Approved
Indalpine	Indalpine may increase the anticoagulant activities of Fluindione.	Investigational, Withdrawn
Indobufen	Indobufen may increase the anticoagulant activities of Fluindione.	Investigational
Indomethacin	Indomethacin may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Indoprofen	Indoprofen may increase the anticoagulant activities of Fluindione.	Withdrawn
Iprindole	Iprindole may increase the anticoagulant activities of Fluindione.	Experimental
Isoxicam	Isoxicam may increase the anticoagulant activities of Fluindione.	Withdrawn
Itraconazole	The serum concentration of Fluindione can be increased when it is combined with Itraconazole.	Approved, Investigational
Ivermectin	Ivermectin may increase the anticoagulant activities of Fluindione.	Approved, Investigational, Vet Approved
Josamycin	The serum concentration of Fluindione can be increased when it is combined with Josamycin.	Approved, Investigational
Kebuzone	Kebuzone may increase the anticoagulant activities of Fluindione.	Experimental
Ketanserin	Ketanserin may increase the anticoagulant activities of Fluindione.	Investigational
Ketoconazole	The serum concentration of Fluindione can be increased when it is combined with Ketoconazole.	Approved, Investigational
Ketoprofen	Ketoprofen may increase the anticoagulant activities of Fluindione.	Approved, Vet Approved
Ketorolac	Ketorolac may increase the anticoagulant activities of Fluindione.	Approved
Kitasamycin	The serum concentration of Fluindione can be increased when it is combined with Kitasamycin.	Experimental
L-Carnitine	L-Carnitine may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Lansoprazole	The serum concentration of Fluindione can be increased when it is combined with Lansoprazole.	Approved, Investigational
Leflunomide	Leflunomide may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Lepirudin	Fluindione may increase the anticoagulant activities of Lepirudin.	Approved
Letaxaban	Letaxaban may increase the anticoagulant activities of Fluindione.	Investigational
Levofloxacin	Levofloxacin may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Levomilnacipran	The risk or severity of adverse effects can be increased when Levomilnacipran is combined with Fluindione.	Approved, Investigational
Levonorgestrel	Levonorgestrel may decrease the anticoagulant activities of Fluindione.	Approved, Investigational
Levothyroxine	Levothyroxine may increase the anticoagulant activities of Fluindione.	Approved
Limaprost	The risk or severity of adverse effects can be increased when Limaprost is combined with Fluindione.	Approved, Investigational
Linsidomine	Linsidomine may increase the anticoagulant activities of Fluindione.	Experimental
Liothyronine	Liothyronine may increase the anticoagulant activities of Fluindione.	Approved, Vet Approved
Liotrix	Liotrix may increase the anticoagulant activities of Fluindione.	Approved
Lisofylline	Lisofylline may increase the anticoagulant activities of Fluindione.	Investigational
Lixisenatide	Lixisenatide can cause a decrease in the absorption of Fluindione resulting in a reduced serum concentration and potentially a decrease in efficacy.	Approved
Lofepramine	Lofepramine may increase the anticoagulant activities of Fluindione.	Experimental
Lomefloxacin	Lomefloxacin may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Lonazolac	Lonazolac may increase the anticoagulant activities of Fluindione.	Experimental
Lornoxicam	Lornoxicam may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Loxoprofen	Loxoprofen may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Lumiracoxib	Lumiracoxib may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Lynestrenol	Lynestrenol may decrease the anticoagulant activities of Fluindione.	Approved, Investigational
Magnesium salicylate	Magnesium salicylate may increase the anticoagulant activities of Fluindione.	Approved
Masoprocol	Masoprocol may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Meclofenamic acid	Meclofenamic acid may increase the anticoagulant activities of Fluindione.	Approved, Vet Approved
Medrogestone	The therapeutic efficacy of Fluindione can be decreased when used in combination with Medrogestone.	Approved
Medroxyprogesterone acetate	Medroxyprogesterone acetate may decrease the anticoagulant activities of Fluindione.	Approved, Investigational
Mefenamic acid	Mefenamic acid may increase the anticoagulant activities of Fluindione.	Approved
Megestrol acetate	The therapeutic efficacy of Fluindione can be decreased when used in combination with Megestrol acetate.	Approved, Investigational, Vet Approved
Melagatran	Fluindione may increase the anticoagulant activities of Melagatran.	Experimental
Melitracen	Melitracen may increase the anticoagulant activities of Fluindione.	Experimental, Investigational
Meloxicam	Meloxicam may increase the anticoagulant activities of Fluindione.	Approved, Vet Approved
Mercaptopurine	Mercaptopurine may decrease the anticoagulant activities of Fluindione.	Approved
Mesalazine	Mesalazine may increase the anticoagulant activities of Fluindione.	Approved
Mesterolone	Mesterolone may increase the anticoagulant activities of Fluindione.	Experimental
Mestranol	Mestranol may decrease the anticoagulant activities of Fluindione.	Approved
Metahexamide	Metahexamide may increase the anticoagulant activities of Fluindione.	Experimental
Metamizole	Metamizole may increase the anticoagulant activities of Fluindione.	Approved, Investigational, Withdrawn
Metampicillin	Metampicillin may increase the anticoagulant activities of Fluindione.	Experimental
Methallenestril	Methallenestril may decrease the anticoagulant activities of Fluindione.	Experimental
Methimazole	Methimazole may decrease the anticoagulant activities of Fluindione.	Approved
Methohexital	The metabolism of Fluindione can be increased when combined with Methohexital.	Approved
Methyl salicylate	Methyl salicylate may increase the anticoagulant activities of Fluindione.	Approved, Vet Approved
Methylestrenolone	The therapeutic efficacy of Fluindione can be decreased when used in combination with Methylestrenolone.	Experimental
Methylphenidate	The serum concentration of Fluindione can be increased when it is combined with Methylphenidate.	Approved, Investigational
Methylphenobarbital	The metabolism of Fluindione can be increased when combined with Methylphenobarbital.	Approved
Methyltestosterone	Methyltestosterone may increase the anticoagulant activities of Fluindione.	Approved
Methylthiouracil	Methylthiouracil may decrease the anticoagulant activities of Fluindione.	Experimental
Meticillin	Meticillin may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Metronidazole	The serum concentration of Fluindione can be increased when it is combined with Metronidazole.	Approved
Mezlocillin	Mezlocillin may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Miconazole	The serum concentration of Fluindione can be increased when it is combined with Miconazole.	Approved, Investigational, Vet Approved
Milnacipran	The risk or severity of adverse effects can be increased when Milnacipran is combined with Fluindione.	Approved, Investigational
Milrinone	Milrinone may increase the anticoagulant activities of Fluindione.	Approved
Minocycline	Minocycline may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Mizoribine	Mizoribine may increase the anticoagulant activities of Fluindione.	Investigational
Mofebutazone	Mofebutazone may increase the anticoagulant activities of Fluindione.	Experimental
Morniflumate	Morniflumate may increase the anticoagulant activities of Fluindione.	Approved
Moxestrol	Moxestrol may decrease the anticoagulant activities of Fluindione.	Experimental
Moxifloxacin	Moxifloxacin may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Mycophenolate mofetil	Mycophenolate mofetil may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Mycophenolic acid	Mycophenolic acid may increase the anticoagulant activities of Fluindione.	Approved
Nabumetone	Nabumetone may increase the anticoagulant activities of Fluindione.	Approved
Nadroparin	Nadroparin may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Nafamostat	Nafamostat may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Nafcillin	Nafcillin may decrease the anticoagulant activities of Fluindione.	Approved, Investigational
Naftifine	Naftifine may increase the anticoagulant activities of Fluindione.	Approved
Naftopidil	Naftopidil may increase the anticoagulant activities of Fluindione.	Investigational
Nalidixic Acid	Nalidixic Acid may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Nandrolone	Nandrolone may increase the anticoagulant activities of Fluindione.	Experimental, Investigational
Nandrolone decanoate	Nandrolone decanoate may increase the anticoagulant activities of Fluindione.	Approved, Illicit
Naproxen	Naproxen may increase the anticoagulant activities of Fluindione.	Approved, Vet Approved
Nefazodone	Nefazodone may increase the anticoagulant activities of Fluindione.	Approved, Withdrawn
Nemonoxacin	Nemonoxacin may increase the anticoagulant activities of Fluindione.	Investigational
Neomycin	Neomycin may increase the anticoagulant activities of Fluindione.	Approved, Vet Approved
Nepafenac	Nepafenac may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Nifenazone	Nifenazone may increase the anticoagulant activities of Fluindione.	Experimental
Niflumic Acid	Niflumic Acid may increase the anticoagulant activities of Fluindione.	Approved
Nimesulide	Nimesulide may increase the anticoagulant activities of Fluindione.	Approved, Investigational, Withdrawn
Nintedanib	The risk or severity of adverse effects can be increased when Fluindione is combined with Nintedanib.	Approved
Nitroaspirin	Nitroaspirin may increase the anticoagulant activities of Fluindione.	Investigational
Nomegestrol	The therapeutic efficacy of Fluindione can be decreased when used in combination with Nomegestrol.	Approved
Nomegestrol acetate	Nomegestrol acetate may decrease the anticoagulant activities of Fluindione.	Approved, Investigational
Norelgestromin	Norelgestromin may decrease the anticoagulant activities of Fluindione.	Approved, Investigational
Norethisterone	The therapeutic efficacy of Fluindione can be decreased when used in combination with Norethisterone.	Approved
Norethynodrel	Norethynodrel may decrease the anticoagulant activities of Fluindione.	Approved
Norfloxacin	Norfloxacin may increase the anticoagulant activities of Fluindione.	Approved
Norgestimate	Norgestimate may decrease the anticoagulant activities of Fluindione.	Approved, Investigational
Norgestrel	Norgestrel may decrease the anticoagulant activities of Fluindione.	Approved
Norgestrienone	The therapeutic efficacy of Fluindione can be decreased when used in combination with Norgestrienone.	Experimental
Nortriptyline	Nortriptyline may increase the anticoagulant activities of Fluindione.	Approved
Obinutuzumab	The risk or severity of adverse effects can be increased when Fluindione is combined with Obinutuzumab.	Approved, Investigational
Ofloxacin	Ofloxacin may increase the anticoagulant activities of Fluindione.	Approved
Oleandomycin	The serum concentration of Fluindione can be increased when it is combined with Oleandomycin.	Vet Approved
Olopatadine	Olopatadine may increase the anticoagulant activities of Fluindione.	Approved
Olsalazine	Olsalazine may increase the anticoagulant activities of Fluindione.	Approved
Omacetaxine mepesuccinate	The risk or severity of bleeding can be increased when Fluindione is combined with Omacetaxine mepesuccinate.	Approved, Investigational
Omega-3 fatty acids	Omega-3 fatty acids may increase the anticoagulant activities of Fluindione.	Approved, Nutraceutical
Omega-3-carboxylic acids	The therapeutic efficacy of Fluindione can be increased when used in combination with Omega-3-carboxylic acids.	Approved, Investigational
Omeprazole	The serum concentration of Fluindione can be increased when it is combined with Omeprazole.	Approved, Investigational, Vet Approved
Opipramol	Opipramol may increase the anticoagulant activities of Fluindione.	Investigational
Orgotein	Orgotein may increase the anticoagulant activities of Fluindione.	Vet Approved
Oritavancin	The serum concentration of Fluindione can be increased when it is combined with Oritavancin.	Approved, Investigational
Otamixaban	Otamixaban may increase the anticoagulant activities of Fluindione.	Investigational
Oxacillin	Oxacillin may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Oxandrolone	Oxandrolone may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Oxaprozin	Oxaprozin may increase the anticoagulant activities of Fluindione.	Approved
Oxolinic acid	Oxolinic acid may increase the anticoagulant activities of Fluindione.	Experimental
Oxymetholone	Oxymetholone may increase the anticoagulant activities of Fluindione.	Approved, Illicit
Oxyphenbutazone	Oxyphenbutazone may increase the anticoagulant activities of Fluindione.	Approved, Withdrawn
Oxytetracycline	Oxytetracycline may increase the anticoagulant activities of Fluindione.	Approved, Investigational, Vet Approved
Ozagrel	Ozagrel may increase the anticoagulant activities of Fluindione.	Investigational
Palmidrol	Palmidrol may increase the anticoagulant activities of Fluindione.	Experimental, Nutraceutical
Parecoxib	Parecoxib may increase the anticoagulant activities of Fluindione.	Approved
Parnaparin	Parnaparin may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Paroxetine	Paroxetine may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Parthenolide	Parthenolide may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Pazufloxacin	Pazufloxacin may increase the anticoagulant activities of Fluindione.	Investigational
Pefloxacin	Pefloxacin may increase the anticoagulant activities of Fluindione.	Approved
Penamecillin	Penamecillin may increase the anticoagulant activities of Fluindione.	Experimental
Pentaerythritol Tetranitrate	Pentaerythritol Tetranitrate may increase the anticoagulant activities of Fluindione.	Approved
Pentobarbital	The metabolism of Fluindione can be increased when combined with Pentobarbital.	Approved, Investigational, Vet Approved
Pentosan Polysulfate	Pentosan Polysulfate may increase the anticoagulant activities of Fluindione.	Approved
Pentoxifylline	Pentoxifylline may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Phenindione	Phenindione may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Phenobarbital	The metabolism of Fluindione can be increased when combined with Phenobarbital.	Approved, Investigational
Phenoxymethylpenicillin	Phenoxymethylpenicillin may increase the anticoagulant activities of Fluindione.	Approved, Vet Approved
Phenprocoumon	Phenprocoumon may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Phenyl aminosalicylate	Phenyl aminosalicylate may increase the anticoagulant activities of Fluindione.	Approved
Phenylbutazone	Phenylbutazone may increase the anticoagulant activities of Fluindione.	Approved, Vet Approved
Phenytoin	Phenytoin may increase the anticoagulant activities of Fluindione.	Approved, Vet Approved
Phylloquinone	Phylloquinone may decrease the anticoagulant activities of Fluindione.	Approved, Investigational
Picotamide	Picotamide may increase the anticoagulant activities of Fluindione.	Experimental
Pimecrolimus	Pimecrolimus may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Pipemidic acid	Pipemidic acid may increase the anticoagulant activities of Fluindione.	Experimental
Piperacillin	Piperacillin may increase the anticoagulant activities of Fluindione.	Approved
Pirfenidone	Pirfenidone may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Piromidic acid	Piromidic acid may increase the anticoagulant activities of Fluindione.	Experimental
Piroxicam	Piroxicam may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Pirprofen	Pirprofen may increase the anticoagulant activities of Fluindione.	Experimental
Pivampicillin	Pivampicillin may increase the anticoagulant activities of Fluindione.	Approved
Pivmecillinam	Pivmecillinam may increase the anticoagulant activities of Fluindione.	Approved
Polyestradiol phosphate	Polyestradiol phosphate may decrease the anticoagulant activities of Fluindione.	Approved
Pomalidomide	Pomalidomide may increase the anticoagulant activities of Fluindione.	Approved
Posaconazole	The serum concentration of Fluindione can be increased when it is combined with Posaconazole.	Approved, Investigational, Vet Approved
Potassium Citrate	Fluindione may increase the anticoagulant activities of Potassium Citrate.	Approved, Investigational, Vet Approved
Potassium Iodide	Potassium Iodide may decrease the anticoagulant activities of Fluindione.	Approved
Pranoprofen	Pranoprofen may increase the anticoagulant activities of Fluindione.	Experimental, Investigational
Prasugrel	Prasugrel may increase the anticoagulant activities of Fluindione.	Approved
Primidone	The metabolism of Fluindione can be increased when combined with Primidone.	Approved, Vet Approved
Procaine benzylpenicillin	Procaine benzylpenicillin may increase the anticoagulant activities of Fluindione.	Approved, Vet Approved
Progesterone	The therapeutic efficacy of Fluindione can be decreased when used in combination with Progesterone.	Approved, Vet Approved
Proglumetacin	Proglumetacin may increase the anticoagulant activities of Fluindione.	Experimental
Promegestone	The therapeutic efficacy of Fluindione can be decreased when used in combination with Promegestone.	Experimental
Promestriene	Promestriene may decrease the anticoagulant activities of Fluindione.	Investigational
Propacetamol	Propacetamol may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Propafenone	The serum concentration of Fluindione can be increased when it is combined with Propafenone.	Approved
Propicillin	Propicillin may increase the anticoagulant activities of Fluindione.	Experimental
Propylthiouracil	Propylthiouracil may decrease the anticoagulant activities of Fluindione.	Approved, Investigational
Propyphenazone	Propyphenazone may increase the anticoagulant activities of Fluindione.	Experimental
Proquazone	Proquazone may increase the anticoagulant activities of Fluindione.	Experimental
Protein C	Protein C may increase the anticoagulant activities of Fluindione.	Approved
Protein S human	Fluindione may increase the anticoagulant activities of Protein S human.	Approved
Protocatechualdehyde	Protocatechualdehyde may increase the anticoagulant activities of Fluindione.	Approved
Protriptyline	Protriptyline may increase the anticoagulant activities of Fluindione.	Approved
Prulifloxacin	Prulifloxacin may increase the anticoagulant activities of Fluindione.	Investigational
PTC299	PTC299 may increase the anticoagulant activities of Fluindione.	Investigational
Quinestrol	Quinestrol may decrease the anticoagulant activities of Fluindione.	Approved
Quingestanol	Quingestanol may decrease the anticoagulant activities of Fluindione.	Experimental
Quinidine	Quinidine may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Quinine	Quinine may increase the anticoagulant activities of Fluindione.	Approved
Ramatroban	Ramatroban may increase the anticoagulant activities of Fluindione.	Investigational
Relcovaptan	Relcovaptan may increase the anticoagulant activities of Fluindione.	Investigational
Resveratrol	Resveratrol may increase the anticoagulant activities of Fluindione.	Approved, Experimental, Investigational
Reteplase	Reteplase may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Reviparin	Reviparin may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Ridogrel	Ridogrel may increase the anticoagulant activities of Fluindione.	Approved
Rifabutin	The metabolism of Fluindione can be increased when combined with Rifabutin.	Approved, Investigational
Rifampicin	The metabolism of Fluindione can be increased when combined with Rifampicin.	Approved
Rifapentine	The metabolism of Fluindione can be increased when combined with Rifapentine.	Approved, Investigational
Rifaximin	The metabolism of Fluindione can be increased when combined with Rifaximin.	Approved, Investigational
Rivaroxaban	Fluindione may increase the anticoagulant activities of Rivaroxaban.	Approved
Rofecoxib	Rofecoxib may increase the anticoagulant activities of Fluindione.	Approved, Investigational, Withdrawn
Ronifibrate	Ronifibrate may increase the anticoagulant activities of Fluindione.	Experimental
Rosiglitazone	Rosiglitazone may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Rosoxacin	Rosoxacin may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Rufloxacin	Rufloxacin may increase the anticoagulant activities of Fluindione.	Experimental
Salicylamide	Salicylamide may increase the anticoagulant activities of Fluindione.	Approved
Salicylic acid	Salicylic acid may increase the anticoagulant activities of Fluindione.	Approved, Investigational, Vet Approved
Salsalate	Salsalate may increase the anticoagulant activities of Fluindione.	Approved
Sarpogrelate	Sarpogrelate may increase the anticoagulant activities of Fluindione.	Investigational
Saruplase	Saruplase may increase the anticoagulant activities of Fluindione.	Experimental
Secobarbital	The metabolism of Fluindione can be increased when combined with Secobarbital.	Approved, Vet Approved
Secoisolariciresinol	Secoisolariciresinol may decrease the anticoagulant activities of Fluindione.	Investigational
Selexipag	Selexipag may increase the anticoagulant activities of Fluindione.	Approved
Seliciclib	Seliciclib may increase the anticoagulant activities of Fluindione.	Investigational
Semapimod	Semapimod may increase the anticoagulant activities of Fluindione.	Investigational
Seratrodast	Seratrodast may increase the anticoagulant activities of Fluindione.	Approved
Serrapeptase	Serrapeptase may increase the anticoagulant activities of Fluindione.	Investigational
Sertraline	Sertraline may increase the anticoagulant activities of Fluindione.	Approved
Sevoflurane	Sevoflurane may increase the anticoagulant activities of Fluindione.	Approved, Vet Approved
Simfibrate	Simfibrate may increase the anticoagulant activities of Fluindione.	Experimental
Sitafloxacin	Sitafloxacin may increase the anticoagulant activities of Fluindione.	Experimental, Investigational
Sodium Citrate	Fluindione may increase the anticoagulant activities of Sodium Citrate.	Approved, Investigational
Solithromycin	The serum concentration of Fluindione can be increased when it is combined with Solithromycin.	Investigational
Sparfloxacin	Sparfloxacin may increase the anticoagulant activities of Fluindione.	Approved, Investigational
SRT501	SRT501 may increase the anticoagulant activities of Fluindione.	Investigational
St. John's Wort	The metabolism of Fluindione can be increased when combined with St. John's Wort.	Approved, Investigational, Nutraceutical
Stanolone	Stanolone may increase the anticoagulant activities of Fluindione.	Illicit, Investigational
Stanozolol	Stanozolol may increase the anticoagulant activities of Fluindione.	Approved, Vet Approved
Streptokinase	The risk or severity of hemorrhage can be increased when Streptokinase is combined with Fluindione.	Approved, Investigational
Sucralfate	Sucralfate may decrease the anticoagulant activities of Fluindione.	Approved
Sugammadex	Sugammadex may increase the anticoagulant activities of Fluindione.	Approved
Sulbenicillin	Sulbenicillin may increase the anticoagulant activities of Fluindione.	Experimental
Sulfadiazine	Sulfadiazine may increase the anticoagulant activities of Fluindione.	Approved, Investigational, Vet Approved
Sulfamethoxazole	Sulfamethoxazole may increase the anticoagulant activities of Fluindione.	Approved
Sulfasalazine	Sulfasalazine may increase the anticoagulant activities of Fluindione.	Approved
Sulfinpyrazone	The metabolism of Fluindione can be decreased when combined with Sulfinpyrazone.	Approved
Sulfisoxazole	Sulfisoxazole may increase the anticoagulant activities of Fluindione.	Approved, Vet Approved
Sulindac	Sulindac may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Sulodexide	Sulodexide may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Sultamicillin	Sultamicillin may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Suprofen	Suprofen may increase the anticoagulant activities of Fluindione.	Approved, Withdrawn
Suxibuzone	Suxibuzone may increase the anticoagulant activities of Fluindione.	Experimental
Synthetic Conjugated Estrogens, A	Synthetic Conjugated Estrogens, A may decrease the anticoagulant activities of Fluindione.	Approved
Synthetic Conjugated Estrogens, B	Synthetic Conjugated Estrogens, B may decrease the anticoagulant activities of Fluindione.	Approved
Talampicillin	Talampicillin may increase the anticoagulant activities of Fluindione.	Experimental
Talniflumate	Talniflumate may increase the anticoagulant activities of Fluindione.	Approved
Tamoxifen	Tamoxifen may increase the anticoagulant activities of Fluindione.	Approved
Tarenflurbil	Tarenflurbil may increase the anticoagulant activities of Fluindione.	Investigational
Tegafur	The serum concentration of Fluindione can be increased when it is combined with Tegafur.	Approved, Investigational
Telithromycin	The serum concentration of Fluindione can be increased when it is combined with Telithromycin.	Approved
Temafloxacin	Temafloxacin may increase the anticoagulant activities of Fluindione.	Withdrawn
Tenecteplase	Tenecteplase may increase the anticoagulant activities of Fluindione.	Approved
Tenidap	Tenidap may increase the anticoagulant activities of Fluindione.	Experimental
Tenoxicam	Tenoxicam may increase the anticoagulant activities of Fluindione.	Approved
Tepoxalin	Tepoxalin may increase the anticoagulant activities of Fluindione.	Vet Approved
Teriflunomide	Teriflunomide may increase the anticoagulant activities of Fluindione.	Approved
Tesmilifene	Tesmilifene may increase the anticoagulant activities of Fluindione.	Investigational
Testosterone	Testosterone may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Testosterone cypionate	The therapeutic efficacy of Fluindione can be increased when used in combination with Testosterone cypionate.	Approved
Testosterone enanthate	The therapeutic efficacy of Fluindione can be increased when used in combination with Testosterone enanthate.	Approved
Testosterone propionate	Testosterone propionate may increase the anticoagulant activities of Fluindione.	Approved, Investigational, Vet Approved, Withdrawn
Testosterone undecanoate	The therapeutic efficacy of Fluindione can be increased when used in combination with Testosterone undecanoate.	Approved, Investigational
Tetracycline	Tetracycline may increase the anticoagulant activities of Fluindione.	Approved, Vet Approved
Thiamylal	The metabolism of Fluindione can be increased when combined with Thiamylal.	Approved, Vet Approved
Thiopental	The metabolism of Fluindione can be increased when combined with Thiopental.	Approved, Vet Approved
Thyroid, porcine	Thyroid, porcine may increase the anticoagulant activities of Fluindione.	Approved
Tianeptine	Tianeptine may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Tiaprofenic acid	Tiaprofenic acid may increase the anticoagulant activities of Fluindione.	Approved
Tibolone	Tibolone may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Ticagrelor	Ticagrelor may increase the anticoagulant activities of Fluindione.	Approved
Ticarcillin	Ticarcillin may increase the anticoagulant activities of Fluindione.	Approved, Investigational, Vet Approved
Ticlopidine	Ticlopidine may increase the anticoagulant activities of Fluindione.	Approved
Tinoridine	Tinoridine may increase the anticoagulant activities of Fluindione.	Investigational
Tinzaparin	Tinzaparin may increase the anticoagulant activities of Fluindione.	Approved
Tioclomarol	Tioclomarol may increase the anticoagulant activities of Fluindione.	Experimental
Tipranavir	Tipranavir may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Tirofiban	Tirofiban may increase the anticoagulant activities of Fluindione.	Approved
Tolazamide	Tolazamide may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Tolbutamide	Tolbutamide may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Tolfenamic Acid	Tolfenamic Acid may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Tolmetin	Tolmetin may increase the anticoagulant activities of Fluindione.	Approved
Toremifene	Toremifene may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Tositumomab	The risk or severity of adverse effects can be increased when Fluindione is combined with Tositumomab.	Approved, Investigational
Tramadol	Tramadol may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Tranilast	Tranilast may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Trapidil	Trapidil may increase the anticoagulant activities of Fluindione.	Approved
Treprostinil	Treprostinil may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Triamcinolone	Triamcinolone may increase the anticoagulant activities of Fluindione.	Approved, Vet Approved
Tribenoside	Tribenoside may increase the anticoagulant activities of Fluindione.	Experimental
Triflusal	Triflusal may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Trimipramine	Trimipramine may increase the anticoagulant activities of Fluindione.	Approved
Triptolide	Triptolide may increase the anticoagulant activities of Fluindione.	Investigational
Trolamine salicylate	Trolamine salicylate may increase the anticoagulant activities of Fluindione.	Approved
Trovafloxacin	Trovafloxacin may increase the anticoagulant activities of Fluindione.	Approved, Investigational, Withdrawn
Troxerutin	Troxerutin may increase the anticoagulant activities of Fluindione.	Investigational
Tylosin	The serum concentration of Fluindione can be increased when it is combined with Tylosin.	Vet Approved
Ulipristal	Ulipristal may decrease the anticoagulant activities of Fluindione.	Approved
Urokinase	Urokinase may increase the anticoagulant activities of Fluindione.	Approved, Investigational, Withdrawn
Valdecoxib	Valdecoxib may increase the anticoagulant activities of Fluindione.	Approved, Investigational, Withdrawn
Venlafaxine	The risk or severity of adverse effects can be increased when Venlafaxine is combined with Fluindione.	Approved
Vitamin E	Vitamin E may increase the anticoagulant activities of Fluindione.	Approved, Nutraceutical, Vet Approved
Vorapaxar	The risk or severity of adverse effects can be increased when Vorapaxar is combined with Fluindione.	Approved
Voriconazole	The serum concentration of Fluindione can be increased when it is combined with Voriconazole.	Approved, Investigational
Vorinostat	Vorinostat may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Warfarin	Warfarin may increase the anticoagulant activities of Fluindione.	Approved
Ximelagatran	Ximelagatran may increase the anticoagulant activities of Fluindione.	Approved, Investigational, Withdrawn
Zafirlukast	The serum concentration of Fluindione can be increased when it is combined with Zafirlukast.	Approved, Investigational
Zaltoprofen	Zaltoprofen may increase the anticoagulant activities of Fluindione.	Approved, Investigational
Zeranol	Zeranol may decrease the anticoagulant activities of Fluindione.	Vet Approved
Zileuton	Zileuton may increase the anticoagulant activities of Fluindione.	Approved, Investigational, Withdrawn
Zimelidine	Zimelidine may increase the anticoagulant activities of Fluindione.	Withdrawn
Zomepirac	Zomepirac may increase the anticoagulant activities of Fluindione.	Withdrawn

Food Interactions

Not Available

References

General References

Not Available

External Links

PubChem Compound: 68942
PubChem Substance: 347829254
ChemSpider: 62167
BindingDB: 50280156
ChEBI: 134975
ChEMBL: CHEMBL24924
Wikipedia: Fluindione

ATC Codes

B01AA12 — Fluindione

Clinical Trials

Clinical Trials

Phase	Status	Purpose	Conditions	Count
3	Recruiting	Treatment	Nonvalvular Atrial Fibrillation	1
4	Completed	Treatment	Disorders, Blood Coagulation	1
4	Completed	Treatment	Nonvalvular Atrial Fibrillation	1
4	Recruiting	Treatment	Anticoagulating Treatment on a Duration at Least 12-month-old Superior / Anticoagulation Treatment at Least > or = to 12-month / Permanent Atrial Fibrillation / Pulmonary Embolism (PE) / Thrombosis, Venous	1
Not Available	Recruiting	Not Available	Pulmonary Arterial Hypertension (PAH)	1

Pharmacoeconomics

Manufacturers: Not Available
Packagers: Not Available
Dosage forms: Not Available
Prices: Not Available
Patents: Not Available

Properties

State

Not Available

Experimental Properties

Not Available

Predicted Properties

Property	Value	Source
Water Solubility	0.0549 mg/mL	ALOGPS
logP	3.09	ALOGPS
logP	3.02	ChemAxon
logS	-3.6	ALOGPS
pKa (Strongest Acidic)	4.19	ChemAxon
pKa (Strongest Basic)	-7.5	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	2	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	34.14 Å²	ChemAxon
Rotatable Bond Count	1	ChemAxon
Refractivity	65.45 m³·mol^-1	ChemAxon
Polarizability	23.35 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	1	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

Predicted ADMET features

Not Available

Spectra

Mass Spec (NIST)

Not Available

Spectra

Spectrum	Spectrum Type	Splash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)	Predicted LC-MS/MS	Not Available

Taxonomy

Description: This compound belongs to the class of organic compounds known as indanediones. These are compounds containing an indane ring bearing two ketone groups.
Kingdom: Organic compounds
Super Class: Benzenoids
Class: Indanes
Sub Class: Indanones
Direct Parent: Indanediones
Alternative Parents: Aryl alkyl ketones / Fluorobenzenes / Beta-diketones / Aryl fluorides / Organofluorides / Organic oxides / Hydrocarbon derivatives
Substituents: Indanedione / Aryl ketone / Aryl alkyl ketone / Fluorobenzene / Halobenzene / 1,3-diketone / 1,3-dicarbonyl compound / Aryl fluoride / Monocyclic benzene moiety / Aryl halide
Molecular Framework: Aromatic homopolycyclic compounds
External Descriptors: Not Available

Enzymes

Details1. Cytochrome P450 2C9

Kind: Protein
Organism: Human
Pharmacological action: Unknown
Actions: Substrate

General Function: Steroid hydroxylase activity
Specific Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name: CYP2C9
Uniprot ID: P11712
Uniprot Name: Cytochrome P450 2C9
Molecular Weight: 55627.365 Da

References

Verstuyft C, Delavenne X, Rousseau A, Robert A, Tod M, Diquet B, Lebot M, Jaillon P, Becquemont L: A pharmacokinetic-pharmacodynamic model for predicting the impact of CYP2C9 and VKORC1 polymorphisms on fluindione and acenocoumarol during induction therapy. Clin Pharmacokinet. 2012 Jan 1;51(1):41-53. doi: 10.2165/11595560-000000000-00000. [PubMed:22149257]

Drug created on October 20, 2016 21:35 / Updated on July 02, 2018 19:46

Fluindione

Identification

Structure for DB13136 (Fluindione)

Pharmacology

Interactions

References

Clinical Trials

Pharmacoeconomics

Properties

Spectra

Taxonomy

Enzymes

References