Pyridine derivatives with one or more keto groups on the ring.
DrugDrug NameDrug Indication
DB00656TrazodoneTrazodone is indicated for the treatment of major depressive disorder (MDD).[L3484] It has been used off-label for adjunct therapy in alcohol dependence, and off-label to treat anxiety and insomnia.[L3484] It may also be used off-label to treat symptoms of dementia, Alzheimer’s disease, schizophrenia, eating disorders, and fibromyalgia due to its effects on various neurotransmitter receptors.[A31634]
DB01055MimosineNot Available
DB09194EtoperidoneEtoperidone has been studied for the treatment of depression[T47], tremors in Parkinson, extrapyramidal symptoms[L1041] and male impotence[L1042]. It is not certain if it was ever approved and marketed but its current status is withdrawn.
DB09366PropyliodoneNot Available
DB13568DiodoneNot Available
DB13740BemegrideNot Available
DB04951PirfenidoneFor the treatment of idiopathic pulmonary fibrosis (IPF).
DB01188CiclopiroxUsed as a topical treatment in immunocompetent patients with mild to moderate onychomycosis of fingernails and toenails without lunula involvement, due to Trichophyton rubrum.
DB08826DeferiproneDeferiprone is indicated in thalassemia syndromes when first line chelation agents are not adequate to treat transfusional iron overload.
DrugDrug NameTargetType
DB00656Trazodone5-hydroxytryptamine receptor 2Atarget
DB00656TrazodoneSodium-dependent serotonin transportertarget
DB00656TrazodoneAlpha-1A adrenergic receptortarget
DB00656TrazodoneAlpha-2A adrenergic receptortarget
DB00656TrazodoneHistamine H1 receptortarget
DB00656Trazodone5-hydroxytryptamine receptor 1Atarget
DB00656TrazodoneCytochrome P450 2D6enzyme
DB00656TrazodoneCytochrome P450 3A4enzyme
DB00656Trazodone5-hydroxytryptamine receptor 2Ctarget
DB00656TrazodoneCytochrome P450 3A5enzyme
DB00656TrazodoneCytochrome P450 3A7enzyme
DB00656TrazodoneP-glycoprotein 1transporter
DB00656Trazodone5-hydroxytryptamine receptor 1Ctarget
DB01055MimosineSerine hydroxymethyltransferase, cytosolictarget
DB01055MimosineC-C motif chemokine 2target
DB01055MimosineTyrosinasetarget
DB09194EtoperidoneAlpha-1 adrenergic receptorstarget
DB09194EtoperidoneAlpha-2 adrenergic receptorstarget
DB09194EtoperidoneDopamine D2 receptortarget
DB09194EtoperidoneMuscarinic acetylcholine receptortarget
DB09194Etoperidone5-hydroxytryptamine receptor 2Atarget
DB09194EtoperidoneSodium-dependent serotonin transportertransporter
DB09194EtoperidoneSodium-dependent noradrenaline transportertransporter
DB09194EtoperidoneSodium-dependent dopamine transportertransporter
DB09194Etoperidone5-hydroxytryptamine receptor 2Ctarget
DB04951PirfenidoneFurintarget
DB04951PirfenidoneCytochrome P450 1A2enzyme
DB01188CiclopiroxSodium/potassium-transporting ATPase subunit alpha-1target
DB08826DeferiproneUDP-glucuronosyltransferase 1-6enzyme