17-Hydroxycorticosteroids

A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased.
DrugDrug NameDrug Indication
DB00687FludrocortisoneFor partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison's disease and for the treatment of salt-losing adrenogenital syndrome.
DB00741HydrocortisoneFor the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease.
DB01380Cortisone acetateFor the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders.
DB05288anecortave acetateInvestigated for use/treatment in glaucoma and macular degeneration.
DB05402ME-609Investigated for use/treatment in herpes labialis infections (cold sores).
DB05410NCX 1022Investigated for use/treatment in atopic dermatitis.
DB09091TixocortolNot Available
DB12081AnecortaveNot Available
DB12499Cortexolone 17α-propionateNot Available