17-Hydroxycorticosteroids

A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased.
DrugDrug NameDrug Indication
DB00687FludrocortisoneFor partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison's disease and for the treatment of salt-losing adrenogenital syndrome.
DB00741HydrocortisoneFor the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease.
DB01380Cortisone acetateFor the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders.
DB05288Anecortave acetateInvestigated for use/treatment in glaucoma and macular degeneration.
DB05410NCX 1022Investigated for use/treatment in atopic dermatitis.
DB09091TixocortolTixocortol is indicated for the treatment of rhinitis as a nasal suspension or aerosol. It is also used in the form of lozenges for the treatment of pharyngitis and in the form of enemas or rectal solution for the treatment of ulcerative colitis. Tixocortol can be used orally in a suspension or powder for the treatment of inflammatory conditions.[L1077] It is also the substance used for the screening of contact allergies to class A steroids.[A31435]
DB12081AnecortaveNot Available
DB12499ClascoteroneNot Available
DB14538Hydrocortisone aceponateFor the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease.
DB14539Hydrocortisone acetateFor the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease.
DB14540Hydrocortisone butyrateFor the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease.
DB14541Hydrocortisone cypionateFor the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease.
DB14542Hydrocortisone phosphateFor the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease.
DB14543Hydrocortisone probutateFor the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease.
DB14544Hydrocortisone valerateFor the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease.
DB14545Hydrocortisone succinateNot Available
DB14681CortisoneNot Available
DrugDrug NameTargetType
DB00687FludrocortisoneMineralocorticoid receptortarget
DB00687FludrocortisoneGlucocorticoid receptortarget
DB00687FludrocortisoneAndrogen receptortarget
DB00687FludrocortisoneCytochrome P450 3A4enzyme
DB00741HydrocortisoneAnnexin A1target
DB00741HydrocortisoneGlucocorticoid receptortarget
DB00741HydrocortisoneSex hormone-binding globulincarrier
DB00741HydrocortisoneCytochrome P450 3A4enzyme
DB00741HydrocortisoneCytochrome P450 3A5enzyme
DB00741HydrocortisoneCytochrome P450 3A7enzyme
DB00741HydrocortisoneMultidrug resistance protein 1transporter
DB00741HydrocortisoneSolute carrier organic anion transporter family member 1A2transporter
DB00741HydrocortisoneATP-binding cassette sub-family G member 2transporter
DB00741HydrocortisoneCytochrome P450 11B1, mitochondrialenzyme
DB00741HydrocortisoneCytochrome P450 11B2, mitochondrialenzyme
DB00741HydrocortisoneCytochrome P450 2C8enzyme
DB00741HydrocortisoneCorticosteroid-binding globulincarrier
DB00741HydrocortisoneCorticosteroid 11-beta-dehydrogenase isozyme 2target
DB00741Hydrocortisone3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target
DB00741HydrocortisoneSolute carrier family 22 member 8transporter
DB01380Cortisone acetateGlucocorticoid receptortarget
DB01380Cortisone acetateCytochrome P450 3A4enzyme
DB09091TixocortolGlucocorticoid receptortarget
DB09091TixocortolHistone deacetylase 2target
DB14538Hydrocortisone aceponateAnnexin A1target
DB14538Hydrocortisone aceponateGlucocorticoid receptortarget
DB14538Hydrocortisone aceponateSex hormone-binding globulincarrier
DB14538Hydrocortisone aceponateCytochrome P450 3A4enzyme
DB14538Hydrocortisone aceponateCytochrome P450 3A5enzyme
DB14538Hydrocortisone aceponateCytochrome P450 3A7enzyme
DB14538Hydrocortisone aceponateMultidrug resistance protein 1transporter
DB14538Hydrocortisone aceponateSolute carrier organic anion transporter family member 1A2transporter
DB14538Hydrocortisone aceponateATP-binding cassette sub-family G member 2transporter
DB14538Hydrocortisone aceponateCytochrome P450 11B1, mitochondrialenzyme
DB14538Hydrocortisone aceponateCytochrome P450 11B2, mitochondrialenzyme
DB14538Hydrocortisone aceponateCytochrome P450 2C8enzyme
DB14538Hydrocortisone aceponateCorticosteroid-binding globulincarrier
DB14538Hydrocortisone aceponateCorticosteroid 11-beta-dehydrogenase isozyme 2target
DB14538Hydrocortisone aceponate3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target
DB14538Hydrocortisone aceponateSolute carrier family 22 member 8transporter
DB14539Hydrocortisone acetateAnnexin A1target
DB14539Hydrocortisone acetateGlucocorticoid receptortarget
DB14539Hydrocortisone acetateSex hormone-binding globulincarrier
DB14539Hydrocortisone acetateCytochrome P450 3A4enzyme
DB14539Hydrocortisone acetateCytochrome P450 3A5enzyme
DB14539Hydrocortisone acetateCytochrome P450 3A7enzyme
DB14539Hydrocortisone acetateMultidrug resistance protein 1transporter
DB14539Hydrocortisone acetateSolute carrier organic anion transporter family member 1A2transporter
DB14539Hydrocortisone acetateATP-binding cassette sub-family G member 2transporter
DB14539Hydrocortisone acetateCytochrome P450 11B1, mitochondrialenzyme
DB14539Hydrocortisone acetateCytochrome P450 11B2, mitochondrialenzyme
DB14539Hydrocortisone acetateCytochrome P450 2C8enzyme
DB14539Hydrocortisone acetateCorticosteroid-binding globulincarrier
DB14539Hydrocortisone acetateCorticosteroid 11-beta-dehydrogenase isozyme 2target
DB14539Hydrocortisone acetate3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target
DB14539Hydrocortisone acetateSolute carrier family 22 member 8transporter
DB14540Hydrocortisone butyrateAnnexin A1target
DB14540Hydrocortisone butyrateGlucocorticoid receptortarget
DB14540Hydrocortisone butyrateSex hormone-binding globulincarrier
DB14540Hydrocortisone butyrateCytochrome P450 3A4enzyme
DB14540Hydrocortisone butyrateCytochrome P450 3A5enzyme
DB14540Hydrocortisone butyrateCytochrome P450 3A7enzyme
DB14540Hydrocortisone butyrateMultidrug resistance protein 1transporter
DB14540Hydrocortisone butyrateSolute carrier organic anion transporter family member 1A2transporter
DB14540Hydrocortisone butyrateATP-binding cassette sub-family G member 2transporter
DB14540Hydrocortisone butyrateCytochrome P450 11B1, mitochondrialenzyme
DB14540Hydrocortisone butyrateCytochrome P450 11B2, mitochondrialenzyme
DB14540Hydrocortisone butyrateCytochrome P450 2C8enzyme
DB14540Hydrocortisone butyrateCorticosteroid-binding globulincarrier
DB14540Hydrocortisone butyrateCorticosteroid 11-beta-dehydrogenase isozyme 2target
DB14540Hydrocortisone butyrate3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target
DB14540Hydrocortisone butyrateSolute carrier family 22 member 8transporter
DB14541Hydrocortisone cypionateAnnexin A1target
DB14541Hydrocortisone cypionateGlucocorticoid receptortarget
DB14541Hydrocortisone cypionateSex hormone-binding globulincarrier
DB14541Hydrocortisone cypionateCytochrome P450 3A4enzyme
DB14541Hydrocortisone cypionateCytochrome P450 3A5enzyme
DB14541Hydrocortisone cypionateCytochrome P450 3A7enzyme
DB14541Hydrocortisone cypionateMultidrug resistance protein 1transporter
DB14541Hydrocortisone cypionateSolute carrier organic anion transporter family member 1A2transporter
DB14541Hydrocortisone cypionateATP-binding cassette sub-family G member 2transporter
DB14541Hydrocortisone cypionateCytochrome P450 11B1, mitochondrialenzyme
DB14541Hydrocortisone cypionateCytochrome P450 11B2, mitochondrialenzyme
DB14541Hydrocortisone cypionateCytochrome P450 2C8enzyme
DB14541Hydrocortisone cypionateCorticosteroid-binding globulincarrier
DB14541Hydrocortisone cypionateCorticosteroid 11-beta-dehydrogenase isozyme 2target
DB14541Hydrocortisone cypionate3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target
DB14541Hydrocortisone cypionateSolute carrier family 22 member 8transporter
DB14542Hydrocortisone phosphateAnnexin A1target
DB14542Hydrocortisone phosphateGlucocorticoid receptortarget
DB14542Hydrocortisone phosphateSex hormone-binding globulincarrier
DB14542Hydrocortisone phosphateCytochrome P450 3A4enzyme
DB14542Hydrocortisone phosphateCytochrome P450 3A5enzyme
DB14542Hydrocortisone phosphateCytochrome P450 3A7enzyme
DB14542Hydrocortisone phosphateMultidrug resistance protein 1transporter
DB14542Hydrocortisone phosphateSolute carrier organic anion transporter family member 1A2transporter
DB14542Hydrocortisone phosphateATP-binding cassette sub-family G member 2transporter
DB14542Hydrocortisone phosphateCytochrome P450 11B1, mitochondrialenzyme
DB14542Hydrocortisone phosphateCytochrome P450 11B2, mitochondrialenzyme
DB14542Hydrocortisone phosphateCytochrome P450 2C8enzyme
DB14542Hydrocortisone phosphateCorticosteroid-binding globulincarrier
DB14542Hydrocortisone phosphateCorticosteroid 11-beta-dehydrogenase isozyme 2target
DB14542Hydrocortisone phosphate3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target
DB14542Hydrocortisone phosphateSolute carrier family 22 member 8transporter
DB14543Hydrocortisone probutateAnnexin A1target
DB14543Hydrocortisone probutateGlucocorticoid receptortarget
DB14543Hydrocortisone probutateSex hormone-binding globulincarrier
DB14543Hydrocortisone probutateCytochrome P450 3A4enzyme
DB14543Hydrocortisone probutateCytochrome P450 3A5enzyme
DB14543Hydrocortisone probutateCytochrome P450 3A7enzyme
DB14543Hydrocortisone probutateMultidrug resistance protein 1transporter
DB14543Hydrocortisone probutateSolute carrier organic anion transporter family member 1A2transporter
DB14543Hydrocortisone probutateATP-binding cassette sub-family G member 2transporter
DB14543Hydrocortisone probutateCytochrome P450 11B1, mitochondrialenzyme
DB14543Hydrocortisone probutateCytochrome P450 11B2, mitochondrialenzyme
DB14543Hydrocortisone probutateCytochrome P450 2C8enzyme
DB14543Hydrocortisone probutateCorticosteroid-binding globulincarrier
DB14543Hydrocortisone probutateCorticosteroid 11-beta-dehydrogenase isozyme 2target
DB14543Hydrocortisone probutate3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target
DB14543Hydrocortisone probutateSolute carrier family 22 member 8transporter
DB14544Hydrocortisone valerateAnnexin A1target
DB14544Hydrocortisone valerateGlucocorticoid receptortarget
DB14544Hydrocortisone valerateSex hormone-binding globulincarrier
DB14544Hydrocortisone valerateCytochrome P450 3A4enzyme
DB14544Hydrocortisone valerateCytochrome P450 3A5enzyme
DB14544Hydrocortisone valerateCytochrome P450 3A7enzyme
DB14544Hydrocortisone valerateMultidrug resistance protein 1transporter
DB14544Hydrocortisone valerateSolute carrier organic anion transporter family member 1A2transporter
DB14544Hydrocortisone valerateATP-binding cassette sub-family G member 2transporter
DB14544Hydrocortisone valerateCytochrome P450 11B1, mitochondrialenzyme
DB14544Hydrocortisone valerateCytochrome P450 11B2, mitochondrialenzyme
DB14544Hydrocortisone valerateCytochrome P450 2C8enzyme
DB14544Hydrocortisone valerateCorticosteroid-binding globulincarrier
DB14544Hydrocortisone valerateCorticosteroid 11-beta-dehydrogenase isozyme 2target
DB14544Hydrocortisone valerate3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target
DB14544Hydrocortisone valerateSolute carrier family 22 member 8transporter
DB14545Hydrocortisone succinateCytochrome P450 3A4enzyme
DB14545Hydrocortisone succinateCytochrome P450 3A5enzyme
DB14545Hydrocortisone succinateCytochrome P450 3A7enzyme
DB14545Hydrocortisone succinateCytochrome P450 2C8enzyme
DB14545Hydrocortisone succinateCytochrome P450 11B1, mitochondrialenzyme
DB14545Hydrocortisone succinateCytochrome P450 11B2, mitochondrialenzyme