Porphyrins

A group of compounds containing the porphin structure, four pyrrole rings connected by methine bridges in a cyclic configuration to which a variety of side chains are attached. The nature of the side chain is indicated by a prefix, as uroporphyrin, hematoporphyrin, etc. The porphyrins, in combination with iron, form the heme component in biologically significant compounds such as hemoglobin and myoglobin.
DrugDrug NameDrug Indication
DB00707Porfimer sodiumIndicated in the treatment of esophageal cancer.
DB01853Bacteriochlorophyll ANot Available
DB01911N-MethylmesoporphyrinNot Available
DB02133Chlorophyll ANot Available
DB02285ProtoporphyrinNot Available
DB02460Hydrogenobyrinic AcidNot Available
DB02577MesohemeNot Available
DB02832SirohemeNot Available
DB03317Heme CNot Available
DB03404HeminUsed in the management of porphyria attacks, particularly in acute intermittent porphyria.
DB03418DiacetyldeuterohemeNot Available
DB03469Heme DNot Available
DB03727Coproporphyrin INot Available
DB04461Coproporphyrinogen IIINot Available
DB04506Chlorophyll BNot Available
DB04803VerdohemeNot Available
DB04912StannsoporfinInvestigated for use/treatment in liver disease, metabolic disease, and pediatric indications.
DB05296Motexafin lutetiumInvestigated for use/treatment in brain cancer, breast cancer, cervical dysplasia/cancer, prostate cancer, cancer/tumors (unspecified), coronary artery disease, macular degeneration, and peripheral vascular disease.
DB05428motexafin gadoliniumInvestigated for use/treatment in brain cancer, cancer/tumors (unspecified), lung cancer, and lymphoma (non-hodgkin's).
DB05874AEOL 10150Investigated for use/treatment in amyotrophic lateral sclerosis (ALS).
DB11630TemoporfinFor use in the treatment of patients with advanced squamous cell carcinoma of the head and neck failing standard therapies and who are unsuitable for radiotherapy, surgery, or systemic chemotherapy [FDA Label].
DB13387HematinNot Available
DB152432-(1-hexyloxyethyl)-2-devinylpyropheophorbide aNot Available
DrugDrug NameTargetType
DB00707Porfimer sodiumLow-density lipoprotein receptortarget
DB00707Porfimer sodiumHigh affinity immunoglobulin gamma Fc receptor Itarget
DB01853Bacteriochlorophyll ABacteriochlorophyll a proteintarget
DB01853Bacteriochlorophyll ABacteriochlorophyll a proteintarget
DB01911N-MethylmesoporphyrinFerrochelatasetarget
DB02133Chlorophyll ABeta-lactamase 2target
DB02285ProtoporphyrinFerritin light chaintarget
DB02460Hydrogenobyrinic AcidPrecorrin-8X methylmutasetarget
DB02832SirohemeSulfite reductase [NADPH] hemoprotein beta-componenttarget
DB03317Heme CNitrite reductasetarget
DB03317Heme CHigh-molecular-weight cytochrome ctarget
DB03317Heme CCytochrome c''target
DB03317Heme CQuinohemoprotein ethanol dehydrogenase type-1target
DB03317Heme CNitrite reductasetarget
DB03317Heme CCytochrome c4target
DB03317Heme CCytochrome ctarget
DB03317Heme CCytochrome c-552target
DB03317Heme CCytochrome c2target
DB03317Heme CCytochrome c-550target
DB03317Heme CCytochrome c-552target
DB03317Heme CCytochrome c-551target
DB03317Heme CCytochrome c3target
DB03317Heme CSplit-Soret cytochrome ctarget
DB03317Heme CGroup 1 truncated hemoglobin GlbNtarget
DB03317Heme CCytochrome c-553target
DB03317Heme CCytochrome P450 2C9target
DB03317Heme CNine-heme cytochrome ctarget
DB03317Heme CCytochrome c3, 13 kDatarget
DB03317Heme CCytochrome c551 peroxidasetarget
DB03317Heme CCytochrome c3target
DB03317Heme CCytochrome c'target
DB03317Heme CCytochrome c3target
DB03469Heme DNitrite reductasetarget
DB03469Heme DNitrite reductasetarget
DB03727Coproporphyrin IUroporphyrinogen decarboxylasetarget
DB04461Coproporphyrinogen IIIUroporphyrinogen decarboxylasetarget
DB04803VerdohemeHeme oxygenase 1target
DB04912StannsoporfinHeme oxygenase 1target
DB04912StannsoporfinHeme oxygenase 2target
DB05428motexafin gadoliniumThioredoxin reductase 1, cytoplasmictarget
DB05428motexafin gadoliniumThioredoxin reductase 2, mitochondrialtarget
DB05428motexafin gadoliniumRibonucleoside-diphosphate reductase subunit M2target
DB11630TemoporfinHigh density lipoproteincarrier
DB11630TemoporfinLow density lipoproteincarrier
DB11630TemoporfinVery low density lipoproteincarrier