Organophosphates

Name
Organophosphates
Accession Number
DBCAT001125
Description

Carbon-containing phosphoric acid derivatives. Included under this heading are compounds that have CARBON atoms bound to one or more OXYGEN atoms of the P(=O)(O)3 structure. Note that several specific classes of endogenous phosphorus-containing compounds such as NUCLEOTIDES; PHOSPHOLIPIDS; and PHOSPHOPROTEINS are listed elsewhere.

Drugs
DrugDrug Description
MalathionA parasympathomimetic organophosphate used to treat head lice.
EchothiophateAn acetylcholinesterase inhibitor used in ophthalmic preparations to increase the drainage of intraocular fluid; most commonly used for the treatment of glaucoma.
AmifostineA cytoprotective adjuvant used for reduction in the cumulative renal toxicity in patients with ovarian cancer and moderate to severe xerostomia in patients undergoing post-operative radiation treatment for head and neck cancer.
Farnesyl thiopyrophosphateNot Available
Farnesyl diphosphateNot Available
Geranylgeranyl diphosphateNot Available
CoumaphosThis drug is a fat-soluble phosphorothioate agent that kills both insects and mites. It is non-volatile in nature and is well known by a variety of names as such a...
DichlorvosDichlorvos or 2,2-dichlorovinyl dimethyl phosphate is a drug of the organophosphate class, frequently used as an insecticide for the control of indoor pests and for the protection of stored products...
FamphurNot Annotated
FenthionFenthion is an organothiophosphate drug used as an insecticide, avicide, and acaricide. Its mode of action is explained by cholinesterase enzyme inhibition, which is similar to other organophosphates. Fenthion is...
PhosmetPhosmet is a phthalimide-derived organophosphate. It is a non-specific insecticide. It is mainly used on apple trees to control codling moths. It is also used on other fruit crops, ornamentals,...
TemefosDiphos has been used in trials studying the treatment of Plasmodium Falciparum Malaria.
ParaoxonNot Annotated
PhosphocysteamineNot Annotated
GlyphosateNot Available
Drugs & Drug Targets
DrugTargetType
MalathionCholinesterasetarget
MalathionCytochrome P450 1A2enzyme
MalathionCytochrome P450 2B6enzyme
EchothiophateCholinesterasetarget
EchothiophateSerum albumincarrier
AmifostineAlkaline phosphatase, germ cell typetarget
AmifostineAlkaline phosphatase, tissue-nonspecific isozymeenzyme
Farnesyl thiopyrophosphateDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)target
Farnesyl thiopyrophosphateGeranylgeranyl pyrophosphate synthasetarget
Farnesyl thiopyrophosphateMevalonate kinasetarget
Farnesyl thiopyrophosphateDehydrosqualene synthasetarget
Farnesyl diphosphateProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alphatarget
Farnesyl diphosphateProtein farnesyltransferase subunit betatarget
Farnesyl diphosphateGTPase KRastarget
Farnesyl diphosphate2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthasetarget
Farnesyl diphosphateFarnesyl pyrophosphate synthasetarget
Farnesyl diphosphateDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)target
Farnesyl diphosphateLantibiotic nisin-Ztarget
Farnesyl diphosphateGeranylgeranyl pyrophosphate synthasetarget
Farnesyl diphosphate(2Z,6E)-farnesyl diphosphate synthasetarget
Farnesyl diphosphateGeranylgeranyl transferase type-2 subunit alphatarget
Farnesyl diphosphateGeranylgeranyl transferase type-2 subunit betatarget
Geranylgeranyl diphosphateProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alphatarget
Geranylgeranyl diphosphateGeranylgeranyl transferase type-1 subunit betatarget
Geranylgeranyl diphosphateProtein farnesyltransferase subunit betatarget
Geranylgeranyl diphosphateGeranylgeranyl pyrophosphate synthasetarget
Geranylgeranyl diphosphateFarnesyl pyrophosphate synthasetarget
Geranylgeranyl diphosphateGeranylgeranyl transferase type-2 subunit alphatarget
Geranylgeranyl diphosphateGeranylgeranyl transferase type-2 subunit betatarget
DichlorvosSerum albumincarrier
DichlorvosSerotransferrintarget
DichlorvosCholinesterasetarget
Glyphosate3-phosphoshikimate 1-carboxyvinyltransferasetarget
Glyphosate3-phosphoshikimate 1-carboxyvinyltransferasetarget
GlyphosateCytochrome P450 19A1target
GlyphosateSerum albumincarrier