Cholic Acids

Name
Cholic Acids
Accession Number
DBCAT001382  (DBCAT003857)
Description

The 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholanic acid family of bile acids in man, usually conjugated with glycine or taurine. They act as detergents to solubilize fats for intestinal absorption, are reabsorbed by the small intestine, and are used as cholagogues and choleretics.

ATC Classification
Drugs
DrugDrug Description
Ursodeoxycholic acidA bile acid used for the treatment of primary biliary cirrhosis (PBC), dissolution of radiolucent gallstones in patients with a functioning gallbladder, and treatment of hepatobiliary disorders associated with cystic fibrosis in pediatric patients.
Glycochenodeoxycholic AcidA bile salt formed in the liver from chenodeoxycholate and glycine, usually as the sodium salt. It acts as a detergent to solubilize fats for absorption and is itself absorbed....
Cholic AcidA bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function.
Deoxycholic acidA cytolytic agent injected subcutaneously to improve the appearance submental fat.
Taurocholic acidThe product of conjugation of cholic acid with taurine. Its sodium salt is the chief ingredient of the bile of carnivorous animals. It acts as a detergent to solubilize fats...
Obeticholic acidA bile acid analog and farnesoid X receptor agonist used to treat primary biliary cholangitis in adult patients with inadequate clinical response or intolerance to UDCA.
Chenodeoxycholic acidA bile acid used for the treatment of primary biliary cirrhosis.
Taurochenodeoxycholic acidTaurochenodeoxycholic acid is likely indicated as a choleretic and cholagogue. It is also being investigated for its role in inflammation and cancer therapy.
Tauroursodeoxycholic acidUsed in the treatment of cholesterol gallstones. Tauroursodeoxycholic acid is also being investigated for use in several conditions such as Primary Biliary Cirrhosis (PBC), insulin resistance, amyloidosis, Cystic Fibrosis, Cholestasis,...
Bamet-UD2Bamet-UD2 is a novel bile acid-platinum derivative.
Dehydrocholic acidNo approved therapeutic indications.
Hyodeoxycholic AcidHyodeoxycholic Acid has been used in trials studying the treatment of Hypercholesterolemia.
Glycocholic acidThe glycine conjugate of cholic acid. It acts as a detergent to solubilize fats for absorption and is itself absorbed.
Drugs & Drug Targets
DrugTargetType
Ursodeoxycholic acidAldo-keto reductase family 1 member C2target
Ursodeoxycholic acidBile salt export pumptransporter
Ursodeoxycholic acidSolute carrier organic anion transporter family member 1A2transporter
Ursodeoxycholic acidCanalicular multispecific organic anion transporter 1transporter
Ursodeoxycholic acidMultidrug resistance-associated protein 4transporter
Ursodeoxycholic acidIleal sodium/bile acid cotransportertransporter
Ursodeoxycholic acidSodium/bile acid cotransportertransporter
Ursodeoxycholic acidCytochrome P450 2E1enzyme
Ursodeoxycholic acidBile acid receptortarget
Glycochenodeoxycholic Acid7-alpha-hydroxysteroid dehydrogenasetarget
Glycochenodeoxycholic AcidBile salt export pumptransporter
Glycochenodeoxycholic AcidSolute carrier organic anion transporter family member 1A2transporter
Glycochenodeoxycholic AcidIleal sodium/bile acid cotransportertransporter
Glycochenodeoxycholic AcidSodium/bile acid cotransportertransporter
Cholic AcidFerrochelatase, mitochondrialtarget
Cholic AcidBile salt export pumptransporter
Cholic AcidP-glycoprotein 1transporter
Cholic AcidMultidrug resistance-associated protein 1transporter
Cholic AcidSolute carrier organic anion transporter family member 1A2transporter
Cholic AcidIleal sodium/bile acid cotransportertransporter
Cholic AcidCanalicular multispecific organic anion transporter 1transporter
Cholic AcidSolute carrier organic anion transporter family member 1B1transporter
Cholic AcidCanalicular multispecific organic anion transporter 2transporter
Cholic AcidMultidrug resistance-associated protein 4transporter
Cholic AcidSodium/bile acid cotransportertransporter
Cholic AcidSolute carrier family 22 member 8transporter
Cholic AcidSolute carrier family 22 member 7transporter
Cholic AcidSolute carrier organic anion transporter family member 1B3transporter
Cholic AcidAlcohol dehydrogenase 1Ctarget
Cholic AcidEstrogen-related receptor gammatarget
Cholic AcidGastrotropintarget
Cholic AcidCytochrome c oxidase subunit 4 isoform 1, mitochondrialtarget
Cholic AcidCytochrome c oxidase subunit 1target
Cholic AcidCytochrome c oxidase subunit 2target
Cholic AcidCytochrome c oxidase subunit 3target
Cholic AcidCytochrome c oxidase subunit 5A, mitochondrialtarget
Cholic AcidCytochrome c oxidase subunit 5B, mitochondrialtarget
Cholic AcidCytochrome c oxidase subunit 6Ctarget
Cholic AcidCytochrome c oxidase subunit 7B, mitochondrialtarget
Cholic AcidCytochrome c oxidase subunit 7C, mitochondrialtarget
Cholic AcidCytochrome c oxidase subunit 8A, mitochondrialtarget
Cholic AcidCytochrome c oxidase subunit 6A2, mitochondrialtarget
Cholic AcidCytochrome c oxidase subunit 6B1target
Cholic AcidCytochrome c oxidase subunit 7A1, mitochondrialtarget
Cholic AcidPhospholipase A2target
Cholic AcidLiver carboxylesterase 1target
Cholic AcidFatty acid-binding protein, livercarrier
Cholic AcidFerrochelatasetarget
Cholic AcidCholoylglycine hydrolasetarget
Cholic AcidBile acid receptortarget
Cholic AcidG-protein coupled bile acid receptor 1target
Deoxycholic acidBile salt export pumptransporter
Deoxycholic acidSolute carrier organic anion transporter family member 1A2transporter
Deoxycholic acidIleal sodium/bile acid cotransportertransporter
Deoxycholic acidSodium/bile acid cotransportertransporter
Deoxycholic acidSteroid Delta-isomerasetarget
Deoxycholic acidPpcAtarget
Deoxycholic acidElongation factor Tu GTP-binding domain-containing protein 1target
Deoxycholic acidCholoylglycine hydrolasetarget
Deoxycholic acidLactaldehyde dehydrogenasetarget
Deoxycholic acidAcriflavine resistance protein Btarget
Deoxycholic acidCytochrome c oxidase subunit 1target
Deoxycholic acidCytochrome c oxidase subunit 2target
Deoxycholic acidBile acid receptortarget
Deoxycholic acidGlutathione S-transferase Ptarget
Deoxycholic acidG-protein coupled bile acid receptor 1target
Taurocholic acidBile salt-activated lipasetarget
Taurocholic acidGastrotropintarget
Taurocholic acidBile salt export pumptransporter
Taurocholic acidMultidrug resistance-associated protein 1transporter
Taurocholic acidSolute carrier organic anion transporter family member 1A2transporter
Taurocholic acidIleal sodium/bile acid cotransportertransporter
Taurocholic acidCanalicular multispecific organic anion transporter 1transporter
Taurocholic acidSolute carrier organic anion transporter family member 1B1transporter
Taurocholic acidCanalicular multispecific organic anion transporter 2transporter
Taurocholic acidMultidrug resistance-associated protein 4transporter
Taurocholic acidP-glycoprotein 1transporter
Taurocholic acidSolute carrier family 22 member 6transporter
Taurocholic acidMultidrug resistance-associated protein 7transporter
Taurocholic acidSolute carrier family 22 member 8transporter
Taurocholic acidSolute carrier organic anion transporter family member 4A1transporter
Taurocholic acidATP-binding cassette sub-family C member 11transporter
Taurocholic acidSolute carrier organic anion transporter family member 1C1transporter
Taurocholic acidSolute carrier organic anion transporter family member 3A1transporter
Taurocholic acidATP-binding cassette sub-family G member 2transporter
Taurocholic acidSolute carrier organic anion transporter family member 2B1transporter
Taurocholic acidMonocarboxylate transporter 1transporter
Taurocholic acidSodium/bile acid cotransportertransporter
Taurocholic acidOrganic solute transporter subunit alphatransporter
Taurocholic acidOrganic solute transporter subunit betatransporter
Taurocholic acidSolute carrier organic anion transporter family member 1B3transporter
Taurocholic acidCystine/glutamate transportertransporter
Taurocholic acidBile acid receptortarget
Obeticholic acidBile acid receptortarget
Obeticholic acidCytochrome P450 1A2enzyme
Obeticholic acidBile salt export pumptransporter
Chenodeoxycholic acidBile acid receptortarget
Chenodeoxycholic acidSterol 26-hydroxylase, mitochondrialenzyme
Chenodeoxycholic acidCytochrome P450 3A4enzyme
Chenodeoxycholic acidUDP-glucuronosyltransferase 2B7enzyme
Chenodeoxycholic acidNuclear receptor subfamily 1 group I member 2target
Chenodeoxycholic acidG-protein coupled bile acid receptor 1target
Chenodeoxycholic acidAldo-keto reductase family 1 member C2target
Taurochenodeoxycholic acidSolute carrier organic anion transporter family member 1A2transporter
Taurochenodeoxycholic acidCystine/glutamate transportertransporter
Taurochenodeoxycholic acidCytochrome P450 3A4enzyme
Tauroursodeoxycholic acidSolute carrier organic anion transporter family member 1A2transporter
Tauroursodeoxycholic acidCystine/glutamate transportertransporter
Tauroursodeoxycholic acidCytochrome P450 3A1enzyme
Tauroursodeoxycholic acidCytochrome P450 3A2enzyme
Tauroursodeoxycholic acidCytochrome P450 2A1enzyme
Tauroursodeoxycholic acidCytochrome P450 2A2enzyme
Tauroursodeoxycholic acidCytochrome P450 2B1enzyme
Tauroursodeoxycholic acidCytochrome P450 2B2enzyme
Tauroursodeoxycholic acidCytochrome P450 2B9enzyme
Bamet-UD2Solute carrier organic anion transporter family member 1B1transporter
Glycocholic acidGastrotropintarget
Glycocholic acidSolute carrier organic anion transporter family member 1A2transporter
Glycocholic acidSolute carrier organic anion transporter family member 1B1transporter
Glycocholic acidSolute carrier organic anion transporter family member 1B3transporter