Cholagogues and Choleretics

Gastrointestinal agents that stimulate the flow of bile into the duodenum (cholagogues) or stimulate the production of bile by the liver (choleretic).
DrugDrug NameDrug Description
DB01586Ursodeoxycholic acidA bile acid used for the treatment of primary biliary cirrhosis (PBC), dissolution of radiolucent gallstones in patients with a functioning gallbladder, and treatment of hepatobiliary disorders associated with cystic fibrosis in pediatric patients.
DB03619Deoxycholic acidA cytolytic agent injected subcutaneously to improve the appearance submental fat.
DB04348Taurocholic acidThe product of conjugation of cholic acid with taurine. Its sodium salt is the chief ingredient of the bile of carnivorous animals. It acts as a detergent to solubilize fats...
DB07767Ferulic acidNot Available
DB08833Taurochenodeoxycholic acidTaurochenodeoxycholic acid is likely indicated as a choleretic and cholagogue. It is also being investigated for its role in inflammation and cancer therapy.
DB08834Tauroursodeoxycholic acidUsed in the treatment of cholesterol gallstones. Tauroursodeoxycholic acid is also being investigated for use in several conditions such as Primary Biliary Cirrhosis (PBC), insulin resistance, amyloidosis, Cystic Fibrosis, Cholestasis,...
DB08862CholecystokininFor use as a diagnostic aid for evaluation of gallbladder disorders. It is also used in conjunction with secretin in pancreatic insufficiency .
DB11622Dehydrocholic acidNo approved therapeutic indications.
DB13711TritoqualineNot Annotated
DB13802EpomediolNot Annotated
DB02691Glycocholic acidThe glycine conjugate of cholic acid. It acts as a detergent to solubilize fats for absorption and is itself absorbed.
DrugDrug NameTargetType
DB01586Ursodeoxycholic acidAldo-keto reductase family 1 member C2target
DB01586Ursodeoxycholic acidBile salt export pumptransporter
DB01586Ursodeoxycholic acidSolute carrier organic anion transporter family member 1A2transporter
DB01586Ursodeoxycholic acidCanalicular multispecific organic anion transporter 1transporter
DB01586Ursodeoxycholic acidMultidrug resistance-associated protein 4transporter
DB01586Ursodeoxycholic acidIleal sodium/bile acid cotransportertransporter
DB01586Ursodeoxycholic acidSodium/bile acid cotransportertransporter
DB01586Ursodeoxycholic acidCytochrome P450 2E1enzyme
DB01586Ursodeoxycholic acidBile acid receptortarget
DB03619Deoxycholic acidBile salt export pumptransporter
DB03619Deoxycholic acidSolute carrier organic anion transporter family member 1A2transporter
DB03619Deoxycholic acidIleal sodium/bile acid cotransportertransporter
DB03619Deoxycholic acidSodium/bile acid cotransportertransporter
DB03619Deoxycholic acidSteroid Delta-isomerasetarget
DB03619Deoxycholic acidPpcAtarget
DB03619Deoxycholic acidElongation factor Tu GTP-binding domain-containing protein 1target
DB03619Deoxycholic acidCholoylglycine hydrolasetarget
DB03619Deoxycholic acidLactaldehyde dehydrogenasetarget
DB03619Deoxycholic acidAcriflavine resistance protein Btarget
DB03619Deoxycholic acidCytochrome c oxidase subunit 1target
DB03619Deoxycholic acidCytochrome c oxidase subunit 2target
DB03619Deoxycholic acidBile acid receptortarget
DB03619Deoxycholic acidGlutathione S-transferase Ptarget
DB03619Deoxycholic acidG-protein coupled bile acid receptor 1target
DB04348Taurocholic acidBile salt-activated lipasetarget
DB04348Taurocholic acidGastrotropintarget
DB04348Taurocholic acidBile salt export pumptransporter
DB04348Taurocholic acidMultidrug resistance-associated protein 1transporter
DB04348Taurocholic acidSolute carrier organic anion transporter family member 1A2transporter
DB04348Taurocholic acidIleal sodium/bile acid cotransportertransporter
DB04348Taurocholic acidCanalicular multispecific organic anion transporter 1transporter
DB04348Taurocholic acidSolute carrier organic anion transporter family member 1B1transporter
DB04348Taurocholic acidCanalicular multispecific organic anion transporter 2transporter
DB04348Taurocholic acidMultidrug resistance-associated protein 4transporter
DB04348Taurocholic acidP-glycoprotein 1transporter
DB04348Taurocholic acidSolute carrier family 22 member 6transporter
DB04348Taurocholic acidMultidrug resistance-associated protein 7transporter
DB04348Taurocholic acidSolute carrier family 22 member 8transporter
DB04348Taurocholic acidSolute carrier organic anion transporter family member 4A1transporter
DB04348Taurocholic acidATP-binding cassette sub-family C member 11transporter
DB04348Taurocholic acidSolute carrier organic anion transporter family member 1C1transporter
DB04348Taurocholic acidSolute carrier organic anion transporter family member 3A1transporter
DB04348Taurocholic acidATP-binding cassette sub-family G member 2transporter
DB04348Taurocholic acidSolute carrier organic anion transporter family member 2B1transporter
DB04348Taurocholic acidMonocarboxylate transporter 1transporter
DB04348Taurocholic acidSodium/bile acid cotransportertransporter
DB04348Taurocholic acidOrganic solute transporter subunit alphatransporter
DB04348Taurocholic acidOrganic solute transporter subunit betatransporter
DB04348Taurocholic acidSolute carrier organic anion transporter family member 1B3transporter
DB04348Taurocholic acidCystine/glutamate transportertransporter
DB04348Taurocholic acidBile acid receptortarget
DB07767Ferulic acidEndo-1,4-beta-xylanase Ytarget
DB07767Ferulic acidEndo-1,4-beta-xylanase Ztarget
DB07767Ferulic acidEst1etarget
DB07767Ferulic acidO-methyltransferasetarget
DB08833Taurochenodeoxycholic acidSolute carrier organic anion transporter family member 1A2transporter
DB08833Taurochenodeoxycholic acidCystine/glutamate transportertransporter
DB08833Taurochenodeoxycholic acidCytochrome P450 3A4enzyme
DB08834Tauroursodeoxycholic acidSolute carrier organic anion transporter family member 1A2transporter
DB08834Tauroursodeoxycholic acidCystine/glutamate transportertransporter
DB08834Tauroursodeoxycholic acidCytochrome P450 3A1enzyme
DB08834Tauroursodeoxycholic acidCytochrome P450 3A2enzyme
DB08834Tauroursodeoxycholic acidCytochrome P450 2A1enzyme
DB08834Tauroursodeoxycholic acidCytochrome P450 2A2enzyme
DB08834Tauroursodeoxycholic acidCytochrome P450 2B1enzyme
DB08834Tauroursodeoxycholic acidCytochrome P450 2B2enzyme
DB08834Tauroursodeoxycholic acidCytochrome P450 2B9enzyme
DB08862CholecystokininSolute carrier organic anion transporter family member 1B3transporter
DB08862CholecystokininCholecystokinin receptor type Atarget
DB08862CholecystokininRAF proto-oncogene serine/threonine-protein kinasetarget
DB08862CholecystokininMitogen-activated protein kinase 3target
DB08862CholecystokininPro-epidermal growth factortarget
DB08862CholecystokininProtein kinase C beta typetarget
DB08862CholecystokininGastrin/cholecystokinin type B receptortarget
DB08862CholecystokininSolute carrier organic anion transporter family member 1B1transporter
DB08862CholecystokininSolute carrier organic anion transporter family member 2B1transporter
DB02691Glycocholic acidGastrotropintarget
DB02691Glycocholic acidSolute carrier organic anion transporter family member 1A2transporter
DB02691Glycocholic acidSolute carrier organic anion transporter family member 1B1transporter
DB02691Glycocholic acidSolute carrier organic anion transporter family member 1B3transporter