Imino Sugars

Name
Imino Sugars
Accession Number
DBCAT001529
Description

Sugars in which the OXYGEN is replaced by a NITROGEN atom. This substitution prevents normal METABOLISM resulting in inhibition of GLYCOSIDASES and GLYCOSYLTRANSFERASES.

Drugs
DrugDrug Description
MiglustatA glucosylceramide synthase inhibitor used for the management of mild to moderate type I Gaucher disease for patients who are not candidates for whole enzyme replacement.
MiglitolAn oral alpha-glucosidase inhibitor used to improve glycemic control by delaying the digestion of carbohydrates.
GhavamiolNot Available
DuvoglustatAn alpha-glucosidase inhibitor with antiviral action. Derivatives of deoxynojirimycin may have anti-HIV activity.
1-deoxymannojirimycinAn alpha-glucosidase inhibitor with antiviral action. Derivatives of deoxynojirimycin may have anti-HIV activity. [PubChem]
AfegostatNot Available
MigalastatAn alpha-galactosidase A chaperone used for the treatment of Fabry disease in patients with an amenable galactosidase alpha gene (GLA) variant.
UlodesineUlodesine has been used in trials studying the treatment of Gout, Arthritis, Hyperuricemia, and Joint Disease.
LucerastatLucerastat is under investigation in clinical trial NCT03425539 (Efficacy and Safety of Lucerastat Oral Monotherapy in Adult Subjects With Fabry Disease).
VoruciclibVoruciclib is under investigation in clinical trial NCT03547115 (A Phase 1 Study of Voruciclib in Subjects With B-Cell Malignancies or AML).
N-9-MethoxynonyldeoxynojirimycinNot Annotated
Drugs & Drug Targets
DrugTargetType
MiglustatCeramide glucosyltransferasetarget
MiglitolMaltase-glucoamylase, intestinaltarget
MiglitolPancreatic alpha-amylaseenzyme
MiglitolLysosomal alpha-glucosidasetarget
MiglitolNeutral alpha-glucosidase ABtarget
MiglitolNeutral alpha-glucosidase Ctarget
GhavamiolAlpha-mannosidase 2target
DuvoglustatCyclomaltodextrin glucanotransferasetarget
DuvoglustatBeta-glucosidase Atarget
DuvoglustatEndoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidasetarget
DuvoglustatMannosyl-oligosaccharide alpha-1,2-mannosidasetarget
DuvoglustatXylose isomerasetarget
1-deoxymannojirimycinAlpha-mannosidase 2target
AfegostatEndoglucanase 5Atarget
AfegostatBeta-glucosidase Atarget
AfegostatPossible cellulase CelA1 (Endoglucanase) (Endo-1,4-beta-glucanase) (FI-cmcase) (Carboxymethyl cellulase)target
MigalastatAlpha-galactosidase Atarget
MigalastatSodium/glucose cotransporter 1transporter