Antipsoriatics

DrugDrug NameDrug Description
DB00136CalcitriolAn active metabolite of vitamin D that is used to treat hyperparathyroidism and is also used in dialysis patients to combat hypocalcemia.
DB00459AcitretinAn oral retinoid used in the treatment of severe psoriasis.
DB00553MethoxsalenA furocoumarin used to treat psoriasis and vitiligo.
DB00799TazaroteneAn acetylenic retinoid used to treat fine wrinkles, mottled pigmentation of the skin, acne vulgaris, and plaque psoriasis.
DB00926EtretinateFor the treatment of severe psoriasis in adults.
DB01677Fumaric AcidNot Available
DB02300CalcipotriolA topical synthetic vitamin D2 derivative used in the treatment of plaque psoriasis.
DB04571TrioxsalenA psoralen derivative that has been used in combination with UV light to treat vitiligo, but has been discontinued by its manufacturer.
DB11157AnthralinAn anthracene used to treat stable plaque psoriasis.
DB12216BergaptenBergapten is under investigation in clinical trial NCT00533195 (Comparison of UVA1 Phototherapy Versus Photochemotherapy for Patients With Severe Generalized Atopic Dermatitis).
DB13689TacalcitolNot Annotated
DrugDrug NameTargetType
DB00136CalcitriolVitamin D3 receptortarget
DB00136Calcitriol1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme
DB00136CalcitriolCytochrome P450 3A4enzyme
DB00136CalcitriolHomeobox protein Hox-A10target
DB00136CalcitriolVitamin D-binding proteincarrier
DB00459AcitretinRetinoic acid receptor alphatarget
DB00459AcitretinRetinoic acid receptor RXR-betatarget
DB00459AcitretinRetinoic acid receptor gammatarget
DB00459AcitretinRetinoic acid receptor betatarget
DB00459AcitretinRetinoic acid receptor RXR-gammatarget
DB00459AcitretinRetinoic acid receptor RXR-alphatarget
DB00459AcitretinSerum albumincarrier
DB00459AcitretinRetinol-binding protein 1target
DB00553MethoxsalenDNAtarget
DB00553MethoxsalenCytochrome P450 2A6enzyme
DB00553MethoxsalenCytochrome P450 1A2enzyme
DB00553MethoxsalenCytochrome P450 1A1enzyme
DB00553MethoxsalenCytochrome P450 2A13enzyme
DB00799TazaroteneRetinoic acid receptor alphatarget
DB00799TazaroteneRetinoic acid receptor RXR-betatarget
DB00799TazaroteneRetinoic acid receptor gammatarget
DB00799TazaroteneRetinoic acid receptor betatarget
DB00799TazaroteneCytochrome P450 2C8enzyme
DB00926EtretinateRetinoic acid receptor alphatarget
DB00926EtretinateRetinoic acid receptor RXR-betatarget
DB00926EtretinateRetinoic acid receptor gammatarget
DB00926EtretinateRetinoic acid receptor betatarget
DB00926EtretinateRetinoic acid receptor RXR-gammatarget
DB00926EtretinateRetinoic acid receptor RXR-alphatarget
DB00926EtretinateCellular retinoic acid-binding protein 1carrier
DB00926EtretinateCytochrome P450 19A1enzyme
DB01677Fumaric AcidMalate dehydrogenasetarget
DB01677Fumaric AcidFumarate reductase flavoprotein subunittarget
DB01677Fumaric AcidNAD-dependent malic enzyme, mitochondrialtarget
DB01677Fumaric AcidFumarylacetoacetasetarget
DB01677Fumaric AcidFumarate reductase flavoprotein subunittarget
DB02300CalcipotriolVitamin D3 receptortarget
DB02300CalcipotriolMyeloperoxidaseenzyme
DB02300Calcipotriol1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme
DB04571TrioxsalenDNAtarget
DB11157AnthralinKeratin, type II cytoskeletal 2 epidermaltarget
DB11157AnthralinC-Jun-amino-terminal kinase-interacting protein 1target
DB11157AnthralinKeratin, type I cytoskeletal 12target