Phenothiazines With Piperazine Structure

DrugDrug NameDrug Indication
DB00433ProchlorperazineFor the symptomatic management of psychotic disorders, short term management of nonpsychotic anxiety in patients with generalized anxiety disorder, and for the control of severe nausea and vomiting of various causes.
DB00623FluphenazineFor management of manifestations of psychotic disorders.
DB00831TrifluoperazineFor the treatment of anxiety disorders, depressive symptoms secondary to anxiety and agitation.
DB00850PerphenazineFor use in the management of the manifestations of psychotic disorders and for the control of severe nausea and vomiting in adults.
DB01063AcetophenazineFor the treatment of disorganized and psychotic thinking. Also used to help treat false perceptions (e.g. hallucinations or delusions.)
DB01622ThioproperazineFor the treatment of all types of acute and chronic schizophrenia, including those which did not respond to the usual neuroleptics; manic syndromes.
DB12710PerazineNot Available
DrugDrug NameTargetType
DB00433ProchlorperazineD(2) dopamine receptortarget
DB00433ProchlorperazineCytochrome P450 2D6enzyme
DB00433ProchlorperazineCytochrome P450 3A4enzyme
DB00623FluphenazineD(2) dopamine receptortarget
DB00623FluphenazineCalmodulintarget
DB00623FluphenazineD(1A) dopamine receptortarget
DB00623FluphenazineCytochrome P450 2D6enzyme
DB00623FluphenazineMultidrug resistance protein 1transporter
DB00623FluphenazineCytochrome P450 1A2enzyme
DB00623FluphenazineCytochrome P450 2E1enzyme
DB00623FluphenazineAndrogen receptortarget
DB00623Fluphenazine5-hydroxytryptamine receptor 2Atarget
DB00623Fluphenazine5-hydroxytryptamine receptor 2Ctarget
DB00831TrifluoperazineD(2) dopamine receptortarget
DB00831TrifluoperazineAlpha-1A adrenergic receptortarget
DB00831TrifluoperazineNeuron-specific vesicular protein calcyontarget
DB00831TrifluoperazineXanthine dehydrogenase/oxidaseenzyme
DB00831TrifluoperazineUDP-glucuronosyltransferase 1-4enzyme
DB00831TrifluoperazineCytochrome P450 1A2enzyme
DB00831TrifluoperazineMultidrug resistance protein 1transporter
DB00831TrifluoperazineCalmodulintarget
DB00831TrifluoperazineTroponin C, slow skeletal and cardiac musclestarget
DB00831TrifluoperazineProtein S100-A4target
DB00850PerphenazineD(1A) dopamine receptortarget
DB00850PerphenazineD(2) dopamine receptortarget
DB00850PerphenazineCalmodulintarget
DB00850PerphenazineCytochrome P450 2D6enzyme
DB00850PerphenazineCytochrome P450 1A2enzyme
DB00850PerphenazineCytochrome P450 2B6enzyme
DB00850PerphenazineCytochrome P450 2C18enzyme
DB00850PerphenazineCytochrome P450 2C19enzyme
DB00850PerphenazineCytochrome P450 2C8enzyme
DB00850PerphenazineCytochrome P450 2C9enzyme
DB00850PerphenazineCytochrome P450 3A4enzyme
DB01063AcetophenazineD(2) dopamine receptortarget
DB01063AcetophenazineD(1A) dopamine receptortarget
DB01063AcetophenazineAndrogen receptortarget
DB01622ThioproperazineD(2) dopamine receptortarget
DB01622ThioproperazineD(1A) dopamine receptortarget
DB01622Thioproperazine5-hydroxytryptamine receptor 2Atarget
DB01622Thioproperazine5-hydroxytryptamine receptor 1Atarget
DB01622ThioproperazineAlpha-1A adrenergic receptortarget
DB01622ThioproperazineAlpha-1B adrenergic receptortarget
DB01622ThioproperazineSolute carrier family 22 member 1transporter
DB01622ThioproperazineSerum albumincarrier