Vasodilators Used in Cardiac Diseases

DrugDrug NameDrug Description
DB00727NitroglycerinA nitrate vasodilator used to treat or prevent angina, treat hypertension, control heart failure in myocardial infarction, and to induce hypotension intraoperatively.
DB00883Isosorbide dinitrateA vasodilator used to treat angina in coronary artery disease.
DB01020Isosorbide mononitrateA nitrate used to prevent and treat angina and to treat angina caused by coronary artery disease.
DB01613Erythrityl tetranitrateFor the prevention of angina.
DB04825PrenylaminePrenylamine was withdrawn from the Canadian, US, and UK markets in 1988 due to concerns regarding cardiac arrhythmias.
DB04899NesiritideA recombinant natriuretic peptide used for the treatment of patients with acutely decompensated congestive heart failure who have dyspnea at rest or with minimal activity.
DB05794SerelaxinInvestigated for use/treatment in cardiovascular disorders, congestive heart failure, infertility, peripheral vascular disease, and scleroderma.
DB06154Pentaerythritol tetranitrateUsed for the treatment of angina pectoris .
DB09220NicorandilIndicated for the prevention and treatment of chronic stable angina pectoris and reduction in the risk of acute coronary syndromes.
DB09282MolsidomineThe indications for use of molsidomine include ischemic heart disease, angina, chronic heart failure, and pulmonary hypertension [L1370, L1371].
DB09283TrapidilUsed in the treatment of chronic stable angina .
DB09284ImolamineImolamine is indicated for the treatment of angina pectoris. The hydrochloride form is used as a local anesthetic.
DB13228FlosequinanFlosequinan was approved in the USA and the UK for a year prior to being withdrawn from the market due to increased mortality in chronic heart failure patients, found in...
DB13255Propatyl nitrateNot Annotated
DB13265HexobendineHexobendine is a medication used to cause vasodilation, to treat several conditions including angina pectoris. It has not been approved in the United States or the United Kingdom, but has...
DB13277BenziodaroneBenziodarone is a uricostatic and a uricosuric agent which is sold also under the name Amplivex-Labaz. It is used in the treatment of gout . It was withdrawn from France...
DB13279CarbocromenCarbocromen was marketed for use in Germany as a vasodilator, however, it has been discontinued due to the risk of arrhythmia development .
DB13291CloridarolCloridarol is an experimental medication in the treatment of heart disease, which acts through vasodilation. It was studied for the treatment of coronary insufficiency in Italy in the 1970s .
DB13333EfloxateNot Annotated
DB13342CinepazetNot Annotated
DB13398OxyfedrineNot Annotated
DB13400LinsidomineNot Annotated
DB13408Methylpropylpropanediol dinitrateNot Annotated
DB13574HeptaminolNot Annotated
DB13585Aminoethyl nitrateNot Annotated
DB13637TenitramineNot Annotated
DB13715DilazepNot Annotated
DB13719TrolnitrateNot Annotated
DB13845EtafenoneEtafenone is a vasodilator.
DrugDrug NameTargetType
DB00727NitroglycerinAtrial natriuretic peptide receptor 1target
DB00727NitroglycerinAldehyde dehydrogenase, mitochondrialenzyme
DB00883Isosorbide dinitrateAtrial natriuretic peptide receptor 1target
DB00883Isosorbide dinitrateCytochrome P450 2E1enzyme
DB01020Isosorbide mononitrateGuanylate cyclase soluble subunit alpha-2target
DB01020Isosorbide mononitrateGlutathione S-transferase Mu 1enzyme
DB01020Isosorbide mononitrateXanthine dehydrogenase/oxidaseenzyme
DB01020Isosorbide mononitrateAlcohol dehydrogenase class-3enzyme
DB01613Erythrityl tetranitrateAtrial natriuretic peptide receptor 1target
DB01613Erythrityl tetranitrateAtrial natriuretic peptide receptor 2target
DB04825PrenylamineCalmodulintarget
DB04825PrenylamineMyosin light chain kinase 2, skeletal/cardiac muscletarget
DB04825PrenylamineCytochrome P450 3A4enzyme
DB04899NesiritideAtrial natriuretic peptide receptor 1target
DB04899NesiritideAtrial natriuretic peptide receptor 2target
DB04899NesiritideAtrial natriuretic peptide receptor 3target
DB06154Pentaerythritol tetranitrateHemoglobin subunit alphatarget
DB06154Pentaerythritol tetranitrateHemoglobin subunit betatarget
DB06154Pentaerythritol tetranitrateGuanylate cyclase soluble subunit alpha-2enzyme
DB06154Pentaerythritol tetranitrateFree radicalstarget
DB06154Pentaerythritol tetranitrateNitric oxide synthase, endothelialenzyme
DB06154Pentaerythritol tetranitrateAldehyde dehydrogenase, mitochondrialenzyme
DB09220NicorandilATP-binding cassette sub-family C member 9target
DB09282MolsidomineGuanylate cyclase soluble subunit alpha-2target
DB09282MolsidomineGuanylate cyclase soluble subunit alpha-2enzyme
DB09282MolsidominecGMP-specific 3',5'-cyclic phosphodiesteraseenzyme
DB09283TrapidilPlatelet-derived growth factor receptor betatarget
DB09283TrapidilCyclic nucleotide phosphodiesterasetarget