Antianginal Agents

DrugDrug NameDrug Indication
DB00381AmlodipineAmlodipine may be used alone or in combination with other antihypertensive and antianginal agents for the treatment of the following conditions [FDA label]: • Hypertension • Coronary artery disease • Chronic stable angina • Vasospastic angina (Prinzmetal’s or Variant angina) • Angiographically documented coronary artery disease in patients without heart failure or an ejection fraction < 40%
DB04863LefradafibanFor the treatment of unstable angina.
DB05306Alferminogene tadenovecInvestigated for use/treatment in angina, coronary artery disease, and heart disease.
DB00243RanolazineRanolazine is approved as a second-line agent in the management of chronic stable angina pectoris that is refractory to conventional anti-ischemic therapy.[A174913] Ranolazine has also been used off-label for the treatment of some arrhythmias such as ventricular tachycardia, however, this use does not have a lot of supporting evidence.[A174940] The use of ranolazine has been researched in the treatment of acute coronary syndrome, microvascular coronary dysfunction, arrhythmia, and glycemic control.[A174898]
DB00727NitroglycerinFor the prevention of angina
DB00883Isosorbide dinitrateFor the prevention of angina pectoris due to coronary artery disease.
DB01020Isosorbide MononitrateFor the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
DB01613Erythrityl tetranitrateFor the prevention of angina.
DB06154Pentaerythritol tetranitrateUsed for the treatment of angina pectoris [L2393].
DB13255Propatyl nitrateNot Available
DB13408Methylpropylpropanediol dinitrateNot Available
DB13637TenitramineNot Available
DB13719TrolnitrateNot Available
DB09401IsosorbideIndicated for the prevention and treatment of angina pectoris due to coronary artery disease. The onset of action of oral isosorbide mononitrate is not sufficiently rapid for this product to be useful in aborting an acute anginal episode.[label]
DB14049NitrateNot Available
DB01612Amyl NitriteFor the rapid relief of angina pectoris.
DrugDrug NameTargetType
DB00381AmlodipineCarbonic anhydrase 1target
DB00381AmlodipineCytochrome P450 3A4enzyme
DB00381AmlodipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB00381AmlodipineCytochrome P450 1A1enzyme
DB00381AmlodipineCytochrome P450 2B6enzyme
DB00381AmlodipineVoltage-dependent N-type calcium channel subunit alpha-1Btarget
DB00381AmlodipineVoltage-dependent L-type calcium channel subunit beta-1target
DB00381AmlodipineVoltage-dependent calcium channel subunit alpha-2/delta-3target
DB00381AmlodipineCytochrome P450 3A5enzyme
DB00381AmlodipineMultidrug resistance protein 1transporter
DB00381AmlodipineCytochrome P450 2C8enzyme
DB00381AmlodipineCytochrome P450 2D6enzyme
DB00381AmlodipineSphingomyelin phosphodiesterasetarget
DB00381AmlodipineLactose monohydratecarrier
DB00381AmlodipineMagnesium stearatecarrier
DB00381AmlodipineMicrocrystalline cellulosecarrier
DB00381AmlodipineMaize starchcarrier
DB00381AmlodipineVoltage-dependent calcium channeltarget
DB00381AmlodipineVoltage-dependent T-type calcium channel subunit alpha-1Itarget
DB00381AmlodipineVoltage-dependent N-type calcium channeltarget
DB04863LefradafibanIntegrin alpha-IIbtarget
DB04863LefradafibanIntegrin beta-3target
DB00243RanolazineCytochrome P450 3A4enzyme
DB00243RanolazineCytochrome P450 2D6enzyme
DB00243RanolazineBile salt export pumptransporter
DB00243RanolazineMultidrug resistance protein 1transporter
DB00243RanolazineSerum albumincarrier
DB00243RanolazineVoltage gated sodium channeltarget
DB00243RanolazineInward rectifier potassium channeltarget
DB00243RanolazineVoltage-dependent L-type calcium channeltarget
DB00243RanolazineAlpha-1 adrenergic receptorstarget
DB00243RanolazineBeta-1 adrenergic receptortarget
DB00243RanolazineFatty acidtarget
DB00243RanolazineAlpha-1-acid glycoprotein 1carrier
DB00727NitroglycerinAtrial natriuretic peptide receptor 1target
DB00727NitroglycerinAldehyde dehydrogenase, mitochondrialenzyme
DB00883Isosorbide dinitrateAtrial natriuretic peptide receptor 1target
DB00883Isosorbide dinitrateCytochrome P450 3A4enzyme
DB00883Isosorbide dinitrateCytochrome P450 2E1enzyme
DB01020Isosorbide MononitrateCytochrome P450 3A4enzyme
DB01020Isosorbide MononitrateGuanylate cyclase soluble subunit alpha-2target
DB01613Erythrityl tetranitrateAtrial natriuretic peptide receptor 1target
DB01613Erythrityl tetranitrateAtrial natriuretic peptide receptor 2target
DB06154Pentaerythritol tetranitrateHemoglobin subunit alphatarget
DB06154Pentaerythritol tetranitrateHemoglobin subunit betatarget
DB06154Pentaerythritol tetranitrateGuanylate cyclase soluble subunit alpha-2enzyme
DB06154Pentaerythritol tetranitrateFree radicalstarget
DB06154Pentaerythritol tetranitrateNitric oxide synthase, endothelialenzyme
DB06154Pentaerythritol tetranitrateAldehyde dehydrogenase, mitochondrialenzyme
DB09401IsosorbideApoptosis regulator Bcl-2target
DB09401IsosorbideBcl-2-like protein 1target
DB09401IsosorbideInduced myeloid leukemia cell differentiation protein Mcl-1target
DB01612Amyl NitriteAtrial natriuretic peptide receptor 1target
DB01612Amyl NitriteAldehyde dehydrogenase, mitochondrialenzyme