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Identification
NameRanolazine
Accession NumberDB00243  (APRD01300)
TypeSmall Molecule
GroupsApproved, Investigational
DescriptionRanolazine is an antianginal medication. On January 31, 2006, ranolazine was approved for use in the United States by the FDA for the treatment of chronic angina. [Wikipedia]
Structure
Thumb
SynonymsNot Available
External Identifiers
  • CVT-303
  • RS-43285-003
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
RanexaTablet, film coated, extended release500 mg/1OralAphena Pharma Solutions Tennessee, Llc2006-01-27Not applicableUs
RanexaTablet, film coated, extended release500 mg/1OralCardinal Health2007-02-12Not applicableUs
RanexaTablet, film coated, extended release500 mg/1OralGilead Sciences, Inc.2006-01-27Not applicableUs
RanexaTablet, film coated, extended release500 mg/1OralCardinal Health2006-01-27Not applicableUs
RanexaTablet, film coated, extended release1000 mg/1OralGilead Sciences, Inc.2007-02-12Not applicableUs
RanexaTablet, film coated, extended release500 mg/1OralGilead Sciences, Inc.2006-01-27Not applicableUs
RanexaTablet, film coated, extended release500 mg/1OralCarilion Materials Management2006-01-27Not applicableUs
RanexaTablet, film coated, extended release1000 mg/1OralGilead Sciences, Inc.2007-02-12Not applicableUs
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Ranolazine hydrochloride
95635-56-6
Thumb
  • InChI Key: RJNSNFZXAZXOFX-UHFFFAOYSA-N
  • Monoisotopic Mass: 499.200462037
  • Average Mass: 500.458
DBSALT000388
Categories
UNIIA6IEZ5M406
CAS number95635-55-5
WeightAverage: 427.5365
Monoisotopic: 427.247106559
Chemical FormulaC24H33N3O4
InChI KeyXKLMZUWKNUAPSZ-UHFFFAOYSA-N
InChI
InChI=1S/C24H33N3O4/c1-18-7-6-8-19(2)24(18)25-23(29)16-27-13-11-26(12-14-27)15-20(28)17-31-22-10-5-4-9-21(22)30-3/h4-10,20,28H,11-17H2,1-3H3,(H,25,29)
IUPAC Name
N-(2,6-dimethylphenyl)-2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl}acetamide
SMILES
COC1=CC=CC=C1OCC(O)CN1CCN(CC(=O)NC2=C(C)C=CC=C2C)CC1
Pharmacology
IndicationFor the treatment of chronic angina. It should be used in combination with amlodipine, beta-blockers or nitrates.
Structured Indications
PharmacodynamicsRanolazine has antianginal and anti-ischemic effects that do not depend upon reductions in heart rate or blood pressure. It is the first new anti-anginal developed in over 20 years.
Mechanism of actionThe mechanism of action of ranolazine is unknown. It does not increase the rate-pressure product, a measure of myocardial work, at maximal exercise. In vitro studies suggest that ranolazine is a P-gp inhibitor. Ranolazine is believed to have its effects via altering the trans-cellular late sodium current. It is by altering the intracellular sodium level that ranolazine affects the sodium-dependent calcium channels during myocardial ischemia. Thus, ranolazine indirectly prevents the calcium overload that causes cardiac ischemia.
TargetKindPharmacological actionActionsOrganismUniProt ID
Sodium channel protein type 5 subunit alphaProteinyes
inhibitor
HumanQ14524 details
Sodium channel protein type 9 subunit alphaProteinunknown
inhibitor
HumanQ15858 details
Related Articles
AbsorptionAbsorption is highly variable. After oral administration of ranolazine as a solution, 73% of the dose is systemically available as ranolazine or metabolites. The bioavailability of oral ranolazine relative to that from a solution is 76%.
Volume of distributionNot Available
Protein binding62%
Metabolism

Hepatic, metabolized mainly by CYP3A and to a lesser extent by CYP2D6. The pharmacologic activity of the metabolites has not been well characterized.

Route of eliminationRanolazine is metabolized rapidly and extensively in the liver and intestine; less than 5% is excreted unchanged in urine and feces.
Half life7 hours
ClearanceNot Available
ToxicityIn the event of overdose, the expected symptoms would be dizziness, nausea/vomiting, diplopia, paresthesia, and confusion. Syncope with prolonged loss of consciousness may develop.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
2-HYDROXY-1,4-NAPHTHOQUINONEThe metabolism of Ranolazine can be decreased when combined with 2-HYDROXY-1,4-NAPHTHOQUINONE.Experimental
2-mercaptobenzothiazoleThe metabolism of Ranolazine can be decreased when combined with 2-mercaptobenzothiazole.Vet Approved
4-MethoxyamphetamineThe metabolism of 4-Methoxyamphetamine can be decreased when combined with Ranolazine.Experimental, Illicit
AbirateroneThe metabolism of Abiraterone can be decreased when combined with Ranolazine.Approved
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Ranolazine.Approved
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Ranolazine.Approved
AcetaminophenThe serum concentration of Ranolazine can be increased when it is combined with Acetaminophen.Approved
AcetylcholineThe metabolism of Acetylcholine can be decreased when combined with Ranolazine.Approved
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Ranolazine.Approved, Vet Approved
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Ranolazine.Approved
AfatinibThe serum concentration of Ranolazine can be increased when it is combined with Afatinib.Approved
AjmalineThe metabolism of Ajmaline can be decreased when combined with Ranolazine.Approved
AlbendazoleThe serum concentration of Ranolazine can be increased when it is combined with Albendazole.Approved, Vet Approved
AlclometasoneThe metabolism of Alclometasone can be decreased when combined with Ranolazine.Approved
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Ranolazine.Experimental
AlectinibThe serum concentration of Ranolazine can be increased when it is combined with Alectinib.Approved
AlfentanilThe serum concentration of Ranolazine can be increased when it is combined with Alfentanil.Approved, Illicit
AlfuzosinThe metabolism of Alfuzosin can be decreased when combined with Ranolazine.Approved, Investigational
AliskirenThe metabolism of Aliskiren can be decreased when combined with Ranolazine.Approved, Investigational
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Ranolazine.Approved, Investigational
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Ranolazine.Approved
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Ranolazine.Approved, Investigational
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Ranolazine.Approved
AlosetronThe metabolism of Alosetron can be decreased when combined with Ranolazine.Approved, Withdrawn
AlprazolamThe metabolism of Alprazolam can be decreased when combined with Ranolazine.Approved, Illicit, Investigational
AlprenololThe metabolism of Alprenolol can be decreased when combined with Ranolazine.Approved, Withdrawn
AmantadineThe serum concentration of Ranolazine can be increased when it is combined with Amantadine.Approved
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Ranolazine.Approved, Investigational
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Ranolazine.Approved
Aminohippuric acidThe serum concentration of Ranolazine can be increased when it is combined with Aminohippuric acid.Approved
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Ranolazine.Approved, Withdrawn
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Ranolazine.Approved
AmiodaroneThe serum concentration of Ranolazine can be increased when it is combined with Amiodarone.Approved, Investigational
AmitriptylineThe serum concentration of Ranolazine can be increased when it is combined with Amitriptyline.Approved
AmlodipineThe serum concentration of Ranolazine can be increased when it is combined with Amlodipine.Approved
AmorolfineThe metabolism of Ranolazine can be decreased when combined with Amorolfine.Approved
AmoxapineThe metabolism of Amoxapine can be decreased when combined with Ranolazine.Approved
AmphetamineThe metabolism of Amphetamine can be decreased when combined with Ranolazine.Approved, Illicit
Amphotericin BThe metabolism of Ranolazine can be decreased when combined with Amphotericin B.Approved, Investigational
AmprenavirThe serum concentration of Ranolazine can be increased when it is combined with Amprenavir.Approved
AmsacrineThe serum concentration of Ranolazine can be increased when it is combined with Amsacrine.Approved
AN2690The metabolism of Ranolazine can be decreased when combined with AN2690.Investigational
AnagrelideRanolazine may increase the QTc-prolonging activities of Anagrelide.Approved
AnidulafunginThe metabolism of Ranolazine can be decreased when combined with Anidulafungin.Approved, Investigational
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Ranolazine.Approved
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Ranolazine.Approved
ApremilastThe metabolism of Apremilast can be decreased when combined with Ranolazine.Approved, Investigational
AprepitantThe serum concentration of Ranolazine can be increased when it is combined with Aprepitant.Approved, Investigational
AprindineThe metabolism of Aprindine can be decreased when combined with Ranolazine.Approved
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Ranolazine.Approved, Investigational
ArgatrobanThe metabolism of Argatroban can be decreased when combined with Ranolazine.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Ranolazine.Approved, Investigational
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Ranolazine.Approved, Investigational
ArtemetherThe metabolism of Ranolazine can be decreased when combined with Artemether.Approved
AsenapineRanolazine may increase the QTc-prolonging activities of Asenapine.Approved
AstemizoleThe serum concentration of Ranolazine can be increased when it is combined with Astemizole.Approved, Withdrawn
AtazanavirThe serum concentration of Ranolazine can be increased when it is combined with Atazanavir.Approved, Investigational
AtenololThe serum concentration of Ranolazine can be increased when it is combined with Atenolol.Approved
AtomoxetineThe serum concentration of Ranolazine can be increased when it is combined with Atomoxetine.Approved
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Ranolazine.Approved
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Ranolazine.Approved
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Ranolazine.Approved, Investigational
AzelastineThe serum concentration of Ranolazine can be increased when it is combined with Azelastine.Approved
AzithromycinThe serum concentration of Ranolazine can be increased when it is combined with Azithromycin.Approved
Bafilomycin A1The metabolism of Ranolazine can be decreased when combined with Bafilomycin A1.Experimental
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Ranolazine.Investigational
BedaquilineRanolazine may increase the QTc-prolonging activities of Bedaquiline.Approved
BenzatropineThe metabolism of Benzatropine can be decreased when combined with Ranolazine.Approved
BenzocaineThe serum concentration of Ranolazine can be increased when it is combined with Benzocaine.Approved
Benzoic AcidThe metabolism of Ranolazine can be decreased when combined with Benzoic Acid.Approved
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Ranolazine.Approved, Illicit
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Ranolazine.Approved
BepridilThe serum concentration of Ranolazine can be increased when it is combined with Bepridil.Approved, Withdrawn
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Ranolazine.Approved, Vet Approved
BetaxololThe metabolism of Betaxolol can be decreased when combined with Ranolazine.Approved
BexaroteneThe serum concentration of Ranolazine can be decreased when it is combined with Bexarotene.Approved, Investigational
BezafibrateThe metabolism of Bezafibrate can be decreased when combined with Ranolazine.Approved
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Ranolazine.Approved
BifonazoleThe metabolism of Ranolazine can be decreased when combined with Bifonazole.Approved
BiperidenThe serum concentration of Ranolazine can be increased when it is combined with Biperiden.Approved
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Ranolazine.Approved
BoceprevirThe serum concentration of Ranolazine can be increased when it is combined with Boceprevir.Approved
BortezomibThe serum concentration of Ranolazine can be increased when it is combined with Bortezomib.Approved, Investigational
BosentanThe serum concentration of Ranolazine can be decreased when it is combined with Bosentan.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Ranolazine.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Ranolazine.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Ranolazine.Approved
BrinzolamideThe metabolism of Brinzolamide can be decreased when combined with Ranolazine.Approved
BromazepamThe metabolism of Bromazepam can be decreased when combined with Ranolazine.Approved, Illicit
BromocriptineThe serum concentration of Ranolazine can be increased when it is combined with Bromocriptine.Approved, Investigational
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Ranolazine.Approved
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Ranolazine.Approved
BudesonideThe metabolism of Budesonide can be decreased when combined with Ranolazine.Approved
BufuralolThe metabolism of Bufuralol can be decreased when combined with Ranolazine.Experimental, Investigational
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Ranolazine.Approved, Investigational
BuprenorphineThe serum concentration of Ranolazine can be increased when it is combined with Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Bupropion can be decreased when combined with Ranolazine.Approved
BuspironeThe serum concentration of Ranolazine can be increased when it is combined with Buspirone.Approved, Investigational
BusulfanThe metabolism of Busulfan can be decreased when combined with Ranolazine.Approved, Investigational
ButenafineThe metabolism of Ranolazine can be decreased when combined with Butenafine.Approved
ButoconazoleThe metabolism of Ranolazine can be decreased when combined with Butoconazole.Approved
CabazitaxelThe serum concentration of Ranolazine can be increased when it is combined with Cabazitaxel.Approved
CabergolineThe metabolism of Cabergoline can be decreased when combined with Ranolazine.Approved
CabozantinibThe metabolism of Cabozantinib can be decreased when combined with Ranolazine.Approved
CaffeineThe serum concentration of Ranolazine can be increased when it is combined with Caffeine.Approved
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Ranolazine.Approved, Nutraceutical
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Ranolazine.Experimental
CanagliflozinThe serum concentration of Ranolazine can be increased when it is combined with Canagliflozin.Approved
CandesartanThe serum concentration of Ranolazine can be increased when it is combined with Candesartan.Approved
CandicidinThe metabolism of Ranolazine can be decreased when combined with Candicidin.Withdrawn
CaptoprilThe serum concentration of Ranolazine can be increased when it is combined with Captopril.Approved
CarbamazepineThe serum concentration of Ranolazine can be decreased when it is combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Ranolazine.Approved
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Ranolazine.Approved
CariprazineThe metabolism of Cariprazine can be decreased when combined with Ranolazine.Approved
CarteololThe metabolism of Carteolol can be decreased when combined with Ranolazine.Approved
CarvedilolThe serum concentration of Ranolazine can be increased when it is combined with Carvedilol.Approved, Investigational
CaspofunginThe metabolism of Ranolazine can be decreased when combined with Caspofungin.Approved
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Ranolazine.Approved, Investigational
CeliprololThe metabolism of Celiprolol can be decreased when combined with Ranolazine.Approved, Investigational
CephalexinThe metabolism of Cephalexin can be decreased when combined with Ranolazine.Approved, Vet Approved
CeritinibThe serum concentration of Ranolazine can be increased when it is combined with Ceritinib.Approved
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Ranolazine.Withdrawn
CeruleninThe metabolism of Ranolazine can be decreased when combined with Cerulenin.Approved
CevimelineThe metabolism of Cevimeline can be decreased when combined with Ranolazine.Approved
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Ranolazine.Approved
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Ranolazine.Approved, Illicit
ChloroquineThe serum concentration of Ranolazine can be increased when it is combined with Chloroquine.Approved, Vet Approved
ChloroxineThe metabolism of Ranolazine can be decreased when combined with Chloroxine.Approved
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Ranolazine.Approved
ChlorpromazineThe serum concentration of Ranolazine can be increased when it is combined with Chlorpromazine.Approved, Vet Approved
ChlorpropamideThe serum concentration of Ranolazine can be increased when it is combined with Chlorpropamide.Approved
ChlorprothixeneThe serum concentration of Ranolazine can be increased when it is combined with Chlorprothixene.Approved, Withdrawn
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Ranolazine.Approved
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Ranolazine.Approved, Nutraceutical
CholesterolThe serum concentration of Ranolazine can be increased when it is combined with Cholesterol.Experimental
CiclesonideThe metabolism of Ciclesonide can be decreased when combined with Ranolazine.Approved, Investigational
CiclopiroxThe metabolism of Ranolazine can be decreased when combined with Ciclopirox.Approved, Investigational
CilazaprilThe serum concentration of Ranolazine can be increased when it is combined with Cilazapril.Approved
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Ranolazine.Approved
CimetidineThe serum concentration of Ranolazine can be increased when it is combined with Cimetidine.Approved
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Ranolazine.Approved
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Ranolazine.Approved
CiprofloxacinThe serum concentration of Ranolazine can be increased when it is combined with Ciprofloxacin.Approved, Investigational
CisaprideRanolazine may increase the QTc-prolonging activities of Cisapride.Approved, Investigational, Withdrawn
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Ranolazine.Approved
CitalopramThe serum concentration of Ranolazine can be increased when it is combined with Citalopram.Approved
ClarithromycinThe serum concentration of Ranolazine can be increased when it is combined with Clarithromycin.Approved
ClemastineThe serum concentration of Ranolazine can be increased when it is combined with Clemastine.Approved
ClevidipineThe metabolism of Clevidipine can be decreased when combined with Ranolazine.Approved
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Ranolazine.Approved, Vet Approved
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Ranolazine.Approved, Illicit
ClofazimineThe serum concentration of Ranolazine can be increased when it is combined with Clofazimine.Approved, Investigational
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Ranolazine.Approved
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Ranolazine.Investigational
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Ranolazine.Approved, Investigational
ClomipramineThe serum concentration of Ranolazine can be increased when it is combined with Clomipramine.Approved, Vet Approved
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Ranolazine.Approved, Illicit
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Ranolazine.Approved
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Ranolazine.Approved, Nutraceutical
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Ranolazine.Approved, Illicit
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Ranolazine.Approved, Illicit
ClotrimazoleThe metabolism of Ranolazine can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Ranolazine.Approved
CobicistatThe serum concentration of Ranolazine can be increased when it is combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Ranolazine.Approved
CocaineThe metabolism of Cocaine can be decreased when combined with Ranolazine.Approved, Illicit
CodeineThe therapeutic efficacy of Codeine can be decreased when used in combination with Ranolazine.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Ranolazine.Approved
ColforsinThe serum concentration of Ranolazine can be increased when it is combined with Colforsin.Experimental
ConivaptanThe serum concentration of Ranolazine can be increased when it is combined with Conivaptan.Approved, Investigational
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Ranolazine.Approved
CordycepinThe metabolism of Ranolazine can be decreased when combined with Cordycepin.Investigational
Cortisone acetateThe metabolism of Cortisone acetate can be decreased when combined with Ranolazine.Approved
CrizotinibThe serum concentration of Ranolazine can be increased when it is combined with Crizotinib.Approved
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Ranolazine.Approved
CyclophosphamideThe serum concentration of Ranolazine can be increased when it is combined with Cyclophosphamide.Approved, Investigational
CyclosporineThe metabolism of Ranolazine can be decreased when combined with Cyclosporine.Approved, Investigational, Vet Approved
CytarabineThe metabolism of Cytarabine can be decreased when combined with Ranolazine.Approved, Investigational
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be increased when it is combined with Ranolazine.Approved
DabrafenibThe serum concentration of Ranolazine can be decreased when it is combined with Dabrafenib.Approved
DaclatasvirThe serum concentration of Ranolazine can be increased when it is combined with Daclatasvir.Approved
DactinomycinThe serum concentration of Ranolazine can be increased when it is combined with Dactinomycin.Approved
DantroleneThe metabolism of Dantrolene can be decreased when combined with Ranolazine.Approved
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Ranolazine.Approved
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Ranolazine.Investigational
DapsoneThe metabolism of Dapsone can be decreased when combined with Ranolazine.Approved, Investigational
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Ranolazine.Approved, Investigational
DarunavirThe serum concentration of Ranolazine can be increased when it is combined with Darunavir.Approved
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Ranolazine.Approved
DasatinibThe serum concentration of Ranolazine can be increased when it is combined with Dasatinib.Approved, Investigational
DaunorubicinThe serum concentration of Ranolazine can be increased when it is combined with Daunorubicin.Approved
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Ranolazine.Approved
Decanoic AcidThe metabolism of Ranolazine can be decreased when combined with Decanoic Acid.Experimental
DeferasiroxThe serum concentration of Ranolazine can be decreased when it is combined with Deferasirox.Approved, Investigational
DelavirdineThe serum concentration of Ranolazine can be increased when it is combined with Delavirdine.Approved
DesipramineThe serum concentration of Ranolazine can be increased when it is combined with Desipramine.Approved
DesloratadineThe serum concentration of Ranolazine can be increased when it is combined with Desloratadine.Approved, Investigational
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Ranolazine.Approved
DexamethasoneThe serum concentration of Ranolazine can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DexfenfluramineThe metabolism of Dexfenfluramine can be decreased when combined with Ranolazine.Approved, Illicit, Withdrawn
DexmethylphenidateThe metabolism of Dexmethylphenidate can be decreased when combined with Ranolazine.Approved
DextroamphetamineThe metabolism of Dextroamphetamine can be decreased when combined with Ranolazine.Approved, Illicit
DextromethorphanThe serum concentration of Ranolazine can be increased when it is combined with Dextromethorphan.Approved
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Ranolazine.Approved, Illicit, Withdrawn
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Ranolazine.Approved, Illicit, Vet Approved
DiclofenacThe serum concentration of Ranolazine can be increased when it is combined with Diclofenac.Approved, Vet Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Ranolazine.Approved
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Ranolazine.Approved
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Ranolazine.Approved
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Ranolazine.Approved, Illicit
DihydroergotamineThe serum concentration of Ranolazine can be increased when it is combined with Dihydroergotamine.Approved
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Ranolazine.Illicit
DiltiazemThe serum concentration of Ranolazine can be increased when it is combined with Diltiazem.Approved
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Ranolazine.Approved
DipyridamoleThe serum concentration of Ranolazine can be increased when it is combined with Dipyridamole.Approved
DisopyramideRanolazine may increase the QTc-prolonging activities of Disopyramide.Approved
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Ranolazine.Approved
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Ranolazine.Approved, Investigational
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Ranolazine.Approved
DolasetronRanolazine may increase the QTc-prolonging activities of Dolasetron.Approved
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Ranolazine.Approved, Investigational, Vet Approved
DonepezilThe metabolism of Donepezil can be decreased when combined with Ranolazine.Approved
DopamineThe metabolism of Dopamine can be decreased when combined with Ranolazine.Approved
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Ranolazine.Approved
DoxazosinThe serum concentration of Ranolazine can be increased when it is combined with Doxazosin.Approved
DoxepinThe serum concentration of Ranolazine can be increased when it is combined with Doxepin.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Ranolazine.Approved, Investigational
DoxycyclineThe serum concentration of Ranolazine can be increased when it is combined with Doxycycline.Approved, Investigational, Vet Approved
DronabinolThe serum concentration of Ranolazine can be increased when it is combined with Dronabinol.Approved, Illicit
DronedaroneThe serum concentration of Ranolazine can be increased when it is combined with Dronedarone.Approved
DroperidolRanolazine may increase the QTc-prolonging activities of Droperidol.Approved, Vet Approved
DuloxetineThe metabolism of Duloxetine can be decreased when combined with Ranolazine.Approved
DutasterideThe metabolism of Dutasteride can be decreased when combined with Ranolazine.Approved, Investigational
EconazoleThe metabolism of Ranolazine can be decreased when combined with Econazole.Approved
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Ranolazine.Approved
EfavirenzThe serum concentration of Ranolazine can be decreased when it is combined with Efavirenz.Approved, Investigational
EfinaconazoleThe metabolism of Ranolazine can be decreased when combined with Efinaconazole.Approved
ElbasvirThe serum concentration of Ranolazine can be increased when it is combined with Elbasvir.Approved
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Ranolazine.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Ranolazine.Approved
ElvitegravirThe metabolism of Elvitegravir can be decreased when combined with Ranolazine.Approved
EnalaprilThe serum concentration of Ranolazine can be increased when it is combined with Enalapril.Approved, Vet Approved
EncainideThe metabolism of Encainide can be decreased when combined with Ranolazine.Approved, Withdrawn
EnclomipheneThe metabolism of Enclomiphene can be decreased when combined with Ranolazine.Investigational
EnzalutamideThe serum concentration of Ranolazine can be decreased when it is combined with Enzalutamide.Approved
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Ranolazine.Approved, Investigational
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Ranolazine.Approved
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Ranolazine.Approved, Nutraceutical
Ergoloid mesylateThe metabolism of Ergoloid mesylate can be decreased when combined with Ranolazine.Approved
ErgonovineThe serum concentration of Ranolazine can be increased when it is combined with Ergonovine.Approved
ErgotamineThe serum concentration of Ranolazine can be increased when it is combined with Ergotamine.Approved
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Ranolazine.Approved, Investigational
ErythromycinThe serum concentration of Ranolazine can be increased when it is combined with Erythromycin.Approved, Vet Approved
EscitalopramRanolazine may increase the QTc-prolonging activities of Escitalopram.Approved, Investigational
Eslicarbazepine acetateThe serum concentration of Ranolazine can be decreased when it is combined with Eslicarbazepine acetate.Approved
EsmirtazapineThe metabolism of Esmirtazapine can be decreased when combined with Ranolazine.Investigational
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Ranolazine.Approved, Investigational
EstazolamThe metabolism of Estazolam can be decreased when combined with Ranolazine.Approved, Illicit
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Ranolazine.Approved, Investigational, Vet Approved
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be decreased when combined with Ranolazine.Approved
EstramustineThe serum concentration of Ranolazine can be increased when it is combined with Estramustine.Approved
EstriolThe serum concentration of Estriol can be increased when it is combined with Ranolazine.Approved, Vet Approved
EstroneThe serum concentration of Estrone can be increased when it is combined with Ranolazine.Approved
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Ranolazine.Approved
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Ranolazine.Approved
EthanolThe metabolism of Ethanol can be decreased when combined with Ranolazine.Approved
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Ranolazine.Approved
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Ranolazine.Approved
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Ranolazine.Approved, Illicit
EtonogestrelThe metabolism of Etonogestrel can be decreased when combined with Ranolazine.Approved, Investigational
EtoposideThe serum concentration of Ranolazine can be increased when it is combined with Etoposide.Approved
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Ranolazine.Approved, Investigational
EtravirineThe serum concentration of Ranolazine can be decreased when it is combined with Etravirine.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Ranolazine.Approved
ExemestaneThe metabolism of Exemestane can be decreased when combined with Ranolazine.Approved, Investigational
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Ranolazine.Approved
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Ranolazine.Approved
FelbamateThe metabolism of Felbamate can be decreased when combined with Ranolazine.Approved
FelodipineThe serum concentration of Ranolazine can be increased when it is combined with Felodipine.Approved, Investigational
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Ranolazine.Approved
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Ranolazine.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Ranolazine.Approved
FexofenadineThe serum concentration of Ranolazine can be increased when it is combined with Fexofenadine.Approved
FidaxomicinThe serum concentration of Ranolazine can be increased when it is combined with Fidaxomicin.Approved
FinasterideThe metabolism of Finasteride can be decreased when combined with Ranolazine.Approved
FingolimodThe metabolism of Fingolimod can be decreased when combined with Ranolazine.Approved, Investigational
FlecainideRanolazine may increase the QTc-prolonging activities of Flecainide.Approved, Withdrawn
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Ranolazine.Approved
FluconazoleThe metabolism of Ranolazine can be decreased when combined with Fluconazole.Approved
FlucytosineThe metabolism of Ranolazine can be decreased when combined with Flucytosine.Approved
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Ranolazine.Approved
FlunisolideThe metabolism of Flunisolide can be decreased when combined with Ranolazine.Approved, Investigational
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Ranolazine.Approved, Illicit
FluorometholoneThe metabolism of Fluorometholone can be decreased when combined with Ranolazine.Approved
FluoxetineThe serum concentration of Ranolazine can be increased when it is combined with Fluoxetine.Approved, Vet Approved
FlupentixolThe serum concentration of Ranolazine can be increased when it is combined with Flupentixol.Approved, Withdrawn
FluphenazineThe serum concentration of Ranolazine can be increased when it is combined with Fluphenazine.Approved
FlurazepamThe serum concentration of Ranolazine can be increased when it is combined with Flurazepam.Approved, Illicit
FlutamideThe metabolism of Flutamide can be decreased when combined with Ranolazine.Approved
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Ranolazine.Approved
Fluticasone PropionateThe metabolism of Fluticasone Propionate can be decreased when combined with Ranolazine.Approved
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Ranolazine.Approved
FluvoxamineThe serum concentration of Ranolazine can be increased when it is combined with Fluvoxamine.Approved, Investigational
FormoterolThe metabolism of Formoterol can be decreased when combined with Ranolazine.Approved, Investigational
FosamprenavirThe serum concentration of Ranolazine can be increased when it is combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Ranolazine can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe serum concentration of Ranolazine can be decreased when it is combined with Fosphenytoin.Approved
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Ranolazine.Approved, Investigational
Fusidic AcidThe serum concentration of Ranolazine can be increased when it is combined with Fusidic Acid.Approved
Gadobenic acidRanolazine may increase the QTc-prolonging activities of Gadobenic acid.Approved
GalantamineThe metabolism of Galantamine can be decreased when combined with Ranolazine.Approved
GefitinibThe serum concentration of Ranolazine can be increased when it is combined with Gefitinib.Approved, Investigational
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Ranolazine.Approved
GemfibrozilThe metabolism of Gemfibrozil can be decreased when combined with Ranolazine.Approved
GemifloxacinRanolazine may increase the QTc-prolonging activities of Gemifloxacin.Approved, Investigational
GenisteinThe serum concentration of Ranolazine can be increased when it is combined with Genistein.Investigational
GlipizideThe metabolism of Glipizide can be decreased when combined with Ranolazine.Approved
GlyburideThe serum concentration of Ranolazine can be increased when it is combined with Glyburide.Approved
GlycerolThe serum concentration of Ranolazine can be increased when it is combined with Glycerol.Experimental
GlyphosateThe metabolism of Ranolazine can be decreased when combined with Glyphosate.Experimental
GoserelinRanolazine may increase the QTc-prolonging activities of Goserelin.Approved
Gramicidin DThe serum concentration of Ranolazine can be increased when it is combined with Gramicidin D.Approved
GranisetronRanolazine may increase the QTc-prolonging activities of Granisetron.Approved, Investigational
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Ranolazine.Approved
GrepafloxacinThe serum concentration of Ranolazine can be increased when it is combined with Grepafloxacin.Withdrawn
GriseofulvinThe metabolism of Ranolazine can be decreased when combined with Griseofulvin.Approved, Vet Approved
GuanfacineThe metabolism of Guanfacine can be decreased when combined with Ranolazine.Approved, Investigational
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Ranolazine.Approved
HaloperidolThe serum concentration of Ranolazine can be increased when it is combined with Haloperidol.Approved
HaloproginThe metabolism of Ranolazine can be decreased when combined with Haloprogin.Approved, Withdrawn
HalothaneThe metabolism of Halothane can be decreased when combined with Ranolazine.Approved, Vet Approved
HexetidineThe metabolism of Ranolazine can be decreased when combined with Hexetidine.Approved
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Ranolazine.Approved
Histamine PhosphateThe metabolism of Histamine Phosphate can be decreased when combined with Ranolazine.Approved
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Ranolazine.Approved, Illicit
HydrocortisoneThe serum concentration of Ranolazine can be increased when it is combined with Hydrocortisone.Approved, Vet Approved
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Ranolazine.Approved, Illicit
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Ranolazine.Approved
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Ranolazine.Approved
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Ranolazine.Approved
IbutilideRanolazine may increase the QTc-prolonging activities of Ibutilide.Approved
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Ranolazine.Approved
IdelalisibThe serum concentration of Ranolazine can be increased when it is combined with Idelalisib.Approved
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Ranolazine resulting in a loss in efficacy.Approved
IloperidoneRanolazine may increase the QTc-prolonging activities of Iloperidone.Approved
ImatinibThe serum concentration of Ranolazine can be increased when it is combined with Imatinib.Approved
ImipramineThe serum concentration of Ranolazine can be increased when it is combined with Imipramine.Approved
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Ranolazine.Approved, Investigational
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Ranolazine.Approved
IndapamideThe metabolism of Indapamide can be decreased when combined with Ranolazine.Approved
IndinavirThe serum concentration of Ranolazine can be increased when it is combined with Indinavir.Approved
IndomethacinThe serum concentration of Ranolazine can be increased when it is combined with Indomethacin.Approved, Investigational
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Ranolazine.Approved
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Ranolazine.Approved, Investigational
IsavuconazoniumThe serum concentration of Ranolazine can be increased when it is combined with Isavuconazonium.Approved, Investigational
IsoconazoleThe metabolism of Ranolazine can be decreased when combined with Isoconazole.Approved
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be decreased when combined with Ranolazine.Approved
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be decreased when combined with Ranolazine.Approved
IsradipineThe serum concentration of Ranolazine can be increased when it is combined with Isradipine.Approved
ItraconazoleThe metabolism of Ranolazine can be decreased when combined with Itraconazole.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Ranolazine.Approved
IvacaftorThe serum concentration of Ivacaftor can be increased when it is combined with Ranolazine.Approved
IvermectinThe serum concentration of Ranolazine can be increased when it is combined with Ivermectin.Approved, Vet Approved
IxabepiloneThe metabolism of Ixabepilone can be decreased when combined with Ranolazine.Approved, Investigational
IxazomibThe metabolism of Ixazomib can be decreased when combined with Ranolazine.Approved
KetamineThe serum concentration of Ranolazine can be increased when it is combined with Ketamine.Approved, Vet Approved
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Ranolazine.Approved
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Ranolazine.Approved
KetoconazoleThe metabolism of Ranolazine can be decreased when combined with Ketoconazole.Approved, Investigational
LabetalolThe metabolism of Labetalol can be decreased when combined with Ranolazine.Approved
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Ranolazine.Approved, Investigational
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Ranolazine.Approved, Investigational
LansoprazoleThe serum concentration of Ranolazine can be increased when it is combined with Lansoprazole.Approved, Investigational
LapatinibThe serum concentration of Ranolazine can be increased when it is combined with Lapatinib.Approved, Investigational
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Ranolazine.Investigational
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Ranolazine.Approved
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Ranolazine.Approved
LercanidipineThe metabolism of Lercanidipine can be decreased when combined with Ranolazine.Approved, Investigational
LetrozoleThe metabolism of Letrozole can be decreased when combined with Ranolazine.Approved, Investigational
LeuprolideRanolazine may increase the QTc-prolonging activities of Leuprolide.Approved, Investigational
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Ranolazine.Approved, Investigational
LevobupivacaineThe metabolism of Levobupivacaine can be decreased when combined with Ranolazine.Approved
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Ranolazine.Approved
LevodopaThe metabolism of Levodopa can be decreased when combined with Ranolazine.Approved
LevofloxacinThe serum concentration of Ranolazine can be increased when it is combined with Levofloxacin.Approved, Investigational
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Ranolazine.Approved
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Ranolazine.Approved
LevonorgestrelThe metabolism of Levonorgestrel can be decreased when combined with Ranolazine.Approved, Investigational
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Ranolazine.Approved
LidocaineThe serum concentration of Ranolazine can be increased when it is combined with Lidocaine.Approved, Vet Approved
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Ranolazine.Approved
LisinoprilThe serum concentration of Ranolazine can be increased when it is combined with Lisinopril.Approved, Investigational
LisurideThe metabolism of Lisuride can be decreased when combined with Ranolazine.Approved
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Ranolazine.Approved
LomustineThe metabolism of Lomustine can be decreased when combined with Ranolazine.Approved
LoperamideThe serum concentration of Ranolazine can be increased when it is combined with Loperamide.Approved
LopinavirThe serum concentration of Ranolazine can be increased when it is combined with Lopinavir.Approved
LoratadineThe serum concentration of Ranolazine can be increased when it is combined with Loratadine.Approved
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Ranolazine.Approved
LosartanThe serum concentration of Ranolazine can be increased when it is combined with Losartan.Approved
LovastatinRanolazine may increase the myopathic rhabdomyolysis activities of Lovastatin.Approved, Investigational
LuliconazoleThe serum concentration of Ranolazine can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Ranolazine can be decreased when it is combined with Lumacaftor.Approved
LumefantrineRanolazine may increase the QTc-prolonging activities of Lumefantrine.Approved
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Ranolazine.Approved
MacitentanThe metabolism of Macitentan can be decreased when combined with Ranolazine.Approved
MannitolThe serum concentration of Mannitol can be increased when it is combined with Ranolazine.Approved, Investigational
MaprotilineThe serum concentration of Ranolazine can be increased when it is combined with Maprotiline.Approved
MaravirocThe metabolism of Maraviroc can be decreased when combined with Ranolazine.Approved, Investigational
MebendazoleThe serum concentration of Ranolazine can be increased when it is combined with Mebendazole.Approved, Vet Approved
Medroxyprogesterone acetateThe metabolism of Medroxyprogesterone acetate can be decreased when combined with Ranolazine.Approved, Investigational
MefloquineThe serum concentration of Ranolazine can be increased when it is combined with Mefloquine.Approved
Megestrol acetateThe serum concentration of Ranolazine can be increased when it is combined with Megestrol acetate.Approved, Vet Approved
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Ranolazine.Approved, Vet Approved
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Ranolazine.Investigational, Withdrawn
MeprobamateThe serum concentration of Ranolazine can be increased when it is combined with Meprobamate.Approved, Illicit
MequitazineThe metabolism of Mequitazine can be decreased when combined with Ranolazine.Approved
MesoridazineThe metabolism of Mesoridazine can be decreased when combined with Ranolazine.Approved
MetforminThe serum concentration of Metformin can be increased when it is combined with Ranolazine.Approved
MethadoneThe serum concentration of Ranolazine can be increased when it is combined with Methadone.Approved
MethamphetamineThe metabolism of Methamphetamine can be decreased when combined with Ranolazine.Approved, Illicit
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Ranolazine.Illicit, Withdrawn
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Ranolazine.Approved
MethotrimeprazineThe metabolism of Methotrimeprazine can be decreased when combined with Ranolazine.Approved
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Ranolazine.Approved
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Ranolazine.Approved, Vet Approved
MethylphenidateThe metabolism of Methylphenidate can be decreased when combined with Ranolazine.Approved, Investigational
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Ranolazine.Approved, Vet Approved
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Ranolazine.Approved
MethyprylonThe metabolism of Methyprylon can be decreased when combined with Ranolazine.Approved, Illicit, Withdrawn
MetoclopramideThe metabolism of Metoclopramide can be decreased when combined with Ranolazine.Approved, Investigational
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Ranolazine.Approved, Investigational
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Ranolazine.Approved
MevastatinThe metabolism of Ranolazine can be decreased when combined with Mevastatin.Experimental
MexiletineThe metabolism of Mexiletine can be decreased when combined with Ranolazine.Approved
MianserinThe metabolism of Mianserin can be decreased when combined with Ranolazine.Approved
MibefradilThe serum concentration of Ranolazine can be increased when it is combined with Mibefradil.Withdrawn
MicafunginThe metabolism of Ranolazine can be decreased when combined with Micafungin.Approved, Investigational
MiconazoleThe metabolism of Ranolazine can be decreased when combined with Miconazole.Approved, Investigational, Vet Approved
MidazolamThe serum concentration of Ranolazine can be increased when it is combined with Midazolam.Approved, Illicit
MifepristoneMifepristone may increase the QTc-prolonging activities of Ranolazine.Approved, Investigational
MiltefosineThe metabolism of Ranolazine can be decreased when combined with Miltefosine.Approved
MinaprineThe metabolism of Minaprine can be decreased when combined with Ranolazine.Approved
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Ranolazine.Approved
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Ranolazine.Approved
MitomycinThe serum concentration of Ranolazine can be increased when it is combined with Mitomycin.Approved
MitotaneThe serum concentration of Ranolazine can be decreased when it is combined with Mitotane.Approved
MitoxantroneThe serum concentration of Ranolazine can be increased when it is combined with Mitoxantrone.Approved, Investigational
MoclobemideThe metabolism of Moclobemide can be decreased when combined with Ranolazine.Approved
ModafinilThe serum concentration of Ranolazine can be decreased when it is combined with Modafinil.Approved, Investigational
MonensinThe metabolism of Ranolazine can be decreased when combined with Monensin.Vet Approved
MontelukastThe metabolism of Montelukast can be decreased when combined with Ranolazine.Approved
MorphineThe serum concentration of Ranolazine can be increased when it is combined with Morphine.Approved, Investigational
MoxifloxacinRanolazine may increase the QTc-prolonging activities of Moxifloxacin.Approved, Investigational
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Ranolazine.Approved, Investigational
MyxothiazolThe metabolism of Ranolazine can be decreased when combined with Myxothiazol.Experimental
NadololThe serum concentration of Nadolol can be increased when it is combined with Ranolazine.Approved
NafcillinThe serum concentration of Ranolazine can be decreased when it is combined with Nafcillin.Approved
NaftifineThe metabolism of Ranolazine can be decreased when combined with Naftifine.Approved
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Ranolazine.Approved
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Ranolazine.Approved, Vet Approved
NaltrexoneThe serum concentration of Ranolazine can be increased when it is combined with Naltrexone.Approved, Investigational, Vet Approved
NaringeninThe serum concentration of Ranolazine can be increased when it is combined with Naringenin.Experimental
NatamycinThe metabolism of Ranolazine can be decreased when combined with Natamycin.Approved
NateglinideThe metabolism of Nateglinide can be decreased when combined with Ranolazine.Approved, Investigational
NebivololThe serum concentration of Nebivolol can be increased when it is combined with Ranolazine.Approved, Investigational
NefazodoneThe serum concentration of Ranolazine can be increased when it is combined with Nefazodone.Approved, Withdrawn
NelfinavirThe serum concentration of Ranolazine can be increased when it is combined with Nelfinavir.Approved
NeostigmineThe serum concentration of Ranolazine can be increased when it is combined with Neostigmine.Approved, Vet Approved
NetupitantThe serum concentration of Ranolazine can be increased when it is combined with Netupitant.Approved
NevirapineThe serum concentration of Ranolazine can be decreased when it is combined with Nevirapine.Approved
NicardipineThe serum concentration of Ranolazine can be increased when it is combined with Nicardipine.Approved
NicergolineThe metabolism of Nicergoline can be decreased when combined with Ranolazine.Approved
NicotineThe metabolism of Nicotine can be decreased when combined with Ranolazine.Approved
NifedipineThe serum concentration of Ranolazine can be increased when it is combined with Nifedipine.Approved
NilotinibThe serum concentration of Ranolazine can be increased when it is combined with Nilotinib.Approved, Investigational
NilvadipineThe metabolism of Nilvadipine can be decreased when combined with Ranolazine.Approved
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Ranolazine.Approved
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Ranolazine.Approved
NisoldipineThe serum concentration of Ranolazine can be increased when it is combined with Nisoldipine.Approved
NitrazepamThe serum concentration of Ranolazine can be increased when it is combined with Nitrazepam.Approved
NitrendipineThe serum concentration of Ranolazine can be increased when it is combined with Nitrendipine.Approved
NitrofuralThe metabolism of Nitrofural can be decreased when combined with Ranolazine.Approved, Vet Approved
NitroxolineThe metabolism of Ranolazine can be decreased when combined with Nitroxoline.Approved
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Ranolazine.Approved
NorethisteroneThe metabolism of Norethisterone can be decreased when combined with Ranolazine.Approved
NorgestrelThe metabolism of Norgestrel can be decreased when combined with Ranolazine.Approved
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Ranolazine.Approved
NystatinThe metabolism of Ranolazine can be decreased when combined with Nystatin.Approved, Vet Approved
OfloxacinRanolazine may increase the QTc-prolonging activities of Ofloxacin.Approved
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Ranolazine.Approved, Investigational
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Ranolazine.Approved
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Ranolazine.Approved
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Ranolazine.Approved
OmeprazoleThe serum concentration of Ranolazine can be increased when it is combined with Omeprazole.Approved, Investigational, Vet Approved
OndansetronRanolazine may increase the QTc-prolonging activities of Ondansetron.Approved
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Ranolazine.Approved
OsimertinibThe serum concentration of Osimertinib can be increased when it is combined with Ranolazine.Approved
OspemifeneThe metabolism of Ospemifene can be decreased when combined with Ranolazine.Approved
OxazepamThe metabolism of Oxazepam can be decreased when combined with Ranolazine.Approved
OxiconazoleThe metabolism of Ranolazine can be decreased when combined with Oxiconazole.Approved
OxybutyninThe metabolism of Oxybutynin can be decreased when combined with Ranolazine.Approved, Investigational
OxycodoneThe risk or severity of adverse effects can be increased when Ranolazine is combined with Oxycodone.Approved, Illicit, Investigational
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Ranolazine.Approved, Investigational, Vet Approved
P-NitrophenolThe serum concentration of Ranolazine can be increased when it is combined with P-Nitrophenol.Experimental
PaclitaxelThe serum concentration of Ranolazine can be increased when it is combined with Paclitaxel.Approved, Vet Approved
pafuramidineThe metabolism of Ranolazine can be decreased when combined with pafuramidine.Investigational
PalbociclibThe serum concentration of Ranolazine can be increased when it is combined with Palbociclib.Approved
PaliperidoneRanolazine may increase the QTc-prolonging activities of Paliperidone.Approved
Palmitic AcidThe serum concentration of Ranolazine can be increased when it is combined with Palmitic Acid.Experimental
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Ranolazine.Approved, Investigational
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Ranolazine.Approved, Investigational
PantoprazoleThe serum concentration of Ranolazine can be increased when it is combined with Pantoprazole.Approved
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Ranolazine.Approved
ParamethasoneThe metabolism of Paramethasone can be decreased when combined with Ranolazine.Approved
ParecoxibThe metabolism of Parecoxib can be decreased when combined with Ranolazine.Approved
ParicalcitolThe metabolism of Paricalcitol can be decreased when combined with Ranolazine.Approved, Investigational
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Ranolazine.Approved
ParoxetineThe serum concentration of Ranolazine can be increased when it is combined with Paroxetine.Approved, Investigational
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Ranolazine.Approved
PentamidineThe metabolism of Ranolazine can be decreased when combined with Pentamidine.Approved
PentobarbitalThe serum concentration of Ranolazine can be decreased when it is combined with Pentobarbital.Approved, Vet Approved
PerampanelThe metabolism of Perampanel can be decreased when combined with Ranolazine.Approved
PerflutrenRanolazine may increase the QTc-prolonging activities of Perflutren.Approved
PergolideThe metabolism of Pergolide can be decreased when combined with Ranolazine.Approved, Vet Approved, Withdrawn
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Ranolazine.Approved
PerindoprilThe serum concentration of Ranolazine can be increased when it is combined with Perindopril.Approved
PermethrinThe metabolism of Permethrin can be decreased when combined with Ranolazine.Approved, Investigational
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Ranolazine.Approved
PethidineThe metabolism of Pethidine can be decreased when combined with Ranolazine.Approved
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Ranolazine.Withdrawn
PhenforminThe metabolism of Phenformin can be decreased when combined with Ranolazine.Approved, Withdrawn
PhenobarbitalThe serum concentration of Ranolazine can be decreased when it is combined with Phenobarbital.Approved
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be decreased when combined with Ranolazine.Approved
PhenprocoumonThe metabolism of Phenprocoumon can be decreased when combined with Ranolazine.Approved
PhenytoinThe serum concentration of Ranolazine can be decreased when it is combined with Phenytoin.Approved, Vet Approved
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Ranolazine.Approved
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Ranolazine.Approved, Investigational
PimozideThe serum concentration of Pimozide can be increased when it is combined with Ranolazine.Approved
PinacidilThe metabolism of Pinacidil can be decreased when combined with Ranolazine.Withdrawn
PindololThe metabolism of Pindolol can be decreased when combined with Ranolazine.Approved
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Ranolazine.Approved, Investigational
PiperazineThe metabolism of Piperazine can be decreased when combined with Ranolazine.Approved, Vet Approved
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Ranolazine.Approved
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Ranolazine.Approved
PodofiloxThe metabolism of Podofilox can be decreased when combined with Ranolazine.Approved
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Ranolazine.Approved
PonatinibThe serum concentration of Ranolazine can be increased when it is combined with Ponatinib.Approved
PosaconazoleThe metabolism of Ranolazine can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
PrasteroneThe metabolism of Prasterone can be decreased when combined with Ranolazine.Approved, Nutraceutical
PrasugrelThe metabolism of Prasugrel can be decreased when combined with Ranolazine.Approved
PravastatinThe serum concentration of Ranolazine can be increased when it is combined with Pravastatin.Approved
PrazepamThe metabolism of Prazepam can be decreased when combined with Ranolazine.Approved, Illicit
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Ranolazine.Approved, Vet Approved
PrazosinThe serum concentration of Ranolazine can be increased when it is combined with Prazosin.Approved
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Ranolazine.Approved, Vet Approved
PrednisoneThe serum concentration of Ranolazine can be increased when it is combined with Prednisone.Approved, Vet Approved
PrimaquineRanolazine may increase the QTc-prolonging activities of Primaquine.Approved
PrimidoneThe serum concentration of Ranolazine can be decreased when it is combined with Primidone.Approved, Vet Approved
ProbenecidThe serum concentration of Ranolazine can be increased when it is combined with Probenecid.Approved
ProcainamideRanolazine may increase the QTc-prolonging activities of Procainamide.Approved
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Ranolazine.Approved, Vet Approved
ProgesteroneThe serum concentration of Ranolazine can be increased when it is combined with Progesterone.Approved, Vet Approved
ProguanilThe metabolism of Proguanil can be decreased when combined with Ranolazine.Approved
PromazineRanolazine may increase the QTc-prolonging activities of Promazine.Approved, Vet Approved
PromethazineThe serum concentration of Ranolazine can be increased when it is combined with Promethazine.Approved
PropafenoneThe serum concentration of Ranolazine can be increased when it is combined with Propafenone.Approved
PropofolThe metabolism of Propofol can be decreased when combined with Ranolazine.Approved, Investigational, Vet Approved
PropranololThe serum concentration of Ranolazine can be increased when it is combined with Propranolol.Approved, Investigational
ProtriptylineThe serum concentration of Ranolazine can be increased when it is combined with Protriptyline.Approved
PseudoephedrineThe metabolism of Pseudoephedrine can be decreased when combined with Ranolazine.Approved
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Ranolazine.Approved
QuazepamThe metabolism of Quazepam can be decreased when combined with Ranolazine.Approved, Illicit
QuercetinThe serum concentration of Ranolazine can be increased when it is combined with Quercetin.Experimental
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Ranolazine.Approved
QuinacrineThe serum concentration of Ranolazine can be increased when it is combined with Quinacrine.Approved
QuinidineThe serum concentration of Ranolazine can be increased when it is combined with Quinidine.Approved
QuinineThe serum concentration of Ranolazine can be increased when it is combined with Quinine.Approved
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Ranolazine.Approved, Investigational
RadicicolThe metabolism of Ranolazine can be decreased when combined with Radicicol.Experimental
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Ranolazine.Approved, Investigational
RamelteonThe metabolism of Ramelteon can be decreased when combined with Ranolazine.Approved, Investigational
RanitidineThe serum concentration of Ranolazine can be increased when it is combined with Ranitidine.Approved
ReboxetineThe serum concentration of Ranolazine can be increased when it is combined with Reboxetine.Approved, Investigational
RegorafenibThe serum concentration of Ranolazine can be increased when it is combined with Regorafenib.Approved
RemoxiprideThe metabolism of Remoxipride can be decreased when combined with Ranolazine.Approved, Withdrawn
RepaglinideThe metabolism of Repaglinide can be decreased when combined with Ranolazine.Approved, Investigational
repinotanThe metabolism of repinotan can be decreased when combined with Ranolazine.Investigational
ReserpineThe serum concentration of Ranolazine can be increased when it is combined with Reserpine.Approved
RetapamulinThe metabolism of Retapamulin can be decreased when combined with Ranolazine.Approved
RifabutinThe serum concentration of Ranolazine can be decreased when it is combined with Rifabutin.Approved
RifampicinThe serum concentration of Ranolazine can be decreased when it is combined with Rifampicin.Approved
RifapentineThe serum concentration of Ranolazine can be decreased when it is combined with Rifapentine.Approved
RilpivirineThe serum concentration of Ranolazine can be increased when it is combined with Rilpivirine.Approved
RimonabantThe metabolism of Rimonabant can be decreased when combined with Ranolazine.Approved, Investigational
RiociguatThe metabolism of Riociguat can be decreased when combined with Ranolazine.Approved
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Ranolazine.Approved, Investigational
RitonavirThe serum concentration of Ranolazine can be increased when it is combined with Ritonavir.Approved, Investigational
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Ranolazine.Approved
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Ranolazine.Investigational, Withdrawn
RolapitantThe serum concentration of Ranolazine can be increased when it is combined with Rolapitant.Approved
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Ranolazine.Approved, Investigational
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Ranolazine.Approved, Investigational
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Ranolazine.Approved
RosuvastatinThe metabolism of Rosuvastatin can be decreased when combined with Ranolazine.Approved
RotigotineThe metabolism of Rotigotine can be decreased when combined with Ranolazine.Approved
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Ranolazine.Approved, Withdrawn
RuxolitinibThe metabolism of Ruxolitinib can be decreased when combined with Ranolazine.Approved
Salicylhydroxamic AcidThe metabolism of Ranolazine can be decreased when combined with Salicylhydroxamic Acid.Experimental
Salicylic acidThe metabolism of Ranolazine can be decreased when combined with Salicylic acid.Approved, Vet Approved
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Ranolazine.Approved
SaquinavirThe serum concentration of Ranolazine can be increased when it is combined with Saquinavir.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Ranolazine.Approved
ScopolamineThe serum concentration of Ranolazine can be increased when it is combined with Scopolamine.Approved
SelegilineThe serum concentration of Ranolazine can be increased when it is combined with Selegiline.Approved, Investigational, Vet Approved
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Ranolazine.Approved
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Ranolazine.Approved, Investigational
SertaconazoleThe metabolism of Ranolazine can be decreased when combined with Sertaconazole.Approved
SertindoleThe metabolism of Sertindole can be decreased when combined with Ranolazine.Approved, Withdrawn
SertralineThe serum concentration of Ranolazine can be increased when it is combined with Sertraline.Approved
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Ranolazine.Approved, Vet Approved
SibutramineThe metabolism of Sibutramine can be decreased when combined with Ranolazine.Approved, Illicit, Investigational, Withdrawn
SildenafilThe serum concentration of Ranolazine can be increased when it is combined with Sildenafil.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Ranolazine.Approved
SiltuximabThe serum concentration of Ranolazine can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Ranolazine.Approved
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Ranolazine.Approved
SinefunginThe metabolism of Ranolazine can be decreased when combined with Sinefungin.Experimental
SirolimusThe metabolism of Ranolazine can be decreased when combined with Sirolimus.Approved, Investigational
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Ranolazine.Approved, Investigational
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Ranolazine.Approved
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Ranolazine.Approved
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Ranolazine.Approved, Investigational
SorafenibThe serum concentration of Ranolazine can be increased when it is combined with Sorafenib.Approved, Investigational
SotalolRanolazine may increase the QTc-prolonging activities of Sotalol.Approved
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Ranolazine.Approved
SparteineThe metabolism of Sparteine can be decreased when combined with Ranolazine.Experimental
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Ranolazine.Experimental
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Ranolazine.Approved
SpironolactoneThe serum concentration of Ranolazine can be increased when it is combined with Spironolactone.Approved
St. John's WortThe serum concentration of Ranolazine can be decreased when it is combined with St. John's Wort.Nutraceutical
StaurosporineThe serum concentration of Ranolazine can be increased when it is combined with Staurosporine.Experimental
StiripentolThe serum concentration of Ranolazine can be increased when it is combined with Stiripentol.Approved
SufentanilThe metabolism of Sufentanil can be decreased when combined with Ranolazine.Approved, Investigational
SulconazoleThe metabolism of Ranolazine can be decreased when combined with Sulconazole.Approved
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Ranolazine.Approved, Vet Approved
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Ranolazine.Approved
SulfinpyrazoneThe serum concentration of Ranolazine can be increased when it is combined with Sulfinpyrazone.Approved
SulfisoxazoleThe serum concentration of Ranolazine can be increased when it is combined with Sulfisoxazole.Approved, Vet Approved
SumatriptanThe serum concentration of Ranolazine can be increased when it is combined with Sumatriptan.Approved, Investigational
SunitinibThe serum concentration of Ranolazine can be increased when it is combined with Sunitinib.Approved, Investigational
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Ranolazine.Approved
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Ranolazine.Approved
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Ranolazine.Approved
TacrineThe serum concentration of Ranolazine can be increased when it is combined with Tacrine.Withdrawn
TacrolimusThe serum concentration of Ranolazine can be increased when it is combined with Tacrolimus.Approved, Investigational
TadalafilThe metabolism of Tadalafil can be decreased when combined with Ranolazine.Approved, Investigational
TamoxifenThe serum concentration of the active metabolites of Tamoxifen can be reduced when Tamoxifen is used in combination with Ranolazine resulting in a loss in efficacy.Approved
TamsulosinThe metabolism of Tamsulosin can be decreased when combined with Ranolazine.Approved, Investigational
TapentadolThe metabolism of Tapentadol can be decreased when combined with Ranolazine.Approved
TasosartanThe metabolism of Tasosartan can be decreased when combined with Ranolazine.Approved
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Ranolazine.Experimental
Taurocholic AcidThe serum concentration of Ranolazine can be increased when it is combined with Taurocholic Acid.Experimental
TavaboroleThe metabolism of Ranolazine can be decreased when combined with Tavaborole.Approved
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Ranolazine.Approved
TegaserodThe metabolism of Tegaserod can be decreased when combined with Ranolazine.Investigational, Withdrawn
TelaprevirThe serum concentration of Ranolazine can be increased when it is combined with Telaprevir.Approved
TelavancinRanolazine may increase the QTc-prolonging activities of Telavancin.Approved
TelithromycinThe serum concentration of Ranolazine can be increased when it is combined with Telithromycin.Approved
TelmisartanThe serum concentration of Ranolazine can be increased when it is combined with Telmisartan.Approved, Investigational
TemazepamThe metabolism of Temazepam can be decreased when combined with Ranolazine.Approved
TemsirolimusThe serum concentration of Ranolazine can be increased when it is combined with Temsirolimus.Approved
TeniposideThe metabolism of Teniposide can be decreased when combined with Ranolazine.Approved
TerazosinThe serum concentration of Ranolazine can be increased when it is combined with Terazosin.Approved
TerbinafineThe metabolism of Ranolazine can be decreased when combined with Terbinafine.Approved, Investigational, Vet Approved
TerconazoleThe metabolism of Ranolazine can be decreased when combined with Terconazole.Approved
TerfenadineThe serum concentration of Ranolazine can be increased when it is combined with Terfenadine.Withdrawn
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Ranolazine.Investigational
TestosteroneThe serum concentration of Ranolazine can be increased when it is combined with Testosterone.Approved, Investigational
TetrabenazineRanolazine may increase the QTc-prolonging activities of Tetrabenazine.Approved
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Ranolazine.Approved, Vet Approved
TheophyllineThe metabolism of Theophylline can be decreased when combined with Ranolazine.Approved
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Ranolazine.Approved
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Ranolazine.Approved
ThymolThe metabolism of Ranolazine can be decreased when combined with Thymol.Approved
TiagabineThe metabolism of Tiagabine can be decreased when combined with Ranolazine.Approved
TicagrelorThe serum concentration of Ranolazine can be increased when it is combined with Ticagrelor.Approved
TiclopidineThe serum concentration of Ranolazine can be increased when it is combined with Ticlopidine.Approved
TimololThe serum concentration of Timolol can be increased when it is combined with Ranolazine.Approved
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Ranolazine.Approved, Investigational
TioconazoleThe metabolism of Ranolazine can be decreased when combined with Tioconazole.Approved
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Ranolazine.Approved
TipranavirThe metabolism of Tipranavir can be decreased when combined with Ranolazine.Approved, Investigational
TocilizumabThe serum concentration of Ranolazine can be decreased when it is combined with Tocilizumab.Approved
TofacitinibThe metabolism of Tofacitinib can be decreased when combined with Ranolazine.Approved, Investigational
TolnaftateThe metabolism of Ranolazine can be decreased when combined with Tolnaftate.Approved, Vet Approved
TolterodineThe metabolism of Tolterodine can be decreased when combined with Ranolazine.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Ranolazine.Approved
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Ranolazine.Approved, Investigational
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Ranolazine.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Ranolazine.Approved, Investigational
TramadolThe therapeutic efficacy of Tramadol can be decreased when used in combination with Ranolazine.Approved, Investigational
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Ranolazine.Approved
TrazodoneThe metabolism of Trazodone can be decreased when combined with Ranolazine.Approved, Investigational
TretinoinThe metabolism of Tretinoin can be decreased when combined with Ranolazine.Approved, Investigational, Nutraceutical
TriamcinoloneThe metabolism of Triamcinolone can be decreased when combined with Ranolazine.Approved, Vet Approved
TriazolamThe metabolism of Triazolam can be decreased when combined with Ranolazine.Approved
TrifluoperazineThe serum concentration of Ranolazine can be increased when it is combined with Trifluoperazine.Approved
TriflupromazineThe serum concentration of Ranolazine can be increased when it is combined with Triflupromazine.Approved, Vet Approved
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Ranolazine.Approved
TrimethoprimThe serum concentration of Ranolazine can be increased when it is combined with Trimethoprim.Approved, Vet Approved
TrimetrexateThe metabolism of Ranolazine can be decreased when combined with Trimetrexate.Approved, Investigational
TrimipramineThe serum concentration of Ranolazine can be increased when it is combined with Trimipramine.Approved
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Ranolazine.Withdrawn
TroleandomycinThe serum concentration of Ranolazine can be increased when it is combined with Troleandomycin.Approved
UdenafilThe metabolism of Udenafil can be decreased when combined with Ranolazine.Approved, Investigational
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Ranolazine.Approved
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Ranolazine.Approved
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Ranolazine.Investigational, Withdrawn
VandetanibRanolazine may increase the QTc-prolonging activities of Vandetanib.Approved
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Ranolazine.Investigational
VardenafilThe metabolism of Vardenafil can be decreased when combined with Ranolazine.Approved
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Ranolazine.Approved
VemurafenibRanolazine may increase the QTc-prolonging activities of Vemurafenib.Approved
VenetoclaxThe serum concentration of Venetoclax can be increased when it is combined with Ranolazine.Approved
VenlafaxineThe serum concentration of Ranolazine can be increased when it is combined with Venlafaxine.Approved
VerapamilThe serum concentration of Ranolazine can be increased when it is combined with Verapamil.Approved
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Ranolazine.Investigational
VilanterolThe metabolism of Vilanterol can be decreased when combined with Ranolazine.Approved
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Ranolazine.Approved
VinblastineThe serum concentration of Ranolazine can be increased when it is combined with Vinblastine.Approved
VincristineThe serum concentration of Ranolazine can be increased when it is combined with Vincristine.Approved, Investigational
VindesineThe serum concentration of Vindesine can be increased when it is combined with Ranolazine.Approved
VinorelbineThe serum concentration of Ranolazine can be increased when it is combined with Vinorelbine.Approved, Investigational
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Ranolazine.Approved
VoriconazoleThe metabolism of Ranolazine can be decreased when combined with Voriconazole.Approved, Investigational
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Ranolazine.Approved
WarfarinThe metabolism of Warfarin can be decreased when combined with Ranolazine.Approved
YohimbineThe metabolism of Yohimbine can be decreased when combined with Ranolazine.Approved, Vet Approved
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Ranolazine.Approved, Investigational
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Ranolazine.Approved
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Ranolazine.Approved, Illicit, Investigational
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Ranolazine.Approved
ZileutonThe metabolism of Zileuton can be decreased when combined with Ranolazine.Approved, Investigational, Withdrawn
ZimelidineThe serum concentration of Ranolazine can be increased when it is combined with Zimelidine.Withdrawn
ZiprasidoneThe serum concentration of Ranolazine can be increased when it is combined with Ziprasidone.Approved
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Ranolazine.Approved
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Ranolazine.Withdrawn
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Ranolazine.Approved, Investigational
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Ranolazine.Approved
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Ranolazine.Approved, Investigational
Food Interactions
  • Grapefruit and grapefruit juice should be avoided throughout treatment.
  • Take without regard to meals.
References
Synthesis Reference

Raghupathi Reddy Anumula, Goverdhan Gilla, Sampath Aalla, Lokeswara Rao Madivada, Prabhaker Macherla, Srinivas Kurella, Kavitha Charagondla, Ramamurthy Kasula, Rajagopala Rao Mandadapu, Krishaniah Charagondla, Malati Vakamulla, Durga Prasad Janaki Bhavanipurapu, “PREPARATION OF RANOLAZINE.” U.S. Patent US20110151258, issued June 23, 2011.

US20110151258
General References
  1. Hale SL, Kloner RA: Ranolazine, an inhibitor of the late sodium channel current, reduces postischemic myocardial dysfunction in the rabbit. J Cardiovasc Pharmacol Ther. 2006 Dec;11(4):249-55. [PubMed:17220471 ]
  2. Fraser H, Belardinelli L, Wang L, Light PE, McVeigh JJ, Clanachan AS: Ranolazine decreases diastolic calcium accumulation caused by ATX-II or ischemia in rat hearts. J Mol Cell Cardiol. 2006 Dec;41(6):1031-8. Epub 2006 Oct 5. [PubMed:17027025 ]
  3. Stone PH, Gratsiansky NA, Blokhin A, Huang IZ, Meng L: Antianginal efficacy of ranolazine when added to treatment with amlodipine: the ERICA (Efficacy of Ranolazine in Chronic Angina) trial. J Am Coll Cardiol. 2006 Aug 1;48(3):566-75. Epub 2006 Jun 15. [PubMed:16875985 ]
  4. Chaitman BR, Pepine CJ, Parker JO, Skopal J, Chumakova G, Kuch J, Wang W, Skettino SL, Wolff AA: Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina: a randomized controlled trial. JAMA. 2004 Jan 21;291(3):309-16. [PubMed:14734593 ]
  5. Morrow DA, Scirica BM, Karwatowska-Prokopczuk E, Murphy SA, Budaj A, Varshavsky S, Wolff AA, Skene A, McCabe CH, Braunwald E: Effects of ranolazine on recurrent cardiovascular events in patients with non-ST-elevation acute coronary syndromes: the MERLIN-TIMI 36 randomized trial. JAMA. 2007 Apr 25;297(16):1775-83. [PubMed:17456819 ]
External Links
ATC CodesC01EB18
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelDownload (203 KB)
MSDSNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption-0.7425
Blood Brain Barrier-0.5334
Caco-2 permeable-0.5853
P-glycoprotein substrateSubstrate0.8667
P-glycoprotein inhibitor IInhibitor0.7566
P-glycoprotein inhibitor IIInhibitor0.7524
Renal organic cation transporterNon-inhibitor0.7648
CYP450 2C9 substrateNon-substrate0.7965
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateSubstrate0.7456
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 inhibitorNon-inhibitor0.907
CYP450 2D6 inhibitorNon-inhibitor0.8287
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorNon-inhibitor0.8309
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8155
Ames testNon AMES toxic0.8529
CarcinogenicityNon-carcinogens0.9128
BiodegradationNot ready biodegradable0.9936
Rat acute toxicity2.3256 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8753
hERG inhibition (predictor II)Inhibitor0.8775
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Gilead sciences inc
Packagers
Dosage forms
FormRouteStrength
Tablet, film coated, extended releaseOral1000 mg/1
Tablet, film coated, extended releaseOral500 mg/1
Prices
Unit descriptionCostUnit
Ranexa 1000 mg 12 Hour tablet6.89USD tablet
Ranexa 1000 mg tablet6.63USD tablet
Ranexa 500 mg 12 Hour tablet4.06USD tablet
Ranexa 500 mg tablet4.04USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US6303607 No1999-05-272019-05-27Us
US6369062 No1999-05-272019-05-27Us
US6479496 No1999-05-272019-05-27Us
US6503911 No1999-05-272019-05-27Us
US6525057 No1999-05-272019-05-27Us
US6562826 No1999-05-272019-05-27Us
US6617328 No1999-05-272019-05-27Us
US6620814 No1999-05-272019-05-27Us
US6852724 No1999-05-272019-05-27Us
US6864258 No1999-05-272019-05-27Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
water solubilityVery slightly solubleNot Available
logP1.6Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.11 mg/mLALOGPS
logP2.08ALOGPS
logP2.83ChemAxon
logS-3.6ALOGPS
pKa (Strongest Acidic)13.6ChemAxon
pKa (Strongest Basic)7.17ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area74.27 Å2ChemAxon
Rotatable Bond Count9ChemAxon
Refractivity123.46 m3·mol-1ChemAxon
Polarizability47.22 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as alpha amino acid amides. These are amide derivatives of alpha amino acids.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentAlpha amino acid amides
Alternative Parents
Substituents
  • Alpha-amino acid amide
  • N-arylamide
  • N-piperazineacetamide
  • Methoxybenzene
  • Phenol ether
  • Anisole
  • N-alkylpiperazine
  • Alkyl aryl ether
  • Benzenoid
  • Piperazine
  • 1,4-diazinane
  • Monocyclic benzene moiety
  • Tertiary aliphatic amine
  • Tertiary amine
  • Secondary carboxylic acid amide
  • Secondary alcohol
  • Carboxamide group
  • 1,2-aminoalcohol
  • Azacycle
  • Organoheterocyclic compound
  • Ether
  • Carboxylic acid amide
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Alcohol
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External DescriptorsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Voltage-gated sodium channel activity involved in sa node cell action potential
Specific Function:
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na(+) channel isoform. This channel is respon...
Gene Name:
SCN5A
Uniprot ID:
Q14524
Molecular Weight:
226937.475 Da
References
  1. Hale SL, Kloner RA: Ranolazine, an inhibitor of the late sodium channel current, reduces postischemic myocardial dysfunction in the rabbit. J Cardiovasc Pharmacol Ther. 2006 Dec;11(4):249-55. [PubMed:17220471 ]
  2. Rajamani S, Shryock JC, Belardinelli L: Block of tetrodotoxin-sensitive, Na(V)1.7 and tetrodotoxin-resistant, Na(V)1.8, Na+ channels by ranolazine. Channels (Austin). 2008 Nov-Dec;2(6):449-60. Epub 2008 Nov 7. [PubMed:19077543 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Voltage-gated sodium channel activity
Specific Function:
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na(+) channel isoform. Plays a role in pain mechanisms, es...
Gene Name:
SCN9A
Uniprot ID:
Q15858
Molecular Weight:
226370.175 Da
References
  1. Rajamani S, Shryock JC, Belardinelli L: Block of tetrodotoxin-sensitive, Na(V)1.7 and tetrodotoxin-resistant, Na(V)1.8, Na+ channels by ranolazine. Channels (Austin). 2008 Nov-Dec;2(6):449-60. Epub 2008 Nov 7. [PubMed:19077543 ]
  2. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
Comments
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Drug created on June 13, 2005 07:24 / Updated on December 11, 2016 02:41