Anaplastic lymphoma kinase (ALK) inhibitors

All categories
Name
Anaplastic lymphoma kinase (ALK) inhibitors
Accession Number
DBCAT005745
Description

Not Available

ATC Classification
Drugs
DrugDrug Description
CrizotinibA receptor tyrosine kinase inhibitor used to treat metastatic non-small cell lung cancer (NSCLC) where the tumors have been confirmed to be anaplastic lymphoma kinase (ALK), or ROS1-positive.
CeritinibAn antineoplastic kinase inhibitor used to treat anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) in patients with inadequate clinical response or intolerance to crizotinib.
AlectinibA kinase inhibitor used to treat anaplastic lymphoma kinase positive metastatic non small cell lung cancer.
LorlatinibAn anaplastic lymphoma kinase inhibitor used to treat anaplastic lymphoma kinase positive metastatic non small cell lung cancer.
BrigatinibAn anaplastic lymphoma kinase inhibitor used to treat anaplastic lymphoma kinase positive metastatic non small cell lung cancer.
Drugs & Drug Targets
DrugTargetType
CrizotinibCytochrome P450 3A4enzyme
CrizotinibCytochrome P450 3A5enzyme
CrizotinibP-glycoprotein 1transporter
CrizotinibALK tyrosine kinase receptortarget
CrizotinibHepatocyte growth factor receptortarget
CrizotinibCytochrome P450 2B6enzyme
CrizotinibCytochrome P450 3A Subfamilyenzyme
CrizotinibSerum albumincarrier
Crizotinibalpha1-acid glycoproteincarrier
CrizotinibProto-oncogene tyrosine-protein kinase ROStarget
CrizotinibMacrophage-stimulating protein receptortarget
CeritinibALK tyrosine kinase receptortarget
CeritinibP-glycoprotein 1transporter
CeritinibCytochrome P450 2C9enzyme
CeritinibCytochrome P450 3A4enzyme
AlectinibALK tyrosine kinase receptortarget
AlectinibATP-binding cassette sub-family G member 2transporter
AlectinibP-glycoprotein 1transporter
LorlatinibALK tyrosine kinase receptortarget
LorlatinibCytochrome P450 3A Subfamilyenzyme
LorlatinibCytochrome P450 3A5enzyme
LorlatinibCytochrome P450 2B6enzyme
LorlatinibCytochrome P450 2C8enzyme
LorlatinibCytochrome P450 2C19enzyme
LorlatinibUDP-glucuronosyltransferase 1-3enzyme
LorlatinibCytochrome P450 3A4enzyme
BrigatinibALK tyrosine kinase receptortarget
BrigatinibEpidermal growth factor receptortarget
BrigatinibTyrosine-protein kinase ABL1target
BrigatinibInsulin-like growth factor 1 receptortarget
BrigatinibReceptor-type tyrosine-protein kinase FLT3target
BrigatinibCytochrome P450 2C8enzyme
BrigatinibCytochrome P450 3A4enzyme
BrigatinibInsulin receptortarget
BrigatinibHepatocyte growth factor receptortarget
BrigatinibReceptor tyrosine-protein kinase erbB-4target
BrigatinibReceptor tyrosine-protein kinase erbB-2target
BrigatinibATP-binding cassette sub-family B member 5transporter
BrigatinibATP-binding cassette sub-family G member 2transporter
BrigatinibSolute carrier family 22 member 1transporter
BrigatinibMultidrug and toxin extrusion protein 1transporter
BrigatinibMultidrug and toxin extrusion protein 2transporter
BrigatinibCytochrome P450 3A Subfamilyenzyme