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Identification
NameCrizotinib
Accession NumberDB08865
TypeSmall Molecule
GroupsApproved
DescriptionCrizotinib an inhibitor of receptor tyrosine kinase for the treatment of non-small cell lung cancer (NSCLC). Verification of the presence of ALK fusion gene is done by Abbott Molecular's Vysis ALK Break Apart FISH Probe Kit. This verification is used to select for patients suitable for treatment. FDA approved in August 26, 2011.
Structure
Thumb
Synonyms
(R)-Crizotinib
C-Met/Hepatocyte Growth Factor Receptor Tyrosine Kinase Inhibitor PF-02341066
C-Met/HGFR Tyrosine Kinase Inhibitor PF-02341066
Crizotinibum
MET Tyrosine Kinase Inhibitor PF-02341066
PF 2341066
PF-2341066
External Identifiers
  • PF-02341066
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
XalkoriCapsule200 mg/1OralPfizer Laboratories Div Pfizer Inc2011-08-26Not applicableUs
XalkoriCapsule200 mgOralPfizer Canada Inc2012-05-10Not applicableCanada
XalkoriCapsule250 mgOralPfizer Ltd2012-10-23Not applicableEu
XalkoriCapsule250 mgOralPfizer Canada Inc2012-05-10Not applicableCanada
XalkoriCapsule250 mgOralPfizer Ltd2012-10-23Not applicableEu
XalkoriCapsule200 mgOralPfizer Ltd2012-10-23Not applicableEu
XalkoriCapsule250 mg/1OralPfizer Laboratories Div Pfizer Inc2011-08-26Not applicableUs
XalkoriCapsule200 mgOralPfizer Ltd2012-10-23Not applicableEu
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNIINot Available
CAS number877399-52-5
WeightAverage: 450.337
Monoisotopic: 449.11854397
Chemical FormulaC21H22Cl2FN5O
InChI KeyKTEIFNKAUNYNJU-GFCCVEGCSA-N
InChI
InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1
IUPAC Name
3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine
SMILES
C[C@@H](OC1=CC(=CN=C1N)C1=CN(N=C1)C1CCNCC1)C1=C(Cl)C=CC(F)=C1Cl
Pharmacology
IndicationCrizotinib is used for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) that is anaplastic-lymphoma kinase (ALK)-positive as detected by a FDA-approved test.
Structured Indications
PharmacodynamicsNot Available
Mechanism of actionCrizotinib is a tyrosine kinase receptor inhibitor. More specifically, it inhibits anaplastic lymphoma kinase (ALK), hepatocyte growth factor receptor (HGFR, c-MET), and Recepteur d'Origine Nantais (RON). Abnormalities in the ALK gene caused by mutations or translocations may lead to expression of oncogenic fusion proteins. In patients with NSCLC, they have the EML4-ALK gene. Crizotinib inhibits ALK tyrosine kinase which ultimately results in decreased proliferation of cells that carry the genetic mutation and tumour survivability.
TargetKindPharmacological actionActionsOrganismUniProt ID
ALK tyrosine kinase receptorProteinyes
inhibitor
HumanQ9UM73 details
Hepatocyte growth factor receptorProteinyes
inhibitor
HumanP08581 details
Related Articles
AbsorptionThe peak serum concentration was reached in 4 to 6 hours following an oral single-dose administration. Steady state was reached within 15 days when a dose of 250 mg twice daily was administered. The mean absolute bioavailability was 43% (range of 32% to 66%) following a single 250 mg oral dose. When taken with high-fat meal, AUC and Cmax were reduced.
Volume of distribution

Mean volume of distribution (Vss) is 1772 L following intravenous administration of a 50 mg dose. This high volume of distribution suggest extensive distribution into tissue from plasma.

Protein bindingCrizotinib is 91% bound to plasma protein. This is not affected by drug concentration.
Metabolism

Crizotinib is metabolized by CYP3A4 and CYP3A5 in which these enzymes mediates the O-dealkylation of the drug.

Route of eliminationFollowing the administration of a single 250 mg radiolabeled crizotinib dose to healthy subjects, 63% and 22% of the administered dose was recovered in feces and urine, respectively. Unchanged crizotinib represented approximately 53% and 2.3% of the administered dose in feces and urine, respectively.
Half lifePlasma terminal half-life, patients = 42 hours
Clearance

The mean apparent clearance (CL/F) of crizotinib was lower at steady state (60 L/hr) after 250 mg twice daily than that after a single 250 mg oral dose (100 L/hr), which was likely due to autoinhibition of CYP3A by crizotinib after multiple dosing.

ToxicityNot Available
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
AbirateroneThe metabolism of Abiraterone can be decreased when combined with Crizotinib.Approved
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Crizotinib.Approved
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Crizotinib.Approved
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Crizotinib.Approved
AcetyldigitoxinAcetyldigitoxin may decrease the cardiotoxic activities of Crizotinib.Approved
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Crizotinib.Approved, Vet Approved
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Crizotinib.Approved
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Crizotinib.Approved
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Crizotinib.Approved, Vet Approved
AlclometasoneThe metabolism of Alclometasone can be decreased when combined with Crizotinib.Approved
AldosteroneThe serum concentration of Crizotinib can be decreased when it is combined with Aldosterone.Experimental
AlectinibThe serum concentration of Crizotinib can be increased when it is combined with Alectinib.Approved
AlfentanilThe serum concentration of Alfentanil can be increased when it is combined with Crizotinib.Approved, Illicit
AlfuzosinAlfuzosin may increase the QTc-prolonging activities of Crizotinib.Approved, Investigational
AliskirenThe metabolism of Aliskiren can be decreased when combined with Crizotinib.Approved, Investigational
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Crizotinib.Approved, Investigational
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Crizotinib.Approved
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Crizotinib.Approved, Investigational
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Crizotinib.Approved
AlosetronThe metabolism of Alosetron can be decreased when combined with Crizotinib.Approved, Withdrawn
AlprazolamThe metabolism of Alprazolam can be decreased when combined with Crizotinib.Approved, Illicit, Investigational
AmantadineAmantadine may increase the QTc-prolonging activities of Crizotinib.Approved
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Crizotinib.Approved, Investigational
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Crizotinib.Approved
Aminohippuric acidThe serum concentration of Crizotinib can be increased when it is combined with Aminohippuric acid.Approved
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Crizotinib.Approved, Withdrawn
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Crizotinib.Approved
AmiodaroneThe serum concentration of Crizotinib can be increased when it is combined with Amiodarone.Approved, Investigational
AmitriptylineAmitriptyline may increase the QTc-prolonging activities of Crizotinib.Approved
AmlodipineThe metabolism of Amlodipine can be decreased when combined with Crizotinib.Approved
AmoxapineAmoxapine may increase the QTc-prolonging activities of Crizotinib.Approved
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Crizotinib.Approved
AmsacrineThe serum concentration of Crizotinib can be increased when it is combined with Amsacrine.Approved
AnagrelideCrizotinib may increase the QTc-prolonging activities of Anagrelide.Approved
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Crizotinib.Approved
AnvirzelAnvirzel may decrease the cardiotoxic activities of Crizotinib.Investigational
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Crizotinib.Approved
ApomorphineApomorphine may increase the QTc-prolonging activities of Crizotinib.Approved, Investigational
ApremilastThe metabolism of Apremilast can be decreased when combined with Crizotinib.Approved, Investigational
AprepitantThe serum concentration of Crizotinib can be increased when it is combined with Aprepitant.Approved, Investigational
ArformoterolArformoterol may increase the QTc-prolonging activities of Crizotinib.Approved, Investigational
ArgatrobanThe metabolism of Argatroban can be decreased when combined with Crizotinib.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Crizotinib.Approved, Investigational
Arsenic trioxideCrizotinib may increase the QTc-prolonging activities of Arsenic trioxide.Approved, Investigational
ArtemetherCrizotinib may increase the QTc-prolonging activities of Artemether.Approved
AsenapineCrizotinib may increase the QTc-prolonging activities of Asenapine.Approved
AstemizoleThe metabolism of Astemizole can be decreased when combined with Crizotinib.Approved, Withdrawn
AtazanavirThe serum concentration of Crizotinib can be increased when it is combined with Atazanavir.Approved, Investigational
AtenololThe serum concentration of Crizotinib can be increased when it is combined with Atenolol.Approved
AtomoxetineAtomoxetine may increase the QTc-prolonging activities of Crizotinib.Approved
AtorvastatinThe metabolism of Atorvastatin can be decreased when combined with Crizotinib.Approved
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Crizotinib.Approved
AxitinibThe metabolism of Axitinib can be decreased when combined with Crizotinib.Approved, Investigational
AzelastineThe metabolism of Azelastine can be decreased when combined with Crizotinib.Approved
AzithromycinAzithromycin may increase the QTc-prolonging activities of Crizotinib.Approved
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Crizotinib.Investigational
BedaquilineCrizotinib may increase the QTc-prolonging activities of Bedaquiline.Approved
BendroflumethiazideBendroflumethiazide may increase the bradycardic activities of Crizotinib.Approved
BenzocaineThe serum concentration of Crizotinib can be increased when it is combined with Benzocaine.Approved
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Crizotinib.Approved, Illicit
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Crizotinib.Approved
BepridilThe serum concentration of Crizotinib can be increased when it is combined with Bepridil.Approved, Withdrawn
BeractantBeractant may increase the bradycardic activities of Crizotinib.Approved
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Crizotinib.Approved, Vet Approved
BetaxololBetaxolol may increase the bradycardic activities of Crizotinib.Approved
BevacizumabBevacizumab may increase the cardiotoxic activities of Crizotinib.Approved, Investigational
BexaroteneThe serum concentration of Crizotinib can be decreased when it is combined with Bexarotene.Approved, Investigational
BezafibrateThe metabolism of Bezafibrate can be decreased when combined with Crizotinib.Approved
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Crizotinib.Approved
BiperidenThe serum concentration of Crizotinib can be increased when it is combined with Biperiden.Approved
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Crizotinib.Approved
BoceprevirThe serum concentration of Crizotinib can be increased when it is combined with Boceprevir.Approved
BortezomibBortezomib may increase the QTc-prolonging activities of Crizotinib.Approved, Investigational
BosentanThe serum concentration of Bosentan can be increased when it is combined with Crizotinib.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Crizotinib.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Crizotinib.Approved
BretyliumBretylium may increase the bradycardic activities of Crizotinib.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Crizotinib.Approved
BrinzolamideThe metabolism of Brinzolamide can be decreased when combined with Crizotinib.Approved
BromazepamThe metabolism of Bromazepam can be decreased when combined with Crizotinib.Approved, Illicit
BromocriptineThe metabolism of Bromocriptine can be decreased when combined with Crizotinib.Approved, Investigational
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Crizotinib.Approved
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Crizotinib.Approved
BudesonideThe metabolism of Budesonide can be decreased when combined with Crizotinib.Approved
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Crizotinib.Approved, Investigational
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Crizotinib.Approved, Illicit, Investigational, Vet Approved
BupropionThe serum concentration of Bupropion can be increased when it is combined with Crizotinib.Approved
BuserelinBuserelin may increase the QTc-prolonging activities of Crizotinib.Approved
BuspironeThe metabolism of Buspirone can be decreased when combined with Crizotinib.Approved, Investigational
BusulfanThe metabolism of Busulfan can be decreased when combined with Crizotinib.Approved, Investigational
CabazitaxelThe risk or severity of adverse effects can be increased when Cabazitaxel is combined with Crizotinib.Approved
CabergolineThe metabolism of Cabergoline can be decreased when combined with Crizotinib.Approved
CabozantinibThe metabolism of Cabozantinib can be decreased when combined with Crizotinib.Approved
CaffeineThe metabolism of Caffeine can be decreased when combined with Crizotinib.Approved
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Crizotinib.Approved, Nutraceutical
CalfactantCalfactant may increase the bradycardic activities of Crizotinib.Approved
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Crizotinib.Experimental
CanagliflozinThe metabolism of Canagliflozin can be decreased when combined with Crizotinib.Approved
CandesartanThe serum concentration of Crizotinib can be increased when it is combined with Candesartan.Approved
CaptoprilThe serum concentration of Crizotinib can be increased when it is combined with Captopril.Approved
CarbamazepineThe serum concentration of Crizotinib can be decreased when it is combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Crizotinib.Approved
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Crizotinib.Approved
CariprazineThe metabolism of Cariprazine can be decreased when combined with Crizotinib.Approved
CarteololCarteolol may increase the bradycardic activities of Crizotinib.Approved
CarvedilolThe metabolism of Carvedilol can be decreased when combined with Crizotinib.Approved, Investigational
CaspofunginThe serum concentration of Crizotinib can be increased when it is combined with Caspofungin.Approved
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Crizotinib.Approved, Investigational
CeliprololThe metabolism of Celiprolol can be decreased when combined with Crizotinib.Approved, Investigational
CephalexinThe metabolism of Cephalexin can be decreased when combined with Crizotinib.Approved, Vet Approved
CeritinibCrizotinib may increase the bradycardic activities of Ceritinib.Approved
CerivastatinThe metabolism of Cerivastatin can be decreased when combined with Crizotinib.Withdrawn
CevimelineThe metabolism of Cevimeline can be decreased when combined with Crizotinib.Approved
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Crizotinib.Approved
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Crizotinib.Approved, Illicit
ChloroquineChloroquine may increase the QTc-prolonging activities of Crizotinib.Approved, Vet Approved
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Crizotinib.Approved
ChlorpromazineChlorpromazine may increase the QTc-prolonging activities of Crizotinib.Approved, Vet Approved
ChlorpropamideThe serum concentration of Crizotinib can be increased when it is combined with Chlorpropamide.Approved
ChlorprothixeneThe serum concentration of Crizotinib can be increased when it is combined with Chlorprothixene.Approved, Withdrawn
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Crizotinib.Approved
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Crizotinib.Approved, Nutraceutical
CholesterolThe serum concentration of Crizotinib can be increased when it is combined with Cholesterol.Experimental
Cholic AcidThe serum concentration of Crizotinib can be decreased when it is combined with Cholic Acid.Approved
CiclesonideThe metabolism of Ciclesonide can be decreased when combined with Crizotinib.Approved, Investigational
CilazaprilThe serum concentration of Crizotinib can be increased when it is combined with Cilazapril.Approved
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Crizotinib.Approved
CimetidineThe serum concentration of Crizotinib can be decreased when it is combined with Cimetidine.Approved
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Crizotinib.Approved
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Crizotinib.Approved
CiprofloxacinCiprofloxacin may increase the QTc-prolonging activities of Crizotinib.Approved, Investigational
CisaprideCrizotinib may increase the QTc-prolonging activities of Cisapride.Approved, Investigational, Withdrawn
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Crizotinib.Approved
CitalopramCrizotinib may increase the QTc-prolonging activities of Citalopram.Approved
ClarithromycinThe serum concentration of Crizotinib can be increased when it is combined with Clarithromycin.Approved
ClemastineThe metabolism of Crizotinib can be decreased when combined with Clemastine.Approved
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Crizotinib.Approved, Vet Approved
ClobazamThe metabolism of Clobazam can be decreased when combined with Crizotinib.Approved, Illicit
ClofazimineThe metabolism of Clofazimine can be decreased when combined with Crizotinib.Approved, Investigational
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Crizotinib.Approved
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Crizotinib.Investigational
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Crizotinib.Approved, Investigational
ClomipramineClomipramine may increase the QTc-prolonging activities of Crizotinib.Approved, Vet Approved
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Crizotinib.Approved, Illicit
ClonidineThe metabolism of Clonidine can be decreased when combined with Crizotinib.Approved
ClopidogrelThe metabolism of Clopidogrel can be decreased when combined with Crizotinib.Approved, Nutraceutical
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Crizotinib.Approved, Illicit
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Crizotinib.Approved, Illicit
ClotrimazoleThe metabolism of Crizotinib can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineClozapine may increase the QTc-prolonging activities of Crizotinib.Approved
CobicistatThe serum concentration of Crizotinib can be increased when it is combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Crizotinib.Approved
CocaineThe metabolism of Cocaine can be decreased when combined with Crizotinib.Approved, Illicit
CodeineThe metabolism of Codeine can be decreased when combined with Crizotinib.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Crizotinib.Approved
ColforsinThe serum concentration of Crizotinib can be increased when it is combined with Colforsin.Experimental
ConivaptanThe serum concentration of Crizotinib can be increased when it is combined with Conivaptan.Approved, Investigational
Conjugated Equine EstrogensThe metabolism of Conjugated Equine Estrogens can be decreased when combined with Crizotinib.Approved
Cortisone acetateThe metabolism of Cortisone acetate can be decreased when combined with Crizotinib.Approved
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Crizotinib.Approved
CyclophosphamideCyclophosphamide may increase the cardiotoxic activities of Crizotinib.Approved, Investigational
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Crizotinib.Approved, Investigational, Vet Approved
CyclosporineThe metabolism of Crizotinib can be decreased when combined with Cyclosporine.Approved, Investigational, Vet Approved
CytarabineThe metabolism of Cytarabine can be decreased when combined with Crizotinib.Approved, Investigational
Dabigatran etexilateThe serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Crizotinib.Approved
DabrafenibThe serum concentration of Crizotinib can be decreased when it is combined with Dabrafenib.Approved
DaclatasvirThe metabolism of Daclatasvir can be decreased when combined with Crizotinib.Approved
DactinomycinThe serum concentration of Crizotinib can be increased when it is combined with Dactinomycin.Approved
DantroleneThe metabolism of Dantrolene can be decreased when combined with Crizotinib.Approved
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Crizotinib.Approved
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Crizotinib.Investigational
DapsoneThe metabolism of Dapsone can be decreased when combined with Crizotinib.Approved, Investigational
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Crizotinib.Approved, Investigational
DarunavirThe serum concentration of Crizotinib can be increased when it is combined with Darunavir.Approved
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Crizotinib.Approved
DasatinibThe serum concentration of Crizotinib can be increased when it is combined with Dasatinib.Approved, Investigational
DaunorubicinThe metabolism of Daunorubicin can be decreased when combined with Crizotinib.Approved
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Crizotinib.Approved
DeferasiroxThe serum concentration of Crizotinib can be decreased when it is combined with Deferasirox.Approved, Investigational
DegarelixDegarelix may increase the QTc-prolonging activities of Crizotinib.Approved
DelavirdineThe metabolism of Crizotinib can be decreased when combined with Delavirdine.Approved
DesfluraneDesflurane may increase the QTc-prolonging activities of Crizotinib.Approved
DesipramineDesipramine may increase the QTc-prolonging activities of Crizotinib.Approved
DeslanosideDeslanoside may decrease the cardiotoxic activities of Crizotinib.Approved
DesloratadineThe serum concentration of Crizotinib can be increased when it is combined with Desloratadine.Approved, Investigational
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Crizotinib.Approved
DexamethasoneThe serum concentration of Crizotinib can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DexmedetomidineDexmedetomidine may increase the bradycardic activities of Crizotinib.Approved, Vet Approved
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Crizotinib.Approved
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Crizotinib.Approved, Illicit, Withdrawn
DiazepamThe metabolism of Diazepam can be decreased when combined with Crizotinib.Approved, Illicit, Vet Approved
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Crizotinib.Approved, Vet Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Crizotinib.Approved
DigitoxinDigitoxin may decrease the cardiotoxic activities of Crizotinib.Approved
DigoxinDigoxin may decrease the cardiotoxic activities of Crizotinib.Approved
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Crizotinib.Approved, Illicit
DihydroergotamineThe serum concentration of Dihydroergotamine can be increased when it is combined with Crizotinib.Approved
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Crizotinib.Illicit
DiltiazemThe metabolism of Crizotinib can be decreased when combined with Diltiazem.Approved
DiphenhydramineDiphenhydramine may increase the QTc-prolonging activities of Crizotinib.Approved
DipyridamoleThe serum concentration of Crizotinib can be increased when it is combined with Dipyridamole.Approved
DisopyramideCrizotinib may increase the QTc-prolonging activities of Disopyramide.Approved
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Crizotinib.Approved
DocetaxelThe risk or severity of adverse effects can be increased when Docetaxel is combined with Crizotinib.Approved, Investigational
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Crizotinib.Approved
DolasetronDolasetron may increase the QTc-prolonging activities of Crizotinib.Approved
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Crizotinib.Approved, Investigational, Vet Approved
DonepezilThe metabolism of Donepezil can be decreased when combined with Crizotinib.Approved
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Crizotinib.Approved
DoxazosinThe serum concentration of Crizotinib can be increased when it is combined with Doxazosin.Approved
DoxepinDoxepin may increase the QTc-prolonging activities of Crizotinib.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Crizotinib.Approved, Investigational
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Crizotinib.Approved, Investigational
DoxycyclineThe metabolism of Crizotinib can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Crizotinib.Approved, Illicit
DronedaroneCrizotinib may increase the QTc-prolonging activities of Dronedarone.Approved
DroperidolDroperidol may increase the QTc-prolonging activities of Crizotinib.Approved, Vet Approved
DutasterideThe metabolism of Dutasteride can be decreased when combined with Crizotinib.Approved, Investigational
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Crizotinib.Approved
EfavirenzThe serum concentration of Crizotinib can be decreased when it is combined with Efavirenz.Approved, Investigational
ElbasvirThe serum concentration of Crizotinib can be increased when it is combined with Elbasvir.Approved
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Crizotinib.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Crizotinib.Approved
ElvitegravirThe metabolism of Elvitegravir can be decreased when combined with Crizotinib.Approved
EnalaprilThe metabolism of Enalapril can be decreased when combined with Crizotinib.Approved, Vet Approved
EnzalutamideThe serum concentration of Crizotinib can be decreased when it is combined with Enzalutamide.Approved
EpinastineThe metabolism of Epinastine can be decreased when combined with Crizotinib.Approved, Investigational
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Crizotinib.Approved
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Crizotinib.Approved, Nutraceutical
Ergoloid mesylateThe metabolism of Ergoloid mesylate can be decreased when combined with Crizotinib.Approved
ErgonovineThe metabolism of Ergonovine can be decreased when combined with Crizotinib.Approved
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Crizotinib.Approved
EribulinEribulin may increase the QTc-prolonging activities of Crizotinib.Approved, Investigational
ErlotinibThe metabolism of Erlotinib can be decreased when combined with Crizotinib.Approved, Investigational
ErythromycinErythromycin may increase the QTc-prolonging activities of Crizotinib.Approved, Vet Approved
EscitalopramCrizotinib may increase the QTc-prolonging activities of Escitalopram.Approved, Investigational
Eslicarbazepine acetateThe serum concentration of Crizotinib can be decreased when it is combined with Eslicarbazepine acetate.Approved
EsmololEsmolol may increase the bradycardic activities of Crizotinib.Approved
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Crizotinib.Approved, Investigational
EstazolamThe metabolism of Estazolam can be decreased when combined with Crizotinib.Approved, Illicit
EstradiolThe metabolism of Estradiol can be decreased when combined with Crizotinib.Approved, Investigational, Vet Approved
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be decreased when combined with Crizotinib.Approved
EstramustineThe metabolism of Estramustine can be decreased when combined with Crizotinib.Approved
EstriolThe serum concentration of Crizotinib can be decreased when it is combined with Estriol.Approved, Vet Approved
EstroneThe metabolism of Estrone can be decreased when combined with Crizotinib.Approved
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Crizotinib.Approved
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Crizotinib.Approved
EthanolThe metabolism of Ethanol can be decreased when combined with Crizotinib.Approved
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be decreased when combined with Crizotinib.Approved
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Crizotinib.Approved
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Crizotinib.Approved, Illicit
EtonogestrelThe metabolism of Etonogestrel can be decreased when combined with Crizotinib.Approved, Investigational
EtoposideThe metabolism of Etoposide can be decreased when combined with Crizotinib.Approved
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Crizotinib.Approved, Investigational
EtravirineThe serum concentration of Crizotinib can be decreased when it is combined with Etravirine.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Crizotinib.Approved
ExemestaneThe metabolism of Exemestane can be decreased when combined with Crizotinib.Approved, Investigational
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Crizotinib.Approved
EzogabineEzogabine may increase the QTc-prolonging activities of Crizotinib.Approved
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Crizotinib.Approved
FamotidineFamotidine may increase the QTc-prolonging activities of Crizotinib.Approved
FelbamateFelbamate may increase the QTc-prolonging activities of Crizotinib.Approved
FelodipineThe metabolism of Felodipine can be decreased when combined with Crizotinib.Approved, Investigational
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Crizotinib.Approved
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Crizotinib.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe metabolism of Fesoterodine can be decreased when combined with Crizotinib.Approved
FexofenadineThe serum concentration of Crizotinib can be increased when it is combined with Fexofenadine.Approved
FidaxomicinThe serum concentration of Crizotinib can be increased when it is combined with Fidaxomicin.Approved
FinasterideThe metabolism of Finasteride can be decreased when combined with Crizotinib.Approved
FingolimodFingolimod may increase the QTc-prolonging activities of Crizotinib.Approved, Investigational
FlecainideFlecainide may increase the QTc-prolonging activities of Crizotinib.Approved, Withdrawn
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Crizotinib.Approved
FluconazoleFluconazole may increase the QTc-prolonging activities of Crizotinib.Approved
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Crizotinib.Approved
FlunisolideThe metabolism of Flunisolide can be decreased when combined with Crizotinib.Approved, Investigational
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Crizotinib.Approved, Illicit
FluorometholoneThe metabolism of Fluorometholone can be decreased when combined with Crizotinib.Approved
FluoxetineCrizotinib may increase the QTc-prolonging activities of Fluoxetine.Approved, Vet Approved
FlupentixolCrizotinib may increase the QTc-prolonging activities of Flupentixol.Approved, Withdrawn
FluphenazineThe serum concentration of Crizotinib can be increased when it is combined with Fluphenazine.Approved
FlurazepamThe metabolism of Flurazepam can be decreased when combined with Crizotinib.Approved, Illicit
FlutamideThe metabolism of Flutamide can be decreased when combined with Crizotinib.Approved
Fluticasone furoateThe metabolism of Fluticasone furoate can be decreased when combined with Crizotinib.Approved
Fluticasone PropionateThe metabolism of Fluticasone Propionate can be decreased when combined with Crizotinib.Approved
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Crizotinib.Approved
FluvoxamineThe metabolism of Crizotinib can be decreased when combined with Fluvoxamine.Approved, Investigational
FormoterolFormoterol may increase the QTc-prolonging activities of Crizotinib.Approved, Investigational
FosamprenavirThe metabolism of Crizotinib can be decreased when combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Crizotinib can be increased when it is combined with Fosaprepitant.Approved
FoscarnetFoscarnet may increase the QTc-prolonging activities of Crizotinib.Approved
FosphenytoinThe serum concentration of Crizotinib can be decreased when it is combined with Fosphenytoin.Approved
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Crizotinib.Approved, Investigational
Fusidic AcidThe serum concentration of Crizotinib can be increased when it is combined with Fusidic Acid.Approved
Gadobenic acidGadobenic acid may increase the QTc-prolonging activities of Crizotinib.Approved
GalantamineGalantamine may increase the QTc-prolonging activities of Crizotinib.Approved
GefitinibThe metabolism of Gefitinib can be decreased when combined with Crizotinib.Approved, Investigational
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Crizotinib.Approved
GemfibrozilThe metabolism of Gemfibrozil can be decreased when combined with Crizotinib.Approved
GemifloxacinGemifloxacin may increase the QTc-prolonging activities of Crizotinib.Approved, Investigational
GenisteinThe serum concentration of Crizotinib can be increased when it is combined with Genistein.Investigational
GlipizideThe metabolism of Glipizide can be decreased when combined with Crizotinib.Approved
GlyburideThe metabolism of Glyburide can be decreased when combined with Crizotinib.Approved
GlycerolThe serum concentration of Crizotinib can be increased when it is combined with Glycerol.Experimental
GoserelinGoserelin may increase the QTc-prolonging activities of Crizotinib.Approved
Gramicidin DThe serum concentration of Crizotinib can be increased when it is combined with Gramicidin D.Approved
GranisetronGranisetron may increase the QTc-prolonging activities of Crizotinib.Approved, Investigational
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Crizotinib.Approved
GrepafloxacinThe metabolism of Grepafloxacin can be decreased when combined with Crizotinib.Withdrawn
GuanfacineThe metabolism of Guanfacine can be decreased when combined with Crizotinib.Approved, Investigational
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Crizotinib.Approved
HaloperidolHaloperidol may increase the QTc-prolonging activities of Crizotinib.Approved
HalothaneThe metabolism of Halothane can be decreased when combined with Crizotinib.Approved, Vet Approved
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Crizotinib.Approved
Histamine PhosphateThe metabolism of Histamine Phosphate can be decreased when combined with Crizotinib.Approved
HistrelinHistrelin may increase the QTc-prolonging activities of Crizotinib.Approved
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Crizotinib.Approved, Illicit
HydrocortisoneThe metabolism of Hydrocortisone can be decreased when combined with Crizotinib.Approved, Vet Approved
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Crizotinib.Approved, Illicit
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Crizotinib.Approved
HydroxyzineHydroxyzine may increase the QTc-prolonging activities of Crizotinib.Approved
IbandronateIbandronate may increase the QTc-prolonging activities of Crizotinib.Approved, Investigational
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Crizotinib.Approved
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Crizotinib.Approved
IbutilideCrizotinib may increase the QTc-prolonging activities of Ibutilide.Approved
IdelalisibThe serum concentration of Crizotinib can be increased when it is combined with Idelalisib.Approved
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Crizotinib resulting in a loss in efficacy.Approved
IloperidoneCrizotinib may increase the QTc-prolonging activities of Iloperidone.Approved
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Crizotinib.Approved
ImipramineImipramine may increase the QTc-prolonging activities of Crizotinib.Approved
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Crizotinib.Approved, Investigational
IndacaterolIndacaterol may increase the QTc-prolonging activities of Crizotinib.Approved
IndapamideIndapamide may increase the QTc-prolonging activities of Crizotinib.Approved
IndinavirThe serum concentration of Crizotinib can be increased when it is combined with Indinavir.Approved
IndomethacinThe serum concentration of Crizotinib can be increased when it is combined with Indomethacin.Approved, Investigational
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Crizotinib.Approved
IrinotecanThe metabolism of Irinotecan can be decreased when combined with Crizotinib.Approved, Investigational
IsavuconazoniumThe metabolism of Crizotinib can be decreased when combined with Isavuconazonium.Approved, Investigational
IsofluraneIsoflurane may increase the QTc-prolonging activities of Crizotinib.Approved, Vet Approved
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be decreased when combined with Crizotinib.Approved
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be decreased when combined with Crizotinib.Approved
IsradipineIsradipine may increase the QTc-prolonging activities of Crizotinib.Approved
ItraconazoleThe serum concentration of Crizotinib can be increased when it is combined with Itraconazole.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Crizotinib.Approved
IvacaftorThe serum concentration of Ivacaftor can be increased when it is combined with Crizotinib.Approved
IvermectinThe metabolism of Ivermectin can be decreased when combined with Crizotinib.Approved, Vet Approved
IxabepiloneThe metabolism of Ixabepilone can be decreased when combined with Crizotinib.Approved, Investigational
IxazomibThe metabolism of Ixazomib can be decreased when combined with Crizotinib.Approved
KetamineThe metabolism of Ketamine can be decreased when combined with Crizotinib.Approved, Vet Approved
KetazolamThe metabolism of Ketazolam can be decreased when combined with Crizotinib.Approved
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Crizotinib.Approved
KetoconazoleThe serum concentration of Crizotinib can be increased when it is combined with Ketoconazole.Approved, Investigational
LabetalolLabetalol may increase the bradycardic activities of Crizotinib.Approved
LacosamideCrizotinib may increase the atrioventricular blocking (AV block) activities of Lacosamide.Approved
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Crizotinib.Approved, Investigational
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Crizotinib.Approved, Investigational
LanreotideLanreotide may increase the bradycardic activities of Crizotinib.Approved
LansoprazoleThe metabolism of Lansoprazole can be decreased when combined with Crizotinib.Approved, Investigational
LapatinibLapatinib may increase the QTc-prolonging activities of Crizotinib.Approved, Investigational
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Crizotinib.Investigational
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Crizotinib.Approved
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Crizotinib.Approved
LenvatinibCrizotinib may increase the QTc-prolonging activities of Lenvatinib.Approved
LercanidipineThe metabolism of Lercanidipine can be decreased when combined with Crizotinib.Approved, Investigational
LetrozoleThe metabolism of Letrozole can be decreased when combined with Crizotinib.Approved, Investigational
LeuprolideLeuprolide may increase the QTc-prolonging activities of Crizotinib.Approved, Investigational
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Crizotinib.Approved, Investigational
LevobunololLevobunolol may increase the bradycardic activities of Crizotinib.Approved
LevobupivacaineThe metabolism of Levobupivacaine can be decreased when combined with Crizotinib.Approved
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Crizotinib.Approved
LevofloxacinLevofloxacin may increase the QTc-prolonging activities of Crizotinib.Approved, Investigational
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Crizotinib.Approved
LevomilnacipranThe metabolism of Levomilnacipran can be decreased when combined with Crizotinib.Approved
LevonorgestrelThe metabolism of Levonorgestrel can be decreased when combined with Crizotinib.Approved, Investigational
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Crizotinib.Approved
LidocaineThe metabolism of Lidocaine can be decreased when combined with Crizotinib.Approved, Vet Approved
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Crizotinib.Approved
LiothyronineThe serum concentration of Crizotinib can be decreased when it is combined with Liothyronine.Approved, Vet Approved
LiotrixThe serum concentration of Crizotinib can be decreased when it is combined with Liotrix.Approved
LisinoprilThe serum concentration of Crizotinib can be increased when it is combined with Lisinopril.Approved, Investigational
LisurideThe metabolism of Lisuride can be decreased when combined with Crizotinib.Approved
LithiumLithium may increase the QTc-prolonging activities of Crizotinib.Approved
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Crizotinib.Approved
LoperamideThe metabolism of Loperamide can be decreased when combined with Crizotinib.Approved
LopinavirThe serum concentration of Crizotinib can be increased when it is combined with Lopinavir.Approved
LoratadineThe metabolism of Loratadine can be decreased when combined with Crizotinib.Approved
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Crizotinib.Approved
LosartanThe metabolism of Losartan can be decreased when combined with Crizotinib.Approved
LovastatinThe metabolism of Crizotinib can be decreased when combined with Lovastatin.Approved, Investigational
LucinactantLucinactant may increase the bradycardic activities of Crizotinib.Approved
LuliconazoleThe serum concentration of Crizotinib can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Crizotinib can be decreased when it is combined with Lumacaftor.Approved
LumefantrineCrizotinib may increase the QTc-prolonging activities of Lumefantrine.Approved
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Crizotinib.Approved
MacitentanThe metabolism of Macitentan can be decreased when combined with Crizotinib.Approved
MalathionThe metabolism of Malathion can be decreased when combined with Crizotinib.Approved, Investigational
MannitolThe serum concentration of Mannitol can be increased when it is combined with Crizotinib.Approved, Investigational
MaprotilineMaprotiline may increase the QTc-prolonging activities of Crizotinib.Approved
MaravirocThe metabolism of Maraviroc can be decreased when combined with Crizotinib.Approved, Investigational
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Crizotinib.Approved, Vet Approved
Medroxyprogesterone acetateThe metabolism of Medroxyprogesterone acetate can be decreased when combined with Crizotinib.Approved, Investigational
MefloquineMefloquine may increase the QTc-prolonging activities of Crizotinib.Approved
Megestrol acetateThe serum concentration of Crizotinib can be increased when it is combined with Megestrol acetate.Approved, Vet Approved
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Crizotinib.Approved, Vet Approved
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Crizotinib.Investigational, Withdrawn
MeprobamateThe serum concentration of Crizotinib can be increased when it is combined with Meprobamate.Approved, Illicit
MethadoneMethadone may increase the QTc-prolonging activities of Crizotinib.Approved
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Crizotinib.Illicit, Withdrawn
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Crizotinib.Approved
MethotrimeprazineMethotrimeprazine may increase the QTc-prolonging activities of Crizotinib.Approved
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Crizotinib.Approved
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Crizotinib.Approved, Vet Approved
MethyldopaMethyldopa may increase the bradycardic activities of Crizotinib.Approved
MethylphenobarbitalThe metabolism of Methylphenobarbital can be decreased when combined with Crizotinib.Approved
MethylprednisoloneThe metabolism of Methylprednisolone can be decreased when combined with Crizotinib.Approved, Vet Approved
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Crizotinib.Approved
MetipranololMetipranolol may increase the bradycardic activities of Crizotinib.Approved
MetoclopramideMetoclopramide may increase the QTc-prolonging activities of Crizotinib.Approved, Investigational
MetoprololThe serum concentration of Crizotinib can be increased when it is combined with Metoprolol.Approved, Investigational
MetronidazoleMetronidazole may increase the QTc-prolonging activities of Crizotinib.Approved
MexiletineThe metabolism of Mexiletine can be decreased when combined with Crizotinib.Approved
MianserinThe metabolism of Mianserin can be decreased when combined with Crizotinib.Approved
MibefradilThe metabolism of Mibefradil can be decreased when combined with Crizotinib.Withdrawn
MiconazoleThe metabolism of Miconazole can be decreased when combined with Crizotinib.Approved, Investigational, Vet Approved
MidazolamThe metabolism of Midazolam can be decreased when combined with Crizotinib.Approved, Illicit
MifepristoneMifepristone may increase the QTc-prolonging activities of Crizotinib.Approved, Investigational
MirabegronMirabegron may increase the QTc-prolonging activities of Crizotinib.Approved
MirtazapineMirtazapine may increase the QTc-prolonging activities of Crizotinib.Approved
MitomycinThe serum concentration of Crizotinib can be increased when it is combined with Mitomycin.Approved
MitotaneThe serum concentration of Crizotinib can be decreased when it is combined with Mitotane.Approved
MitoxantroneThe serum concentration of Crizotinib can be decreased when it is combined with Mitoxantrone.Approved, Investigational
ModafinilThe serum concentration of Crizotinib can be decreased when it is combined with Modafinil.Approved, Investigational
MoexiprilMoexipril may increase the QTc-prolonging activities of Crizotinib.Approved
MontelukastThe metabolism of Montelukast can be decreased when combined with Crizotinib.Approved
MorphineThe metabolism of Morphine can be decreased when combined with Crizotinib.Approved, Investigational
MoxifloxacinMoxifloxacin may increase the QTc-prolonging activities of Crizotinib.Approved, Investigational
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be decreased when combined with Crizotinib.Approved, Investigational
NadololThe serum concentration of Nadolol can be increased when it is combined with Crizotinib.Approved
NafcillinThe serum concentration of Crizotinib can be decreased when it is combined with Nafcillin.Approved
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Crizotinib.Approved
NaloxoneThe metabolism of Naloxone can be decreased when combined with Crizotinib.Approved, Vet Approved
NaltrexoneThe serum concentration of Crizotinib can be increased when it is combined with Naltrexone.Approved, Investigational, Vet Approved
NaringeninThe serum concentration of Crizotinib can be increased when it is combined with Naringenin.Experimental
NateglinideThe metabolism of Nateglinide can be decreased when combined with Crizotinib.Approved, Investigational
NebivololNebivolol may increase the bradycardic activities of Crizotinib.Approved, Investigational
NefazodoneThe serum concentration of Crizotinib can be increased when it is combined with Nefazodone.Approved, Withdrawn
NelfinavirThe serum concentration of Crizotinib can be increased when it is combined with Nelfinavir.Approved
NeostigmineThe serum concentration of Crizotinib can be increased when it is combined with Neostigmine.Approved, Vet Approved
NetupitantThe serum concentration of Crizotinib can be increased when it is combined with Netupitant.Approved
NevirapineThe serum concentration of Crizotinib can be decreased when it is combined with Nevirapine.Approved
NicardipineNicardipine may increase the QTc-prolonging activities of Crizotinib.Approved
NicotineThe metabolism of Nicotine can be decreased when combined with Crizotinib.Approved
NifedipineThe metabolism of Nifedipine can be decreased when combined with Crizotinib.Approved
NilotinibCrizotinib may increase the QTc-prolonging activities of Nilotinib.Approved, Investigational
NilvadipineThe metabolism of Nilvadipine can be decreased when combined with Crizotinib.Approved
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Crizotinib.Approved
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Crizotinib.Approved
NisoldipineThe metabolism of Nisoldipine can be decreased when combined with Crizotinib.Approved
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Crizotinib.Approved
NitrendipineThe metabolism of Nitrendipine can be decreased when combined with Crizotinib.Approved
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Crizotinib.Approved
NorethisteroneThe metabolism of Norethisterone can be decreased when combined with Crizotinib.Approved
NorfloxacinNorfloxacin may increase the QTc-prolonging activities of Crizotinib.Approved
NorgestrelThe metabolism of Norgestrel can be decreased when combined with Crizotinib.Approved
NortriptylineNortriptyline may increase the QTc-prolonging activities of Crizotinib.Approved
OctreotideOctreotide may increase the QTc-prolonging activities of Crizotinib.Approved, Investigational
OfloxacinOfloxacin may increase the QTc-prolonging activities of Crizotinib.Approved
OlanzapineOlanzapine may increase the QTc-prolonging activities of Crizotinib.Approved, Investigational
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Crizotinib.Approved
OlodaterolOlodaterol may increase the QTc-prolonging activities of Crizotinib.Approved
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Crizotinib.Approved
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Crizotinib.Approved
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Crizotinib.Approved, Investigational, Vet Approved
OndansetronOndansetron may increase the QTc-prolonging activities of Crizotinib.Approved
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Crizotinib.Approved
OsimertinibThe serum concentration of Crizotinib can be increased when it is combined with Osimertinib.Approved
OspemifeneThe metabolism of Ospemifene can be decreased when combined with Crizotinib.Approved
OuabainOuabain may decrease the cardiotoxic activities of Crizotinib.Approved
OxazepamThe metabolism of Oxazepam can be decreased when combined with Crizotinib.Approved
OxybutyninThe metabolism of Oxybutynin can be decreased when combined with Crizotinib.Approved, Investigational
OxycodoneThe risk or severity of adverse effects can be increased when Crizotinib is combined with Oxycodone.Approved, Illicit, Investigational
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Crizotinib.Approved, Investigational, Vet Approved
OxytocinOxytocin may increase the QTc-prolonging activities of Crizotinib.Approved, Vet Approved
P-NitrophenolThe serum concentration of Crizotinib can be increased when it is combined with P-Nitrophenol.Experimental
PaclitaxelThe risk or severity of adverse effects can be increased when Paclitaxel is combined with Crizotinib.Approved, Vet Approved
PalbociclibThe serum concentration of Crizotinib can be increased when it is combined with Palbociclib.Approved
PaliperidoneCrizotinib may increase the QTc-prolonging activities of Paliperidone.Approved
Palmitic AcidThe serum concentration of Crizotinib can be increased when it is combined with Palmitic Acid.Experimental
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Crizotinib.Approved, Investigational
PanobinostatPanobinostat may increase the QTc-prolonging activities of Crizotinib.Approved, Investigational
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Crizotinib.Approved
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Crizotinib.Approved
ParamethasoneThe metabolism of Paramethasone can be decreased when combined with Crizotinib.Approved
ParecoxibThe metabolism of Parecoxib can be decreased when combined with Crizotinib.Approved
ParicalcitolThe metabolism of Paricalcitol can be decreased when combined with Crizotinib.Approved, Investigational
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Crizotinib.Approved
ParoxetineParoxetine may increase the QTc-prolonging activities of Crizotinib.Approved, Investigational
PasireotidePasireotide may increase the QTc-prolonging activities of Crizotinib.Approved
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Crizotinib.Approved
PenbutololPenbutolol may increase the bradycardic activities of Crizotinib.Approved, Investigational
PentamidinePentamidine may increase the QTc-prolonging activities of Crizotinib.Approved
PentobarbitalThe serum concentration of Crizotinib can be decreased when it is combined with Pentobarbital.Approved, Vet Approved
PerampanelThe metabolism of Perampanel can be decreased when combined with Crizotinib.Approved
PerflutrenPerflutren may increase the QTc-prolonging activities of Crizotinib.Approved
PergolideThe metabolism of Pergolide can be decreased when combined with Crizotinib.Approved, Vet Approved, Withdrawn
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Crizotinib.Approved
PerindoprilThe serum concentration of Crizotinib can be increased when it is combined with Perindopril.Approved
PermethrinThe metabolism of Permethrin can be decreased when combined with Crizotinib.Approved, Investigational
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Crizotinib.Approved
PethidineThe metabolism of Pethidine can be decreased when combined with Crizotinib.Approved
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Crizotinib.Withdrawn
PhenobarbitalThe serum concentration of Crizotinib can be decreased when it is combined with Phenobarbital.Approved
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be decreased when combined with Crizotinib.Approved
PhenprocoumonThe metabolism of Phenprocoumon can be decreased when combined with Crizotinib.Approved
PhenytoinThe serum concentration of Crizotinib can be decreased when it is combined with Phenytoin.Approved, Vet Approved
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Crizotinib.Approved
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Crizotinib.Approved, Investigational
PimozideCrizotinib may increase the QTc-prolonging activities of Pimozide.Approved
PinacidilThe metabolism of Pinacidil can be decreased when combined with Crizotinib.Withdrawn
PindololPindolol may increase the bradycardic activities of Crizotinib.Approved
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Crizotinib.Approved, Investigational
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Crizotinib.Approved
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Crizotinib.Approved
Platelet Activating FactorThe serum concentration of Crizotinib can be decreased when it is combined with Platelet Activating Factor.Experimental
PodofiloxThe metabolism of Podofilox can be decreased when combined with Crizotinib.Approved
PomalidomideThe metabolism of Pomalidomide can be decreased when combined with Crizotinib.Approved
PonatinibThe metabolism of Ponatinib can be decreased when combined with Crizotinib.Approved
Poractant alfaCrizotinib may increase the bradycardic activities of Poractant alfa.Approved
PosaconazoleThe serum concentration of Crizotinib can be increased when it is combined with Posaconazole.Approved, Investigational, Vet Approved
PrasteroneThe metabolism of Prasterone can be decreased when combined with Crizotinib.Approved, Nutraceutical
PrasugrelThe metabolism of Prasugrel can be decreased when combined with Crizotinib.Approved
PravastatinThe metabolism of Pravastatin can be decreased when combined with Crizotinib.Approved
PrazepamThe metabolism of Prazepam can be decreased when combined with Crizotinib.Approved, Illicit
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Crizotinib.Approved, Vet Approved
PrazosinThe serum concentration of Crizotinib can be increased when it is combined with Prazosin.Approved
PrednisoloneThe metabolism of Prednisolone can be decreased when combined with Crizotinib.Approved, Vet Approved
PrednisoneThe metabolism of Prednisone can be decreased when combined with Crizotinib.Approved, Vet Approved
PrimaquinePrimaquine may increase the QTc-prolonging activities of Crizotinib.Approved
PrimidoneThe serum concentration of Crizotinib can be decreased when it is combined with Primidone.Approved, Vet Approved
ProbenecidThe serum concentration of Crizotinib can be increased when it is combined with Probenecid.Approved
ProcainamideCrizotinib may increase the QTc-prolonging activities of Procainamide.Approved
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Crizotinib.Approved, Vet Approved
ProgesteroneThe metabolism of Progesterone can be decreased when combined with Crizotinib.Approved, Vet Approved
ProguanilThe metabolism of Proguanil can be decreased when combined with Crizotinib.Approved
PromazinePromazine may increase the QTc-prolonging activities of Crizotinib.Approved, Vet Approved
PromethazinePromethazine may increase the QTc-prolonging activities of Crizotinib.Approved
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Crizotinib.Approved
PropofolPropofol may increase the QTc-prolonging activities of Crizotinib.Approved, Investigational, Vet Approved
PropranololThe metabolism of Propranolol can be decreased when combined with Crizotinib.Approved, Investigational
ProtriptylineProtriptyline may increase the QTc-prolonging activities of Crizotinib.Approved
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Crizotinib.Approved
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Crizotinib.Approved
QuazepamThe metabolism of Quazepam can be decreased when combined with Crizotinib.Approved, Illicit
QuercetinThe serum concentration of Crizotinib can be increased when it is combined with Quercetin.Experimental
QuetiapineCrizotinib may increase the QTc-prolonging activities of Quetiapine.Approved
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Crizotinib.Approved
QuinidineCrizotinib may increase the QTc-prolonging activities of Quinidine.Approved
QuinineCrizotinib may increase the QTc-prolonging activities of Quinine.Approved
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Crizotinib.Approved, Investigational
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Crizotinib.Approved, Investigational
RamelteonThe metabolism of Ramelteon can be decreased when combined with Crizotinib.Approved, Investigational
RanitidineThe serum concentration of Crizotinib can be increased when it is combined with Ranitidine.Approved
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Crizotinib.Approved, Investigational
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Crizotinib.Approved, Investigational
RegorafenibThe metabolism of Regorafenib can be decreased when combined with Crizotinib.Approved
RepaglinideThe metabolism of Repaglinide can be decreased when combined with Crizotinib.Approved, Investigational
ReserpineThe serum concentration of Crizotinib can be decreased when it is combined with Reserpine.Approved
RetapamulinThe metabolism of Retapamulin can be decreased when combined with Crizotinib.Approved
RifabutinThe serum concentration of Crizotinib can be decreased when it is combined with Rifabutin.Approved
RifampicinThe serum concentration of Crizotinib can be decreased when it is combined with Rifampicin.Approved
RifapentineThe serum concentration of Crizotinib can be decreased when it is combined with Rifapentine.Approved
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Crizotinib.Approved, Investigational
RilpivirineRilpivirine may increase the QTc-prolonging activities of Crizotinib.Approved
RimonabantThe metabolism of Rimonabant can be decreased when combined with Crizotinib.Approved, Investigational
RiociguatThe metabolism of Riociguat can be decreased when combined with Crizotinib.Approved
RisperidoneRisperidone may increase the QTc-prolonging activities of Crizotinib.Approved, Investigational
RitonavirThe serum concentration of Crizotinib can be increased when it is combined with Ritonavir.Approved, Investigational
RivaroxabanThe metabolism of Rivaroxaban can be decreased when combined with Crizotinib.Approved
RivastigmineRivastigmine may increase the bradycardic activities of Crizotinib.Approved, Investigational
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Crizotinib.Investigational, Withdrawn
RolapitantThe metabolism of Rolapitant can be decreased when combined with Crizotinib.Approved
RomidepsinThe metabolism of Romidepsin can be decreased when combined with Crizotinib.Approved, Investigational
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Crizotinib.Approved, Investigational
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Crizotinib.Approved
RosuvastatinThe metabolism of Rosuvastatin can be decreased when combined with Crizotinib.Approved
RotigotineThe metabolism of Rotigotine can be decreased when combined with Crizotinib.Approved
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Crizotinib.Approved, Withdrawn
RuxolitinibRuxolitinib may increase the bradycardic activities of Crizotinib.Approved
SalbutamolSalbutamol may increase the QTc-prolonging activities of Crizotinib.Approved, Vet Approved
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Crizotinib.Approved, Vet Approved
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Crizotinib.Approved
SaquinavirThe serum concentration of Crizotinib can be increased when it is combined with Saquinavir.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Crizotinib.Approved
ScopolamineThe serum concentration of Crizotinib can be increased when it is combined with Scopolamine.Approved
SelegilineThe metabolism of Selegiline can be decreased when combined with Crizotinib.Approved, Investigational, Vet Approved
SelexipagThe metabolism of Selexipag can be decreased when combined with Crizotinib.Approved
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Crizotinib.Approved, Investigational
SertindoleThe metabolism of Sertindole can be decreased when combined with Crizotinib.Approved, Withdrawn
SertralineSertraline may increase the QTc-prolonging activities of Crizotinib.Approved
SevofluraneSevoflurane may increase the QTc-prolonging activities of Crizotinib.Approved, Vet Approved
SibutramineThe metabolism of Sibutramine can be decreased when combined with Crizotinib.Approved, Illicit, Investigational, Withdrawn
SildenafilThe metabolism of Crizotinib can be decreased when combined with Sildenafil.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Crizotinib.Approved
SiltuximabThe serum concentration of Crizotinib can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Crizotinib.Approved
SimvastatinThe metabolism of Simvastatin can be decreased when combined with Crizotinib.Approved
SirolimusThe serum concentration of Sirolimus can be increased when it is combined with Crizotinib.Approved, Investigational
SitagliptinThe metabolism of Sitagliptin can be decreased when combined with Crizotinib.Approved, Investigational
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Crizotinib.Approved
SolifenacinSolifenacin may increase the QTc-prolonging activities of Crizotinib.Approved
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Crizotinib.Approved, Investigational
SorafenibSorafenib may increase the QTc-prolonging activities of Crizotinib.Approved, Investigational
SotalolCrizotinib may increase the QTc-prolonging activities of Sotalol.Approved
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Crizotinib.Approved
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Crizotinib.Experimental
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Crizotinib.Approved
SpironolactoneThe serum concentration of Crizotinib can be increased when it is combined with Spironolactone.Approved
St. John's WortThe serum concentration of Crizotinib can be decreased when it is combined with St. John's Wort.Nutraceutical
StaurosporineThe serum concentration of Crizotinib can be increased when it is combined with Staurosporine.Experimental
StiripentolThe serum concentration of Crizotinib can be increased when it is combined with Stiripentol.Approved
StreptozocinThe serum concentration of Crizotinib can be decreased when it is combined with Streptozocin.Approved
SufentanilThe metabolism of Sufentanil can be decreased when combined with Crizotinib.Approved, Investigational
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Crizotinib.Approved, Vet Approved
SulfamethoxazoleSulfamethoxazole may increase the QTc-prolonging activities of Crizotinib.Approved
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Crizotinib.Approved
SulfisoxazoleSulfisoxazole may increase the QTc-prolonging activities of Crizotinib.Approved, Vet Approved
SumatriptanThe serum concentration of Crizotinib can be increased when it is combined with Sumatriptan.Approved, Investigational
SunitinibSunitinib may increase the QTc-prolonging activities of Crizotinib.Approved, Investigational
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Crizotinib.Approved
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Crizotinib.Approved
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Crizotinib.Approved
TacrineThe serum concentration of Crizotinib can be increased when it is combined with Tacrine.Withdrawn
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Crizotinib.Approved, Investigational
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Crizotinib.Approved, Investigational
TadalafilThe metabolism of Tadalafil can be decreased when combined with Crizotinib.Approved, Investigational
TamoxifenTamoxifen may increase the QTc-prolonging activities of Crizotinib.Approved
TamsulosinThe metabolism of Tamsulosin can be decreased when combined with Crizotinib.Approved, Investigational
TasosartanThe metabolism of Tasosartan can be decreased when combined with Crizotinib.Approved
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Crizotinib.Experimental
Taurocholic AcidThe serum concentration of Crizotinib can be increased when it is combined with Taurocholic Acid.Experimental
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Crizotinib.Approved
TelaprevirThe serum concentration of Crizotinib can be increased when it is combined with Telaprevir.Approved
TelavancinTelavancin may increase the QTc-prolonging activities of Crizotinib.Approved
TelithromycinThe serum concentration of Crizotinib can be increased when it is combined with Telithromycin.Approved
TelmisartanThe serum concentration of Crizotinib can be increased when it is combined with Telmisartan.Approved, Investigational
TemazepamThe metabolism of Temazepam can be decreased when combined with Crizotinib.Approved
TemsirolimusThe metabolism of Temsirolimus can be decreased when combined with Crizotinib.Approved
TeniposideThe metabolism of Teniposide can be decreased when combined with Crizotinib.Approved
TerazosinThe serum concentration of Crizotinib can be increased when it is combined with Terazosin.Approved
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Crizotinib.Approved, Investigational, Vet Approved
TerbutalineTerbutaline may increase the QTc-prolonging activities of Crizotinib.Approved
TerfenadineThe metabolism of Terfenadine can be decreased when combined with Crizotinib.Withdrawn
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Crizotinib.Investigational
TestosteroneThe metabolism of Testosterone can be decreased when combined with Crizotinib.Approved, Investigational
TetrabenazineCrizotinib may increase the QTc-prolonging activities of Tetrabenazine.Approved
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Crizotinib.Approved, Vet Approved
TheophyllineThe metabolism of Theophylline can be decreased when combined with Crizotinib.Approved
ThioridazineCrizotinib may increase the QTc-prolonging activities of Thioridazine.Approved
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Crizotinib.Approved
ThiothixeneThiothixene may increase the QTc-prolonging activities of Crizotinib.Approved
TiagabineThe metabolism of Tiagabine can be decreased when combined with Crizotinib.Approved
TicagrelorThe metabolism of Ticagrelor can be decreased when combined with Crizotinib.Approved
TiclopidineThe metabolism of Crizotinib can be decreased when combined with Ticlopidine.Approved
TimololThe serum concentration of Timolol can be increased when it is combined with Crizotinib.Approved
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Crizotinib.Approved, Investigational
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Crizotinib.Approved
TipranavirThe metabolism of Tipranavir can be decreased when combined with Crizotinib.Approved, Investigational
TizanidineTizanidine may increase the QTc-prolonging activities of Crizotinib.Approved
TocilizumabThe serum concentration of Crizotinib can be decreased when it is combined with Tocilizumab.Approved
TofacitinibTofacitinib may increase the bradycardic activities of Crizotinib.Approved, Investigational
TolterodineTolterodine may increase the QTc-prolonging activities of Crizotinib.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Crizotinib.Approved
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Crizotinib.Approved, Investigational
ToremifeneCrizotinib may increase the QTc-prolonging activities of Toremifene.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Crizotinib.Approved, Investigational
TramadolThe metabolism of Tramadol can be decreased when combined with Crizotinib.Approved, Investigational
TrastuzumabTrastuzumab may increase the cardiotoxic activities of Crizotinib.Approved, Investigational
Trastuzumab emtansineThe metabolism of Trastuzumab emtansine can be decreased when combined with Crizotinib.Approved
TrazodoneTrazodone may increase the QTc-prolonging activities of Crizotinib.Approved, Investigational
TreprostinilTreprostinil may increase the QTc-prolonging activities of Crizotinib.Approved, Investigational
TretinoinThe metabolism of Tretinoin can be decreased when combined with Crizotinib.Approved, Investigational, Nutraceutical
TriamcinoloneThe metabolism of Triamcinolone can be decreased when combined with Crizotinib.Approved, Vet Approved
TriazolamThe metabolism of Triazolam can be decreased when combined with Crizotinib.Approved
TrifluoperazineThe serum concentration of Crizotinib can be increased when it is combined with Trifluoperazine.Approved
TriflupromazineThe serum concentration of Crizotinib can be increased when it is combined with Triflupromazine.Approved, Vet Approved
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Crizotinib.Approved
TrimethoprimTrimethoprim may increase the QTc-prolonging activities of Crizotinib.Approved, Vet Approved
TrimipramineTrimipramine may increase the QTc-prolonging activities of Crizotinib.Approved
TriptorelinTriptorelin may increase the QTc-prolonging activities of Crizotinib.Approved, Vet Approved
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Crizotinib.Withdrawn
TroleandomycinThe metabolism of Troleandomycin can be decreased when combined with Crizotinib.Approved
UdenafilThe metabolism of Udenafil can be decreased when combined with Crizotinib.Approved, Investigational
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Crizotinib.Approved
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Crizotinib.Approved
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Crizotinib.Investigational, Withdrawn
Valproic AcidThe metabolism of Valproic Acid can be decreased when combined with Crizotinib.Approved, Investigational
VandetanibCrizotinib may increase the QTc-prolonging activities of Vandetanib.Approved
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Crizotinib.Investigational
VardenafilVardenafil may increase the QTc-prolonging activities of Crizotinib.Approved
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Crizotinib.Approved
VemurafenibCrizotinib may increase the QTc-prolonging activities of Vemurafenib.Approved
VenetoclaxThe metabolism of Venetoclax can be decreased when combined with Crizotinib.Approved
VenlafaxineVenlafaxine may increase the QTc-prolonging activities of Crizotinib.Approved
VerapamilThe metabolism of Crizotinib can be decreased when combined with Verapamil.Approved
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Crizotinib.Investigational
VilanterolVilanterol may increase the QTc-prolonging activities of Crizotinib.Approved
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Crizotinib.Approved
VinblastineThe metabolism of Vinblastine can be decreased when combined with Crizotinib.Approved
VincristineThe serum concentration of Vincristine can be increased when it is combined with Crizotinib.Approved, Investigational
VincristineThe metabolism of Vincristine can be decreased when combined with Crizotinib.Approved, Investigational
VindesineThe serum concentration of Vindesine can be increased when it is combined with Crizotinib.Approved
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Crizotinib.Approved, Investigational
VismodegibThe metabolism of Vismodegib can be decreased when combined with Crizotinib.Approved
VoriconazoleThe serum concentration of Crizotinib can be increased when it is combined with Voriconazole.Approved, Investigational
VorinostatVorinostat may increase the QTc-prolonging activities of Crizotinib.Approved, Investigational
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Crizotinib.Approved
WarfarinThe metabolism of Warfarin can be decreased when combined with Crizotinib.Approved
YohimbineThe metabolism of Yohimbine can be decreased when combined with Crizotinib.Approved, Vet Approved
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Crizotinib.Approved, Investigational
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Crizotinib.Approved
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Crizotinib.Approved, Illicit, Investigational
ZidovudineThe metabolism of Zidovudine can be decreased when combined with Crizotinib.Approved
ZileutonThe metabolism of Zileuton can be decreased when combined with Crizotinib.Approved, Investigational, Withdrawn
ZimelidineThe serum concentration of Crizotinib can be increased when it is combined with Zimelidine.Withdrawn
ZiprasidoneCrizotinib may increase the QTc-prolonging activities of Ziprasidone.Approved
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Crizotinib.Approved
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Crizotinib.Withdrawn
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Crizotinib.Approved, Investigational
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Crizotinib.Approved
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Crizotinib.Approved, Investigational
Food Interactions
  • When given with a high-fat meal, AUC and Cmax were reduced by 14%. Despite this, crizotinib may be given with or without food.
References
Synthesis ReferenceNot Available
General References
  1. Timm A, Kolesar JM: Crizotinib for the treatment of non-small-cell lung cancer. Am J Health Syst Pharm. 2013 Jun 1;70(11):943-7. doi: 10.2146/ajhp120261. [PubMed:23686600 ]
  2. Forde PM, Rudin CM: Crizotinib in the treatment of non-small-cell lung cancer. Expert Opin Pharmacother. 2012 Jun;13(8):1195-201. doi: 10.1517/14656566.2012.688029. [PubMed:22594847 ]
External Links
ATC CodesL01XE16
AHFS Codes
  • 10:00
PDB EntriesNot Available
FDA labelDownload (279 KB)
MSDSDownload (105 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+1.0
Blood Brain Barrier+0.9721
Caco-2 permeable-0.5672
P-glycoprotein substrateSubstrate0.6938
P-glycoprotein inhibitor INon-inhibitor0.6713
P-glycoprotein inhibitor IIInhibitor0.7105
Renal organic cation transporterInhibitor0.5464
CYP450 2C9 substrateNon-substrate0.7545
CYP450 2D6 substrateNon-substrate0.7023
CYP450 3A4 substrateSubstrate0.6029
CYP450 1A2 substrateInhibitor0.6676
CYP450 2C9 inhibitorInhibitor0.5
CYP450 2D6 inhibitorNon-inhibitor0.8662
CYP450 2C19 inhibitorInhibitor0.6237
CYP450 3A4 inhibitorNon-inhibitor0.6301
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.8676
Ames testNon AMES toxic0.5981
CarcinogenicityNon-carcinogens0.8018
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.6581 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Strong inhibitor0.643
hERG inhibition (predictor II)Inhibitor0.7877
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage forms
FormRouteStrength
CapsuleOral200 mg
CapsuleOral200 mg/1
CapsuleOral250 mg/1
CapsuleOral250 mg
PricesNot Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2517256 No2013-04-302024-02-26Canada
CA2577937 No2010-12-212025-08-15Canada
CA2578066 No2011-10-112025-08-15Canada
CA2632286 No2011-11-152026-11-23Canada
US7230098 No2005-08-262025-08-26Us
US7825137 No2007-05-122027-05-12Us
US7858643 No2009-10-082029-10-08Us
US8217057 No2009-11-062029-11-06Us
US8785632 No2005-03-012025-03-01Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
logP1.83 MSDS
Predicted Properties
PropertyValueSource
Water Solubility0.00611 mg/mLALOGPS
logP3.82ALOGPS
logP3.57ChemAxon
logS-4.9ALOGPS
pKa (Strongest Basic)10.12ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area77.99 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity128.43 m3·mol-1ChemAxon
Polarizability45.44 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as pyrazolylpyridines. These are compounds containing a pyrazolylpyridine skeleton, which consists of a pyrazole linked (not fused) to a pyridine by a bond.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassPyridines and derivatives
Sub ClassPyrazolylpyridines
Direct ParentPyrazolylpyridines
Alternative Parents
Substituents
  • 3-pyrazolylpyridine
  • 1,3-dichlorobenzene
  • Halobenzene
  • Fluorobenzene
  • Chlorobenzene
  • Aminopyridine
  • 4-aminopiperidine
  • Alkyl aryl ether
  • Imidolactam
  • Benzenoid
  • Primary aromatic amine
  • Piperidine
  • Monocyclic benzene moiety
  • Aryl halide
  • Aryl fluoride
  • Aryl chloride
  • Heteroaromatic compound
  • Pyrazole
  • Azole
  • Azacycle
  • Secondary amine
  • Ether
  • Secondary aliphatic amine
  • Hydrocarbon derivative
  • Primary amine
  • Organooxygen compound
  • Organonitrogen compound
  • Organofluoride
  • Organochloride
  • Organohalogen compound
  • Amine
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
  • 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine (CHEBI:64310 )

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Transmembrane receptor protein tyrosine kinase activity
Specific Function:
Neuronal orphan receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost...
Gene Name:
ALK
Uniprot ID:
Q9UM73
Molecular Weight:
176440.535 Da
References
  1. Forde PM, Rudin CM: Crizotinib in the treatment of non-small-cell lung cancer. Expert Opin Pharmacother. 2012 Jun;13(8):1195-201. doi: 10.1517/14656566.2012.688029. [PubMed:22594847 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Protein tyrosine kinase activity
Specific Function:
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream sig...
Gene Name:
MET
Uniprot ID:
P08581
Molecular Weight:
155540.035 Da
References
  1. Forde PM, Rudin CM: Crizotinib in the treatment of non-small-cell lung cancer. Expert Opin Pharmacother. 2012 Jun;13(8):1195-201. doi: 10.1517/14656566.2012.688029. [PubMed:22594847 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Timm A, Kolesar JM: Crizotinib for the treatment of non-small-cell lung cancer. Am J Health Syst Pharm. 2013 Jun 1;70(11):943-7. doi: 10.2146/ajhp120261. [PubMed:23686600 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Timm A, Kolesar JM: Crizotinib for the treatment of non-small-cell lung cancer. Am J Health Syst Pharm. 2013 Jun 1;70(11):943-7. doi: 10.2146/ajhp120261. [PubMed:23686600 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Timm A, Kolesar JM: Crizotinib for the treatment of non-small-cell lung cancer. Am J Health Syst Pharm. 2013 Jun 1;70(11):943-7. doi: 10.2146/ajhp120261. [PubMed:23686600 ]
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Drug created on March 28, 2013 11:22 / Updated on December 05, 2016 02:43