Formyltetrahydrofolates
- Name
- Formyltetrahydrofolates
- Accession Number
- DBCAT004981
- Description
Tetrahydrofolates which are substituted by a formyl group at either the nitrogen atom in the 5 position or the nitrogen atom in the 10 position. N(5)-Formyltetrahydrofolate is leucovorin (citrovorum factor) while N(10)-formyltetrahydrofolate is an active coenzyme which functions as a carrier of the formyl group in a number of enzymatic reactions.
- Drugs
Drug Drug Description Leucovorin A folate analog used to treat the toxic effects of methotrexate and other folate antagonists, to treat megaloblastic anemia, and to provide palliative treatment of colorectal cancer. Levoleucovorin A folate analog used after high dose methotrexate for osteosarcoma, to reduce the toxic effects of folate analogs, and with 5-fluorouracil in palliative treatment of advanced metastatic colorectal cancer. - Drugs & Drug Targets
Drug Target Type Leucovorin Solute carrier family 22 member 8 transporter Levoleucovorin Serine hydroxymethyltransferase target