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Identification
NameLeucovorin
Accession NumberDB00650  (APRD00698)
TypeSmall Molecule
GroupsApproved
DescriptionFolinic Acid (also known as 5-formyl tetrahydrofolic acid or leucovorin) is the 5-formyl derivative of tetrahydrofolic acid, a necessary co-factor in the body. Commercially available leucovorin is composed of a 1:1 racemic mixture of the dextrorotary and levorotary isomers, while levoleucovorin contains only the pharmacologically active levo-isomer. In vitro, the levo-isomer has been shown to be rapidly converted to the biologically available methyl-tetrahydrofolate form while the dextro form is slowly excreted by the kidneys. Despite this difference in activity, the two commercially available forms have been shown to be pharmacokinetically identical and may be used interchangeably with limited differences in efficacy or side effects (Kovoor et al, 2009). As folate analogs, leucovorin and levoleucovorin are both used to counteract the toxic effects of folic acid antagonists, such as methotrexate, which act by inhibiting the enzyme dihydrofolate reductase (DHFR). They are indicated for use as rescue therapy following use of high-dose methotrexate in the treatment of osteosarcoma or for diminishing the toxicity associated with inadvertent overdosage of folic acid antagonists. Injectable forms are also indicated for use in the treatment of megaloblastic anemias due to folic acid deficiency when oral therapy is not feasible and for use in combination with 5-fluorouracil to prolong survival in the palliative treatment of patients with advanced colorectal cancer. Folic acid is an essential B vitamin required by the body for the synthesis of purines, pyrimidines, and methionine before incorporation into DNA or protein. However, in order to function in this role, it must first be reduced by the enzyme dihydrofolate reductase (DHFR) into the cofactors dihydrofolate (DHF) and tetrahydrofolate (THF). This important pathway, which is required for de novo synthesis of nucleic acids and amino acids, is disrupted when high-dose methotrexate is used for cancer therapy. As methotrexate functions as a DHFR inhibitor to prevent DNA synthesis in rapidly dividing cells, it also prevents the formation of DHF and THF. This results in a deficiency of coenzymes and a resultant buildup of toxic substances that are responsible for numerous adverse side effects associated with methotrexate therapy. As levoleucovorin and leucovorin are analogs of tetrahydrofolate (THF), they are able to bypass DHFR reduction and act as a cellular replacement for the co-factor THF, thereby preventing these toxic side effects.
Structure
Thumb
Synonyms
(5-formyl-5,6,7,8-tetrahydropteroyl)glutamate
10-Formyl-7,8-dihydrofolic acid
5-Formyl-5,6,7,8-tetrahydrofolic acid
5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid
5-Formyltetrahydrofolate
5-formyltetrahydrofolic acid
Acide folinique
folinate
Folinic acid
L(-)-5-Formyl-5,6,7,8-tetrahydrofolic acid
Leucovorinum
N-(5-formyl-5,6,7,8-tetrahydropteroyl)-L-glutamic acid
N5-Formyl-5,6,7,8-tetrahydrofolic acid
N5-Formyltetrahydrofolic acid
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Lederle LeucovorinTablet5 mgOralPfizer1996-10-25Not applicableCanada
Lederle Leucovorin - Liq Im IV 10mg/mlLiquid10 mgIntramuscular; IntravenousWyeth Ayerst Canada Inc.1997-02-042001-10-29Canada
Lederle Leucovorin 350mg/vialPowder, for solution350 mgIntramuscular; IntravenousLederle Cyanamid Canada Inc.1991-12-311999-04-12Canada
Lederle Leucovorin 50mg/vialPowder, for solution50 mgIntramuscular; IntravenousLederle Cyanamid Canada Inc.1991-12-311997-08-14Canada
Lederle Leucovorin Liq 10mg/mlLiquid10 mgIntramuscular; IntravenousLederle Cyanamid Canada Inc.1991-12-311999-04-12Canada
Lederle Leucovorin-pws Im IV 350mg/vialPowder, for solution350 mgIntramuscular; IntravenousWyeth Ayerst Canada Inc.1997-02-042002-05-17Canada
Lederle Leucovorin-pws Im IV 50mg/vialPowder, for solution50 mgIntramuscular; IntravenousWyeth Ayerst Canada Inc.1997-02-042001-06-05Canada
Leucovorin Calcium Inj 10mg/mlLiquid10 mgIntramuscular; IntravenousDavid Bull Laboratories (Pty) Ltd.1992-12-311997-08-14Canada
Leucovorin Calcium InjectionSolution10 mgIntramuscular; IntravenousTeva1994-12-31Not applicableCanada
Leucovorin Calcium InjectionSolution10 mgIntramuscular; IntravenousSandoz Canada IncorporatedNot applicableNot applicableCanada
Leucovorin Calcium Injection USPLiquid10 mgIntravenousHospira, Inc.1997-05-09Not applicableCanada
Leucovorin Calcium Injection USPLiquid10 mgIntramuscular; IntravenousHospira, Inc.1997-08-07Not applicableCanada
Leucovorin Calcium Tab 5mgTablet5 mgOralLederle Cyanamid Canada Inc.1980-12-311997-08-14Canada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
LeucovorinInjection, powder, for solution350 mg/17.5mLIntramuscular; IntravenousSagent Pharmaceuticals2012-09-15Not applicableUs
LeucovorinInjection, powder, for solution50 mg/5mLIntramuscular; IntravenousSagent Pharmaceuticals2012-09-15Not applicableUs
LeucovorinInjection, powder, for solution10 mg/mLIntramuscular; IntravenousBlue Point Laboratories2016-07-01Not applicableUs
LeucovorinInjection, powder, for solution100 mg/10mLIntramuscular; IntravenousSagent Pharmaceuticals2012-09-15Not applicableUs
LeucovorinInjection, powder, for solution20 mg/mLIntramuscular; IntravenousBlue Point Laboratories2016-07-01Not applicableUs
LeucovorinInjection, powder, for solution200 mg/20mLIntramuscular; IntravenousSagent Pharmaceuticals2012-09-15Not applicableUs
Leucovorin CalciumTablet5 mg/1OralRemedy Repack2013-09-272016-10-13Us
Leucovorin CalciumInjection, powder, lyophilized, for solution50 mg/5mLIntramuscular; IntravenousWest Ward Pharmaceutical1987-09-14Not applicableUs
Leucovorin CalciumInjection, powder, lyophilized, for solution100 mg/10mLIntramuscular; IntravenousTeva Parenteral Medicines, Inc.1994-02-01Not applicableUs
Leucovorin CalciumTablet15 mg/1OralWest Ward Pharmaceutical1993-02-22Not applicableUs
Leucovorin CalciumInjection, powder, lyophilized, for solution200 mg/20mLIntramuscular; IntravenousFresenius Kabi2010-09-18Not applicableUs
Leucovorin CalciumTablet5 mg/1OralTeva1990-06-30Not applicableUs
Leucovorin CalciumInjection, powder, lyophilized, for solution350 mg/17.5mLIntramuscular; IntravenousWest Ward Pharmaceutical2000-04-20Not applicableUs
Leucovorin CalciumTablet5 mg/1OralRemedy Repack2013-05-222017-01-12Us
Leucovorin CalciumTablet25 mg/1OralAmerincan Health Packaging2016-10-01Not applicableUs
Leucovorin CalciumTablet25 mg/1OralWest Ward Pharmaceutical1993-02-22Not applicableUs
Leucovorin CalciumInjection, powder, lyophilized, for solution500 mg/50mLIntramuscular; IntravenousFresenius Kabi2010-09-18Not applicableUs
Leucovorin CalciumTablet25 mg/1OralTeva1990-06-30Not applicableUs
Leucovorin CalciumInjection, powder, lyophilized, for solution200 mg/20mLIntramuscular; IntravenousWest Ward Pharmaceutical1995-05-23Not applicableUs
Leucovorin CalciumTablet5 mg/1OralMylan Institutional1996-02-26Not applicableUs
Leucovorin CalciumTablet5 mg/1OralPhysicians Total Care, Inc.2002-04-15Not applicableUs
Leucovorin CalciumTablet5 mg/1OralWest Ward Pharmaceutical1993-02-22Not applicableUs
Leucovorin CalciumTablet5 mg/1OralWest Ward Pharmaceutical1993-02-22Not applicableUs
Leucovorin CalciumTablet25 mg/1OralMylan Institutional1997-08-27Not applicableUs
Leucovorin CalciumInjection, powder, lyophilized, for solution100 mg/10mLIntramuscular; IntravenousWest Ward Pharmaceutical1988-03-28Not applicableUs
Leucovorin CalciumTablet15 mg/1OralPhysicians Total Care, Inc.2008-07-08Not applicableUs
Leucovorin CalciumInjection, powder, lyophilized, for solution350 mg/17.5mLIntramuscular; IntravenousTeva Parenteral Medicines, Inc.1997-06-12Not applicableUs
Leucovorin CalciumTablet10 mg/1OralWest Ward Pharmaceutical1993-02-22Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
UzelNot Available
WellcovorinNot Available
Brand mixtures
NameLabellerIngredients
Pyrimethamine LeucovorinSouth Coast Specialty Compounding, Inc. D/B/A Park Compounding
Salts
Name/CASStructureProperties
Leucovorin calcium
1492-18-8
Thumb
  • InChI Key: KVUAALJSMIVURS-ZEDZUCNESA-L
  • Monoisotopic Mass: 511.1128369
  • Average Mass: 511.508
DBSALT000342
Leucovorin calcium pentahydrate
6035-45-6
Thumb
  • InChI Key: NPPBLUASYYNAIG-ZIGBGYJWSA-L
  • Monoisotopic Mass: 601.1656604
  • Average Mass: 601.583
DBSALT001441
Leucovorin sodium
163254-40-8
Thumb
  • InChI Key: FSDMNNPYPVJNAT-RIWFDJIXSA-L
  • Monoisotopic Mass: 517.129785411
  • Average Mass: 517.403
DBSALT000789
Categories
UNIIQ573I9DVLP
CAS number58-05-9
WeightAverage: 473.446
Monoisotopic: 473.165896109
Chemical FormulaC20H23N7O7
InChI KeyVVIAGPKUTFNRDU-ABLWVSNPSA-N
InChI
InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/t12?,13-/m0/s1
IUPAC Name
(2S)-2-[(4-{[(2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid
SMILES
[H]C(=O)N1C(CNC2=CC=C(C=C2)C(=O)N[C@@H](CCC(O)=O)C(O)=O)CNC2=C1C(=O)NC(N)=N2
Pharmacology
IndicationFor the treatment of osteosarcoma (after high dose methotrexate therapy). Used to diminish the toxicity and counteract the effects of impaired methotrexate elimination and of inadvertent overdosages of folic acid antagonists, and to treat megaloblastic anemias due to folic acid deficiency. Also used in combination with 5-fluorouracil to prolong survival in the palliative treatment of patients with advanced colorectal cancer.
Structured Indications
PharmacodynamicsLeucovorin is one of several active, chemically reduced derivatives of folic acid. It is useful as an antidote to drugs which act as folic acid antagonists. Leucovorin is a mixture of the diastereoisomers of the 5-formyl derivative of tetrahydrofolic acid (THF). The biologically active compound of the mixture is the (-)-l-isomer, known as Citrovorum factor or (-)-folinic acid. Leucovorin does not require reduction by the enzyme dihydrofolate reductase in order to participate in reactions utilizing folates as a source of “one-carbon” moieties. Administration of leucovorin can counteract the therapeutic and toxic effects of folic acid antagonists such as methotrexate, which act by inhibiting dihydrofolate reductase. Leucovorin has also been used to enhance the activity of fluorouracil.
Mechanism of actionAs leucovorin is a derivative of folic acid, it can be used to increase levels of folic acid under conditions favoring folic acid inhibition (following treatment of folic acid antagonists such as methotrexate). Leucovorin enhances the activity of fluorouracil by stabilizing the bond of the active metabolite (5-FdUMP) to the enzyme thymidylate synthetase.
Related Articles
AbsorptionFollowing oral administration, leucovorin is rapidly absorbed. The apparent bioavailability of leucovorin was 97% for 25 mg, 75% for 50 mg, and 37% for 100 mg.
Volume of distributionNot Available
Protein binding~15%
Metabolism

Hepatic and intestinal mucosal, the main metabolite being the active 5-methyltetrahydrofolate. Leucovorin is readily converted to another reduced folate, 5,10-methylenetetrahydrofolate, which acts to stabilize the binding of fluorodeoxyridylic acid to thymidylate synthase and thereby enhances the inhibition of this enzyme.

SubstrateEnzymesProduct
Leucovorin
Not Available
5-MethyltetrahydrofolateDetails
Route of eliminationNot Available
Half life6.2 hours
ClearanceNot Available
ToxicityLD50>8000 mg/kg (orally in rats). Excessive amounts of leucovorin may nullify the chemotherapeutic effect of folic acid antagonists.
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Methylenetetrahydrofolate Reductase Deficiency (MTHFRD)DiseaseSMP00543
Methotrexate Action PathwayDrug actionSMP00432
Folate MetabolismMetabolicSMP00053
Folate malabsorption, hereditaryDiseaseSMP00724
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
CapecitabineThe risk or severity of adverse effects can be increased when Leucovorin is combined with Capecitabine.Approved, Investigational
FluorouracilThe risk or severity of adverse effects can be increased when Leucovorin is combined with Fluorouracil.Approved
FosphenytoinThe serum concentration of Fosphenytoin can be decreased when it is combined with Leucovorin.Approved
GlucarpidaseThe serum concentration of the active metabolites of Leucovorin can be reduced when Leucovorin is used in combination with Glucarpidase resulting in a loss in efficacy.Approved
PhenobarbitalThe serum concentration of Phenobarbital can be decreased when it is combined with Leucovorin.Approved
PhenytoinThe serum concentration of Phenytoin can be decreased when it is combined with Leucovorin.Approved, Vet Approved
PrimidoneThe serum concentration of Primidone can be decreased when it is combined with Leucovorin.Approved, Vet Approved
RaltitrexedThe therapeutic efficacy of Raltitrexed can be decreased when used in combination with Leucovorin.Approved, Investigational
TegafurThe risk or severity of adverse effects can be increased when Leucovorin is combined with Tegafur.Approved
Food InteractionsNot Available
References
Synthesis Reference

James C. Wisowaty, Roy A. Swaringen, David A. Yeowell, “Synthesis of leucovorin.” U.S. Patent US4500711, issued July, 1955.

US4500711
General References
  1. Jardine LF, Ingram LC, Bleyer WA: Intrathecal leucovorin after intrathecal methotrexate overdose. J Pediatr Hematol Oncol. 1996 Aug;18(3):302-4. [PubMed:8689347 ]
  2. Zittoun J: Pharmacokinetics and in vitro studies of l-leucovorin. Comparison with the d and d,l-leucovorin. Ann Oncol. 1993;4 Suppl 2:1-5. [PubMed:8353099 ]
  3. Chuang VT, Suno M: Levoleucovorin as replacement for leucovorin in cancer treatment. Ann Pharmacother. 2012 Oct;46(10):1349-57. doi: 10.1345/aph.1Q677. Epub 2012 Oct 2. [PubMed:23032661 ]
  4. Stover PJ, Field MS: Trafficking of intracellular folates. Adv Nutr. 2011 Jul;2(4):325-31. doi: 10.3945/an.111.000596. Epub 2011 Jun 28. [PubMed:22332074 ]
  5. Allegra CJ, Chabner BA, Drake JC, Lutz R, Rodbard D, Jolivet J: Enhanced inhibition of thymidylate synthase by methotrexate polyglutamates. J Biol Chem. 1985 Aug 15;260(17):9720-6. [PubMed:2410416 ]
  6. Kovoor PA, Karim SM, Marshall JL: Is levoleucovorin an alternative to racemic leucovorin? A literature review. Clin Colorectal Cancer. 2009 Oct;8(4):200-6. doi: 10.3816/CCC.2009.n.034. [PubMed:19822510 ]
External Links
ATC CodesV03AF03
AHFS Codes
  • 92:00.00
PDB EntriesNot Available
FDA labelDownload (2.95 MB)
MSDSDownload (72.7 KB)
Clinical Trials
Clinical Trials
PhaseStatusPurposeConditionsCount
0Not Yet RecruitingTreatmentAdenocarcinoma of the Rectum / Cancer of Rectum / Cancer of the Rectum / Rectal Cancers / Rectum Cancer / Rectum Neoplasms1
1Active Not RecruitingSupportive CareGraft Versus Host Disease (GVHD) / Leukemias / Lymphoma NOS / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes1
1Active Not RecruitingTreatmentAcinar Cell Adenocarcinoma of the Pancreas / Duct Cell Adenocarcinoma of the Pancreas / Recurrent Pancreatic Cancer / Stage IV Pancreatic Cancer1
1Active Not RecruitingTreatmentAdenocarcinoma of the Pancreas / Stage III Pancreatic Cancer1
1Active Not RecruitingTreatmentAdvanced Cancers1
1Active Not RecruitingTreatmentAnal Cancer / Carcinoma of the Appendix / Colorectal Cancers / Esophageal Cancers / Extrahepatic Bile Duct Cancer / Gallbladder Cancer / Gastric Cancers / Gastrointestinal Carcinoid Tumor / Gastrointestinal Stromal Tumors / Liver Cancer / Pancreatic Cancers / Small Intestine Cancer1
1Active Not RecruitingTreatmentCancer of Colon / Cancer of Pancreas / Colon Carcinoma / Colorectal Cancers / Malignant Neoplasm of Large Intestine / Malignant Tumor of Colon / Neoplasms, Pancreatic / Pancreatic Cancers1
1Active Not RecruitingTreatmentCancers1
1Active Not RecruitingTreatmentColorectal Cancers2
1Active Not RecruitingTreatmentColorectal Cancers / Metastatic Cancers1
1Active Not RecruitingTreatmentEsophageal Cancers / Gastric Cancers1
1Active Not RecruitingTreatmentNeoplasms, Pancreatic1
1Active Not RecruitingTreatmentRecurrent Colon Cancer / Recurrent Rectal Cancer / Stage IVA Colon Cancer / Stage IVA Rectal Cancer / Stage IVB Colon Cancer / Stage IVB Rectal Cancer1
1Active Not RecruitingTreatmentRecurrent Colon Carcinoma / Recurrent Rectal Carcinoma / Stage IVA Colon Cancer / Stage IVA Rectal Cancer / Stage IVB Colon Cancer / Stage IVB Rectal Cancer1
1CompletedBasic ScienceMild Hyperhomocysteinemia1
1CompletedBasic ScienceRheumatoid Arthritis (RA)1
1CompletedDiagnosticRecurrent or Metastatic Colorectal Cancer1
1CompletedTreatmentAdenocarcinoma of the Rectum / Mucinous Adenocarcinoma of the Rectum / Signet Ring Adenocarcinoma of the Rectum / Stage IIA Rectal Cancer / Stage IIB Rectal Cancer / Stage IIC Rectal Cancer / Stage IIIA Rectal Cancer / Stage IIIB Rectal Cancer / Stage IIIC Rectal Cancer1
1CompletedTreatmentAdenocarcinomas / Colorectal / Metastatic1
1CompletedTreatmentAdvanced Cancers1
1CompletedTreatmentAdvanced Colorectal Carcinoma1
1CompletedTreatmentAdvanced Solid Tumors1
1CompletedTreatmentAdvanced Solid Tumors / Liver Cancer1
1CompletedTreatmentBrain and Central Nervous System Tumors / Sarcomas / Unspecified Childhood Solid Tumor, Protocol Specific1
1CompletedTreatmentCancers1
1CompletedTreatmentChildhood Central Nervous System Choriocarcinoma / Childhood Central Nervous System Embryonal Tumor / Childhood Central Nervous System Germ Cell Tumor / Childhood Central Nervous System Germinoma / Childhood Central Nervous System Mixed Germ Cell Tumor / Childhood Central Nervous System Teratoma / Childhood Central Nervous System Yolk Sac Tumor / Recurrent Childhood Brain Stem Glioma / Recurrent Childhood Central Nervous System Embryonal Tumor / Unspecified Childhood Solid Tumor, Protocol Specific1
1CompletedTreatmentChronic Myeloproliferative Disorders / Leukemias / Lymphoma NOS / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Precancerous Conditions / Unspecified Adult Solid Tumor, Protocol Specific1
1CompletedTreatmentColorectal Cancers5
1CompletedTreatmentColorectal Cancers / Diarrhea / Neutropenias1
1CompletedTreatmentColorectal Cancers / Esophageal Cancers / Extrahepatic Bile Duct Cancer / Gallbladder Cancer / Liver Cancer / Lung Cancers / Lymphoma NOS / Pancreatic Cancers / Small Intestine Cancer / Unspecified Adult Solid Tumor, Protocol Specific1
1CompletedTreatmentColorectal Cancers / Lung Cancers1
1CompletedTreatmentColorectal Cancers / Metastatic Cancers1
1CompletedTreatmentEsophageal Cancers / Gastric Cancers / Liver Cancer1
1CompletedTreatmentGastro-Intestinal Cancer1
1CompletedTreatmentHealthy Adults1
1CompletedTreatmentInfection, Human Immunodeficiency Virus / Non-Hodgkin's Lymphoma (NHL)1
1CompletedTreatmentInfection, Human Immunodeficiency Virus / Pneumonia, Pneumocystis Carinii2
1CompletedTreatmentInfection, Human Immunodeficiency Virus / Toxoplasmosis, Cerebral2
1CompletedTreatmentLymphoma NOS / Neoplasms1
1CompletedTreatmentLymphoma NOS / Unspecified Adult Solid Tumor, Protocol Specific1
1CompletedTreatmentMetastatic Colorectal Cancers1
1CompletedTreatmentMucinous Adenocarcinoma of the Colon / Mucinous Adenocarcinoma of the Rectum / Recurrent Colon Cancer / Recurrent Rectal Cancer / Signet Ring Adenocarcinoma of the Colon / Signet Ring Adenocarcinoma of the Rectum / Stage IIIA Colon Cancer / Stage IIIA Rectal Cancer / Stage IIIB Colon Cancer / Stage IIIB Rectal Cancer / Stage IIIC Colon Cancer / Stage IIIC Rectal Cancer / Stage IVA Colon Cancer / Stage IVA Rectal Cancer / Stage IVB Colon Cancer / Stage IVB Rectal Cancer1
1CompletedTreatmentNeoplasms1
1CompletedTreatmentNeoplasms Malignant1
1CompletedTreatmentNeoplasms Metastasis / Neoplasms, Colorectal / Neoplasms, Liver1
1CompletedTreatmentPeritoneal Cavity Cancer1
1CompletedTreatmentRecurrent Colon Cancer / Recurrent Rectal Cancer / Stage III Colon Cancer / Stage III Rectal Cancer / Stage IV Colon Cancer / Stage IV Rectal Cancer / Unspecified Adult Solid Tumor, Protocol Specific1
1CompletedTreatmentRecurrent Colon Cancer / Recurrent Rectal Cancer / Stage IV Colon Cancer / Stage IV Rectal Cancer1
1CompletedTreatmentSarcomas2
1CompletedTreatmentUnspecified Adult Solid Tumor, Protocol Specific11
1Enrolling by InvitationTreatmentMucinous Adenocarcinoma of the Rectum / Rectal Adenocarcinoma / Recurrent Rectal Cancer / Signet Ring Adenocarcinoma of the Rectum / Stage IIA Rectal Cancer / Stage IIA to IIIC Rectal Cancer / Stage IIB Rectal Cancer / Stage IIC Rectal Cancer / Stage IIIA Rectal Cancer / Stage IIIB Rectal Cancer / Stage IIIC Rectal Cancer1
1Not Yet RecruitingTreatmentTumors, Solid1
1RecruitingTreatmentAcinar Cell Adenocarcinoma of the Pancreas / Adenocarcinoma of the Gallbladder / Adenocarcinoma of Unknown Primary / Adult Primary Cholangiocellular Carcinoma / Advanced Adult Primary Liver Cancer / Cholangiocarcinoma of the Extrahepatic Bile Duct / Cholangiocarcinoma of the Gallbladder / Diffuse Adenocarcinoma of the Stomach / Duct Cell Adenocarcinoma of the Pancreas / Intestinal Adenocarcinoma of the Stomach / Localized Unresectable Adult Primary Liver Cancer / Metastatic Carcinoma of Unknown Primary / Metastatic Extrahepatic Bile Duct Cancer / Mixed Adenocarcinoma of the Stomach / Mucinous Adenocarcinoma of the Colon / Mucinous Adenocarcinoma of the Rectum / Newly Diagnosed Carcinoma of Unknown Primary / Signet Ring Adenocarcinoma of the Colon / Signet Ring Adenocarcinoma of the Rectum / Stage III Pancreatic Cancer / Stage IIIA Colon Cancer / Stage IIIA Gallbladder Cancer / Stage IIIA Gastric Cancer / Stage IIIA Rectal Cancer / Stage IIIB Colon Cancer / Stage IIIB Gallbladder Cancer / Stage IIIB Gastric Cancer / Stage IIIB Rectal Cancer / Stage IIIC Colon Cancer / Stage IIIC Gastric Cancer / Stage IIIC Rectal Cancer / Stage IV Gastric Cancer / Stage IV Pancreatic Cancer / Stage IVA Colon Cancer / Stage IVA Gallbladder Cancer / Stage IVA Rectal Cancer / Stage IVB Colon Cancer / Stage IVB Gallbladder Cancer / Stage IVB Rectal Cancer / Unresectable Extrahepatic Bile Duct Cancer1
1RecruitingTreatmentAdenocarcinomas / Neoplasms, Pancreatic / Pancreatic Cancers1
1RecruitingTreatmentAdult Anaplastic Astrocytoma / Adult Anaplastic Oligodendroglioma / Adult Giant Cell Glioblastoma / Adult Glioblastoma / Adult Gliosarcoma / Anaplastic Oligoastrocytoma / Recurrent Adult Brain Tumor1
1RecruitingTreatmentAdvanced Gastrointestinal Cancers1
1RecruitingTreatmentCancer, Breast / Colorectal Cancers / Esophagogastric Cancer / Non-Small-Cell Lung Carcinoma (NSCLC) / Pancreatic Cancers / Tumors1
1RecruitingTreatmentCancers1
1RecruitingTreatmentColorectal Cancers / Liver Metastases1
1RecruitingTreatmentContiguous Stage II Adult Lymphoblastic Lymphoma / Noncontiguous Stage II Adult Lymphoblastic Lymphoma / Stage I Adult Lymphoblastic Lymphoma / Stage III Adult Lymphoblastic Lymphoma / Stage IV Adult Lymphoblastic Lymphoma / Untreated Adult Acute Lymphoblastic Leukemia1
1RecruitingTreatmentKRAS Mutant Metastatic Colorectal Cancer1
1RecruitingTreatmentMalignant Digestive System Neoplasm1
1RecruitingTreatmentMetastatic Colorectal Cancers1
1RecruitingTreatmentMetastatic Colorectal Cancers / Recurrent Colorectal Cancer1
1RecruitingTreatmentMetastatic Pancreatic Adenocarcinoma1
1RecruitingTreatmentNeoplasms Metastasis / Neoplasms, Colorectal1
1RecruitingTreatmentNeoplasms, Colorectal1
1RecruitingTreatmentPancreatic Adenocarcinoma1
1RecruitingTreatmentPancreatic Cancers1
1RecruitingTreatmentTumors, Solid2
1RecruitingTreatmentUnresectable Advanced Cancer1
1TerminatedTreatmentAdvanced Colorectal Cancer1
1TerminatedTreatmentLung Metastases / Osteosarcomas1
1TerminatedTreatmentRecurrent Colon Cancer / Recurrent Rectal Cancer / Stage IV Colon Cancer / Stage IV Rectal Cancer1
1TerminatedTreatmentTumors, Solid1
1WithdrawnTreatmentStage IVA Colorectal Cancer / Stage IVB Colorectal Cancer1
1WithdrawnTreatmentUnspecified Adult Solid Tumor, Protocol Specific2
1, 2Active Not RecruitingTreatmentAdenocarcinoma of the Esophagus / Adenocarcinomas of the Gastroesophageal Junction / Diffuse Adenocarcinoma of the Stomach / Intestinal Adenocarcinoma of the Stomach / Mixed Adenocarcinoma of the Stomach / Recurrent Esophageal Cancer / Recurrent Gastric Cancer / Stage IV Esophageal Cancer / Stage IV Gastric Cancer1
1, 2Active Not RecruitingTreatmentColorectal Cancers2
1, 2Active Not RecruitingTreatmentMetastatic Colorectal Cancers1
1, 2Active Not RecruitingTreatmentRecurrent Childhood Acute Lymphoblastic Leukemia1
1, 2CompletedTreatmentAcute Undifferentiated Leukemia (AUL) / B-cell Adult Acute Lymphoblastic Leukemia / B-cell Childhood Acute Lymphoblastic Leukemia / L1 Adult Acute Lymphoblastic Leukemia / L1 Childhood Acute Lymphoblastic Leukemia / L2 Adult Acute Lymphoblastic Leukemia / L2 Childhood Acute Lymphoblastic Leukemia / Philadelphia Chromosome Negative Adult Precursor Acute Lymphoblastic Leukemia / Philadelphia Chromosome Positive Adult Precursor Acute Lymphoblastic Leukemia / Philadelphia Chromosome Positive Childhood Precursor Acute Lymphoblastic Leukemia / T-cell Adult Acute Lymphoblastic Leukemia / T-cell Childhood Acute Lymphoblastic Leukemia / Untreated Adult Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia1
1, 2CompletedTreatmentCarcinoma of Head and/or Neck / Squamous Cell Carcinoma (SCC)1
1, 2CompletedTreatmentChemotherapeutic Agent Toxicity / Lymphoma NOS / Mucositis / Neurotoxicity1
1, 2CompletedTreatmentColorectal Cancers6
1, 2CompletedTreatmentGangliosidoses, GM2 / Sandhoff Disease / Tay-Sachs Disease1
1, 2CompletedTreatmentGastroEsophageal Cancer / Malignant Solid Tumours1
1, 2CompletedTreatmentMetastatic Colorectal Cancers1
1, 2CompletedTreatmentNeoplasms Metastasis / Neoplasms, Gastrointestinal1
1, 2Not Yet RecruitingTreatmentAdenocarcinoma of the Esophagus / Adenocarcinomas of the Gastroesophageal Junction / Diffuse Adenocarcinoma of the Stomach / Gastrointestinal Cancers / Intestinal Adenocarcinoma of the Stomach / Mixed Adenocarcinoma of the Stomach / Stage IIIA Esophageal Cancer / Stage IIIA Gastric Cancer / Stage IIIB Esophageal Cancer / Stage IIIB Gastric Cancer / Stage IIIC Esophageal Cancer / Stage IIIC Gastric Cancer / Stage IV Esophageal Cancer / Stage IV Gastric Cancer1
1, 2RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL)1
1, 2RecruitingTreatmentAcute Myeloid Leukaemias (AML) / Myelodysplastic Syndrome1
1, 2RecruitingTreatmentAdenocarcinoma of Unknown Primary / Adult Cholangiocarcinoma / Gallbladder Carcinoma / Gastric Adenocarcinoma / Malignant Gastrointestinal Neoplasm / Metastatic Pancreatic Adenocarcinoma / Pancreatic Adenocarcinoma / Stage III Ampulla of Vater Cancer / Stage III Pancreatic Cancer / Stage IIIA Gallbladder Cancer / Stage IIIA Gastric Cancer / Stage IIIB Gallbladder Cancer / Stage IIIB Gastric Cancer / Stage IV Ampulla of Vater Cancer / Stage IV Gallbladder Cancer / Stage IV Gastric Cancer / Stage IV Pancreatic Cancer1
1, 2RecruitingTreatmentAdenocarcinomas / Colon Cancer / Metastasis / Rectal Cancers1
1, 2RecruitingTreatmentMetastatic Pancreas Adenocarcinoma1
1, 2RecruitingTreatmentMetastatic Pancreatic Adenocarcinoma1
1, 2RecruitingTreatmentOsteosarcomas1
1, 2SuspendedTreatmentMetastatic Pancreatic Adenocarcinoma / Recurrent Pancreatic Carcinoma / Stage III Pancreatic Cancer / Stage IV Pancreatic Cancer1
1, 2TerminatedTreatmentNeoplasms1
1, 2TerminatedTreatmentStage II Rectal Cancer / Stage III Rectal Cancer1
1, 2TerminatedTreatmentSubjects With Resectable Local or Locally Advanced, Non-Metastatic (T2-T4, N0-N3, M0; Stages II and III) and Histologically-Confirmed Intestinal GC1
1, 2WithdrawnTreatmentColorectal Cancers1
1, 2WithdrawnTreatmentPancreatic Cancers1
2Active Not RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL)1
2Active Not RecruitingTreatmentAdenocarcinoma of the Esophagus / Adenocarcinomas of the Gastroesophageal Junction / Diffuse Adenocarcinoma of the Stomach / Intestinal Adenocarcinoma of the Stomach / Mixed Adenocarcinoma of the Stomach / Squamous Cell Carcinoma of the Esophagus / Stage IA Esophageal Cancer / Stage IA Gastric Cancer / Stage IB Esophageal Cancer / Stage IB Gastric Cancer / Stage IIA Esophageal Cancer / Stage IIA Gastric Cancer / Stage IIB Esophageal Cancer / Stage IIB Gastric Cancer / Stage IIIA Esophageal Cancer / Stage IIIA Gastric Cancer / Stage IIIB Esophageal Cancer / Stage IIIB Gastric Cancer / Stage IIIC Esophageal Cancer / Stage IIIC Gastric Cancer1
2Active Not RecruitingTreatmentAdenocarcinomas of the Gastroesophageal Junction / Esophageal Cancers1
2Active Not RecruitingTreatmentAdenocarcinomas of the Gastroesophageal Junction / Esophageal Cancers / Gastric Cancers1
2Active Not RecruitingTreatmentAdult Acute Lymphoblastic Leukemia in Remission / Adult B Acute Lymphoblastic Leukemia / Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34;q11.2); BCR-ABL1 / Adult L1 Acute Lymphoblastic Leukemia / Adult L2 Acute Lymphoblastic Leukemia / Adult T Acute Lymphoblastic Leukemia / Recurrent Adult Acute Lymphoblastic Leukemia / Untreated Adult Acute Lymphoblastic Leukemia1
2Active Not RecruitingTreatmentAdult B Acute Lymphoblastic Leukemia With t(9;22)(q34;q11.2); BCR-ABL1 / Untreated Adult Acute Lymphoblastic Leukemia1
2Active Not RecruitingTreatmentAdult Cholangiocarcinoma / Advanced Adult Hepatocellular Carcinoma / BCLC Stage C Adult Hepatocellular Carcinoma / BCLC Stage D Adult Hepatocellular Carcinoma / Hilar Cholangiocarcinoma / Localized Non-Resectable Adult Liver Carcinoma / Recurrent Adult Liver Carcinoma / Recurrent Childhood Liver Cancer / Recurrent Extrahepatic Bile Duct Carcinoma / Recurrent Gallbladder Carcinoma / Stage II Gallbladder Cancer / Stage III Childhood Hepatocellular Carcinoma / Stage IIIA Gallbladder Cancer / Stage IIIB Gallbladder Cancer / Stage IV Childhood Hepatocellular Carcinoma / Stage IV Distal Bile Duct Cancer / Stage IVA Gallbladder Cancer / Stage IVB Gallbladder Cancer / Unresectable Extrahepatic Bile Duct Carcinoma1
2Active Not RecruitingTreatmentAdult Primary Cholangiocellular Carcinoma / Advanced Adult Primary Liver Cancer / Cholangiocarcinoma of the Extrahepatic Bile Duct / Cholangiocarcinoma of the Gallbladder / Localized Unresectable Adult Primary Liver Cancer / Periampullary Adenocarcinoma / Recurrent Adult Primary Liver Cancer / Recurrent Extrahepatic Bile Duct Cancer / Recurrent Gallbladder Cancer / Unresectable Extrahepatic Bile Duct Cancer / Unresectable Gallbladder Cancer1
2Active Not RecruitingTreatmentB-cell Adult Acute Lymphoblastic Leukemia / B-cell Childhood Acute Lymphoblastic Leukemia / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Adult Lymphoblastic Lymphoma / Recurrent Childhood Acute Lymphoblastic Leukemia / Recurrent Childhood Lymphoblastic Lymphoma / T-cell Adult Acute Lymphoblastic Leukemia / T-cell Childhood Acute Lymphoblastic Leukemia1
2Active Not RecruitingTreatmentBladder Cancers / Urachal Cancer / Urethral Cancer1
2Active Not RecruitingTreatmentCancer, Breast1
2Active Not RecruitingTreatmentCancer, Ovarian1
2Active Not RecruitingTreatmentCarcinoma of the Appendix / Colorectal Cancers / Primary Peritoneal Cavity Cancer1
2Active Not RecruitingTreatmentColorectal Cancers13
2Active Not RecruitingTreatmentColorectal Cancers / Metastatic Cancers5
2Active Not RecruitingTreatmentColorectal Cancers / Metastatic Cancers / Primary Peritoneal Cavity Cancer1
2Active Not RecruitingTreatmentEsophageal Cancers1
2Active Not RecruitingTreatmentEsophageal Cancers / Gastric Cancers2
2Active Not RecruitingTreatmentExtrahepatic Bile Duct Cancer / Pancreatic Cancers1
2Active Not RecruitingTreatmentGastric Adenocarcinoma With Peritoneal Carcinomatosis / Siewert Type II Adenocarcinoma of Esophagogastric Junction With Peritoneal Carcinomatosis / Siewert Type III Adenocarcinoma of Esophagogastric Junction With Peritoneal Carcinomatosis1
2Active Not RecruitingTreatmentGastrointestinal Carcinoid Tumor / Islet Cell Tumor / Neoplastic Syndrome1
2Active Not RecruitingTreatmentHead and Neck Cancers2
2Active Not RecruitingTreatmentLeukemias2
2Active Not RecruitingTreatmentLymphoma NOS2
2Active Not RecruitingTreatmentMalignant Neoplasm of Esophagus / Malignant Neoplasm of Stomach1
2Active Not RecruitingTreatmentMetastatic Pancreatic Adenocarcinoma1
2Active Not RecruitingTreatmentNeoplasms, Colorectal1
2Active Not RecruitingTreatmentPancreatic Adenocarcinoma1
2Active Not RecruitingTreatmentPancreatic Adenocarcinoma / Poorly Differentiated Malignant Neoplasm / Resectable Pancreatic Cancers / Stage IA Pancreatic Cancer / Stage IB Pancreatic Cancer / Stage IIA Pancreatic Cancer / Stage IIB Pancreatic Cancer / Stage III Pancreatic Cancer / Undifferentiated Pancreatic Carcinoma1
2Active Not RecruitingTreatmentPancreatic Cancers2
2Active Not RecruitingTreatmentRectal Adenocarcinoma / Stage II Rectal Cancer / Stage III Rectal Cancer1
2Active Not RecruitingTreatmentTumors, Solid1
2AvailableNot AvailableHepatocellular Carcinomas / Injury; Blood Vessel, Hepatic, Artery1
2CompletedDiagnosticUpper Gastrointestinal Tumours1
2CompletedPreventionInfection, Human Immunodeficiency Virus / Toxoplasmosis, Cerebral1
2CompletedSupportive CareColorectal Cancers1
2CompletedSupportive CareColorectal Cancers / Nausea and Vomiting1
2CompletedTreatment5q Minus Syndrome / Myelodysplastic Syndrome1
2CompletedTreatmentAcute Lymphocytic Leukemia (ALL)1
2CompletedTreatmentAdenocarcinoma of the Colon / Adenocarcinoma of the Rectum / Advanced Colorectal Cancer1
2CompletedTreatmentAdenocarcinoma of the Colon / Adenocarcinoma of the Rectum / Recurrent Colon Cancer / Recurrent Rectal Cancer / Stage IV Colon Cancer / Stage IV Rectal Cancer1
2CompletedTreatmentAdenocarcinoma of the Rectum / Mucinous Adenocarcinoma of the Colon / Recurrent Colon Cancer / Recurrent Rectal Cancer / Signet Ring Adenocarcinoma of the Colon / Stage IV Colon Cancer / Stage IV Rectal Cancer1
2CompletedTreatmentAdenocarcinoma of the Stomach / Adenocarcinomas of the Gastroesophageal Junction / Recurrent Gastric Cancer / Stage IIIA Gastric Cancer / Stage IIIB Gastric Cancer / Stage IIIC Gastric Cancer / Stage IV Gastric Cancer1
2CompletedTreatmentAdenocarcinomas of the Esophagogastric Junction / Gastric Cancers2
2CompletedTreatmentAdult Acute Lymphoblastic Leukemia in Remission1
2CompletedTreatmentBiliary Tract Diseases1
2CompletedTreatmentBrain and Central Nervous System Tumors2
2CompletedTreatmentCancer of the Rectum / Colorectal Cancers / Rectal Cancers1
2CompletedTreatmentCancer, Breast / Neoplasms, Breast1
2CompletedTreatmentCancer, Ovarian / Extragonadal Germ Cell Tumor1
2CompletedTreatmentCancers / Colon Cancer / Colorectal Cancers / Metastatic Cancers / Metastatic Colorectal Cancers / Rectal Cancers1
2CompletedTreatmentCarcinoma of Head/Neck / Squamous Cell Carcinoma (SCC)1
2CompletedTreatmentCarcinoma of Unknown Primary / Colorectal Cancers / Unspecified Adult Solid Tumor, Protocol Specific / Unspecified Childhood Solid Tumor, Protocol Specific1
2CompletedTreatmentCarcinoma, Colorectal2
2CompletedTreatmentCentral Nervous System Tumor, Pediatric1
2CompletedTreatmentChildhood Burkitt Lymphoma / Childhood Diffuse Large Cell Lymphoma / Childhood Immunoblastic Large Cell Lymphoma / Stage I Childhood Large Cell Lymphoma / Stage I Childhood Small Noncleaved Cell Lymphoma / Stage II Childhood Large Cell Lymphoma / Stage II Childhood Small Noncleaved Cell Lymphoma / Stage III Childhood Large Cell Lymphoma / Stage III Childhood Small Noncleaved Cell Lymphoma / Stage IV Childhood Large Cell Lymphoma / Stage IV Childhood Small Noncleaved Cell Lymphoma / Untreated Childhood Acute Lymphoblastic Leukemia1
2CompletedTreatmentColon Cancer1
2CompletedTreatmentColon Cancer / Rectal Cancers1
2CompletedTreatmentColorectal Cancer (CRC)1
2CompletedTreatmentColorectal Cancer Stage II1
2CompletedTreatmentColorectal Cancers37
2CompletedTreatmentColorectal Cancers / Liver Metastases1
2CompletedTreatmentColorectal Cancers / Metastatic Cancers5
2CompletedTreatmentColorectal Cancers / Neoplasms, Colorectal1
2CompletedTreatmentEsophageal Cancers2
2CompletedTreatmentEsophageal Cancers / Gastric Cancers3
2CompletedTreatmentEsophageal Cancers / Stomach Cancer1
2CompletedTreatmentExtrahepatic Bile Duct Cancer / Gallbladder Cancer / Liver Cancer1
2CompletedTreatmentGastric Adenocarcinoma / Gastric Cancers1
2CompletedTreatmentGastric Cancers8
2CompletedTreatmentGastric Cancers / Stomach Cancer1
2CompletedTreatmentGastric cancer stage IV1
2CompletedTreatmentHepatocellular Carcinomas1
2CompletedTreatmentHodgkins Disease (HD)1
2CompletedTreatmentInfection, Human Immunodeficiency Virus / Toxoplasmosis, Cerebral1
2CompletedTreatmentLangerhans Cell Histiocytosis (LCH)1
2CompletedTreatmentLeukemias10
2CompletedTreatmentLeukemias / Lymphoma NOS5
2CompletedTreatmentLeukemias / Lymphoma NOS / Sarcomas1
2CompletedTreatmentLeukemias / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Neoplasms1
2CompletedTreatmentLeukemias / Neutropenias / Thrombocytopenias1
2CompletedTreatmentLiver Cancer / Pancreatic Cancers1
2CompletedTreatmentLiver Metastases / Recurrent Colon Cancer / Recurrent Rectal Cancer / Stage IV Colon Cancer / Stage IV Rectal Cancer1
2CompletedTreatmentLymphoma NOS12
2CompletedTreatmentLymphoma NOS / Multiple Myeloma and Plasma Cell Neoplasm1
2CompletedTreatmentMetastatic Adenocarcinoma of Gastric Cardia / Metastatic Adenocarcinoma of the Esophagus / Unresectable Adenocarcinoma of Gastric Cardia / Unresectable Adenocarcinoma of the Esophagus1
2CompletedTreatmentMetastatic Breast Cancer (MBC)1
2CompletedTreatmentMetastatic Colorectal Cancers4
2CompletedTreatmentMetastatic Osteosarcoma1
2CompletedTreatmentNeoplasms Metastasis / Neoplasms, Colorectal1
2CompletedTreatmentNeoplasms, Colorectal2
2CompletedTreatmentNeoplasms, Esophageal / Stomach Neoplasms2
2CompletedTreatmentPancreatic Cancers2
2CompletedTreatmentRectal Cancers3
2CompletedTreatmentRectal Neoplasms1
2CompletedTreatmentRecurrent Extragonadal Seminoma / Recurrent Malignant Extragonadal Germ Cell Tumor / Recurrent Malignant Extragonadal Non-Seminomatous Germ Cell Tumor / Recurrent Malignant Testicular Germ Cell Tumor / Recurrent Ovarian Germ Cell Tumor / Stage III Testicular Cancer / Stage IV Extragonadal Non-Seminomatous Germ Cell Tumor / Stage IV Extragonadal Seminoma / Stage IV Ovarian Germ Cell Tumor1
2CompletedTreatmentSarcomas1
2CompletedTreatmentUnresectable Biliary Tract Cancer1
2Not Yet RecruitingTreatmentAdenocarcinoma of the Colon / Adenocarcinoma of the Rectum1
2Not Yet RecruitingTreatmentColorectal Adenocarcinoma / Stage IVA Colorectal Cancer / Stage IVB Colorectal Cancer1
2Not Yet RecruitingTreatmentColorectal Cancers1
2Not Yet RecruitingTreatmentStomach Neoplasms1
2RecruitingBasic ScienceMetastatic Colorectal Cancers1
2RecruitingDiagnosticColorectal Cancers1
2RecruitingPreventionPeripheral T-cell lymphoma unspecified refractory / Relapsed Peripheral T-Cell Lymphoma1
2RecruitingTreatmentAcinar Cell Adenocarcinoma of the Pancreas / Duct Cell Adenocarcinoma of the Pancreas / Recurrent Pancreatic Cancer / Stage IV Pancreatic Cancer1
2RecruitingTreatmentAcinar Cell Adenocarcinoma of the Pancreas / Duct Cell Adenocarcinoma of the Pancreas / Stage I Pancreatic Cancer / Stage IIA Pancreatic Cancer / Stage IIB Pancreatic Cancer1
2RecruitingTreatmentAcute Lymphocytic Leukemia (ALL) / Adult Lymphoblastic Lymphoma1
2RecruitingTreatmentAdenocarcinoma of the Esophagus / Adenocarcinoma of the Gastric Cardia / Adenocarcinomas of the Gastroesophageal Junction / Stage IIIA Esophageal Cancer / Stage IIIB Esophageal Cancer / Stage IIIC Esophageal Cancer1
2RecruitingTreatmentAdenocarcinoma of the Esophagus / Adenocarcinomas of the Gastroesophageal Junction / Stage II Esophageal Cancer1
2RecruitingTreatmentAdenocarcinomas of the Gastroesophageal Junction / Gastric Cancers1
2RecruitingTreatmentAdenocarincoma of Pancreas / Stage III Pancreatic Cancer / Stage IVA Pancreatic Cancer / Stage IVB Pancreatic Cancer1
2RecruitingTreatmentAdvanced Esophageal Carcinoma1
2RecruitingTreatmentAppendix Cancer / Colorectal Cancers1
2RecruitingTreatmentBiliary Tract Cancer2
2RecruitingTreatmentCancers1
2RecruitingTreatmentCarcinoma, Colorectal1
2RecruitingTreatmentChemotherapeutic Agent Toxicity / Colorectal Cancers / Neurotoxicity1
2RecruitingTreatmentColon Cancer1
2RecruitingTreatmentColorectal Cancers10
2RecruitingTreatmentColorectal Cancers / Metastatic Cancers1
2RecruitingTreatmentColorectal Cancers / Peritoneal Cavity Cancer1
2RecruitingTreatmentDiffuse Large B Cell Lymphoma (DLBCL)1
2RecruitingTreatmentEsophageal Cancers / Gastric Cancers1
2RecruitingTreatmentGastric Cancers1
2RecruitingTreatmentGastric Cancers / Gastroesophageal Junction Adenocarcinoma1
2RecruitingTreatmentHead and Neck Cancers1
2RecruitingTreatmentHepatocellular Cancer1
2RecruitingTreatmentHepatocellular Carcinomas1
2RecruitingTreatmentLeukemias3
2RecruitingTreatmentLymphoma NOS2
2RecruitingTreatmentLymphoma, AIDS Related / Neoplasms, Brain1
2RecruitingTreatmentMetastatic Breast Cancer (MBC)1
2RecruitingTreatmentMetastatic Colorectal Cancers7
2RecruitingTreatmentMetastatic Pancreatic Adenocarcinoma / Recurrent Pancreatic Carcinoma / Stage IV Pancreatic Cancer1
2RecruitingTreatmentMucinous Adenocarcinoma of the Colon / Mucinous Adenocarcinoma of the Rectum / Recurrent Colon Cancer / Recurrent Rectal Cancer / Signet Ring Adenocarcinoma of the Colon / Signet Ring Adenocarcinoma of the Rectum / Stage IV Colon Cancer / Stage IV Rectal Cancer1
2RecruitingTreatmentMucinous Adenocarcinoma of the Colon / Mucinous Adenocarcinoma of the Rectum / Signet Ring Adenocarcinoma of the Colon / Signet Ring Adenocarcinoma of the Rectum / Stage IV Colon Cancer / Stage IV Rectal Cancer1
2RecruitingTreatmentMucinous Adenocarcinoma of the Rectum / Signet Ring Adenocarcinoma of the Rectum / Stage IIA Rectal Cancer / Stage IIB Rectal Cancer / Stage IIC Rectal Cancer / Stage IIIA Rectal Cancer / Stage IIIB Rectal Cancer / Stage IIIC Rectal Cancer1
2RecruitingTreatmentNeoplasms, Esophageal1
2RecruitingTreatmentNeoplasms, Esophageal / Stomach Neoplasms1
2RecruitingTreatmentPancreatic Adenocarcinoma1
2RecruitingTreatmentPancreatic Adenocarcinoma / Resectable Pancreatic Cancers / Stage IA Pancreatic Cancer / Stage IB Pancreatic Cancer / Stage IIA Pancreatic Cancer / Stage IIB Pancreatic Cancer / Stage III Pancreatic Cancer1
2RecruitingTreatmentPancreatic Adenocarcinoma / Stage IIA Pancreatic Cancer / Stage IIB Pancreatic Cancer / Stage III Pancreatic Cancer1
2RecruitingTreatmentPancreatic Cancer Metastatic2
2RecruitingTreatmentPancreatic Cancers4
2RecruitingTreatmentPancreatic Cancers / Pancreatic Carcinoma Non-resectable1
2RecruitingTreatmentPancreatic Metastatic Cancer / Toxicity1
2RecruitingTreatmentRectal Adenocarcinoma / Stage II Rectal Cancer / Stage III Rectal Cancer1
2RecruitingTreatmentRectal Cancers2
2RecruitingTreatmentRectal Neoplasms1
2RecruitingTreatmentRecurrent Colorectal Carcinoma / Stage IVA Colorectal Cancer / Stage IVB Colorectal Cancer1
2RecruitingTreatmentResectable Pancreatic Ductal Adenocarcinoma1
2RecruitingTreatmentSinonasal Tumors1
2RecruitingTreatmentUnresectable Sinonasal Tumors1
2SuspendedTreatmentEpstein Barr Virus Associated Hodgkin's Lymphoma / Epstein Barr Virus Associated Non Hodgkin's Lymphoma / Post-transplant Lymphoproliferative Disease (PTLD)1
2SuspendedTreatmentLymphoma NOS1
2TerminatedTreatmentAdenocarcinoma of Pancreas1
2TerminatedTreatmentAdenocarcinoma of the Colon / Adenocarcinoma of the Rectum / Mucinous Adenocarcinoma of the Colon / Mucinous Adenocarcinoma of the Rectum / Recurrent Colon Cancer / Recurrent Rectal Cancer / Signet Ring Adenocarcinoma of the Colon / Signet Ring Adenocarcinoma of the Rectum / Stage IV Colon Cancer / Stage IV Rectal Cancer1
2TerminatedTreatmentAsperger's Syndrome / Autism / Autism Spectrum Disorder (ASD) / Autistic Disorder / Pervasive Development Disorders1
2TerminatedTreatmentAtypical Burkitt Lymphoma / Burkitt's Lymphoma / Non-Hodgkin's Lymphoma (NHL)1
2TerminatedTreatmentCancer, Breast1
2TerminatedTreatmentCardiac Toxicity / Sarcomas1
2TerminatedTreatmentChronic Myeloproliferative Disorders / Graft Versus Host Disease (GVHD) / Leukemias / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes1
2TerminatedTreatmentColon Cancer1
2TerminatedTreatmentColorectal Cancers5
2TerminatedTreatmentColorectal Cancers / Metastases1
2TerminatedTreatmentColorectal Cancers / Metastatic Cancers1
2TerminatedTreatmentColorectal Liver Metastases1
2TerminatedTreatmentDiarrhea / Neoplasms, Colorectal1
2TerminatedTreatmentEsophageal Cancers2
2TerminatedTreatmentGastric Cancers3
2TerminatedTreatmentLiver Metastases / Recurrent Colon Cancer / Recurrent Rectal Cancer / Stage IVA Colon Cancer / Stage IVA Rectal Cancer / Stage IVB Colon Cancer / Stage IVB Rectal Cancer1
2TerminatedTreatmentLymphoma NOS1
2TerminatedTreatmentMetastatic Colorectal Cancers2
2TerminatedTreatmentNeoplasm Metastases / Neoplasms, Colorectal1
2TerminatedTreatmentNeoplasms Metastasis / Neoplasms, Colorectal1
2TerminatedTreatmentNeoplasms, Colorectal2
2TerminatedTreatmentOsteosarcomas1
2TerminatedTreatmentOsteosarcomas / Spindle Cell Sarcoma of Bone1
2TerminatedTreatmentPatients With Colorectal Cancer With Unresectable Synchronous Metastasis in Whom Resection of the Primitive Tumour is Indicated1
2TerminatedTreatmentPeritoneal Neoplasms1
2TerminatedTreatmentRectal Neoplasms1
2TerminatedTreatmentRecurrent Adult Acute Lymphoblastic Leukemia1
2TerminatedTreatmentStage IB Esophageal Adenocarcinoma / Stage IIA Esophageal Adenocarcinoma / Stage IIB Esophageal Adenocarcinoma / Stage IIIA Esophageal Adenocarcinoma / Stage IIIB Esophageal Adenocarcinoma / Stage IIIC Esophageal Adenocarcinoma1
2TerminatedTreatmentStage IV Colon Cancer / Stage IV Rectal Cancer1
2TerminatedTreatmentUterine Neoplasms1
2WithdrawnTreatmentAdenocarcinoma of the Colon / Adenocarcinoma of the Rectum / Recurrent Colon Cancer / Recurrent Rectal Cancer / Stage IVA Colon Cancer / Stage IVA Rectal Cancer / Stage IVB Colon Cancer / Stage IVB Rectal Cancer1
2WithdrawnTreatmentB-cell Adult Acute Lymphoblastic Leukemia / Blastic Phase Chronic Myelogenous Leukemia / Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Philadelphia Chromosome Positive Adult Precursor Acute Lymphoblastic Leukemia / Untreated Adult Acute Lymphoblastic Leukemia1
2WithdrawnTreatmentBrain and Central Nervous System Tumors / Neuroblastomas / Retinoblastoma / Sarcomas1
2WithdrawnTreatmentColorectal Cancers2
2WithdrawnTreatmentColorectal Cancers / Metastatic Cancers1
2WithdrawnTreatmentColorectal Cancers / Metastatic Colorectal Cancers1
2WithdrawnTreatmentEsophagogastric Cancer1
2WithdrawnTreatmentMetastatic Colorectal Cancers3
2WithdrawnTreatmentMucinous Adenocarcinoma of the Colon / Mucinous Adenocarcinoma of the Rectum / Recurrent Colon Cancer / Recurrent Rectal Cancer / Signet Ring Adenocarcinoma of the Colon / Signet Ring Adenocarcinoma of the Rectum / Stage IVA Colon Cancer / Stage IVA Rectal Cancer / Stage IVB Colon Cancer / Stage IVB Rectal Cancer1
2WithdrawnTreatmentNeoplasms, Colorectal1
2, 3Active Not RecruitingTreatmentChildhood B Acute Lymphoblastic Leukemia / Childhood Burkitt Leukemia / Childhood Diffuse Large Cell Lymphoma / Mediastinal (Thymic) Large B-Cell Lymphoma / Stage III Childhood Large Cell Lymphoma / Stage IV Childhood Large Cell Lymphoma1
2, 3Active Not RecruitingTreatmentColorectal Cancers3
2, 3Active Not RecruitingTreatmentGastric Cancers1
2, 3Active Not RecruitingTreatmentGastrointestinal Carcinoid Tumor / Islet Cell Tumor / Lung Cancers / Neoplastic Syndrome / Neuroendocrine Tumors1
2, 3Active Not RecruitingTreatmentPancreatic Cancers1
2, 3CompletedDiagnosticColorectal Cancers1
2, 3CompletedTreatmentDown Syndrome (DS)1
2, 3CompletedTreatmentEsophageal Cancers1
2, 3CompletedTreatmentPancreatic Cancers1
2, 3Not Yet RecruitingPreventionAllogeneic Hematopoietic Cell Transplantation / Graft Versus Host Disease (GVHD) / Mucositis1
2, 3Not Yet RecruitingTreatmentColorectal Cancers1
2, 3RecruitingTreatmentMature B-Cell Lymphoma1
2, 3RecruitingTreatmentRectal Cancers1
2, 3WithdrawnTreatmentCarcinoma, Colorectal / Liver Metastases1
3Active Not RecruitingTreatmentAcute Undifferentiated Leukemia (AUL) / T-cell Childhood Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia1
3Active Not RecruitingTreatmentAdult T Acute Lymphoblastic Leukemia / Childhood T Acute Lymphoblastic Leukemia / Stage II Adult T-Cell Leukemia/Lymphoma / Stage II Childhood Lymphoblastic Lymphoma / Stage II Contiguous Adult Lymphoblastic Lymphoma / Stage II Non-Contiguous Adult Lymphoblastic Lymphoma / Stage III Adult Lymphoblastic Lymphoma / Stage III Adult T-Cell Leukemia/Lymphoma / Stage III Childhood Lymphoblastic Lymphoma / Stage IV Adult Lymphoblastic Lymphoma / Stage IV Adult T-Cell Leukemia/Lymphoma / Stage IV Childhood Lymphoblastic Lymphoma / Untreated Adult Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia1
3Active Not RecruitingTreatmentB-cell Childhood Acute Lymphoblastic Leukemia / Intermediate Risk Recurrent Childhood Acute Lymphoblastic Leukemia / L1 Childhood Acute Lymphoblastic Leukemia / L2 Childhood Acute Lymphoblastic Leukemia1
3Active Not RecruitingTreatmentB-cell Childhood Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia1
3Active Not RecruitingTreatmentCarcinoma of Unknown Primary1
3Active Not RecruitingTreatmentChildhood Atypical Teratoid/Rhabdoid Tumor1
3Active Not RecruitingTreatmentCognitive/Functional Effects / Colorectal Cancers / Neurotoxicity1
3Active Not RecruitingTreatmentColon Cancer / Metastatic Colorectal Cancers / Rectal Cancers1
3Active Not RecruitingTreatmentColon Mucinous Adenocarcinoma / Colon Signet Ring Cell Adenocarcinoma / Lynch Syndrome / Stage IIA Colon Cancer / Stage IIB Colon Cancer / Stage IIC Colon Cancer1
3Active Not RecruitingTreatmentColorectal Cancers21
3Active Not RecruitingTreatmentColorectal Cancers / Metastatic Cancers3
3Active Not RecruitingTreatmentColorectal Cancers / Neoplasms Metastasis1
3Active Not RecruitingTreatmentDigestive System Neoplasms / Intestinal Neoplasms / Neoplasms Metastasis / Neoplasms, Colorectal / Neoplasms, Gastrointestinal1
3Active Not RecruitingTreatmentDrug/Agent Toxicity by Tissue/Organ / Leukemias1
3Active Not RecruitingTreatmentEsophageal Cancers / Gastric Cancers1
3Active Not RecruitingTreatmentLeukemias3
3Active Not RecruitingTreatmentLeukemias / Lymphoma NOS1
3Active Not RecruitingTreatmentLocally Advanced Malignant Neoplasm / Pancreatic Cancers / Pancreatic Carcinoma Non-resectable1
3Active Not RecruitingTreatmentLymphoma NOS2
3Active Not RecruitingTreatmentMetastatic Colorectal Cancers1
3Active Not RecruitingTreatmentNeoplasms, Colorectal1
3Active Not RecruitingTreatmentUntreated Childhood Medulloblastoma / Untreated Childhood Supratentorial Primitive Neuroectodermal Tumor1
3CompletedPreventionHCV Coinfection / Infection, Human Immunodeficiency Virus1
3CompletedSupportive CareCardiac Toxicity / Leukemias / Lymphoma NOS1
3CompletedTreatmentAcute Lymphoblastic Leukaemias (ALL)1
3CompletedTreatmentAdenocarcinoma of the Colon / Adenocarcinoma of the Rectum / Recurrent Colon Cancer / Recurrent Rectal Cancer / Stage III Colon Cancer / Stage III Rectal Cancer / Stage IV Colon Cancer / Stage IV Rectal Cancer1
3CompletedTreatmentAdenocarcinoma of the Colon / Stage IIA Colon Cancer / Stage IIB Colon Cancer / Stage IIC Colon Cancer / Stage IIIA Colon Cancer / Stage IIIB Colon Cancer / Stage IIIC Colon Cancer1
3CompletedTreatmentAdenocarcinoma of the Colon / Stage III Colon Cancer2
3CompletedTreatmentAdenocarcinoma of the Stomach / Adenocarcinomas of the Gastroesophageal Junction1
3CompletedTreatmentAdult B Acute Lymphoblastic Leukemia With t(9;22)(q34;q11.2); BCR-ABL1 / Childhood B Acute Lymphoblastic Leukemia With t(9;22)(q34;q11.2); BCR-ABL1 / Untreated Adult Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia1
3CompletedTreatmentChildhood Acute Lymphoblastic Leukemia in Remission / Recurrent Childhood Acute Lymphoblastic Leukemia1
3CompletedTreatmentColon Cancer Stage II1
3CompletedTreatmentColorectal Cancers27
3CompletedTreatmentColorectal Cancers / Metastasis1
3CompletedTreatmentColorectal Cancers / Metastatic Cancers3
3CompletedTreatmentEpidermal Growth Factor Receptor (EGFR) Expressing Metastatic Colorectal Cancer1
3CompletedTreatmentGastric Cancers1
3CompletedTreatmentHead and Neck Cancers1
3CompletedTreatmentInfection, Human Immunodeficiency Virus / Non-Hodgkin's Lymphoma (NHL)1
3CompletedTreatmentInfection, Human Immunodeficiency Virus / Pneumonia, Pneumocystis Carinii5
3CompletedTreatmentLeukemias3
3CompletedTreatmentLeukemias / Lymphoma NOS2
3CompletedTreatmentLymphoma NOS3
3CompletedTreatmentMajor Depressive Disorder (MDD) / Schizophrenia1
3CompletedTreatmentMetastatic Colorectal Cancers3
3CompletedTreatmentMucinous Adenocarcinoma of the Colon / Mucinous Adenocarcinoma of the Rectum / Recurrent Colon Cancer / Recurrent Rectal Cancer / Signet Ring Adenocarcinoma of the Colon / Signet Ring Adenocarcinoma of the Rectum / Stage IIIA Colon Cancer / Stage IIIA Rectal Cancer / Stage IIIB Colon Cancer / Stage IIIB Rectal Cancer / Stage IIIC Colon Cancer / Stage IIIC Rectal Cancer / Stage IVA Colon Cancer / Stage IVA Rectal Cancer / Stage IVB Colon Cancer / Stage IVB Rectal Cancer1
3CompletedTreatmentNeoplasms, Pancreatic1
3CompletedTreatmentPancreatic Cancer Metastatic1
3CompletedTreatmentPancreatic Cancers3
3CompletedTreatmentStage II Colon Cancer / Stage III Colon Cancer1
3Not Yet RecruitingTreatmentAcute Lymphoblastic Leukemia, Pediatric1
3Not Yet RecruitingTreatmentGastric Cancers1
3RecruitingPreventionChemotherapy-Induced Neutropenia / Colorectal Cancers1
3RecruitingTreatmentAdenocarcinomas of the Esophagogastric Junction / Esophageal Adenocarcinoma (UICC TNM7)1
3RecruitingTreatmentAdult B Lymphoblastic Lymphoma / Childhood B Acute Lymphoblastic Leukemia / Childhood B Acute Lymphoblastic Leukemia With t(9;22)(q34;q11.2); BCR-ABL1 / Childhood B Lymphoblastic Lymphoma / Down Syndrome (DS) / Stage I B Lymphoblastic Lymphoma / Stage II B Lymphoblastic Lymphoma / Untreated Adult Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia1
3RecruitingTreatmentAdult T Acute Lymphoblastic Leukemia / Childhood T Acute Lymphoblastic Leukemia / Stage II Childhood Lymphoblastic Lymphoma / Stage II Contiguous Adult Lymphoblastic Lymphoma / Stage II Non-Contiguous Adult Lymphoblastic Lymphoma / Stage III Adult Lymphoblastic Lymphoma / Stage III Childhood Lymphoblastic Lymphoma / Stage IV Adult Lymphoblastic Lymphoma / Stage IV Childhood Lymphoblastic Lymphoma / Untreated Adult Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia1
3RecruitingTreatmentAmpullary Cancer / Biliary Tract Cancer / Cholangiocarcinomas / Gallbladder Cancer1
3RecruitingTreatmentB Acute Lymphoblastic Leukemia / Bone Necrosis / Central Nervous System Leukemia / Cognitive Side Effects of Cancer Therapy / Neurotoxicity Syndrome / Pain / Testicular Leukemia / Therapy-Related Toxicity / Untreated Adult Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia2
3RecruitingTreatmentB Acute Lymphoblastic Leukemia / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Childhood Acute Lymphoblastic Leukemia1
3RecruitingTreatmentBRAF V600E-mutant Metastatic Colorectal Cancer1
3RecruitingTreatmentCRC1
3RecruitingTreatmentCarcinomas / Pancreatic Cancers1
3RecruitingTreatmentChoriocarcinoma / FIGO Stage I Gestational Trophoblastic Tumor / FIGO Stage II Gestational Trophoblastic Tumor / FIGO Stage III Gestational Trophoblastic Tumor / Hydatidiform Mole1
3RecruitingTreatmentColon Cancer1
3RecruitingTreatmentColorectal Cancers3
3RecruitingTreatmentColorectal Cancers / Metastasis1
3RecruitingTreatmentColorectal Cancers / Metastatic Cancers1
3RecruitingTreatmentColorectal Cancers / Primary Peritoneal Cavity Cancer1
3RecruitingTreatmentDown Syndrome (DS)1
3RecruitingTreatmentGastric Adenocarcinoma1
3RecruitingTreatmentGastric Cancers / Gastroesophageal Junction Cancer1
3RecruitingTreatmentHepatocellular Carcinomas1
3RecruitingTreatmentLeukemias1
3RecruitingTreatmentMetastatic Colorectal Cancers1
3RecruitingTreatmentMetastatic Pancreas Cancer1
3RecruitingTreatmentNasopharyngeal Carcinoma1
3RecruitingTreatmentPancreatic Cancers2
3RecruitingTreatmentStage ⅡA Pancreatic Cancer / Stage ⅡB Pancreatic Cancer1
3RecruitingTreatmentUnresectable, Locally Advanced or Metastatic, Adenocarcinoma of the Stomach, or of the Gastro Esophageal Junction1
3SuspendedTreatmentBrain Cancer / Choroid Plexus Tumors1
3TerminatedTreatmentAdenocarcinoma of the Colon / Adenocarcinoma of the Rectum / Recurrent Colon Cancer / Recurrent Rectal Cancer / Stage III Colon Cancer / Stage III Rectal Cancer / Stage IV Colon Cancer / Stage IV Rectal Cancer1
3TerminatedTreatmentAdenocarcinoma of the Rectum / Stage II Rectal Cancer / Stage III Rectal Cancer1
3TerminatedTreatmentColorectal Cancers1
3TerminatedTreatmentGastric Cancers1
3TerminatedTreatmentInfection, Human Immunodeficiency Virus / Pneumonia, Pneumocystis Carinii1
3TerminatedTreatmentLymphoma NOS1
3TerminatedTreatmentMucinous Adenocarcinoma of the Rectum / Recurrent Rectal Cancer / Signet Ring Adenocarcinoma of the Rectum / Stage IIA Rectal Cancer / Stage IIB Rectal Cancer / Stage IIC Rectal Cancer / Stage IIIA Rectal Cancer / Stage IIIB Rectal Cancer / Stage IIIC Rectal Cancer / Stage IVA Rectal Cancer / Stage IVB Rectal Cancer1
3TerminatedTreatmentRectal Cancer Dukes B, Dukes C1
3TerminatedTreatmentRecurrent Colon Cancer / Recurrent Rectal Cancer / Stage IVA Colon Cancer / Stage IVA Rectal Cancer / Stage IVB Colon Cancer / Stage IVB Rectal Cancer1
4Active Not RecruitingTreatmentGastric Cancers / Stage IV Colorectal Cancer1
4CompletedTreatmentColorectal Cancers1
4CompletedTreatmentStage-Ⅱ Colorectal Cancer1
4Not Yet RecruitingTreatmentAutism Spectrum Disorder (ASD)1
4RecruitingTreatmentEsophageal Adenocarcinomas / Gastric Adenocarcinoma / Stage IIB Gastric Cancer / Stage IIIA Esophageal Adenocarcinoma / Stage IIIA Gastric Cancer / Stage IIIB Esophageal Adenocarcinoma / Stage IIIB Gastric Cancer / Stage IIIC Esophageal Adenocarcinoma / Stage IIIC Gastric Cancer1
4RecruitingTreatmentToxoplasmosis1
Not AvailableActive Not RecruitingTreatmentAcinar Cell Adenocarcinoma of the Pancreas / Duct Cell Adenocarcinoma of the Pancreas / Recurrent Pancreatic Cancer / Stage II Pancreatic Cancer / Stage III Pancreatic Cancer1
Not AvailableActive Not RecruitingTreatmentLeukemias1
Not AvailableActive Not RecruitingTreatmentLymphoma NOS1
Not AvailableActive Not RecruitingTreatmentMalignant Neoplasm of Fourth Ventricle of Brain / Tumor, Brain1
Not AvailableActive Not RecruitingTreatmentPancreatic Cancers1
Not AvailableCompletedNot AvailableTrisiomy 21 (Down Syndrome)1
Not AvailableCompletedTreatmentBrain and Central Nervous System Tumors / Lymphoma NOS1
Not AvailableCompletedTreatmentChildhood Langerhans Cell Histiocytosis1
Not AvailableCompletedTreatmentColorectal Cancers2
Not AvailableCompletedTreatmentInfection, Human Immunodeficiency Virus / Non-Hodgkin's Lymphoma (NHL)1
Not AvailableCompletedTreatmentInfection, Human Immunodeficiency Virus / Pneumonia, Pneumocystis Carinii5
Not AvailableCompletedTreatmentInfection, Human Immunodeficiency Virus / Toxoplasmosis, Cerebral1
Not AvailableCompletedTreatmentL1 Childhood Acute Lymphoblastic Leukemia / L2 Childhood Acute Lymphoblastic Leukemia / Non-T, Non-B Childhood Acute Lymphoblastic Leukemia / Recurrent Childhood Acute Lymphoblastic Leukemia / T-cell Childhood Acute Lymphoblastic Leukemia1
Not AvailableCompletedTreatmentLymphoma NOS1
Not AvailableCompletedTreatmentMetastatic Colorectal Cancers1
Not AvailableCompletedTreatmentT-cell Childhood Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia1
Not AvailableNot Yet RecruitingTreatmentAcute Leukemias of Ambiguous Lineage / Childhood B Acute Lymphoblastic Leukemia / Mixed Phenotype Acute Leukemia (MPAL)1
Not AvailableRecruitingTreatmentEsophageal Cancers / Gastric Cancers1
Not AvailableRecruitingTreatmentLeukemias1
Not AvailableRecruitingTreatmentMetastatic Colorectal Cancers1
Not AvailableTerminatedTreatmentInfection, Human Immunodeficiency Virus / Non-Hodgkin's Lymphoma (NHL)1
Not AvailableTerminatedTreatmentOsteosarcomas1
Not AvailableWithdrawnTreatmentLymphoma NOS1
Not AvailableWithdrawnTreatmentRecurrent Colon Cancer / Recurrent Rectal Cancer / Stage IVA Colon Cancer / Stage IVA Rectal Cancer / Stage IVB Colon Cancer / Stage IVB Rectal Cancer1
Pharmacoeconomics
Manufacturers
  • Hospira inc
  • Abic ltd
  • Abraxis pharmaceutical products
  • Bedford laboratories div ben venue laboratories inc
  • Elkins sinn div ah robins co inc
  • Pharmachemie bv
  • Pharmachemie usa inc
  • Teva parenteral medicines inc
  • App pharmaceuticals llc
  • Luitpold pharmaceuticals inc
  • Glaxosmithkline
  • Barr pharmaceuticals
  • Corepharma llc
  • Par pharmaceutical inc
  • Roxane laboratories inc
  • Sandoz inc
  • Xanodyne pharmaceutics inc
  • Spectrum pharmaceuticals inc
Packagers
Dosage forms
FormRouteStrength
TabletOral5 mg
Powder, for solutionIntramuscular; Intravenous350 mg
Powder, for solutionIntramuscular; Intravenous50 mg
LiquidIntramuscular; Intravenous10 mg
Injection, powder, for solutionIntramuscular; Intravenous10 mg/mL
Injection, powder, for solutionIntramuscular; Intravenous100 mg/10mL
Injection, powder, for solutionIntramuscular; Intravenous20 mg/mL
Injection, powder, for solutionIntramuscular; Intravenous200 mg/20mL
Injection, powder, for solutionIntramuscular; Intravenous350 mg/17.5mL
Injection, powder, for solutionIntramuscular; Intravenous50 mg/5mL
Injection, powder, lyophilized, for solutionIntramuscular; Intravenous100 mg/10mL
Injection, powder, lyophilized, for solutionIntramuscular; Intravenous200 mg/20mL
Injection, powder, lyophilized, for solutionIntramuscular; Intravenous350 mg/17.5mL
Injection, powder, lyophilized, for solutionIntramuscular; Intravenous50 mg/5mL
Injection, powder, lyophilized, for solutionIntramuscular; Intravenous500 mg/50mL
TabletOral10 mg/1
TabletOral15 mg/1
TabletOral25 mg/1
TabletOral5 mg/1
SolutionIntramuscular; Intravenous10 mg
LiquidIntravenous10 mg
CapsuleOral
Prices
Unit descriptionCostUnit
Leucovorin calcium 25 mg tablet24.73USD tablet
Leucovorin calcium 500 mg vial24.42USD vial
Leucovorin calcium 200 mg vial14.4USD vial
Leucovorin calcium 350 mg vial11.86USD vial
Leucovorin Calcium 10 mg/ml10.93USD ml
Leucovorin calcium 15 mg tablet10.61USD tablet
Leucovorin calcium 10 mg tablet7.69USD tablet
Lederle Leucovorin Calcium 5 mg Tablet6.85USD tablet
Leucovorin calcium 100 mg vial6.0USD vial
Leucovorin calcium 50 mg vial3.6USD vial
Leucovorin calcium 5 mg tablet2.05USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point245 ºCNot Available
water solubilityCompleteNot Available
logP-3.2Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.297 mg/mLALOGPS
logP-0.46ALOGPS
logP-2.3ChemAxon
logS-3.2ALOGPS
pKa (Strongest Acidic)3.47ChemAxon
pKa (Strongest Basic)2.81ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count11ChemAxon
Hydrogen Donor Count7ChemAxon
Polar Surface Area215.55 Å2ChemAxon
Rotatable Bond Count9ChemAxon
Refractivity126.66 m3·mol-1ChemAxon
Polarizability46.33 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption-0.5642
Blood Brain Barrier-0.7779
Caco-2 permeable-0.8957
P-glycoprotein substrateSubstrate0.7344
P-glycoprotein inhibitor INon-inhibitor0.918
P-glycoprotein inhibitor IINon-inhibitor0.984
Renal organic cation transporterNon-inhibitor0.8708
CYP450 2C9 substrateNon-substrate0.7887
CYP450 2D6 substrateNon-substrate0.814
CYP450 3A4 substrateNon-substrate0.5852
CYP450 1A2 substrateNon-inhibitor0.8748
CYP450 2C9 inhibitorNon-inhibitor0.9123
CYP450 2D6 inhibitorNon-inhibitor0.9326
CYP450 2C19 inhibitorNon-inhibitor0.8984
CYP450 3A4 inhibitorNon-inhibitor0.9475
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9292
Ames testNon AMES toxic0.7955
CarcinogenicityNon-carcinogens0.9361
BiodegradationNot ready biodegradable0.8534
Rat acute toxicity2.4254 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9283
hERG inhibition (predictor II)Non-inhibitor0.5331
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as tetrahydrofolic acids. These are heterocyclic compounds based on the 5,6,7,8-tetrahydropteroic acid skeleton conjugated with at least one L-glutamic acid unit.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassPteridines and derivatives
Sub ClassPterins and derivatives
Direct ParentTetrahydrofolic acids
Alternative Parents
Substituents
  • Tetrahydrofolic acid
  • Glutamic acid or derivatives
  • Hippuric acid or derivatives
  • Hippuric acid
  • N-acyl-alpha amino acid or derivatives
  • N-acyl-alpha-amino acid
  • Alpha-amino acid or derivatives
  • Aminobenzamide
  • Aminobenzoic acid or derivatives
  • Benzamide
  • Benzoic acid or derivatives
  • Benzoyl
  • Phenylalkylamine
  • Aniline or substituted anilines
  • Aminopyrimidine
  • Secondary aliphatic/aromatic amine
  • Pyrimidone
  • Dicarboxylic acid or derivatives
  • Monocyclic benzene moiety
  • Primary aromatic amine
  • Benzenoid
  • Pyrimidine
  • Heteroaromatic compound
  • Vinylogous amide
  • Tertiary carboxylic acid amide
  • Amino acid
  • Amino acid or derivatives
  • Secondary carboxylic acid amide
  • Carboxamide group
  • Carboxylic acid
  • Carboxylic acid derivative
  • Secondary amine
  • Azacycle
  • Organic nitrogen compound
  • Carbonyl group
  • Organonitrogen compound
  • Organooxygen compound
  • Primary amine
  • Hydrocarbon derivative
  • Organic oxide
  • Organopnictogen compound
  • Organic oxygen compound
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Comments
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 13:48