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Target Identification Data Package

This package has 11 modules. The Structured Pharmacology Module has 5 tables. Preview the first five rows of each table or Explore the schema

Structured Pharmacology Module

5 Tables

The Structured pharmacology module provides essential pharmacokinetic parameters: LD50, Clearance, Half-Life, Volume of Distribution, and Bioavailability.

LD50

Structured pharmacokinetic data derived from text data stored in the toxicity field of the pharmacologies table. Comprises median lethal dosages (LD50), a measure of substance toxicity indicating the dose that causes death in 50% of animal test subjects.

id
value
min
max
unit
fda_label_reference
msds_reference
drug_id
organism_id
dosage_route_id
3
300.0
mg/kg
1
1
8920
1582
84
6
39.0
mg/kg
0
0
40
1579
70
9
27.0
mg/kg
1
1
73
1582
84
12
32.0
mg/m³
1
1
73
1582
93
15
37.0
mg/m³
1
1
73
1579
93
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Clearance

Structured pharmacokinetic data derived from text data stored in the clearance field of the pharmacologies table. Comprises clearance (CL) data, a measurement of the rate at which a drug leaves the body.

id
drug_id
value
min
max
unit
normalized_value
normalized_min
normalized_max
normalized_unit
dosage_route_id
dosage_form_id
dose_value
dose_min
dose_max
dose_unit
normalized_dose_value
normalized_dose_min
normalized_dose_max
normalized_dose_unit
fda_label_reference
7
1
139.0
mL/min
8.34
L/h
0
12
1
61.0
mL/min
3.66
L/h
0
17
1
114.0
mL/min
6.84
L/h
0
22
6
3.4
mL/min/kg
0.204
L/h/kg
0
27
6
2.7
mL/min/kg
0.162
L/h/kg
0
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Half-Life

Structured pharmacokinetic data derived from text data stored in the half-life field of the pharmacologies table. Comprises half-lives (t1/2), a measurement indicating the time required for the concentration of an administered drug within the body to decrease by half.

id
drug_id
value
min
max
unit
normalized_value
normalized_min
normalized_max
normalized_unit
dosage_route_id
dosage_form_id
dose_value
dose_min
dose_max
dose_unit
normalized_dose_value
normalized_dose_min
normalized_dose_max
normalized_dose_unit
fda_label_reference
8998
4
70.0
80.0
minutes
1.166666667
1.333333333
h
0
9003
8
164.0
84.0
353.0
hours
164.0
84.0
353.0
h
1
9008
16
4.0
hours
4.0
h
70
65
1
9013
16
6.0
hours
6.0
h
70
65
1
9018
16
4.0
13.0
hours
4.0
13.0
h
70
65
1
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Volume of Distribution

Structured pharmacokinetic data derived from text data stored in the volume of distribution field of the pharmacologies table. Comprises volumes of distribution (Vd), a measurement that describes the distribution of a drug throughout the body following administration.

id
drug_id
value
min
max
unit
normalized_value
normalized_min
normalized_max
normalized_unit
dosage_route_id
dosage_form_id
dose_value
dose_min
dose_max
dose_unit
normalized_dose_value
normalized_dose_min
normalized_dose_max
normalized_dose_unit
fda_label_reference
27463
5084
50.0
L
50.0
L
0
27468
1281
0.07
L/kg
0.07
L/kg
70
0
27473
1281
0.09
L/kg
0.09
L/kg
70
0
27478
1281
0.11
L/kg
0.11
L/kg
98
0
27483
15619
100.0
L
100.0
L
70
0
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Bioavailability

Structured pharmacokinetic data derived from text data stored in the absorption field of the pharmacologies table. Comprises bioavailabilities (F), a measure of the extent to which a drug is absorbed into the systemic circulation.

id
drug_id
value
min
max
unit
normalized_value
normalized_min
normalized_max
normalized_unit
dosage_route_id
dosage_form_id
dose_value
dose_min
dose_max
dose_unit
normalized_dose_value
normalized_dose_min
normalized_dose_max
normalized_dose_unit
fda_label_reference
23323
17
71.0
%
71.0
%
98
0
23328
17
66.0
%
66.0
%
50
0
23333
17
3.0
5.0
%
3.0
5.0
%
58
0
23338
26
95.0
%
95.0
%
98
65
70.0
mg
70.0
mg
0
23343
38
80.0
%
80.0
%
0
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Showing 5 of 5 tables