Identification
NameN-Formylmethionine
Accession NumberDB04464  (EXPT01455)
TypeSmall Molecule
GroupsExperimental
Description

Effective in the initiation of protein synthesis. The initiating methionine residue enters the ribosome as N-formylmethionyl tRNA. This process occurs in Escherichia coli and other bacteria as well as in the mitochondria of eucaryotic cells. [PubChem]

Structure
Thumb
SynonymsNot Available
External IDs Not Available
Product Ingredients Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
Categories
UNIIPS9357B4XH
CAS numberNot Available
WeightAverage: 177.221
Monoisotopic: 177.045963913
Chemical FormulaC6H11NO3S
InChI KeyPYUSHNKNPOHWEZ-YFKPBYRVSA-N
InChI
InChI=1S/C6H11NO3S/c1-11-3-2-5(6(9)10)7-4-8/h4-5H,2-3H2,1H3,(H,7,8)(H,9,10)/t5-/m0/s1
IUPAC Name
(2S)-2-formamido-4-(methylsulfanyl)butanoic acid
SMILES
[H][C@@](CCSC)(NC=O)C(O)=O
Pharmacology
IndicationNot Available
Structured Indications Not Available
PharmacodynamicsNot Available
Mechanism of action
TargetKindPharmacological actionActionsOrganismUniProt ID
Glutamate--cysteine ligaseProteinunknownNot AvailableEscherichia coli (strain K12)P0A6W9 details
Ribonuclease pancreaticProteinunknownNot AvailableHumanP07998 details
Putative ATP-dependent Clp protease proteolytic subunit, mitochondrialProteinunknownNot AvailableHumanQ16740 details
Geranylgeranyl transferase type-2 subunit alphaProteinunknownNot AvailableHumanQ92696 details
Geranylgeranyl transferase type-2 subunit betaProteinunknownNot AvailableHumanP53611 details
Photosynthetic reaction center cytochrome c subunitProteinunknownNot AvailableRhodopseudomonas viridisP07173 details
Reaction center protein H chainProteinunknownNot AvailableRhodopseudomonas viridisP06008 details
Reaction center protein L chainProteinunknownNot AvailableRhodopseudomonas viridisP06009 details
Reaction center protein M chainProteinunknownNot AvailableRhodopseudomonas viridisP06010 details
Light-harvesting protein B-800/820 alpha chainProteinunknownNot AvailableRhodopseudomonas acidophilaP35089 details
Light-harvesting protein B-800/820 beta chainProteinunknownNot AvailableRhodopseudomonas acidophilaP35094 details
Light-harvesting protein B-800/850 alpha chainProteinunknownNot AvailableRhodopseudomonas acidophilaP26789 details
Light-harvesting protein B-800/850 beta chainProteinunknownNot AvailableRhodopseudomonas acidophilaP26790 details
Antithrombin-IIIProteinunknownNot AvailableHumanP01008 details
Beta-2-microglobulinProteinunknownNot AvailableHumanP61769 details
NADH-ubiquinone oxidoreductase chain 1ProteinunknownNot AvailableHumanP03886 details
HLA class I histocompatibility antigen, B-27 alpha chainProteinunknownNot AvailableHumanP03989 details
Respiratory nitrate reductase 1 alpha chainProteinunknownNot AvailableEscherichia coli (strain K12)P09152 details
Respiratory nitrate reductase 1 beta chainProteinunknownNot AvailableEscherichia coli (strain K12)P11349 details
Respiratory nitrate reductase 1 gamma chainProteinunknownNot AvailableEscherichia coli (strain K12)P11350 details
Protein S100-GProteinunknownNot AvailableHumanP29377 details
RubredoxinProteinunknownNot AvailableDesulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303)P00269 details
Cytochrome c oxidase subunit 4 isoform 1, mitochondrialProteinunknownNot AvailableHumanP13073 details
Cytochrome c oxidase subunit 1ProteinunknownNot AvailableHumanP00395 details
Cytochrome c oxidase subunit 2ProteinunknownNot AvailableHumanP00403 details
Cytochrome c oxidase subunit 3ProteinunknownNot AvailableHumanP00414 details
Cytochrome c oxidase subunit 5A, mitochondrialProteinunknownNot AvailableHumanP20674 details
Cytochrome c oxidase subunit 5B, mitochondrialProteinunknownNot AvailableHumanP10606 details
Cytochrome c oxidase subunit 6CProteinunknownNot AvailableHumanP09669 details
Cytochrome c oxidase subunit 7B, mitochondrialProteinunknownNot AvailableHumanP24311 details
Cytochrome c oxidase subunit 7C, mitochondrialProteinunknownNot AvailableHumanP15954 details
Cytochrome c oxidase subunit 8A, mitochondrialProteinunknownNot AvailableHumanP10176 details
Cytochrome c oxidase subunit 6A2, mitochondrialProteinunknownNot AvailableHumanQ02221 details
Cytochrome c oxidase subunit 6B1ProteinunknownNot AvailableHumanP14854 details
Cytochrome c oxidase subunit 7A1, mitochondrialProteinunknownNot AvailableHumanP24310 details
Methionyl-tRNA formyltransferaseProteinunknownNot AvailableEscherichia coli (strain K12)P23882 details
StreptavidinProteinunknownNot AvailableStreptomyces avidiniiP22629 details
Protein S100-BProteinunknownNot AvailableHumanP04271 details
Delta-hemolysinProteinunknownNot AvailableStaphylococcus aureusP0C1V1 details
Polyubiquitin-CProteinunknownNot AvailableHumanP0CG48 details
AtpHProteinunknownNot AvailableArthrospira platensis HN01A5HEI4 details
Probable L-ascorbate-6-phosphate lactonase UlaGProteinunknownNot AvailableEscherichia coli (strain K12)P39300 details
Immunoglobulin G-binding protein GProteinunknownNot AvailableStreptococcus sp. group GP19909 details
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organismsNot Available
PathwaysNot Available
Pharmacogenomic Effects/ADRs Not Available
Interactions
Drug Interactions Not Available
Food InteractionsNot Available
References
Synthesis ReferenceNot Available
General ReferencesNot Available
External Links
ATC CodesNot Available
AHFS CodesNot Available
PDB Entries
FDA labelNot Available
MSDSNot Available
Clinical Trials
Clinical Trials Not Available
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage formsNot Available
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental PropertiesNot Available
Predicted Properties
PropertyValueSource
Water Solubility9.75 mg/mLALOGPS
logP-0.61ALOGPS
logP-0.16ChemAxon
logS-1.3ALOGPS
pKa (Strongest Acidic)3.93ChemAxon
pKa (Strongest Basic)-0.91ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area66.4 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity42.54 m3·mol-1ChemAxon
Polarizability17.53 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9413
Blood Brain Barrier+0.9176
Caco-2 permeable-0.6728
P-glycoprotein substrateNon-substrate0.5324
P-glycoprotein inhibitor INon-inhibitor0.9525
P-glycoprotein inhibitor IINon-inhibitor0.985
Renal organic cation transporterNon-inhibitor0.933
CYP450 2C9 substrateNon-substrate0.7296
CYP450 2D6 substrateNon-substrate0.787
CYP450 3A4 substrateNon-substrate0.6463
CYP450 1A2 substrateNon-inhibitor0.849
CYP450 2C9 inhibitorNon-inhibitor0.9239
CYP450 2D6 inhibitorNon-inhibitor0.9684
CYP450 2C19 inhibitorNon-inhibitor0.9381
CYP450 3A4 inhibitorNon-inhibitor0.9824
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9951
Ames testNon AMES toxic0.8335
CarcinogenicityNon-carcinogens0.9495
BiodegradationNot ready biodegradable0.6075
Rat acute toxicity1.2614 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9831
hERG inhibition (predictor II)Non-inhibitor0.973
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
GC-MSGC-MS Spectrum - GC-MS (2 TMS)splash10-0pdi-1920000000-7ead52d367d0c14c2f83View in MoNA
GC-MSGC-MS Spectrum - GC-MS (1 TMS)splash10-002r-9800000000-d6bd1c4a45710fcff139View in MoNA
GC-MSGC-MS Spectrum - EI-Bsplash10-004i-1900000000-dbd5e7526844833f2769View in MoNA
GC-MSGC-MS Spectrum - EI-Bsplash10-002b-1931000000-f6d54f9e00989580bf16View in MoNA
GC-MSGC-MS Spectrum - GC-EI-TOFsplash10-0zi1-0920000000-eff4a723ccd21264f857View in MoNA
GC-MSGC-MS Spectrum - GC-EI-TOFsplash10-002r-6900000000-f44202a7297064bce497View in MoNA
GC-MSGC-MS Spectrum - GC-EI-TOFsplash10-0pdj-0920000000-4d46bd9a6a5f645fdee9View in MoNA
GC-MSGC-MS Spectrum - GC-EI-TOFsplash10-00di-9410000000-0d6268555c7a6ebf60efView in MoNA
Taxonomy
DescriptionThis compound belongs to the class of chemical entities known as methionine and derivatives. These are compounds containing methionine or a derivative thereof resulting from reaction of methionine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
KingdomChemical entities
Super ClassOrganic compounds
ClassOrganic acids and derivatives
Sub ClassCarboxylic acids and derivatives
Direct ParentMethionine and derivatives
Alternative ParentsN-acyl-L-alpha-amino acids / N-formyl-alpha amino acids / Thia fatty acids / Secondary carboxylic acid amides / Sulfenyl compounds / Monocarboxylic acids and derivatives / Dialkylthioethers / Carboxylic acids / Organopnictogen compounds / Organonitrogen compounds
SubstituentsMethionine or derivatives / N-acyl-l-alpha-amino acid / N-formyl-alpha-amino acid / N-formyl-alpha amino acid or derivatives / Thia fatty acid / Fatty acid / Fatty acyl / Carboxamide group / Secondary carboxylic acid amide / Dialkylthioether
Molecular FrameworkAliphatic acyclic compounds
External Descriptorsproteinogenic amino acid, L-methionine derivative, N-formyl amino acid (CHEBI:16552 ) / Other amino acids (C03145 )

Targets

Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
unknown
General Function:
Metal ion binding
Specific Function:
Not Available
Gene Name:
gshA
Uniprot ID:
P0A6W9
Uniprot Name:
Glutamate--cysteine ligase
Molecular Weight:
58268.695 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Ribonuclease a activity
Specific Function:
Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA.
Gene Name:
RNASE1
Uniprot ID:
P07998
Uniprot Name:
Ribonuclease pancreatic
Molecular Weight:
17644.125 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Serine-type endopeptidase activity
Specific Function:
Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates.
Gene Name:
CLPP
Uniprot ID:
Q16740
Uniprot Name:
ATP-dependent Clp protease proteolytic subunit, mitochondrial
Molecular Weight:
30179.76 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Zinc ion binding
Specific Function:
Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.
Gene Name:
RABGGTA
Uniprot ID:
Q92696
Uniprot Name:
Geranylgeranyl transferase type-2 subunit alpha
Molecular Weight:
65071.06 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Zinc ion binding
Specific Function:
Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.
Gene Name:
RABGGTB
Uniprot ID:
P53611
Uniprot Name:
Geranylgeranyl transferase type-2 subunit beta
Molecular Weight:
36924.04 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Rhodopseudomonas viridis
Pharmacological action
unknown
General Function:
Iron ion binding
Specific Function:
The reaction center of purple bacteria contains a tightly bound cytochrome molecule which re-reduces the photo oxidized primary electron donor.
Gene Name:
pufC
Uniprot ID:
P07173
Uniprot Name:
Photosynthetic reaction center cytochrome c subunit
Molecular Weight:
39370.915 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Rhodopseudomonas viridis
Pharmacological action
unknown
General Function:
Electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
Specific Function:
The reaction center is a membrane-bound complex that mediates the initial photochemical event in the electron transfer process of photosynthesis.
Gene Name:
puhA
Uniprot ID:
P06008
Uniprot Name:
Reaction center protein H chain
Molecular Weight:
28498.245 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Rhodopseudomonas viridis
Pharmacological action
unknown
General Function:
Metal ion binding
Specific Function:
The reaction center is a membrane-bound complex that mediates the initial photochemical event in the electron transfer process of photosynthesis.
Gene Name:
pufL
Uniprot ID:
P06009
Uniprot Name:
Reaction center protein L chain
Molecular Weight:
30578.225 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Rhodopseudomonas viridis
Pharmacological action
unknown
General Function:
Metal ion binding
Specific Function:
The reaction center is a membrane-bound complex that mediates the initial photochemical event in the electron transfer process of photosynthesis.
Gene Name:
pufM
Uniprot ID:
P06010
Uniprot Name:
Reaction center protein M chain
Molecular Weight:
36035.285 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Rhodopseudomonas acidophila
Pharmacological action
unknown
General Function:
Metal ion binding
Specific Function:
Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers.
Gene Name:
Not Available
Uniprot ID:
P35089
Uniprot Name:
Light-harvesting protein B-800/820 alpha chain
Molecular Weight:
5545.65 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Rhodopseudomonas acidophila
Pharmacological action
unknown
General Function:
Metal ion binding
Specific Function:
Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers.
Gene Name:
Not Available
Uniprot ID:
P35094
Uniprot Name:
Light-harvesting protein B-800/820 beta chain
Molecular Weight:
4725.425 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Rhodopseudomonas acidophila
Pharmacological action
unknown
General Function:
Metal ion binding
Specific Function:
Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers.
Gene Name:
Not Available
Uniprot ID:
P26789
Uniprot Name:
Light-harvesting protein B-800/850 alpha chain
Molecular Weight:
5653.73 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Rhodopseudomonas acidophila
Pharmacological action
unknown
General Function:
Metal ion binding
Specific Function:
Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers.
Gene Name:
Not Available
Uniprot ID:
P26790
Uniprot Name:
Light-harvesting protein B-800/850 beta chain
Molecular Weight:
4554.18 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Serine-type endopeptidase inhibitor activity
Specific Function:
Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.
Gene Name:
SERPINC1
Uniprot ID:
P01008
Uniprot Name:
Antithrombin-III
Molecular Weight:
52601.935 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Identical protein binding
Specific Function:
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
Gene Name:
B2M
Uniprot ID:
P61769
Uniprot Name:
Beta-2-microglobulin
Molecular Weight:
13714.43 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Nadh dehydrogenase (ubiquinone) activity
Specific Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Gene Name:
MT-ND1
Uniprot ID:
P03886
Uniprot Name:
NADH-ubiquinone oxidoreductase chain 1
Molecular Weight:
35660.055 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Peptide antigen binding
Specific Function:
Involved in the presentation of foreign antigens to the immune system.
Gene Name:
HLA-B
Uniprot ID:
P03989
Uniprot Name:
HLA class I histocompatibility antigen, B-27 alpha chain
Molecular Weight:
40427.835 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
unknown
General Function:
Nitrate reductase activity
Specific Function:
The nitrate reductase enzyme complex allows E.coli to use nitrate as an electron acceptor during anaerobic growth. The alpha chain is the actual site of nitrate reduction.
Gene Name:
narG
Uniprot ID:
P09152
Uniprot Name:
Respiratory nitrate reductase 1 alpha chain
Molecular Weight:
140488.49 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
unknown
General Function:
Oxidoreductase activity
Specific Function:
The nitrate reductase enzyme complex allows E.coli to use nitrate as an electron acceptor during anaerobic growth. The beta chain is an electron transfer unit containing four cysteine clusters involved in the formation of iron-sulfur centers. Electrons are transferred from the gamma chain to the molybdenum cofactor of the alpha subunit.
Gene Name:
narH
Uniprot ID:
P11349
Uniprot Name:
Respiratory nitrate reductase 1 beta chain
Molecular Weight:
58065.915 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
unknown
General Function:
Nitrate reductase activity
Specific Function:
The nitrate reductase enzyme complex allows E.coli to use nitrate as an electron acceptor during anaerobic growth. The gamma chain is a membrane-embedded heme-iron unit resembling cytochrome b, which transfers electrons from quinones to the beta subunit.
Gene Name:
narI
Uniprot ID:
P11350
Uniprot Name:
Respiratory nitrate reductase 1 gamma chain
Molecular Weight:
25497.16 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Vitamin d binding
Specific Function:
Not Available
Gene Name:
S100G
Uniprot ID:
P29377
Uniprot Name:
Protein S100-G
Molecular Weight:
9016.14 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303)
Pharmacological action
unknown
General Function:
Iron ion binding
Specific Function:
Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.Electron acceptor for cytoplasmic lactate dehydrogenase.
Gene Name:
rub
Uniprot ID:
P00269
Uniprot Name:
Rubredoxin
Molecular Weight:
5574.145 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Cytochrome-c oxidase activity
Specific Function:
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Gene Name:
COX4I1
Uniprot ID:
P13073
Uniprot Name:
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
Molecular Weight:
19576.6 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Iron ion binding
Specific Function:
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
Gene Name:
MT-CO1
Uniprot ID:
P00395
Uniprot Name:
Cytochrome c oxidase subunit 1
Molecular Weight:
57040.91 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Cytochrome-c oxidase activity
Specific Function:
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.
Gene Name:
MT-CO2
Uniprot ID:
P00403
Uniprot Name:
Cytochrome c oxidase subunit 2
Molecular Weight:
25564.73 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Cytochrome-c oxidase activity
Specific Function:
Subunits I, II and III form the functional core of the enzyme complex.
Gene Name:
MT-CO3
Uniprot ID:
P00414
Uniprot Name:
Cytochrome c oxidase subunit 3
Molecular Weight:
29950.6 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Metal ion binding
Specific Function:
This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Gene Name:
COX5A
Uniprot ID:
P20674
Uniprot Name:
Cytochrome c oxidase subunit 5A, mitochondrial
Molecular Weight:
16761.985 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Metal ion binding
Specific Function:
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Gene Name:
COX5B
Uniprot ID:
P10606
Uniprot Name:
Cytochrome c oxidase subunit 5B, mitochondrial
Molecular Weight:
13695.57 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Cytochrome-c oxidase activity
Specific Function:
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Gene Name:
COX6C
Uniprot ID:
P09669
Uniprot Name:
Cytochrome c oxidase subunit 6C
Molecular Weight:
8781.36 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Cytochrome-c oxidase activity
Specific Function:
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Plays a role in proper central nervous system (CNS) development in vertebrates.
Gene Name:
COX7B
Uniprot ID:
P24311
Uniprot Name:
Cytochrome c oxidase subunit 7B, mitochondrial
Molecular Weight:
9160.485 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Cytochrome-c oxidase activity
Specific Function:
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Gene Name:
COX7C
Uniprot ID:
P15954
Uniprot Name:
Cytochrome c oxidase subunit 7C, mitochondrial
Molecular Weight:
7245.45 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Cytochrome-c oxidase activity
Specific Function:
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Gene Name:
COX8A
Uniprot ID:
P10176
Uniprot Name:
Cytochrome c oxidase subunit 8A, mitochondrial
Molecular Weight:
7579.0 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Cytochrome-c oxidase activity
Specific Function:
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Gene Name:
COX6A2
Uniprot ID:
Q02221
Uniprot Name:
Cytochrome c oxidase subunit 6A2, mitochondrial
Molecular Weight:
10815.32 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Cytochrome-c oxidase activity
Specific Function:
Connects the two COX monomers into the physiological dimeric form.
Gene Name:
COX6B1
Uniprot ID:
P14854
Uniprot Name:
Cytochrome c oxidase subunit 6B1
Molecular Weight:
10192.345 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Cytochrome-c oxidase activity
Specific Function:
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Gene Name:
COX7A1
Uniprot ID:
P24310
Uniprot Name:
Cytochrome c oxidase subunit 7A1, mitochondrial
Molecular Weight:
9117.44 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
unknown
General Function:
Methyltransferase activity
Specific Function:
Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP.
Gene Name:
fmt
Uniprot ID:
P23882
Uniprot Name:
Methionyl-tRNA formyltransferase
Molecular Weight:
34168.16 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Streptomyces avidinii
Pharmacological action
unknown
General Function:
Not Available
Specific Function:
The biological function of streptavidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of streptavidin).
Gene Name:
Not Available
Uniprot ID:
P22629
Uniprot Name:
Streptavidin
Molecular Weight:
18833.61 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Zinc ion binding
Specific Function:
Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within...
Gene Name:
S100B
Uniprot ID:
P04271
Uniprot Name:
Protein S100-B
Molecular Weight:
10712.985 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Staphylococcus aureus
Pharmacological action
unknown
General Function:
Not Available
Specific Function:
Lyses erythrocytes and many other mammalian cells.
Gene Name:
hld
Uniprot ID:
P0C1V1
Uniprot Name:
Delta-hemolysin
Molecular Weight:
2978.515 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Protease binding
Specific Function:
Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiqui...
Gene Name:
UBC
Uniprot ID:
P0CG48
Uniprot Name:
Polyubiquitin-C
Molecular Weight:
77038.08 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Arthrospira platensis HN01
Pharmacological action
unknown
General Function:
Hydrogen ion transmembrane transporter activity
Specific Function:
Not Available
Gene Name:
atpH
Uniprot ID:
A5HEI4
Uniprot Name:
AtpH
Molecular Weight:
8180.505 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
unknown
General Function:
Manganese ion binding
Specific Function:
Probably catalyzes the hydrolysis of L-ascorbate-6-P into 3-keto-L-gulonate-6-P. Is essential for L-ascorbate utilization under anaerobic conditions. Also shows phosphodiesterase activity, hydrolyzing phosphodiester bond in the artificial chromogenic substrate bis-p-nitrophenyl phosphate (bis-pNPP).
Gene Name:
ulaG
Uniprot ID:
P39300
Uniprot Name:
Probable L-ascorbate-6-phosphate lactonase UlaG
Molecular Weight:
40060.435 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Streptococcus sp. group G
Pharmacological action
unknown
General Function:
Not Available
Specific Function:
Not Available
Gene Name:
spg
Uniprot ID:
P19909
Uniprot Name:
Immunoglobulin G-binding protein G
Molecular Weight:
63291.11 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Drug created on June 13, 2005 07:24 / Updated on June 11, 2017 20:55