Identification

Logo pink
Are you a
new drug developer?
Contact us to learn more about our customized products and solutions.
Name
AP1903
Accession Number
DB04974
Type
Small Molecule
Groups
Investigational
Description
Not Available
Synonyms
Not Available
Categories
UNII
Not Available
CAS number
Not Available
Weight
Not Available
Chemical Formula
Not Available
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

Pharmacology

Indication

Investigated for use/treatment in bone marrow transplant and graft versus host disease.

Pharmacodynamics
Not Available
Mechanism of action
TargetActionsOrganism
USerine/threonine-protein kinase mTORNot AvailableHumans
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
Not Available
External Links
PubChem Substance
347909868

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1Active Not RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / Chronic Chronic myelogenous leukemia / Epstein Barr Virus Infections / Familial Hemophagocytic Lymphohistiocytosis / Hemophagocytic Syndrome / Leukemia Acute Myeloid Leukemia (AML) / Lymphohistiocytosis, Hemophagocytic / Myelodysplastic Syndrome / Non Hodgkin Lymphoma (NHL) / X-Linked Lymphoproliferative Disease1
1Active Not RecruitingTreatmentHaemoglobinopathies congenital / Inherited Bone Marrow Failure Syndromes / Lymphohistiocytosis, Hemophagocytic / Metabolic Disorders / Primary Immune Deficiency Disorders (PIDD)1
1Active Not RecruitingTreatmentLeukemias / Malignant Lymphomas / Multiple Myeloma (MM) / Myelodysplastic Syndromes / Neoplasms, Hematologic1
1CompletedTreatmentCastrate Resistant Prostate Cancer (CRPC)1
1CompletedTreatmentMelanoma / Neuroblastomas / Sarcoma, Osteogenic / Sarcomas1
1Not Yet RecruitingTreatmentAcute Bilineal Leukemia / Acute Lymphoblastic Leukaemia Recurrent / Acute, recurrent Myeloid Leukemia / Chronic, recurrent Lymphocytic Leukemia / Minimal Residual Disease / Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable / Myelodysplastic/Myeloproliferative Neoplasms / Myeloproliferative Neoplasms / Recurrent Acute Biphenotypic Leukemia / Recurrent Blastic Plasmacytoid Dendritic Cell Neoplasm / Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Recurrent Chronic Myelomonocytic Leukemia / Recurrent Myelodysplastic Syndrome1
1RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / Immune System Diseases / Immunoproliferative Disorders1
1RecruitingTreatmentCancer, Breast / Metastatic HER2-negative Breast1
1RecruitingTreatmentImmune System Diseases / Immunoproliferative Disorders / Lymphatic Diseases / Lymphoma, B-Cell / Malignant Lymphomas1
1RecruitingTreatmentMalignancies, Hematologic1
1WithdrawnTreatmentLeukemias / Malignant Lymphomas / Multiple Myeloma (MM) / Myelodysplastic Syndromes / Other High-risk Hematological Malignancies1
1WithdrawnTreatmentMalignancies, Hematologic / Neoplasms, Hematologic1
1, 2Active Not RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / Acute Myelogenous Leukaemia (AML) / Malignant Lymphomas1
1, 2Active Not RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / Aplastic Anaemia (AA) / Congenital Hypoplastic Anemia / Congenital Immunodeficiency / Cytopenias / Diamond Blackfan Anemia / Haemoglobinopathies congenital / Immunologic Deficiency Syndromes / Leukemia Acute Myeloid Leukemia (AML) / Leukemia, Acute Myeloid (AML), Child / Myelodysplastic Syndrome / Non-Hodgkin's Lymphoma (NHL) / Osteopetrosis / Sickle Cell Disorders / Thalassaemic disorders1
1, 2Active Not RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / Aplastic Anaemia (AA) / Cytopenias / Hemoglobinopathy in Children / Immunologic Deficiency Syndromes / Leukemia, Acute Myeloid (AML), Child / Myelodysplastic Syndromes / Non-Hodgkin's Lymphoma (NHL) / Osteopetrosis / Primary Immune Deficiency Disorders (PIDD)1
1, 2Active Not RecruitingTreatmentAcute Myelocytic Leukemia / Leukemia Acute Myeloid Leukemia (AML) / Myelodysplastic Syndrome / Uveal Melanoma1
1, 2RecruitingTreatmentAcute Lymphocytic Leukemia (ALL) / B-lymphoid Malignancies / Chronic Lymphocytic Leukaemia (CLL) / Non-Hodgkin's Lymphoma (NHL)1
1, 2RecruitingTreatmentAdenocarcinoma of the Pancreas / Adenocarcinoma, Prostate / Gastric Adenocarcinoma / Non-Resectable Pancreatic Cancer1
1, 2TerminatedTreatmentLeukemias / Myeloproliferative Disorders / Plasma Cell Myeloma1
2, 3RecruitingTreatmentLeukemia Acute Myeloid Leukemia (AML) / Myelodysplastic Syndromes1
Not AvailableAvailableNot AvailableHurler's Syndrome / Inborn Errors of Metabolism / Inherited Metabolic Disorder / Lysosomal Storage Disorder / Metachromatic Leukodystrophy1
Not AvailableNo Longer AvailableNot AvailableAcute Lymphoblastic Leukaemias (ALL) / Immune System Diseases / Immunoproliferative Disorders1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Targets

Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Tfiiic-class transcription factor binding
Specific Function
Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly...
Gene Name
MTOR
Uniprot ID
P42345
Uniprot Name
Serine/threonine-protein kinase mTOR
Molecular Weight
288889.05 Da

Drug created on October 21, 2007 16:23 / Updated on June 04, 2019 06:13