Identification
NameAP1903
Accession NumberDB04974
TypeSmall Molecule
GroupsInvestigational
DescriptionNot Available
Structure
Thumb
SynonymsNot Available
External IDs Not Available
Product Ingredients Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
Categories
UNIINot Available
CAS numberNot Available
WeightNot Available
Chemical FormulaNot Available
InChI KeyNot Available
InChINot Available
IUPAC NameNot Available
SMILESNot Available
Pharmacology
Indication

Investigated for use/treatment in bone marrow transplant and graft versus host disease.

Structured Indications Not Available
PharmacodynamicsNot Available
Mechanism of action
TargetKindPharmacological actionActionsOrganismUniProt ID
Serine/threonine-protein kinase mTORProteinunknownNot AvailableHumanP42345 details
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organismsNot Available
PathwaysNot Available
Pharmacogenomic Effects/ADRs Not Available
Interactions
Drug Interactions Not Available
Food InteractionsNot Available
References
Synthesis ReferenceNot Available
General ReferencesNot Available
External LinksNot Available
ATC CodesNot Available
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSNot Available
Clinical Trials
Clinical Trials
PhaseStatusPurposeConditionsCount
1Active Not RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / Acute Myeloid Leukaemias (AML) / Chronic Myelogenous Leukemia (CML) / Epstein Barr Virus Infections / Familial Hemophagocytic Lymphohistiocytosis / Hemophagocytic Syndrome / Lymphohistiocytosis, Hemophagocytic / Myelodysplastic Syndrome / Non Hodgkin Lymphoma (NHL) / X-Linked Lymphoproliferative Disease1
1CompletedTreatmentCastrate Resistant Prostate Cancer (CRPC)1
1CompletedTreatmentMelanoma / Neuroblastomas / Sarcoma, Osteogenic / Sarcomas1
1Not Yet RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / Immune System Diseases / Immunoproliferative Disorders1
1Not Yet RecruitingTreatmentLeukemias / Malignant Lymphomas / Multiple Myeloma (MM) / Myelodysplastic Syndromes / Other High-risk Hematological Malignancies1
1Not Yet RecruitingTreatmentMalignancies, Hematologic / Neoplasms, Hematologic1
1RecruitingTreatmentAcute Myelocytic Leukemia / Acute Myeloid Leukaemias (AML) / Myelodysplastic Syndrome1
1RecruitingTreatmentCancer, Breast / Metastatic HER2-negative Breast1
1RecruitingTreatmentHaemoglobinopathies congenital / Inherited Bone Marrow Failure Syndromes / Lymphohistiocytosis, Hemophagocytic / Metabolic Disorders / Primary Immune Deficiency Disorders (PIDD)1
1RecruitingTreatmentNeoplasms, Hematologic1
1RecruitingTreatmentNon-Resectable Pancreatic Cancer1
1, 2RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / Acute Myelogenous Leukaemia (AML) / Malignant Lymphomas1
1, 2RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / Immunologic Deficiency Syndromes / Leukaemias acute myeloid / Myelodysplastic Syndrome / Non-Hodgkin's Lymphoma (NHL)1
1, 2RecruitingTreatmentAcute Lymphocytic Leukemia (ALL) / B-lymphoid Malignancies / Chronic Lymphocytic Leukaemia (CLL) / Non-Hodgkin's Lymphoma (NHL)1
1, 2TerminatedTreatmentLeukemias / Myeloproliferative Diseases / Plasma Cell Myeloma1
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage formsNot Available
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental PropertiesNot Available
Predicted PropertiesNot Available
Predicted ADMET featuresNot Available
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Taxonomy
ClassificationNot classified

Targets

Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Tfiiic-class transcription factor binding
Specific Function:
Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activ...
Gene Name:
MTOR
Uniprot ID:
P42345
Uniprot Name:
Serine/threonine-protein kinase mTOR
Molecular Weight:
288889.05 Da
Drug created on October 21, 2007 16:23 / Updated on August 17, 2016 12:24