Identification

Name
AP1903
Accession Number
DB04974
Type
Small Molecule
Groups
Investigational
Description
Not Available
Synonyms
Not Available
Categories
UNII
Not Available
CAS number
Not Available
Weight
Not Available
Chemical Formula
Not Available
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

Pharmacology

Indication

Investigated for use/treatment in bone marrow transplant and graft versus host disease.

Structured Indications
Not Available
Pharmacodynamics
Not Available
Mechanism of action
TargetActionsOrganism
USerine/threonine-protein kinase mTORNot AvailableHuman
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
Not Available
External Links
PubChem Substance
347909868

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1Active Not RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / Chronic Myelogenous Leukemia (CML) / Epstein Barr Virus Infections / Familial Hemophagocytic Lymphohistiocytosis / Hemophagocytic Syndrome / Leukemia Acute Myeloid Leukemia (AML) / Lymphohistiocytosis, Hemophagocytic / Myelodysplastic Syndrome / Non Hodgkin Lymphoma (NHL) / X-Linked Lymphoproliferative Disease1
1CompletedTreatmentCastrate Resistant Prostate Cancer (CRPC)1
1CompletedTreatmentMelanoma / Neuroblastomas / Sarcoma, Osteogenic / Sarcomas1
1Not Yet RecruitingTreatmentLeukemias / Malignant Lymphomas / Multiple Myeloma (MM) / Myelodysplastic Syndromes / Other High-risk Hematological Malignancies1
1Not Yet RecruitingTreatmentMalignancies, Hematologic / Neoplasms, Hematologic1
1RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / Immune System Diseases / Immunoproliferative Disorders1
1RecruitingTreatmentAcute Myelocytic Leukemia / Leukemia Acute Myeloid Leukemia (AML) / Myelodysplastic Syndrome1
1RecruitingTreatmentCancer, Breast / Metastatic HER2-negative Breast1
1RecruitingTreatmentHaemoglobinopathies congenital / Inherited Bone Marrow Failure Syndromes / Lymphohistiocytosis, Hemophagocytic / Metabolic Disorders / Primary Immune Deficiency Disorders (PIDD)1
1RecruitingTreatmentNeoplasms, Hematologic1
1RecruitingTreatmentNon-Resectable Pancreatic Cancer1
1, 2RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / Acute Myelogenous Leukaemia (AML) / Malignant Lymphomas1
1, 2RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / Immunologic Deficiency Syndromes / Leukemia Acute Myeloid Leukemia (AML) / Leukemia, Acute Myeloid (AML), Child / Myelodysplastic Syndrome / Non-Hodgkin's Lymphoma (NHL)1
1, 2RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / Immunologic Deficiency Syndromes / Leukemia, Acute Myeloid (AML), Child / Myelodysplastic Syndromes / Non-Hodgkin's Lymphoma (NHL)1
1, 2RecruitingTreatmentAcute Lymphocytic Leukemia (ALL) / B-lymphoid Malignancies / Chronic Lymphocytic Leukaemia (CLL) / Non-Hodgkin's Lymphoma (NHL)1
1, 2TerminatedTreatmentLeukemias / Myeloproliferative Disorders / Plasma Cell Myeloma1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Targets

Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Tfiiic-class transcription factor binding
Specific Function
Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly...
Gene Name
MTOR
Uniprot ID
P42345
Uniprot Name
Serine/threonine-protein kinase mTOR
Molecular Weight
288889.05 Da

Drug created on October 21, 2007 16:23 / Updated on November 06, 2017 06:45