PTC299
Identification
- Name
- PTC299
- Accession Number
- DB05173
- Type
- Small Molecule
- Groups
- Investigational
- Description
PTC299 is a novel, orally administered small-molecule designed to inhibit the production of vascular endothelial growth factor (VEGF) in tumors. Overexpression of VEGF plays a key role in multiple diseases including cancer and macular degeneration. PTC299 was discovered through PTC's GEMS technology by targeting the post-transcriptional processes that regulate VEGF formation, and is currently being developed for the treatment of cancer.
- Synonyms
- Not Available
- Categories
- UNII
- Not Available
- CAS number
- Not Available
- Weight
- Not Available
- Chemical Formula
- Not Available
- InChI Key
- Not Available
- InChI
- Not Available
- IUPAC Name
- Not Available
- SMILES
- Not Available
Pharmacology
- Indication
Investigated for use/treatment in cancer/tumors (unspecified) and solid tumors.
- Pharmacodynamics
PTC299 demonstrated a broad range of activity in blocking VEGF synthesis in multiple tumor types, including breast, cervical, colorectal, fibrosarcoma, gastric, lung, melanoma, neuroblastoma, ovarian, pancreatic, prostate and renal cell cancer lines. PTC299 as a monotherapy significantly reduced VEGF concentrations in tumors and plasma, reduced tumor blood vessel density, and substantially impeded tumor progression.
- Mechanism of action
PTC299 was designed to inhibit VEGF production in tumors by targeting the post-transcriptional control processes that regulate VEGF formation. Because PTC299 inhibits VEGF production, its action occurs at a different point in the VEGF pathway than therapies, such as Avastin® or Sutent®. PTC299 may be active both as a single agent or when used in combination with other anti-angiogenic agents or with chemotherapy agents for the treatment of cancers.
- Absorption
- Not Available
- Volume of distribution
- Not Available
- Protein binding
- Not Available
- Metabolism
- Not Available
- Route of elimination
- Not Available
- Half life
- Not Available
- Clearance
- Not Available
- Toxicity
- Not Available
- Affected organisms
- Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
Drug Interaction (4R)-limonene The risk or severity of adverse effects can be increased when PTC299 is combined with (4R)-limonene. 16-Bromoepiandrosterone The risk or severity of adverse effects can be increased when PTC299 is combined with 16-Bromoepiandrosterone. 19-norandrostenedione The risk or severity of adverse effects can be increased when PTC299 is combined with 19-norandrostenedione. 5-androstenedione The risk or severity of adverse effects can be increased when PTC299 is combined with 5-androstenedione. Aceclofenac The risk or severity of adverse effects can be increased when PTC299 is combined with Aceclofenac. Acemetacin The risk or severity of adverse effects can be increased when PTC299 is combined with Acemetacin. Alclofenac The risk or severity of adverse effects can be increased when PTC299 is combined with Alclofenac. Aldosterone The risk or severity of adverse effects can be increased when PTC299 is combined with Aldosterone. Alminoprofen The risk or severity of adverse effects can be increased when PTC299 is combined with Alminoprofen. Andrographolide The risk or severity of adverse effects can be increased when PTC299 is combined with Andrographolide. - Food Interactions
- Not Available
References
- General References
- Not Available
- External Links
- PubChem Substance
- 347909999
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 1 Completed Treatment Metastatic Breast Cancer (MBC) 1 1 Suspended Treatment Cancer, Advanced 1 2 Terminated Treatment Neurofibromatosis 2 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
- Not Available
- Predicted ADMET features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Taxonomy
- Classification
- Not classified
Drug created on October 21, 2007 16:24 / Updated on October 01, 2018 13:59