MP4

Identification

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Name
MP4
Accession Number
DB05313
Type
Small Molecule
Groups
Investigational
Description

MP4 is a hemoglobin-based oxygen carrier designed to serve as an alternative for blood transfusions. It is free of harmful vasoactivity and provides targeted oxygen delivery to tissues at risk of oxygen deprivation.

Synonyms
Not Available
International/Other Brands
Hemospan
Categories
Not Available
UNII
Not Available
CAS number
Not Available
Weight
Not Available
Chemical Formula
Not Available
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

Pharmacology

Indication

Investigated for use/treatment in hemorrhage and transfusion.

Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
  1. Bjorkholm M, Fagrell B, Przybelski R, Winslow N, Young M, Winslow RM: A phase I single blind clinical trial of a new oxygen transport agent (MP4), human hemoglobin modified with maleimide-activated polyethylene glycol. Haematologica. 2005 Apr;90(4):505-15. [PubMed:15820947]
External Links
PubChem Substance
347910075
Wikipedia
MP4

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1, 2CompletedTreatmentArterial Hypotension / Arterial hypoxia1
2CompletedTreatmentBlood Loss,Surgical / General Surgery / Prostate Cancer1
2CompletedTreatmentCritical Lower Limb Ischemia / Vascular Diseases1
2CompletedTreatmentLactic Acidosis / Shock, Hemorrhagic / Traumatic Shock2
2WithdrawnTreatmentLactic Acidosis / Shock, Hemorrhagic / Traumas1
3CompletedTreatmentArterial Hypotension / Transient ischemia attacks2

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on November 18, 2007 11:23 / Updated on June 04, 2019 06:15