NAV

Hydronidone

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Hydronidone
DrugBank Accession Number
DB06299
Background

Hydronidone has antifibrotic activity.

Type
Small Molecule
Groups
Investigational
Structure
3D
Similar Structures
Weight
Average: 201.225
Monoisotopic: 201.078978598
Chemical Formula
C12H11NO2
Synonyms
  • N-(4-Hydroxyphenyl)-5-methyl-2-pyridone
External IDs
  • F 351
  • F-351
  • F351
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Pharmacology

Indication

Investigated for use/treatment in liver disease.

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as pyridinones. These are compounds containing a pyridine ring, which bears a ketone.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Pyridines and derivatives
Sub Class
Hydropyridines
Direct Parent
Pyridinones
Alternative Parents
Methylpyridines / Dihydropyridines / 1-hydroxy-2-unsubstituted benzenoids / Benzene and substituted derivatives / Heteroaromatic compounds / Lactams / Azacyclic compounds / Organooxygen compounds / Organonitrogen compounds / Organic oxides
show 1 more
Substituents
1-hydroxy-2-unsubstituted benzenoid / Aromatic heteromonocyclic compound / Azacycle / Benzenoid / Dihydropyridine / Heteroaromatic compound / Hydrocarbon derivative / Lactam / Methylpyridine / Monocyclic benzene moiety
show 7 more
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
RXQ128313W
CAS number
851518-71-3
InChI Key
NETTXQJYJRFTFS-UHFFFAOYSA-N
InChI
InChI=1S/C12H11NO2/c1-9-2-7-12(15)13(8-9)10-3-5-11(14)6-4-10/h2-8,14H,1H3
IUPAC Name
1-(4-hydroxyphenyl)-5-methyl-1,2-dihydropyridin-2-one
SMILES
CC1=CN(C(=O)C=C1)C1=CC=C(O)C=C1

References

General References
Not Available
ChemSpider
9392955
ZINC
ZINC000021981322

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3RecruitingTreatmentLiver Fibrosis2
2CompletedTreatmentChronic Hepatitis B Infection1
1CompletedBasic ScienceHepatitis b & Liver Dysfunction1
1CompletedBasic ScienceHydronidone1
1CompletedBasic SciencePharmacokinetics of Hydronidone1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility3.15 mg/mLALOGPS
logP1.63ALOGPS
logP1.84Chemaxon
logS-1.8ALOGPS
pKa (Strongest Acidic)9.3Chemaxon
pKa (Strongest Basic)-1.2Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count2Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area40.54 Å2Chemaxon
Rotatable Bond Count1Chemaxon
Refractivity58.98 m3·mol-1Chemaxon
Polarizability21.3 Å3Chemaxon
Number of Rings2Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-0udi-0090000000-f1682f45c7debe3cb8bb
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-0udi-0090000000-33bdb8975d986c698a41
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-0uk9-0940000000-3625deadc96d0e7e41b3
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0fka-0930000000-748dffe1884b1bcd4e04
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-0n29-7900000000-c32da729603639e99632
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-05fr-2900000000-19f134dcd69c4794f6bf
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-153.1540121
predicted
DarkChem Lite v0.1.0
[M+H]+153.7076121
predicted
DarkChem Lite v0.1.0
[M+Na]+152.8439121
predicted
DarkChem Lite v0.1.0

Drug created at March 19, 2008 16:23 / Updated at June 12, 2020 16:52