Identification

Name
Bafilomycin B1
Accession Number
DB06734
Type
Small Molecule
Groups
Experimental
Description
Not Available
Synonyms
  • Setamycin
Categories
UNII
Not Available
CAS number
88899-56-3
Weight
Not Available
Chemical Formula
Not Available
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
TargetActionsOrganism
AV-type proton ATPase catalytic subunit A
inhibitor
Human
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Bafilomycin B1.
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Bafilomycin B1.
Ascorbic acidThe serum concentration of Ascorbic acid can be increased when it is combined with Bafilomycin B1.
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Bafilomycin B1.
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Bafilomycin B1.
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Bafilomycin B1.
CimetidineThe serum concentration of Cimetidine can be increased when it is combined with Bafilomycin B1.
CiprofloxacinThe serum concentration of Ciprofloxacin can be increased when it is combined with Bafilomycin B1.
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Bafilomycin B1.
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Bafilomycin B1.
Food Interactions
Not Available

References

General References
Not Available
External Links
PubChem Substance
347910364

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Targets

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Proton-transporting atpase activity, rotational mechanism
Specific Function
Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
Gene Name
ATP6V1A
Uniprot ID
P38606
Uniprot Name
V-type proton ATPase catalytic subunit A
Molecular Weight
68303.5 Da
References
  1. Schuhmann T, Grond S: Biosynthetic investigations of the V-type ATPase inhibitors bafilomycin A1, B1 and concanamycin A. J Antibiot (Tokyo). 2004 Oct;57(10):655-61. [PubMed:15638326]

Drug created on August 25, 2010 14:42 / Updated on August 02, 2018 05:39