Name
Lactones
Accession Number
DBCAT000498
Description

Cyclic esters of hydroxy carboxylic acids, containing a 1-oxacycloalkan-2-one structure. Large cyclic lactones of over a dozen atoms are MACROLIDES.

Drugs
DrugDrug Description
ErythromycinA macrolide antibiotic used to treat and prevent a variety of bacterial infections.
AzithromycinA macrolide antibiotic used to treat a variety of bacterial infections.
PimecrolimusA topical calcineurin inhibitor used in the treatment of mild-moderate atopic dermatitis who are not candidates for other types of therapy due to previous lack of response or other reasons.
SpironolactoneAn aldosterone receptor antagonist used for the treatment of hypertension, hyperaldosteronism, edema due to various conditions, hirsutism (off-label) and hypokalemia.
PicrotoxinUsed internally for relieving respiratory distress. Also for use as an antidote in poisoning by CNS depressants, especially barbiturates.
IvermectinAn anti parasite medication used to treat head lice, onchocerciasis, strongyloidiasis, ascariasis, trichuriasis, and enterobiasis.
NystatinA polyene ionophore antifungal used to treat cutaneous, mucocutaneous, and gastrointestinal mycotic infections, particularly those caused by Candida species.
Amphotericin BAn antifungal used to treat fungal infections in neutropenic patients, cryptococcal meningitis in HIV infection, fungal infections, and leishmaniasis.
EplerenoneAn aldosterone receptor antagonist used to improve survival of patients with symptomatic heart failure and to reduce blood pressure.
RoxithromycinUsed to treat respiratory tract, urinary and soft tissue infections.
NatamycinA macrolide antifungal used to treat fungal infections of the eye.
TacrolimusA calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis.
SirolimusAn immunosuppressant used to prevent organ transplant rejections and to treat lymphangioleiomyomatosis.
DirithromycinFor the treatment of the following mild-to-moderate infections caused by susceptible strains of microorganisms: acute bacterial exacerbations of chronic bronchitis, secondary bacterial infection of acute bronchitis, community-acquired pneumonia, pharyngitis/tonsilitis, and...
TelithromycinAn ketolide used to treat community acquired pneumonia of mild to moderate severity.
CandicidinUsed in the topical treatment of vulvovaginal candidiasis.
ClarithromycinA macrolide antibiotic used for the treatment of a wide variety of bacterial infections such as acute otitis, pharyngitis, tonsillitis, respiratory tract infections, uncomplicated skin infections, and helicobacter pylori infection.
JosamycinFor the treatment of bacterial infections.
EverolimusA mammalian target of rapamycin (mTOR) kinase inhibitor used to treat various types of malignancies.
Epothilone DInvestigated for use/treatment in colorectal cancer, lung cancer, breast cancer, solid tumors, and prostate cancer.
Homoserine LactoneNot Available
Soraphen ANot Available
PatupiloneInvestigated for use/treatment in ovarian cancer, lung cancer, brain cancer, breast cancer, and gastric cancer.
RadicicolNot Available
6-Deoxyerythronolide BNot Available
Aplyronine ANot Available
gamma-butyrolactoneOne of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used...
Reidispongiolide ANot Available
IxabepiloneA microtubule inhibitor administered in combination with capecitabine or alone in the treatment of metastatic or locally advanced breast cancer that has shown inadequate response to taxanes and anthracyclines.
Trastuzumab emtansineAn antineoplastic agent and antibody-drug conjugate used to treat HER2-overexpressing breast cancer.
GPI-1485Investigated for use/treatment in erectile dysfunction and parkinson's disease.
KOS-1584Investigated for use/treatment in solid tumors.
SpiramycinA macrolide antimicrobial agent used in the treatment of various bacterial infections.
RidaforolimusInvestigated for use/treatment in solid tumors, sarcoma, cancer/tumors (unspecified), endometrial cancer, prostate cancer, and bone metastases.
TemsirolimusA antineoplastic agent used in the treatment of renal cell carcinoma (RCC) that works by inhibiting mTOR.
AVE9633Investigated for use/treatment in leukemia (myeloid).
Coltuximab ravtansineInvestigated for use/treatment in lymphoma (non-hodgkin's).
CethromycinA ketolide antibiotic with broad-spectrum activity against Gram-positive, Gram-negative, and atypical bacteria that may be useful for treating several conditions including community-acquired pneumonia, inhalation anthrax, plague, and tularemia.
MitemcinalInvestigated for use/treatment in gastroparesis and irritable bowel syndrome (IBS).
Bafilomycin A1The bafilomycins refer to a category of toxic macrolide antibiotics that are derivatives of Streptomyces griseus. These compounds all appear in the same fermentation and have similar biological activity. Bafilomycins...
Bafilomycin B1Not Available
Brefeldin AA metabolite from Penicillium brefeldianum that exhibits a wide range of antibiotic activity.
SpinosadA pediculicide used topically to treat head lice.
Dehydroascorbic acidThere is no approved indication for dehydroascorbic acid, but it has potential therapeutic use in patients with certain viruses and ischemic stroke.
FirocoxibUsed for the treatment of pain inflammation and fever in horses and dogs.
SolithromycinInvestigated for the treatment of community-acquired pneumonia (CAP).
KitasamycinKitasamycin is a macrolide antibiotic derived from Streptomyces kitasatoensis.
PropiolactonePropiolactone was used for vaccines, tissue grafts, surgical instruments, and enzymes, as a sterilant of blood plasma, water, milk and nutrient broth as a vapor-phase disinfectant in enclosed spaces. Its...
CarbomycinCarbomycin, also called magnamycin, is crystalline macrolide antibiotic. This antibacterial is obtained from Streptomyces halstedii and it presents a large inhibitory effect against Gram-positive bacteria and some Mycoplasma strains. The...
DoramectinDoramectin is a veterinary drug approved by the Food and Drug Administration for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in...
EprinomectinNot Annotated
GamithromycinGamithromycin is an antibiotic used in cattle.
MoxidectinMoxidectin is indicated for the treatment of river blindness, also called onchocerciasis, in patients aged 12 years and older. River blindness is caused by a parasitic worm Onchocerca volvulus and...
OleandomycinOleandomycin is a macrolide antibiotic, though it is less effective than erythromycin. It is synthesized from strains of Streptomyces antibioticus.
SelamectinSelamectin is a topical parasiticide and antihelminthic used on dogs and cats to treat and prevent infections of heartworms, fleas, ear mites, sarcoptic mange, and certain types of ticks in...
TildipirosinTildipirosin is a veterinary antibiotic.
TilmicosinTilmicosin is a macrolide antibiotic. It is used in veterinary medicine for the treatment of bovine respiratory disease and ovine respiratory disease associated with Mannheimia haemolytica.
TylosinTylosin is a bacteriostatic macrolide antibiotic and feed additive used in veterinary medicine. It has a broad spectrum of activity against Gram-positive organisms and a limited range of Gram-negative organisms....
ZeranolZeranol is a non-steroidal estrogen agonist. It is a mycotoxin, derived from fungi in the Fusarium family, and may be found as a contaminant in fungus-infected crops. It is 3-4x...
TylvalosinNot Annotated
Bryostatin 1Bryostatin 1 has been investigated for the treatment of HIV Infection and Alzheimer's Disease.
Lorvotuzumab mertansineLorvotuzumab mertansine has been used in trials studying the treatment of SCLC, Leukemia, Ovarian Cancer, Multiple Myeloma, and Merkel Cell Carcinoma, among others.
EpofolateEpofolate has been used in trials studying the treatment of Advanced Solid Tumors.
SagopiloneSagopilone has been used in trials studying the treatment of Melanoma, Neoplasms, CNS Disease, Breast Cancer, and Breast Neoplasms, among others. It is a so-called fully synthetic epothilone and is...
Mirvetuximab SoravtansineMirvetuximab Soravtansine has been used in trials studying the treatment of Ovarian cancer, Endometrial Cancer, Fallopian tube cancer, Epithelial Ovarian Cancer, and Primary Peritoneal Cancer, among others.
PM-060184PM060184 has been used in trials studying Solid Tumors.
TroleandomycinFor the treatment of bacterial infection.
MiocamycinMiocamycin is a macrolide type antimicrobial . This drug may be marketed in Japan for clinical use as it is listed in the Japanese pharmacopeia . It has shown to...
FlurithromycinNot Annotated
RokitamycinNot Annotated
MidecamycinMidecamycin was used for the treatment of infections in the oral cavity, upper and lower respiratory tracts and skin and soft tissue infections. The alone use of midecamycin was mainly...
PentamycinNot Annotated
MepartricinNot Annotated
Concanamycin AConcanamycin A is an H+-ATPase (vacuolar) inhibitor.
Anetumab ravtansineAnetumab ravtansine is under investigation in clinical trial NCT03455556 (Anetumab Ravtansine and Atezolizumab in Treating Participants With Advanced Non-small Cell Lung Cancer).
OrlistatA reversible inhibitor of gastrointestinal lipases indicated for weight loss and weight maintenance.
FidaxomicinA macrolide antibiotic used to treat diarrhea associated with Clostridium difficile infection.
UmirolimusNot Annotated
Drugs & Drug Targets
DrugTargetType
Erythromycin23S ribosomal RNAtarget
ErythromycinCytochrome P450 3A4enzyme
ErythromycinCytochrome P450 3A7enzyme
ErythromycinP-glycoprotein 1transporter
ErythromycinSolute carrier organic anion transporter family member 1B1transporter
ErythromycinMotilin receptortarget
ErythromycinPotassium voltage-gated channel subfamily H member 2target
ErythromycinCytochrome P450 3A5enzyme
ErythromycinSolute carrier organic anion transporter family member 1B3transporter
ErythromycinBile salt export pumptransporter
ErythromycinCanalicular multispecific organic anion transporter 1transporter
ErythromycinSolute carrier organic anion transporter family member 1A2transporter
Azithromycin23S ribosomal RNAtarget
AzithromycinP-glycoprotein 1transporter
AzithromycinCytochrome P450 3A4enzyme
AzithromycinProtein-arginine deiminase type-4target
AzithromycinCanalicular multispecific organic anion transporter 1transporter
PimecrolimusPeptidyl-prolyl cis-trans isomerase FKBP1Atarget
PimecrolimusSerine/threonine-protein kinase mTORtarget
PimecrolimusCytochrome P450 3A4enzyme
SpironolactoneMineralocorticoid receptortarget
SpironolactoneCytochrome P450 2C8enzyme
SpironolactoneCanalicular multispecific organic anion transporter 1transporter
SpironolactoneP-glycoprotein 1transporter
SpironolactoneSolute carrier organic anion transporter family member 1A2transporter
SpironolactoneCytochrome P450 11B1, mitochondrialenzyme
SpironolactoneAndrogen receptortarget
SpironolactoneProgesterone receptortarget
SpironolactoneGlucocorticoid receptortarget
SpironolactoneCytochrome P450 11B2, mitochondrialtarget
SpironolactoneSteroid 17-alpha-hydroxylase/17,20 lyasetarget
Spironolactone3-oxo-5-alpha-steroid 4-dehydrogenasetarget
SpironolactoneSex hormone-binding globulintarget
SpironolactoneVoltage-dependent calcium channeltarget
SpironolactoneNuclear receptor subfamily 1 group I member 2target
SpironolactoneBile salt export pumptransporter
SpironolactoneSerum albumincarrier
Spironolactonealpha1-acid glycoproteincarrier
PicrotoxinGamma-aminobutyric acid receptor subunit rho-1target
PicrotoxinGamma-aminobutyric acid receptor subunit alpha-1target
PicrotoxinGlycine receptor subunit alpha-2target
PicrotoxinGlycine receptor subunit alpha-3target
PicrotoxinCytochrome P450 1A1enzyme
PicrotoxinGlutamine synthetaseenzyme
PicrotoxinGlycine receptor subunit alpha-1target
IvermectinGamma-aminobutyric acid receptor subunit beta-3target
IvermectinGlycine receptor subunit alpha-3target
IvermectinP-glycoprotein 1transporter
IvermectinMultidrug resistance-associated protein 1transporter
IvermectinCanalicular multispecific organic anion transporter 1transporter
IvermectinATP-binding cassette sub-family G member 2transporter
IvermectinCytochrome P450 3A4enzyme
IvermectinSolute carrier organic anion transporter family member 1B1transporter
IvermectinSolute carrier organic anion transporter family member 1B3transporter
NystatinErgosteroltarget
NystatinSolute carrier organic anion transporter family member 1B1transporter
NystatinSolute carrier organic anion transporter family member 1B3transporter
Amphotericin BErgosteroltarget
Amphotericin BCytochrome P450 3A4enzyme
EplerenoneMineralocorticoid receptortarget
EplerenoneCytochrome P450 3A4enzyme
EplerenoneCytochrome P450 3A5enzyme
EplerenoneCytochrome P450 11B2, mitochondrialenzyme
Roxithromycin50S ribosomal protein L10target
RoxithromycinP-glycoprotein 1target
RoxithromycinCytochrome P450 3A4enzyme
RoxithromycinCytochrome P450 2B6enzyme
NatamycinErgosteroltarget
NatamycinCytochrome P450 3A4enzyme
TacrolimusPeptidyl-prolyl cis-trans isomerase FKBP1Atarget
TacrolimusCytochrome P450 3A4enzyme
TacrolimusCytochrome P450 3A5enzyme
TacrolimusP-glycoprotein 1transporter
TacrolimusATP-binding cassette sub-family A member 5transporter
TacrolimusSerum albumincarrier
TacrolimusAlpha-1-acid glycoprotein 1carrier
TacrolimusSolute carrier organic anion transporter family member 1B1transporter
SirolimusPeptidyl-prolyl cis-trans isomerase FKBP1Atarget
SirolimusCytochrome P450 3A4enzyme
SirolimusSerine/threonine-protein kinase mTORtarget
SirolimusFibroblast growth factor 2target
SirolimusCytochrome P450 3A5enzyme
SirolimusCytochrome P450 3A7enzyme
SirolimusP-glycoprotein 1transporter
SirolimusSolute carrier organic anion transporter family member 1B1transporter
SirolimusMultidrug and toxin extrusion protein 1transporter
Dirithromycin23S ribosomal RNAtarget
DirithromycinCytochrome P450 3A4enzyme
Telithromycin23S ribosomal RNAtarget
TelithromycinCytochrome P450 3A4enzyme
TelithromycinSolute carrier organic anion transporter family member 1B1transporter
TelithromycinSolute carrier organic anion transporter family member 1B3transporter
CandicidinErgosteroltarget
CandicidinCytochrome P450 3A4enzyme
Clarithromycin50S ribosomal protein L10target
ClarithromycinCytochrome P450 3A4enzyme
ClarithromycinCytochrome P450 3A5enzyme
ClarithromycinP-glycoprotein 1transporter
ClarithromycinSolute carrier family 22 member 7transporter
ClarithromycinPotassium voltage-gated channel subfamily H member 2target
ClarithromycinSolute carrier organic anion transporter family member 1B1target
ClarithromycinSolute carrier organic anion transporter family member 1B3target
ClarithromycinBile salt export pumptransporter
ClarithromycinSolute carrier organic anion transporter family member 1B1transporter
ClarithromycinSolute carrier organic anion transporter family member 1B3transporter
Josamycin50S ribosomal protein L4target
EverolimusSerine/threonine-protein kinase mTORtarget
EverolimusCytochrome P450 3A4enzyme
EverolimusSolute carrier organic anion transporter family member 1B1transporter
EverolimusSolute carrier organic anion transporter family member 1B3transporter
EverolimusSolute carrier organic anion transporter family member 1A2transporter
EverolimusCytochrome P450 2D6enzyme
EverolimusP-glycoprotein 1transporter
Epothilone DTubulin alpha-3C/D chaintarget
Epothilone DTubulin beta chaintarget
Epothilone DTubulin beta-1 chaintarget
Epothilone DTubulin beta-4B chaintarget
Epothilone DTubulin beta-4A chaintarget
Epothilone DTubulin alpha-4A chaintarget
Epothilone DTubulin beta-3 chaintarget
Epothilone DTubulin alpha-1C chaintarget
Epothilone DTubulin alpha-8 chaintarget
Epothilone DTubulin alpha-1B chaintarget
Epothilone DTubulin alpha-1A chaintarget
Epothilone DCytochrome P450 3A4enzyme
Homoserine LactoneSodium/hydrogen exchanger 1target
Soraphen AAcetyl-CoA carboxylase 2target
PatupiloneTubulin alpha-3C/D chaintarget
PatupiloneTubulin beta chaintarget
PatupiloneTubulin beta-1 chaintarget
PatupiloneTubulin beta-4B chaintarget
PatupiloneTubulin beta-4A chaintarget
PatupiloneTubulin alpha-4A chaintarget
PatupiloneTubulin beta-3 chaintarget
PatupiloneTubulin alpha-1C chaintarget
PatupiloneTubulin alpha-8 chaintarget
PatupiloneTubulin alpha-1B chaintarget
PatupiloneTubulin alpha-1A chaintarget
PatupiloneCytochrome P450 3A4enzyme
RadicicolHeat shock protein HSP 90-betatarget
RadicicolEndoplasmintarget
RadicicolDihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrialtarget
Radicicol[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrialtarget
RadicicolVirulence sensor histidine kinase PhoQtarget
6-Deoxyerythronolide B6-deoxyerythronolide B hydroxylasetarget
6-Deoxyerythronolide BCytochrome P450 3A4enzyme
Aplyronine AActin, alpha skeletal muscletarget
gamma-butyrolactoneO-GlcNAcase NagJtarget
Reidispongiolide AActin, alpha skeletal muscletarget
IxabepiloneTubulin beta-3 chaintarget
IxabepiloneCytochrome P450 3A4enzyme
IxabepiloneP-glycoprotein 1transporter
Trastuzumab emtansineReceptor tyrosine-protein kinase erbB-2target
Trastuzumab emtansineP-glycoprotein 1transporter
Trastuzumab emtansineCytochrome P450 3A4enzyme
Trastuzumab emtansineCytochrome P450 3A5enzyme
GPI-1485Peptidyl-prolyl cis-trans isomerase FKBP1Atarget
GPI-1485Cytochrome P450 3A4enzyme
KOS-1584Cytochrome P450 3A4enzyme
Spiramycin50S ribosomal protein L3target
RidaforolimusSerine/threonine-protein kinase mTORtarget
RidaforolimusCytochrome P450 3A4enzyme
TemsirolimusSerine/threonine-protein kinase mTORtarget
TemsirolimusCytochrome P450 3A4enzyme
TemsirolimusCytochrome P450 3A5enzyme
TemsirolimusCytochrome P450 3A7enzyme
TemsirolimusCytochrome P450 2D6enzyme
TemsirolimusP-glycoprotein 1transporter
AVE9633Myeloid cell surface antigen CD33target
AVE9633Cytochrome P450 3A4enzyme
Coltuximab ravtansineB-lymphocyte antigen CD19target
Coltuximab ravtansineCytochrome P450 3A4enzyme
Cethromycin23S ribosomal RNAtarget
CethromycinCytochrome P450 3A5enzyme
CethromycinCytochrome P450 3A4enzyme
CethromycinP-glycoprotein 1transporter
MitemcinalMotilin receptortarget
MitemcinalCytochrome P450 3A4enzyme
Bafilomycin A1V-type proton ATPase catalytic subunit Atarget
Bafilomycin B1V-type proton ATPase catalytic subunit Atarget
Brefeldin ACytohesin-2target
Brefeldin AADP-ribosylation factor 1target
Brefeldin ACytochrome P450 3A4enzyme
Dehydroascorbic acidSolute carrier family 2, facilitated glucose transporter member 1transporter
FirocoxibProstaglandin G/H synthase 2target
SolithromycinCytochrome P450 3A4enzyme
KitasamycinCytochrome P450 3A4enzyme
PropiolactoneDNAtarget
PropiolactoneSerum albumincarrier
CarbomycinCytochrome P450 3A4enzyme
DoramectinCytochrome P450 3A4enzyme
EprinomectinCytochrome P450 3A4enzyme
MoxidectinCYP2B proteinenzyme
MoxidectinGlutamate-gated chloride channeltarget
MoxidectinGABA-A gated chloride channeltarget
MoxidectinABC transporterstarget
OleandomycinCytochrome P450 3A4enzyme
SelamectinCytochrome P450 3A4enzyme
TildipirosinCytochrome P450 3A4enzyme
TilmicosinCytochrome P450 3A4enzyme
TylosinCytochrome P450 3A4enzyme
ZeranolEstrogen receptor alphatarget
ZeranolSex hormone-binding globulintarget
TylvalosinCytochrome P450 3A4enzyme
Bryostatin 1Cytochrome P450 3A4enzyme
Bryostatin 1Protein kinase C alpha typetarget
Bryostatin 1Protein kinase C epsilon typetarget
Bryostatin 1Caspase-8target
Bryostatin 1Protein unc-13 homolog Btarget
Bryostatin 1Serine/threonine-protein kinase D1target
Bryostatin 1T-lymphocyte activation antigen CD86target
Bryostatin 1Prostaglandin G/H synthase 2target
Bryostatin 1G1/S-specific cyclin-D1target
Bryostatin 1Tumor necrosis factortarget
Lorvotuzumab mertansineCytochrome P450 3A4enzyme
EpofolateCytochrome P450 3A4enzyme
SagopiloneCytochrome P450 3A4enzyme
Mirvetuximab SoravtansineCytochrome P450 3A4enzyme
TroleandomycinCytochrome P450 3A5enzyme
TroleandomycinCytochrome P450 3A43enzyme
Troleandomycin50S ribosomal protein L4target
Troleandomycin50S ribosomal protein L32target
TroleandomycinP-glycoprotein 1transporter
TroleandomycinCytochrome P450 2C8enzyme
TroleandomycinCytochrome P450 3A4enzyme
TroleandomycinNuclear receptor subfamily 1 group I member 2target
TroleandomycinCytochrome P450 3A7enzyme
MiocamycinCytochrome P450 3A4enzyme
FlurithromycinCytochrome P450 3A4enzyme
RokitamycinCytochrome P450 3A4enzyme
MidecamycinCytochrome P450 3A4enzyme
MepartricinCytochrome P450 3A4enzyme
Concanamycin AP-glycoprotein 1target
Concanamycin AP-glycoprotein 1transporter
OrlistatPancreatic triacylglycerol lipasetarget
OrlistatFatty acid synthasetarget
OrlistatGastric triacylglycerol lipasetarget
OrlistatCytochrome P450 3A4enzyme
OrlistatCytosolic phospholipase A2enzyme
FidaxomicinP-glycoprotein 1transporter
FidaxomicinRNA polymerase sigma factortarget
FidaxomicinCytochrome P450 3A4enzyme