Aluminum zirconium octachlorohydrex gly

Identification

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Name
Aluminum zirconium octachlorohydrex gly
Accession Number
DB11200
Type
Small Molecule
Groups
Approved
Description

Aluminum zirconium octachlorohydrex gly is complex that consists of aluminum zirconium octachlorohydrate and glycine. It is an active antiperspirant agent 8, 9. It diffuses into the sweat pores and prevents perspiration (sweat) from leaving the pores. The anhydrous form of the compound also has water-absorbing properties. Currently, the FDA allows the inclusion of this substance in concentrations of up to 20% in antiperspirants 11.

Interestingly, this chemical has been studied in relation to its possible impact on the microbiome of the human underarms 2.

Structure
Thumb
Synonyms
  • Aluminium zirconium octachlorohydrex gly
  • Aluminium zirconium octachlorohydrex glycine complex
  • Aluminum zirconium octachlorohydrex glycine complex
Active Moieties
NameKindUNIICASInChI Key
AluminiumunknownCPD4NFA9037429-90-5XAGFODPZIPBFFR-UHFFFAOYSA-N
Aluminum cationionic3XHB1D032B22537-23-1REDXJYDRNCIFBQ-UHFFFAOYSA-N
Chloride ionionicQ32ZN4869816887-00-6VEXZGXHMUGYJMC-UHFFFAOYSA-M
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
24 Hour High Performance AntiperspirantStick18.6 mL/100mLTopicalAramis Inc.1984-04-01Not applicableUs
5 DayLiquid20 g/100mLTopicalNumark Brands, Inc1937-04-10Not applicableUs
Active Antiperspirant and Deodorant for MenCream17.8 g/100gTopicalHarrison Specialty Co., Inc.2011-04-092014-03-10Us
Adidas 24H Anti Perspirant Deep Energy 2.8Stick12.6 g/79gTopicalCoty Canada Inc.2012-10-01Not applicableUs
Adidas 24H Anti Perspirant Dynamic Pulse 2.8Stick12.6 g/79gTopicalCoty Canada Inc.2012-10-01Not applicableUs
Adidas 24H Anti Perspirant Pure Game 2.8Stick12.6 g/79gTopicalCoty Canada Inc.2012-10-01Not applicableUs
Adidas Action 3 ControlStick14.2 g/79gTopicalCoty Canada Inc.2009-01-01Not applicableUs
Adidas Action 3 FreshStick18 mg/100gTopicalCoty Canada Inc.2009-01-01Not applicableUs
Adidas Action 3 FreshStick18 mg/100gTopicalCoty Canada Inc.2009-01-01Not applicableUs
Adidas Action 3 IntenseStick18 mg/100gTopicalCoty Canada Inc.2009-01-01Not applicableUs
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
DELTA RON 2019 AMENITY With Colgate Cavity ProtectionAluminum zirconium octachlorohydrex gly (15.2 g/100g) + Sodium fluorophosphate (7.6 mg/1g)KitTopicalBuzz Export Services Pty., Ltd.2019-04-01Not applicableUs
Lactovit DEODORANT AND ANTIPERSPIRANT INVISIBLE ANTISTAINAluminum zirconium octachlorohydrex gly (8 mg/1) + Aluminum sesquichlorohydrate (1 mg/1)LiquidTopicalLaboratorios Genesse Sl2016-11-19Not applicableUs
Lactovit DEODORANT ROLL-ON MEN INVISIBLEAluminum zirconium octachlorohydrex gly (5.28 mg/1) + Aluminum sesquichlorohydrate (0.8 mg/1)LiquidTopicalLaboratorios Genesse Sl2017-04-06Not applicableUs
Ron 2Aluminum zirconium octachlorohydrex gly (15.2 g/100g) + Sodium fluorophosphate (7.6 mg/1g)KitTopicalBuzz Export Services Pty., Ltd.2015-03-30Not applicableUs
Categories
Not Available
UNII
P9D3YP29MY
CAS number
174514-58-0
Weight
Average: 263.74
Monoisotopic: 261.89768
Chemical Formula
C2H8AlClNO4Zr
InChI Key
WYANSMZYIOPJFV-UHFFFAOYSA-L
InChI
InChI=1S/C2H5NO2.Al.ClH.2H2O.Zr/c3-1-2(4)5;;;;;/h1,3H2,(H,4,5);;1H;2*1H2;/q;+3;;;;+4/p-2
IUPAC Name
zirconium(4+) aluminium(3+) 2-aminoacetate dihydrate chloride
SMILES
O.O.[Al+3].[Cl-].[Zr+4].NCC([O-])=O

Pharmacology

Indication

Aluminum-based antiperspirant preparations intended for the reduction of normal underarm perspiration, and indicated for use in hyperhidrosis 12.

Pharmacodynamics

Reduces perspiration and body odor 8.

Mechanism of action

Aluminium salts in antiperspirants, such as chlorohydrates, form insoluble plugs within sweat ducts to temporarily prevent sweat reaching the surface of the skin 14, 5, 6, 8.

TargetActionsOrganism
ASweat ducts
antagonist
Humans
Additional Data Available
Adverse Effects

Comprehensive structured data on known drug adverse effects with statistical prevalence. MedDRA and ICD10 ids are provided for adverse effect conditions and symptoms.

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Additional Data Available
Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

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Additional Data Available
Blackbox Warnings

Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.

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Absorption

A preliminary study of the dermal absorption of aluminium from antiperspirants using aluminum-26 was performed. After repeated exposure for 6 days to aluminum chlorohydrate 21 % (about 13 mg of aluminium) to each axilla under occlusive dressing in two volunteers (one man and a woman), on skin previously tape stripped twice, blood and urine samples were obtained. Aluminium was detected in the blood 6 hours after the primary application and remained detectable for 15 days therafter. The results of this study estimate that the proportion of aluminium is absorbed averaged 0.012%. The shortcomings of this study are that it was not done in accordance with good practice (GCP) and it was performed using only 2 volunteers 7.

Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity

The EU has published a statement of caution that antiperspirant should not be applied to damaged or irritated skin, yet it is common to shave the underarm area before applying antiperspirant 14.

The possible health risks of aluminum containing antiperspirant use are not well studied. Although it has been suggested that deodorant and/or antiperspirant use is associated with incidence or age of breast cancer diagnosis 3, a causal relationship between aluminium product use and breast cancer has not been established 2, 4.

The oral toxicity of aluminium compounds for which data are available (bromide, nitrate, chloride and sulfate) is moderate to low, with LD50 values in the range of 162 to 750 mg Al/kg in rats, and from 164 to 980 mg Al/kg in mice, depending on the type of aluminium compound studied 14.

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

References

General References
  1. Reynolds K, Darrigrand A, Roberts D, Knapik J, Pollard J, Duplantis K, Jones B: Effects of an antiperspirant with emollients on foot-sweat accumulation and blister formation while walking in the heat. J Am Acad Dermatol. 1995 Oct;33(4):626-30. [PubMed:7673497]
  2. Urban J, Fergus DJ, Savage AM, Ehlers M, Menninger HL, Dunn RR, Horvath JE: The effect of habitual and experimental antiperspirant and deodorant product use on the armpit microbiome. PeerJ. 2016 Feb 2;4:e1605. doi: 10.7717/peerj.1605. eCollection 2016. [PubMed:26855863]
  3. Darbre PD: Aluminium, antiperspirants and breast cancer. J Inorg Biochem. 2005 Sep;99(9):1912-9. doi: 10.1016/j.jinorgbio.2005.06.001. [PubMed:16045991]
  4. Allam MF: Breast Cancer and Deodorants/Antiperspirants: a Systematic Review. Cent Eur J Public Health. 2016 Sep;24(3):245-247. doi: 10.21101/cejph.a4475. [PubMed:27755864]
  5. ALUMINUM ZIRCONIUM OCTACHLOROHYDREX GLY [Link]
  6. Aluminum zirconium pentachlorohydrex Gly [Link]
  7. Product Assessment Against Criteria: Antiperspirants [Link]
  8. LABEL: SECRET COOL WATERLILY CLEAR- aluminum zirconium octachlorohydrex gly gel [Link]
  9. SECRET ACTIVE COOL INVISIBLE- aluminum zirconium tetrachlorohydrex gly stick [Link]
  10. Household Product Database, NIH [Link]
  11. FDA CFR - Code of Federal Regulations Title 21, PART 350: ANTIPERSPIRANT DRUG PRODUCTS FOR OVER-THE-COUNTER HUMAN USE [Link]
  12. Health Canada Document : Chemical Substance - Aluminum zirconium octachlorohydrex glycine [Link]
  13. Breast Cancer Organization, UK [Link]
  14. Scientific Committee on Consumer Safety SCCS [File]
  15. ZIRKONAL® L435G [File]
External Links
PubChem Substance
347911153
ChemSpider
32698594

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1Active Not RecruitingDiagnosticHealthy Volunteers1
1CompletedTreatmentLeukemias1
1RecruitingTreatmentGlioblastoma Multiforme (GBM) / Glioblastomas1
1WithdrawnTreatmentGlioblastomas1
2CompletedTreatmentCystic Fibrosis (CF)1
2Enrolling by InvitationTreatmentDisseminated Sclerosis1
3CompletedTreatmentPlasmodium Infections1
4Unknown StatusTreatmentGastritis, Gastric Ulcer, and Duodenal Ulcer1
Not AvailableRecruitingNot AvailableThrombotic Thrombocytopenic Purpura (TTP)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
StickTopical18.6 mL/100mL
LiquidTopical20 g/100mL
StickTopical12.6 g/79g
StickTopical14.2 g/79g
StickTopical18 mg/100g
StickTopical11.39 g/64g
StickTopical6.02 g/70g
GelTopical20 g/100g
StickTopical17.8 g/100g
GelTopical10.08 g/63g
StickTopical70 g/100g
StickTopical10.146 g/57g
CreamTopical17 g/100g
GelTopical16.15 g/85g
AerosolTopical19 g/100g
LiquidTopical20 mL/100mL
SolutionTopical0.3 g/100mL
GelTopical0.3 mL/100mL
SolutionTopical0.3 g/100g
StickTopical7.8 g/100g
LotionTopical16 g/100g
LotionTopical.165 g/1g
LiquidTopical18 mg/1mL
StickTopical18.6 g/100g
StickTopical11.65 g/64g
StickTopical20 g/48g
StickTopical18.5 g/100g
StickTopical10 g/100g
StickTopical19.2 g/100g
StickTopical15.2 g/100g
StickTopical182 mg/1g
StickTopical19.0 g/100g
StickTopical20 g/100g
KitTopical150 mg/1g
PasteTopical150 mg/1g
StickTopical11.4 g/100g
StickTopical14.8 g/100g
StickTopical12.9 g/100g
StickTopical.204 g/1.36g
StickTopical14.6 g/73g
LiquidTopical16.3 mL/96.1mL
StickTopical15.4 g/73g
StickTopical13.94 g/85g
LiquidTopical16.3 g/100mL
StickTopical9.6 g/48g
StickTopical13.47 g/76.5g
GelTopical8.75 g/1g
GelTopical0.2 g/1g
StickTopical0.2 g/1g
StickTopical17 g/100g
GelTopical
LotionTopical15 mL/100mL
GelTopical18 g/57g
LotionTopical15 g/100g
LiquidTopical
LiquidTopical110 mg/1mL
CreamTopical99 mg/1mL
StickTopical200 mg/1g
StickCutaneous250 mg/1g
StickTopical151 mg/1g
StickTopical15.4 g/100g
StickTopical170 mg/1g
StickTopical100 mg/1g
StickTopical159 mg/1g
LiquidTopical0.20 g/1mL
StickTopical156 mg/1g
LiquidTopical0.2 g/1mL
CreamTopical80 mg/1mL
CreamTopical17.8 g/100g
StickTopical0.15 g/1g
StickTopical18 g/100g
KitTopical18 g/100g
StickTopical0.16 g/1g
GelTopical16 g/100g
CreamTopical19 g/100g
StickTopical15 g/100g
StickTopical25 g/100g
StickTopical17.5 g/100g
StickTopical13.49 g/71g
StickTopical10.83 1/57g
StickTopical1.2 g/75g
StickTopical14.062 g/79g
StickTopical2.0944 g/11.9g
StickTopical48 g/48g
StickTopical10.318 g/73.7g
StickTopical7.14 g/51g
GelTopical13.94 1/85g
StickTopical14.00 g/73g
GelTopical18.5 g/113g
StickTopical4.902 g/57g
StickTopical17.3 g/100g
KitTopical
StickTopical22 g/100g
GelTopical15 g/100g
StickTopical190 mg/1g
CreamTopical20 g/100g
StickTopical.028 g/1g
GelTopical0.16 g/1g
StickTopical13.87 g/73g
GelTopical17 g/100g
StickTopical0.19 g/1g
StickTopical0.192 g/1g
StickTopical0.18 g/1g
StickTopical10.83 g/57g
StickTopical19 g/57g
CreamTopical18.6 g/100g
StickTopical18.6 g/100mL
StickTopical13. g/73g
StickTopical13 g/65g
StickTopical85 g/85g
StickTopical164 mg/1g
StickTopical153 mg/1g
StickTopical161 mg/1g
StickTopical172 mg/1g
StickTopical158 mg/1g
StickTopical160 mg/1g
StickTopical154 mg/1g
StickTopical14.4 g/75g
StickTopical18.2 g/100g
StickTopical19 g/100g
StickTopical16 g/100g
StickTopical0.17 g/1g
StickTopical18.4 g/100g
GelTopical19 g/100g
LiquidTopical21 g/100mL
StickTopical12.8 g/64g
StickCutaneous17.8 1/1
StickCutaneous16.0 1/1
StickTopical0.20 g/1g
CreamTopical0.20 g/1g
StickTopical180 mg/1g
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility11.9 mg/mLALOGPS
logP0.36ALOGPS
logP-3.4ChemAxon
logS-1.2ALOGPS
pKa (Strongest Acidic)2.31ChemAxon
pKa (Strongest Basic)9.24ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area66.15 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity26.84 m3·mol-1ChemAxon
Polarizability6.25 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Targets

1. Sweat ducts
Kind
Group
Organism
Humans
Pharmacological action
Yes
Actions
Antagonist
References
  1. LABEL: SECRET COOL WATERLILY CLEAR- aluminum zirconium octachlorohydrex gly gel [Link]
  2. Health Canada Document : Chemical Substance - Aluminum zirconium octachlorohydrex glycine [Link]
  3. Scientific Committee on Consumer Safety SCCS [File]

Drug created on December 03, 2015 09:51 / Updated on September 02, 2019 19:21