NAV

Povidone K30

Identification

Brand Names
Freshkote, Minidrops
Generic Name
Povidone K30
DrugBank Accession Number
DB14478
Background

A polyvinyl polymer of variable molecular weight; used as suspending and dispersing agent and vehicle for pharmaceuticals; also used as blood volume expander. See povidone for full details.

Type
Small Molecule
Groups
Approved, Experimental
Synonyms
  • 1-vinylpyrrolidin-2-one homopolymer
  • Plasdone K29-32
  • Plasdone K29/32
  • Polyvinylpyrrolidone K 30
  • Polyvinylpyrrolidone K-29/32
  • Polyvinylpyrrolidone K30
  • Povidone K29-32
  • Povidone K29/32
  • PVP K-30
  • PVP K30
  • PVP-K 30
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Pharmacology

Indication

When in complex with iodine, indicated for inducing antisepsis for prevention of infection in minor cuts, scrapes, and burns.

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Povidone itself has no microbicidal activity. Povidone-iodine exhibits rapid, potent, broad-spectrum antimicrobial properties 2. The clinical effectiveness of povidon-iodine on wound healing remains somewhat controversial; in few clinical studies investigating the effects of povidone-iodine on wound healing, topical administration of the complex was associated with no significant infections, but slower healing and mild to moderate discomfort on application 1.

Mechanism of action

Povidone-iodine is a water-soluble complex that mediates a bactericidal or virucidal action following the gradual liberation of free iodine from the complex at the application site to react with the pathogen 1. Please refer to the drug entry for Povidone-iodine for the full mechanism of action of the complex.

Absorption

This pharmacokinetic data does not apply to povidone.

Volume of distribution

This pharmacokinetic data does not apply to povidone.

Protein binding

This pharmacokinetic data does not apply to povidone.

Metabolism

This pharmacokinetic data does not apply to povidone.

Route of elimination

This pharmacokinetic data does not apply to povidone.

Half-life

This pharmacokinetic data does not apply to povidone.

Clearance

This pharmacokinetic data does not apply to povidone.

Adverse Effects
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Toxicity

Oral LD50 in mouse, rat, and rabbit are >40 mg/kg, 100 mg/kg, and 1040 mg/kg, respectively MSDS. No cases of overdose in humans have been reported.

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
No interactions found.

Products

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
FreshKote Lubricant Eye DropsPovidone K30 (20 g/1000mL) + Polyvinyl alcohol (27 g/1000mL)Solution / dropsOphthalmicFocus Laboratories, Inc.2006-04-01Not applicableUS flag
MiniDropsPovidone K30 (.6 mL/100mL) + Polyvinyl alcohol (1.4 mL/100mL)LiquidOphthalmicTaiwan Biotech Co., Ltd.1991-04-01Not applicableUS flag

Categories

Drug Categories
Not Available
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
U725QWY32X
CAS number
9003-39-8
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

References

General References
  1. Kramer SA: Effect of povidone-iodine on wound healing: a review. J Vasc Nurs. 1999 Mar;17(1):17-23. [Article]
  2. Bigliardi PL, Alsagoff SAL, El-Kafrawi HY, Pyon JK, Wa CTC, Villa MA: Povidone iodine in wound healing: A review of current concepts and practices. Int J Surg. 2017 Aug;44:260-268. doi: 10.1016/j.ijsu.2017.06.073. Epub 2017 Jun 23. [Article]
Not Available

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
PowderCutaneous
PowderCutaneous19.30 g
Solution / dropsOphthalmic
LiquidOphthalmic
PowderNot applicable1 g/1g
Drug delivery systemTopical
Drug delivery systemCutaneous
SolutionOphthalmic0.500 mg
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at July 06, 2018 19:36 / Updated at December 01, 2022 11:28