Telaglenastat

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

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Name
Telaglenastat
Accession Number
DB15232
Type
Small Molecule
Groups
Investigational
Description

Telaglenastat is under investigation in clinical trial NCT02071862 (Study of the Glutaminase Inhibitor CB-839 in Solid Tumors).

Structure
Thumb
Synonyms
Not Available
External IDs
CB-839
Categories
UNII
U6CL98GLP4
CAS number
1439399-58-2
Weight
Average: 571.58
Monoisotopic: 571.161343324
Chemical Formula
C26H24F3N7O3S
InChI Key
PRAAPINBUWJLGA-UHFFFAOYSA-N
InChI
InChI=1S/C26H24F3N7O3S/c27-26(28,29)39-20-9-5-6-17(14-20)15-22(37)31-21-12-11-18(33-34-21)7-1-2-10-24-35-36-25(40-24)32-23(38)16-19-8-3-4-13-30-19/h3-6,8-9,11-14H,1-2,7,10,15-16H2,(H,31,34,37)(H,32,36,38)
IUPAC Name
SMILES
FC(F)(F)OC1=CC(CC(=O)NC2=NN=C(CCCCC3=NN=C(NC(=O)CC4=NC=CC=C4)S3)C=C2)=CC=C1

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
Not Available
External Links
ChemSpider
34959639
BindingDB
109086
ChEMBL
CHEMBL3639788

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1Active Not RecruitingTreatmentFumarate Hydratase (FH)-Deficient Tumors / Lung Cancer Non-Small Cell Cancer (NSCLC) / Mesothelioma / Renal Cell Adenocarcinoma / Succinate Dehydrogenase (SDH)-Deficient Gastrointestinal Stromal Tumors (GIST) / Succinate Dehydrogenase (SDH)-Deficient Non-gastrointestinal Stromal Tumors / Triple-Negative Breast Cancer (TNBC) / Tumors Harboring Amplifications in the cMyc Gene / Tumors Harboring Isocitrate Dehydrogenase-1 (IDH1) and IDH2 Mutations / Tumors, Solid1
1CompletedTreatmentAcute Lymphocytic Leukemia (ALL) / Leukemia Acute Myeloid Leukemia (AML)1
1CompletedTreatmentHealthy Volunteers1
1CompletedTreatmentLymphoma, Large B-Cell, Diffuse (DLBCL) / Multiple Myeloma (MM) / Non-Hodgkin's Lymphoma (NHL) / Other B-cell NHL Subtypes, Including WM / T-cell NHL / Waldenström's Macroglobulinemia (WM)1
1, 2Not Yet RecruitingTreatmentCRC / KRAS Gene Mutation / Lung Cancer Non-Small Cell Cancer (NSCLC) / Tumors, Solid1
1, 2RecruitingTreatmentAcute Myeloid Leukemia With Multilineage Dysplasia / Blasts 20-30 Percent of Bone Marrow Nucleated Cells / Blasts 20-30 Percent of Peripheral Blood White Cells / Chronic Myelomonocytic Leukemia / High Risk Myelodysplastic Syndrome / IPSS Risk Category Intermediate-2 / Myelodysplastic Syndrome / Other Diseases of Blood and Blood-Forming Organs1
1, 2RecruitingTreatmentAdvanced Lung Carcinoma / EGFR Activating Mutation / EGFR Exon 19 Deletion Mutation / EGFR NP_005219.2:p.L858R / EGFR T790M Mutation Negative / Lung Non-Small Cell Carcinoma / Metastatic Lung Carcinoma / Stage IV Lung Cancer AJCC v8 / Stage IVA Lung Cancer AJCC v8 / Stage IVB Lung Cancer AJCC v81
1, 2RecruitingTreatmentCcRCC / Clear Cell Renal Cell Carcinoma / Colorectal Cancers / CRC / RCC / TNBC - Triple-Negative Breast Cancer / Tumors, Solid1
1, 2RecruitingTreatmentClear Cell Renal Cell Carcinoma / Lung Cancer Non-Small Cell Cancer (NSCLC) / Melanoma1
1, 2RecruitingTreatmentColorectal Cancers / Malignant Neoplasm of Colon / Rectal Carcinoma / Tumors, Solid1
2RecruitingTreatmentAdvanced Renal Cell Carcinoma / Metastatic Renal Cell Carcinoma1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on May 20, 2019 09:02 / Updated on May 21, 2019 12:38