Telaglenastat
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Telaglenastat
- DrugBank Accession Number
- DB15232
- Background
Telaglenastat is under investigation in clinical trial NCT02071862 (Study of the Glutaminase Inhibitor CB-839 in Solid Tumors).
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 571.58
Monoisotopic: 571.161343324 - Chemical Formula
- C26H24F3N7O3S
- Synonyms
- Telaglenastat
- External IDs
- CB-839
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as phenylacetamides. These are amide derivatives of phenylacetic acids.
- Kingdom
- Organic compounds
- Super Class
- Benzenoids
- Class
- Benzene and substituted derivatives
- Sub Class
- Phenylacetamides
- Direct Parent
- Phenylacetamides
- Alternative Parents
- Phenoxy compounds / Phenol ethers / N-arylamides / Pyridines and derivatives / Pyridazines and derivatives / Imidolactams / Thiadiazoles / Heteroaromatic compounds / Trihalomethanes / Secondary carboxylic acid amides show 6 more
- Substituents
- Alkyl fluoride / Alkyl halide / Aromatic heteromonocyclic compound / Azacycle / Azole / Carbonyl group / Carboxamide group / Carboxylic acid derivative / Halomethane / Heteroaromatic compound show 19 more
- Molecular Framework
- Aromatic heteromonocyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- U6CL98GLP4
- CAS number
- 1439399-58-2
- InChI Key
- PRAAPINBUWJLGA-UHFFFAOYSA-N
- InChI
- InChI=1S/C26H24F3N7O3S/c27-26(28,29)39-20-9-5-6-17(14-20)15-22(37)31-21-12-11-18(33-34-21)7-1-2-10-24-35-36-25(40-24)32-23(38)16-19-8-3-4-13-30-19/h3-6,8-9,11-14H,1-2,7,10,15-16H2,(H,31,34,37)(H,32,36,38)
- IUPAC Name
- N-[6-(4-{5-[2-(pyridin-2-yl)acetamido]-1,3,4-thiadiazol-2-yl}butyl)pyridazin-3-yl]-2-[3-(trifluoromethoxy)phenyl]acetamide
- SMILES
- FC(F)(F)OC1=CC(CC(=O)NC2=NN=C(CCCCC3=NN=C(NC(=O)CC4=NC=CC=C4)S3)C=C2)=CC=C1
References
- General References
- Not Available
- External Links
- ChemSpider
- 34959639
- BindingDB
- 109086
- ChEMBL
- CHEMBL3639788
- ZINC
- ZINC000169698697
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 2 Active Not Recruiting Treatment Advanced Malignant Solid Tumor / Metastatic Malignant Solid Neoplasms / NF1 Mutation Positive Malignant Peripheral Nerve Sheath Tumor / Unresectable Malignant Solid Neoplasm 1 2 Completed Treatment Advanced Renal Cell Carcinoma / Metastatic Renal Cell Carcinoma ( mRCC) 1 2 Completed Treatment Clear Cell Renal Cell Carcinoma 1 2 Completed Treatment Triple-Negative Breast Cancer 1 2 Not Yet Recruiting Treatment Advanced Cervical Carcinoma / Cervical Cancer 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.00151 mg/mL ALOGPS logP 3.73 ALOGPS logP 4.74 Chemaxon logS -5.6 ALOGPS pKa (Strongest Acidic) 6.94 Chemaxon pKa (Strongest Basic) 4.33 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 8 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 131.88 Å2 Chemaxon Rotatable Bond Count 13 Chemaxon Refractivity 141.14 m3·mol-1 Chemaxon Polarizability 55.53 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at May 20, 2019 15:02 / Updated at February 21, 2021 18:55