TZP-102
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- TZP-102
- DrugBank Accession Number
- DB16129
- Background
TZP-102 is under investigation in clinical trial NCT01452815 (Affects of Once-daily Oral Administration of TZP-102 on the Treatment of Symptoms Associated With Diabetic Gastroparesis).
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 500.684
Monoisotopic: 500.336255913 - Chemical Formula
- C28H44N4O4
- Synonyms
- Not Available
- External IDs
- TZP-102
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Not Available
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 9NFY3MS3SL
- CAS number
- 1008993-65-4
- InChI Key
- HIIMPSTXUQUYOO-KRANKMRJSA-N
- InChI
- InChI=1S/C28H44N4O4/c1-17(2)15-23-27(34)30-18(3)11-12-21-9-7-8-10-24(21)36-19(4)16-29-25(22-13-14-22)28(35)32(6)20(5)26(33)31-23/h7-10,17-20,22-23,25,29H,11-16H2,1-6H3,(H,30,34)(H,31,33)/t18-,19?,20+,23?,25?/m0/s1
- IUPAC Name
- (2R,5S,8R,11R,14S)-5-cyclopropyl-2,7,8,14-tetramethyl-11-(2-methylpropyl)-3,4,5,6,7,8,9,10,11,12,13,14,15,16-tetradecahydro-2H-1,4,7,10,13-benzoxatetrazacyclooctadecine-6,9,12-trione
- SMILES
- CC(C)C[C@H]1NC(=O)[C@@H](C)N(C)C(=O)[C@@H](NC[C@@H](C)OC2=C(CC[C@H](C)NC1=O)C=CC=C2)C1CC1
References
- General References
- Not Available
- External Links
- Not Available
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 2 Completed Treatment Diabetes Mellitus / Gastroparesis 1 2 Completed Treatment Gastroparesis / Type 1 Diabetes Mellitus / Type 2 Diabetes Mellitus 1 2 Terminated Treatment Diabetic Gastroparesis 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.02 mg/mL ALOGPS logP 2.7 ALOGPS logP 3.06 Chemaxon logS -4.4 ALOGPS pKa (Strongest Acidic) 11.46 Chemaxon pKa (Strongest Basic) 6.27 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 3 Chemaxon Polar Surface Area 99.77 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 139.65 m3·mol-1 Chemaxon Polarizability 56.3 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at December 15, 2020 18:13 / Updated at December 20, 2020 03:37