Type 2 Diabetes Mellitus

Also known as: Diabetes Mellitus Non-insulin-dependent / Type-2 Diabetes Mellitus / Non-insulin-dependent Diabetes Mellitus / Diabetes Mellitus Type-2 / Diabetes Mellitus Type 2 (T2DM) / Type 2 Diabetes (T2DM) / Diabetes, Type 2 / Diabetes Mellitus,Type 2 / Diabetes Mellitus, Type 2 (T2DM) / Diabetes Type II / Diabetes Mellitus 2 Type / Type-II Diabetes Mellitus / DIABETES MELLITUS Type 2 / Diabetes Mellitus Type II / Type 2 Diabetes / Type II Diabetes / Type 2 Diabetes Mellitus (T2DM) / Diabetes Mellitus, Type 2 / Diabetes Mellitus - Type 2 / Diabetes, Type II / Diabetes Mellitus. Type 2 / Diabetes Type 2 / Type 2 Diabetes Mellitus (T2D) / Type 2 Diabetes (T2D) / Type II; Diabetes / Type II Diabetes Mellitus / Diabetes Mellitus, Type II / NIDDM / Type-2 Diabetes / Type 2 Diabetes Mellitus(T2DM) / Type 2-diabetes / Type-2-diabetes Mellitus / T2DM (Type 2 Diabetes Mellitus) / Diabetes mellitus -adult onset / Diabetes mellitus non insulin-dep / Maturity onset diabetes / Diabetes mellitus maturity onset

DrugDrug NameDrug Description
DB00284AcarboseAn inhibitor of alpha glucosidase that retards the digestion and absorption of carbohydrates in the small intestine and hence reduces the increase in blood-glucose concentrations after a carbohydrate load. It is given orally to non-insulin dependent diabetes mellitus patients where diet modification or oral hypoglycemic agents do not control their condition. (From Martindale The Extra Pharmacopoeia, 31st ed)
DB09043AlbiglutideAlbiglutide is a glucagon-like peptide-1 agonist (GLP-1) biologic drug indicated in the treatment of type 2 diabetes. It is marketed under the brands Eperzan and Tanzeum by GSK (GlaxoSmithKline). It is a dipeptidyl peptidase-4-resistant glucagon-like peptide-1 dimer fused to human albumin. Albiglutide was approved on April 15, 2014 by the FDA.
DB06203AlogliptinAlogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4). Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. FDA approved January 25, 2013.
DB01076AtorvastatinAtorvastatin (Lipitor) is a member of the drug class known as statins. It is used for lowering cholesterol. Atorvastatin is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-determining enzyme in cholesterol biosynthesis via the mevalonate pathway. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate. Atorvastatin acts primarily in the liver. Decreased hepatic cholesterol levels increases hepatic uptake of cholesterol and reduces plasma cholesterol levels.
DB01200BromocriptineBromocriptine mesylate is a semisynthetic ergot alkaloid derivative with potent dopaminergic activity. It is indicated for the management of signs and symptoms of Parkinsonian Syndrome. Bromocriptine also inhibits prolactin secretion and may be used to treat dysfunctions associated with hyperprolactinemia. It also causes sustained suppression of somatotropin (growth hormone) secretion in some patients with acromegaly. Bromocriptine has been associated with pulmonary fibrosis.
DB08907CanagliflozinCanagliflozin belongs to a new class of anti-diabetic drugs that works by inhibiting the sodium-glucose transport protein (SGLT2). This transport protein is found in the kidney and is responsible for reabsorbing glucose that has been filtered. FDA approved on March 29, 2013.
DB00672ChlorpropamideChlorpropamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination and binding site on their target pancreatic β cell receptor. Sulfonylureas also increase peripheral glucose utilization, decrease hepatic gluconeogenesis and may increase the number and sensitivity of insulin receptors. Sulfonylureas are associated with weight gain, though less so than insulin. Due to their mechanism of action, sulfonylureas may cause hypoglycemia and require consistent food intake to decrease this risk. The risk of hypoglycemia is increased in elderly, debilitated and malnourished individuals. Chlorpropamide is not recommended for the treatment of NIDDM as it increases blood pressure and the risk of retinopathy (UKPDS-33). Up to 80% of the single oral dose of chlorpropramide is metabolized, likely in the liver; 80-90% of the dose is excreted in urine as unchanged drug and metabolites. Renal and hepatic dysfunction may increase the risk of hypoglycemia.
DB00930ColesevelamColesevelam is a bile acid sequestrant. Colesevelam is used with exercise and diet changes (restriction of cholesterol and fat intake) to reduce the amount of cholesterol and certain fatty substances in the blood. It works by binding bile acids in the intestine. Bile acids are made when cholesterol is broken down in the body. Removing these bile acids helps to lower blood cholesterol.
DB06292DapagliflozinDapagliflozin is indicated for the management of diabetes mellitus type 2, and functions to improve glycemic control in adults when combined with diet and exercise. Dapagliflozin is a sodium-glucose cotransporter 2 inhibitor, which prevents glucose reabsorption in the kidney. Using dapagliflozin leads to heavy glycosuria (glucose excretion in the urine), which can lead to weight loss and tiredness. Dapagliflozin was approved by the FDA on Jan 08, 2014. Dapagliflozin is not recommended for patients with type 1 diabetes mellitus or for the treatment of diabetic ketoacidosis.
DB09045DulaglutideDulaglutide is a novel glucagon-like peptide-1 agonist (GLP-1) biologic drug consisting of a dipeptidyl peptidase-IV-protected GLP-1 analogue covalently linked to a human IgG4-Fc heavy chain by a small peptide linker. Dulaglutide is indicated in the treatment of type 2 diabetes and can be used once a week. It was approved by the FDA in September 2014. Dulaglutide is manufactured and marketed by Eli Lily under the brand Trulicity™. It is not known if dulaglutide can increase the risk of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2, and is thus not recommended for use in populations with a personal or family history of these conditions.
DB09038EmpagliflozinEmpagliflozin is a sodium glucose co-transporter-2 (SGLT-2) inhibitor indicated as an adjunct to diet and exercise to improve glycemic control in adult patients with type 2 diabetes. SGLT2 co-transporters are responsible for reabsorption of glucose from the glomerular filtrate in the kidney. The glucuretic effect resulting from SGLT2 inhibition reduces renal absorption and lowers the renal threshold for glucose, therefore resulting in increased glucose excretion. Additionally, it contributes to reduced hyperglycaemia and also assists weight loss and blood pressure reduction.
DB01276ExenatideExenatide, derived from a compound found in the saliva of the Gila monster, a large lizard native to the southwestern US, is a functional analog of Glucagon-Like Peptide-1 (GLP-1), a naturally occuring peptide.
DB01120GliclazideGliclazide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination and binding site on their target pancreatic β cell receptor. Sulfonylureas also increase peripheral glucose utilization, decrease hepatic gluconeogenesis and may increase the number and sensitivity of insulin receptors. Sulfonylureas are associated with weight gain, though less so than insulin. Due to their mechanism of action, sulfonylureas may cause hypoglycemia and require consistent food intake to decrease this risk. The risk of hypoglycemia is increased in elderly, debilitated and malnourished individuals. Gliclazide has been shown to decrease fasting plasma glucose, postprandial blood glucose and glycosolated hemoglobin (HbA1c) levels (reflective of the last 8-10 weeks of glucose control). Gliclazide is extensively metabolized by the liver; its metabolites are excreted in both urine (60-70%) and feces (10-20%).
DB00222GlimepirideGlimepiride is the first III generation sulphonyl urea it is a very potent sulphonyl urea with long duration of action.
DB01067GlipizideAn oral hypoglycemic agent which is rapidly absorbed and completely metabolized.
DB01016GlyburideGlyburide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination and binding site on their target pancreatic β cell receptor. Sulfonylureas also increase peripheral glucose utilization, decrease hepatic gluconeogenesis and may increase the number and sensitivity of insulin receptors. Sulfonylureas are associated with weight gain, though less so than insulin. Due to their mechanism of action, sulfonylureas may cause hypoglycemia and require consistent food intake to decrease this risk. The risk of hypoglycemia is increased in elderly, debilitated and malnourished individuals. Glyburide has been shown to decrease fasting plasma glucose, postprandial blood glucose and glycosolated hemoglobin (HbA1c) levels (reflective of the last 8-10 weeks of glucose control). Glyburide appears to be completely metabolized, likely in the liver. Although its metabolites exert a small hypoglycemic effect, their contribution to glyburide's hypoglycemic effect is thought to be clinically unimportant. Glyburide metabolites are excreted in urine and feces in approximately equal proportions.
DB01306Insulin AspartInsulin aspart is a recombinant, biosynthetic, fast-acting insulin analogue. It has a single amino acid substitution at position B28 where proline is replaced with aspartic acid. This substitution decreases its propensity to form hexamers and gives it a higher rate of absorption following subcutaneous administration compared to native insulin. Insulin aspart is produced in a genetically modified strain of _Saccharomyces cerevisiae_ and harvested from a bioreactor.
DB01307Insulin DetemirInsulin detemir is a long-acting human insulin analogue used to maintain basal levels of insulin in diabetic individuals. It is produced using recombinant DNA technology in yeast cells. This insulin analogue has a 14-C fatty acid, myristic acid, bound to the lysine amino acid at position B29. The myristoyl side chain increases self-association and albumin binding. This along with slow systemic absorption from the injection site prolongs distribution of the hormone into tissues and results in a long duration of action. Novo Nordisk markets insulin detemir under the trade name Levemir.
DB01309Insulin GlulisineInsulin glulisine is a biosynthetic, rapid-acting human insulin analogue produced in a non-pathogenic laboratory strain of _Escherichia coli_ (K12). This recombinant hormone differs from native human insulin in that the amino acid arginine at position B3 is replaced by lysine and the lysine at position B29 is replaced by glutamic acid. These structural modifications decrease hexamer formation, stabilize insulin glulisine monomers and increase the rate of absorption and onset of action compared to human insulin.
DB08882LinagliptinLinagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes [Wikipedia]. Two pharmacological characteristics that sets linagliptin apart from other DPP-4 inhibitors is that it has a non-linear pharmacokinetic profile and is not primarily eliminated by the renal system. FDA approved on May 2, 2011.
DB06655LiraglutideVictoza contains liraglutide, an analog of human GLP-1 and acts as a GLP-1 receptor agonist. The peptide precursor of liraglutide, produced by a process that includes expression of recombinant DNA in Saccharomyces cerevisiae, has been engineered to be 97% homologous to native human GLP-1 by substituting arginine for lysine at position 34. Liraglutide is made by attaching a C-16 fatty acid (palmitic acid) with a glutamic acid spacer on the remaining lysine residue at position 26 of the peptide precursor.
DB09265LixisenatideLixisenatide is a glucagon-like peptide-1 (GLP-1) receptor agonist used in the treatment of type 2 diabetes mellitus (T2DM). It is sold under the brand name Adlyxin by Sanofi-Aventis. Adlyxin recieved FDA approval July 28, 2016 [L763].
DB00331MetforminMetformin is a biguanide antihyperglycemic agent used for treating non-insulin-dependent diabetes mellitus (NIDDM). It improves glycemic control by decreasing hepatic glucose production, decreasing glucose absorption and increasing insulin-mediated glucose uptake. Metformin may induce weight loss and is the drug of choice for obese NIDDM patients. Use of metformin is associated with modest weight loss. When used alone, metformin does not cause hypoglycemia; however, it may potentiate the hypoglycemic effects of sulfonylureas and insulin. Its main side effects are dyspepsia, nausea and diarrhea. Dose titration and/or use of smaller divided doses may decrease side effects. Metformin should be avoided in those with severely compromised renal function (creatinine clearance < 30 ml/min), acute/decompensated heart failure, severe liver disease and for 48 hours after the use of iodinated contrast dyes due to the risk of lactic acidosis. Lower doses should be used in the elderly and those with decreased renal function. Metformin decreases fasting plasma glucose, postprandial blood glucose and glycosolated hemoglobin (HbA1c) levels, which are reflective of the last 8-10 weeks of glucose control. Metformin may also have a positive effect on lipid levels. In 2012, a combination tablet of linagliptin plus metformin hydrochloride was marketed under the name Jentadueto for use in patients when treatment with both linagliptin and metformin is appropriate.
DB00491MiglitolMiglitol is an oral anti-diabetic drug that acts by inhibiting the ability of the patient to breakdown complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the body. Miglitol inhibits glycoside hydrolase enzymes called alpha-glucosidases. Since miglitol works by preventing digestion of carbohydrates, it lowers the degree of postprandial hyperglycemia. It must be taken at the start of main meals to have maximal effect. Its effect will depend on the amount of non-monosaccharide carbohydrates in a person's diet. In contrast to acarbose (another alpha-glucosidase inhibitor), miglitol is systemically absorbed; however, it is not metabolized and is excreted by the kidneys.
DB00731NateglinideNateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that induces an early insulin response to meals decreasing postprandial blood glucose levels. It should only be taken with meals and meal-time doses should be skipped with any skipped meal. Approximately one month of therapy is required before a decrease in fasting blood glucose is seen. Meglitnides may have a neutral effect on weight or cause a slight increase in weight. The average weight gain caused by meglitinides appears to be lower than that caused by sulfonylureas and insulin and appears to occur only in those naïve to oral antidiabetic agents. Due to their mechanism of action, meglitinides may cause hypoglycemia although the risk is thought to be lower than that of sulfonylureas since their action is dependent on the presence of glucose. In addition to reducing postprandial and fasting blood glucose, meglitnides have been shown to decrease glycosylated hemoglobin (HbA1c) levels, which are reflective of the last 8-10 weeks of glucose control. Meglitinides appear to be more effective at lowering postprandial blood glucose than metformin, sulfonylureas and thiazolidinediones. Nateglinide is extensively metabolized in the liver and excreted in urine (83%) and feces (10%). The major metabolites possess less activity than the parent compound. One minor metabolite, the isoprene, has the same potency as its parent compound.
DB01132PioglitazonePioglitazone is a medication belonging to the thiazolidinedione class of drugs that are used as adjuncts to diet, exercise, and other diabetes medications to manage type 2 diabetes mellitus. The thiazolidinedione class of medications exerts its pharmacological effect primarily by promoting insulin sensitivity and the improved uptake of blood glucose. Following entry into fat cell nuclei, pioglitazone selectively binds to the Peroxisome Proliferator-Activated Receptor Gamma (PPARγ)[A19757]. PPARs are ligand-activated transcription factors that are involved in the expression of more than 100 genes, and affect numerous metabolic processes, notably lipid and glucose homeostasis [A19759]. PPARγ in particular is abundantly expressed in lipid cells (adipocytes), where it plays a central role in lipid production and regulation of lipid metabolism.
DB01278PramlintidePramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes.
DB00912RepaglinideRepaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response to meals decreasing postprandial blood glucose levels. It should only be taken with meals and meal-time doses should be skipped with any skipped meal. Approximately one month of therapy is required before a decrease in fasting blood glucose is seen. Meglitnides may have a neutral effect on weight or cause a slight increase in weight. The average weight gain caused by meglitinides appears to be lower than that caused by sulfonylureas and insulin and appears to occur only in those naïve to oral antidiabetic agents. Due to their mechanism of action, meglitinides may cause hypoglycemia although the risk is thought to be lower than that of sulfonylureas since their action is dependent on the presence of glucose. In addition to reducing postprandial and fasting blood glucose, meglitnides have been shown to decrease glycosylated hemoglobin (HbA1c) levels, which are reflective of the last 8-10 weeks of glucose control. Meglitinides appear to be more effective at lowering postprandial blood glucose than metformin, sulfonylureas and thiazolidinediones. Repaglinide is extensively metabolized in the liver and excreted in bile. Repaglinide metabolites do not possess appreciable hypoglycemic activity. Approximately 90% of a single orally administered dose is eliminated in feces and 8% in urine.
DB00412RosiglitazoneRosiglitazone is an anti-diabetic drug in the thiazolidinedione class of drugs. It is marketed by the pharmaceutical company GlaxoSmithKline as a stand-alone drug (Avandia) and in combination with metformin (Avandamet) or with glimepiride (Avandaryl). Like other thiazolidinediones, the mechanism of action of rosiglitazone is by activation of the intracellular receptor class of the peroxisome proliferator-activated receptors (PPARs), specifically PPARγ. Rosiglitazone is a selective ligand of PPARγ, and has no PPARα-binding action. Apart from its effect on insulin resistance, it appears to have an anti-inflammatory effect: nuclear factor kappa-B (NFκB) levels fall and inhibitor (IκB) levels increase in patients on rosiglitazone. Recent research has suggested that rosiglitazone may also be of benefit to a subset of patients with Alzheimer's disease not expressing the ApoE4 allele. This is the subject of a clinical trial currently underway.
DB06335SaxagliptinSaxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009.
DB01261SitagliptinSitagliptin is a new oral hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. This enzyme-inhibiting drug is to be used either alone or in combination with metformin or a thiazolidinedione for control of type 2 diabetes mellitus. The drug works to competitively inhibit a protein/enzyme, dipeptidyl peptidase 4 (DPP-4), that results in an increased amount of active incretins (GLP-1 and GIP), reduced amount of release of glucagon (diminishes its release) and increased release of insulin.
DB00839TolazamideA sulphonylurea hypoglycemic agent with actions and uses similar to those of chlorpropamide.
DB01124TolbutamideTolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination and binding site on their target pancreatic β cell receptor. Sulfonylureas also increase peripheral glucose utilization, decrease hepatic gluconeogenesis and may increase the number and sensitivity of insulin receptors. Sulfonylureas are associated with weight gain, though less so than insulin. Due to their mechanism of action, sulfonylureas may cause hypoglycemia and require consistent food intake to decrease this risk. The risk of hypoglycemia is increased in elderly, debilitated and malnourished individuals. Tolbutamide appears to be metabolized in the liver. Tolbutamide and its metabolites are excreted in urine (75-85%) and feces.
DB04876VildagliptinVildagliptin, previously identified as LAF237, is a new oral anti-hyperglycemic agent (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. Vildagliptin inhibits the inactivation of GLP-1 and GIP by DPP-4, allowing GLP-1 and GIP to potentiate the secretion of insulin in the beta cells and suppress glucaon release by the alpha cells of the islets of Langerhans in the pancreas. It is currently in clinical trials in the U.S. and has been shown to reduce hyperglycemia in type 2 diabetes mellitus. While the drug is still not approved for use in the US, it was approved in Feb 2008 by European Medicines Agency for use within the EU and is listed on the Australian PBS with certain restrictions.
DrugDrug NameTargetType
DB00284AcarboseMaltase-glucoamylase, intestinaltarget
DB00284AcarboseLysosomal alpha-glucosidasetarget
DB00284AcarboseSucrase-isomaltase, intestinaltarget
DB00284AcarbosePancreatic alpha-amylasetarget
DB09043AlbiglutideGlucagon-like peptide 1 receptortarget
DB06203AlogliptinDipeptidyl peptidase 4target
DB06203AlogliptinCytochrome P450 3A4enzyme
DB06203AlogliptinCytochrome P450 2D6enzyme
DB01076AtorvastatinCytochrome P450 3A4enzyme
DB01076AtorvastatinCytochrome P450 3A5enzyme
DB01076AtorvastatinCytochrome P450 3A7enzyme
DB01076AtorvastatinCytochrome P450 2C8enzyme
DB01076AtorvastatinCytochrome P450 2D6enzyme
DB01076AtorvastatinCytochrome P450 2C9enzyme
DB01076AtorvastatinCytochrome P450 2C19enzyme
DB01076AtorvastatinCytochrome P450 2B6enzyme
DB01076AtorvastatinUDP-glucuronosyltransferase 1-1enzyme
DB01076AtorvastatinUDP-glucuronosyltransferase 1-3enzyme
DB01076AtorvastatinUDP-glucuronosyltransferase 2B7enzyme
DB01076Atorvastatin3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
DB01076AtorvastatinDipeptidyl peptidase 4target
DB01076AtorvastatinAryl hydrocarbon receptortarget
DB01076AtorvastatinMultidrug resistance protein 1transporter
DB01076AtorvastatinSolute carrier organic anion transporter family member 1A2transporter
DB01076AtorvastatinSolute carrier organic anion transporter family member 1B1transporter
DB01076AtorvastatinMultidrug resistance-associated protein 4transporter
DB01076AtorvastatinMultidrug resistance-associated protein 5transporter
DB01076AtorvastatinMultidrug resistance-associated protein 1transporter
DB01076AtorvastatinSolute carrier organic anion transporter family member 2B1transporter
DB01076AtorvastatinSolute carrier organic anion transporter family member 1B3transporter
DB01076AtorvastatinCanalicular multispecific organic anion transporter 1transporter
DB01200BromocriptineD(2) dopamine receptortarget
DB01200BromocriptineCytochrome P450 3A4enzyme
DB01200Bromocriptine5-hydroxytryptamine receptor 1Dtarget
DB01200BromocriptineAlpha-2A adrenergic receptortarget
DB01200BromocriptineD(3) dopamine receptortarget
DB01200Bromocriptine5-hydroxytryptamine receptor 1Atarget
DB01200BromocriptineAlpha-2C adrenergic receptortarget
DB01200BromocriptineAlpha-2B adrenergic receptortarget
DB01200Bromocriptine5-hydroxytryptamine receptor 2Btarget
DB01200BromocriptineD(4) dopamine receptortarget
DB01200Bromocriptine5-hydroxytryptamine receptor 2Atarget
DB01200Bromocriptine5-hydroxytryptamine receptor 1Btarget
DB01200Bromocriptine5-hydroxytryptamine receptor 2Ctarget
DB01200BromocriptineD(1B) dopamine receptortarget
DB01200BromocriptineD(1A) dopamine receptortarget
DB01200BromocriptineAlpha-1A adrenergic receptortarget
DB01200BromocriptineAlpha-1B adrenergic receptortarget
DB01200BromocriptineAlpha-1D adrenergic receptortarget
DB01200Bromocriptine5-hydroxytryptamine receptor 7target
DB01200BromocriptineMultidrug resistance protein 1transporter
DB01200BromocriptineCytochrome P450 1A2enzyme
DB08907CanagliflozinUDP-glucuronosyltransferase 1-9enzyme
DB08907CanagliflozinUDP-glucuronosyltransferase 2B4enzyme
DB08907CanagliflozinCytochrome P450 3A4enzyme
DB08907CanagliflozinSerum albumincarrier
DB08907CanagliflozinSodium/glucose cotransporter 2target
DB08907CanagliflozinMultidrug resistance protein 1transporter
DB08907CanagliflozinCanalicular multispecific organic anion transporter 1transporter
DB08907CanagliflozinSodium/glucose cotransporter 1target
DB08907CanagliflozinAlpha-1-acid glycoprotein 1carrier
DB00672ChlorpropamideATP-binding cassette sub-family C member 8target
DB00672ChlorpropamideMultidrug resistance protein 1transporter
DB00672ChlorpropamideSolute carrier family 15 member 1transporter
DB00672ChlorpropamideSolute carrier family 15 member 2transporter
DB00672ChlorpropamideSolute carrier family 22 member 6transporter
DB00672ChlorpropamideCytochrome P450 2C9enzyme
DB00672ChlorpropamideCytochrome P450 2C19enzyme
DB00672ChlorpropamideProstaglandin G/H synthase 1enzyme
DB00930ColesevelamBile acidstarget
DB06292DapagliflozinSodium/glucose cotransporter 2target
DB06292DapagliflozinCytochrome P450 1A1enzyme
DB06292DapagliflozinCytochrome P450 1A2enzyme
DB06292DapagliflozinCytochrome P450 2A6enzyme
DB06292DapagliflozinCytochrome P450 2C9enzyme
DB06292DapagliflozinCytochrome P450 2D6enzyme
DB06292DapagliflozinCytochrome P450 3A4enzyme
DB06292DapagliflozinUDP-glucuronosyltransferase 1-9enzyme
DB06292DapagliflozinUDP-glucuronosyltransferase 2B4enzyme
DB06292DapagliflozinUDP-glucuronosyltransferase 2B7enzyme
DB06292DapagliflozinMultidrug resistance protein 1transporter
DB09045DulaglutideGlucagon-like peptide 1 receptortarget
DB09038EmpagliflozinSodium/glucose cotransporter 2target
DB01276ExenatideGlucagon-like peptide 1 receptortarget
DB01276ExenatideSerum albumincarrier
DB01120GliclazideATP-binding cassette sub-family C member 8target
DB01120GliclazideSerum albumincarrier
DB01120GliclazideVascular endothelial growth factor Atarget
DB01120GliclazideCytochrome P450 2C9enzyme
DB01120GliclazideCytochrome P450 2C19enzyme
DB00222GlimepirideATP-sensitive inward rectifier potassium channel 1target
DB00222GlimepirideATP-sensitive inward rectifier potassium channel 11target
DB00222GlimepirideCytochrome P450 2C9enzyme
DB00222GlimepirideATP-binding cassette sub-family C member 8target
DB01067GlipizideCytochrome P450 2C9enzyme
DB01067GlipizidePeroxisome proliferator-activated receptor gammatarget
DB01067GlipizideATP-binding cassette sub-family C member 8target
DB01067GlipizideCytochrome P450 3A4enzyme
DB01016GlyburideATP-binding cassette sub-family C member 9target
DB01016GlyburideBile salt export pumptarget
DB01016GlyburideATP-binding cassette sub-family A member 1target
DB01016GlyburideCystic fibrosis transmembrane conductance regulatortarget
DB01016GlyburideSulfonylurea receptor 1, Kir6.2target
DB01016GlyburideG protein-activated inward rectifier potassium channel 4target
DB01016GlyburideCytochrome P450 2C9enzyme
DB01016GlyburideCanalicular multispecific organic anion transporter 2transporter
DB01016GlyburideBile salt export pumptransporter
DB01016GlyburideMultidrug resistance protein 1transporter
DB01016GlyburideMultidrug resistance-associated protein 1transporter
DB01016GlyburideSolute carrier family 15 member 1transporter
DB01016GlyburideSolute carrier organic anion transporter family member 1A2transporter
DB01016GlyburideSolute carrier family 15 member 2transporter
DB01016GlyburideSolute carrier family 22 member 6transporter
DB01016GlyburideCanalicular multispecific organic anion transporter 1transporter
DB01016GlyburideATP-binding cassette sub-family G member 2transporter
DB01016GlyburideSolute carrier family 22 member 7transporter
DB01016GlyburideSolute carrier organic anion transporter family member 2B1transporter
DB01016GlyburideCytochrome P450 2C19enzyme
DB01016GlyburideCytochrome P450 3A4enzyme
DB01016GlyburideSerum albumincarrier
DB01016GlyburideMitochondrial ATP-sensitive potassium channeltarget
DB01016GlyburideCarnitine O-palmitoyltransferase 1, liver isoformtarget
DB01306Insulin AspartInsulin receptortarget
DB01306Insulin AspartCytochrome P450 1A2enzyme
DB01307Insulin DetemirInsulin receptortarget
DB01307Insulin DetemirSerum albumincarrier
DB01307Insulin DetemirCytochrome P450 1A2enzyme
DB01309Insulin GlulisineInsulin receptortarget
DB01309Insulin GlulisineCytochrome P450 1A2enzyme
DB08882LinagliptinDipeptidyl peptidase 4target
DB08882LinagliptinCytochrome P450 3A4enzyme
DB08882LinagliptinMultidrug resistance protein 1transporter
DB06655LiraglutideGlucagon-like peptide 1 receptortarget
DB06655LiraglutideDipeptidyl peptidase 4enzyme
DB06655LiraglutideNeprilysinenzyme
DB09265LixisenatideGlucagon-like peptide 1 receptortarget
DB00331Metformin5'-AMP-activated protein kinase subunit beta-1target
DB00331MetforminSolute carrier family 22 member 2transporter
DB00331MetforminSolute carrier family 22 member 1transporter
DB00331MetforminMultidrug and toxin extrusion protein 1transporter
DB00331MetforminEquilibrative nucleoside transporter 4transporter
DB00331MetforminSolute carrier family 22 member 3transporter
DB00491MiglitolMaltase-glucoamylase, intestinaltarget
DB00491MiglitolPancreatic alpha-amylaseenzyme
DB00491MiglitolLysosomal alpha-glucosidasetarget
DB00491MiglitolNeutral alpha-glucosidase ABtarget
DB00491MiglitolNeutral alpha-glucosidase Ctarget
DB00731NateglinideATP-binding cassette sub-family C member 8target
DB00731NateglinideCytochrome P450 3A4enzyme
DB00731NateglinideCytochrome P450 2C9enzyme
DB00731NateglinidePeroxisome proliferator-activated receptor gammatarget
DB00731NateglinideCytochrome P450 3A5enzyme
DB00731NateglinideCytochrome P450 3A7enzyme
DB00731NateglinideSolute carrier family 15 member 1transporter
DB00731NateglinideSolute carrier family 15 member 2transporter
DB00731NateglinideSolute carrier family 22 member 6transporter
DB00731NateglinideMonocarboxylate transporter 1transporter
DB00731NateglinideProstaglandin G/H synthase 1enzyme
DB00731NateglinideUDP-glucuronosyltransferase 1-9enzyme
DB00731NateglinideCytochrome P450 2D6enzyme
DB00731NateglinideMultidrug resistance-associated protein 4transporter
DB00731NateglinideSerum albumincarrier
DB00731NateglinideAlpha-1-acid glycoprotein 1carrier
DB01132PioglitazonePeroxisome proliferator-activated receptor gammatarget
DB01132PioglitazoneCytochrome P450 2C8enzyme
DB01132PioglitazoneCytochrome P450 3A4enzyme
DB01132PioglitazoneSolute carrier organic anion transporter family member 1B3transporter
DB01132PioglitazoneSolute carrier organic anion transporter family member 1B1transporter
DB01132PioglitazoneProstaglandin G/H synthase 1enzyme
DB01132PioglitazoneCytochrome P450 2C19enzyme
DB01132PioglitazoneCytochrome P450 2C9enzyme
DB01132PioglitazoneCytochrome P450 2D6enzyme
DB01132PioglitazonePeroxisome proliferator-activated receptor deltatarget
DB01132PioglitazonePeroxisome proliferator-activated receptor alphatarget
DB01132PioglitazoneAmine oxidase [flavin-containing] Btarget
DB01278PramlintideReceptor activity-modifying protein 1target
DB01278PramlintideReceptor activity-modifying protein 2target
DB01278PramlintideReceptor activity-modifying protein 3target
DB01278PramlintideCalcitonin receptortarget
DB00912RepaglinideATP-binding cassette sub-family C member 8target
DB00912RepaglinideCytochrome P450 2C8enzyme
DB00912RepaglinidePeroxisome proliferator-activated receptor gammatarget
DB00912RepaglinideCytochrome P450 3A4enzyme
DB00912RepaglinideSerum albumincarrier
DB00912RepaglinideSolute carrier organic anion transporter family member 1B1transporter
DB00412RosiglitazonePeroxisome proliferator-activated receptor gammatarget
DB00412RosiglitazoneCytochrome P450 2C8enzyme
DB00412RosiglitazoneCytochrome P450 2C9enzyme
DB00412RosiglitazoneLong-chain-fatty-acid--CoA ligase 4target
DB00412RosiglitazoneSolute carrier organic anion transporter family member 1B1transporter
DB00412RosiglitazoneProstaglandin G/H synthase 1enzyme
DB00412RosiglitazoneCytochrome P450 1A2enzyme
DB00412RosiglitazoneCytochrome P450 2A6enzyme
DB00412RosiglitazoneCytochrome P450 2C19enzyme
DB00412RosiglitazoneCytochrome P450 2D6enzyme
DB00412RosiglitazoneSerum albumincarrier
DB00412RosiglitazonePeroxisome proliferator-activated receptor alphatarget
DB00412RosiglitazonePeroxisome proliferator-activated receptor deltatarget
DB00412RosiglitazoneRetinoic acid receptor RXR-alphatarget
DB00412RosiglitazoneRetinoic acid receptor RXR-betatarget
DB00412RosiglitazoneRetinoic acid receptor RXR-gammatarget
DB06335SaxagliptinDipeptidyl peptidase 4target
DB06335SaxagliptinCytochrome P450 3A4enzyme
DB06335SaxagliptinCytochrome P450 3A5enzyme
DB06335SaxagliptinMultidrug resistance-associated protein 1transporter
DB06335SaxagliptinSolute carrier organic anion transporter family member 4C1transporter
DB06335SaxagliptinSolute carrier family 22 member 8transporter
DB01261SitagliptinDipeptidyl peptidase 4target
DB01261SitagliptinCytochrome P450 3A4enzyme
DB01261SitagliptinCytochrome P450 2C8enzyme
DB01261SitagliptinMultidrug resistance protein 1transporter
DB00839TolazamideSulfonylurea receptor 1, Kir6.2target
DB01124TolbutamideSerum albumincarrier
DB01124TolbutamideCytochrome P450 2C19enzyme
DB01124TolbutamideCytochrome P450 2C9enzyme
DB01124TolbutamideCytochrome P450 2C8enzyme
DB01124TolbutamideCytochrome P450 2C18enzyme
DB01124TolbutamideATP-sensitive inward rectifier potassium channel 1target
DB01124TolbutamideATP-binding cassette sub-family C member 8target
DB01124TolbutamideSolute carrier family 15 member 1transporter
DB01124TolbutamideSolute carrier organic anion transporter family member 1A2transporter
DB01124TolbutamideSolute carrier family 15 member 2transporter
DB01124TolbutamideSolute carrier family 22 member 6transporter
DB01124TolbutamideSolute carrier organic anion transporter family member 2B1transporter
DB04876VildagliptinDipeptidyl peptidase 4target
DrugDrug NamePhaseStatusCount
DB00594Amiloride0Terminated1
DB00201Caffeine0Completed1
DB09303Evolocumab0Not Yet Recruiting1
DB00999Hydrochlorothiazide0Terminated1
DB01261Sitagliptin0Withdrawn1
DB12084ADP-5971Completed2
DB12084ADP-5971Terminated1
DB00284Acarbose1Completed3
DB00316Acetaminophen1Completed1
DB11704Adomeglivant1Completed4
DB05162Albiglutide1Completed2
DB09043Albiglutide1Completed3
DB08915Aleglitazar1Completed1
DB06203Alogliptin1Completed2
DB00381Amlodipine1Completed1
DB12417Anagliptin1Completed1
DB01019Bethanechol1Completed1
DB12236Bexagliflozin1Completed1
DB12236Bexagliflozin1Not Yet Recruiting1
DB01200Bromocriptine1Completed1
DB00887Bumetanide1Completed1
DB01156Bupropion1Completed1
DB08907Canagliflozin1Completed8
DB08907Canagliflozin1Enrolling by Invitation1
DB00169Cholecalciferol1Completed1
DB11255Chromium picolinate1Terminated1
DB12815Crotedumab1Terminated1
DB06292Dapagliflozin1Active Not Recruiting1
DB06292Dapagliflozin1Completed17
DB06292Dapagliflozin1Recruiting1
DB06292Dapagliflozin1Terminated1
DB00390Digoxin1Completed3
DB09045Dulaglutide1Completed10
DB09038Empagliflozin1Completed7
DB09038Empagliflozin1Not Yet Recruiting1
DB00700Eplerenone1Not Yet Recruiting1
DB00153Ergocalciferol1Completed1
DB11827Ertugliflozin1Completed6
DB00898Ethanol1Terminated1
DB00977Ethinyl Estradiol1Completed4
DB12625Evogliptin1Completed1
DB12625Evogliptin1Unknown Status1
DB01276Exenatide1Completed8
DB00712Flurbiprofen1Completed1
DB00695Furosemide1Completed1
DB12627GSK-12922631Completed1
DB11729GSK-23306721Completed2
DB12654GSK-3765011Completed4
DB01241Gemfibrozil1Completed2
DB12412Gemigliptin1Completed1
DB06062Gevokizumab1Completed1
DB11895Ghrelin1Recruiting1
DB00222Glimepiride1Completed5
DB00222Glimepiride1Terminated1
DB01067Glipizide1Active Not Recruiting1
DB01067Glipizide1Completed1
DB00040Glucagon recombinant1Completed4
DB09341Glucose1Completed1
DB09341Glucose1Recruiting1
DB01016Glyburide1Completed2
DB01016Glyburide1Unknown Status1
DB11939Henagliflozin1Completed4
DB11939Henagliflozin1Recruiting1
DB11939Henagliflozin1Unknown Status2
DB00999Hydrochlorothiazide1Completed2
DB05506ISIS 1137151Completed1
DB12509Imeglimin1Completed1
DB01306Insulin Aspart1Completed6
DB01306Insulin Aspart1Recruiting1
DB09564Insulin Degludec1Completed6
DB09564Insulin Degludec1Not Yet Recruiting1
DB09564Insulin Degludec1Recruiting1
DB09564Insulin Degludec1Terminated1
DB01307Insulin Detemir1Completed4
DB00047Insulin Glargine1Completed13
DB00047Insulin Glargine1Recruiting1
DB01309Insulin Glulisine1Completed3
DB00030Insulin Human1Completed2
DB00046Insulin Lispro1Completed5
DB00046Insulin Lispro1Not Yet Recruiting2
DB00046Insulin Lispro1Withdrawn1
DB11698Ipragliflozin1Completed1
DB01026Ketoconazole1Completed2
DB00125L-Arginine1Not Yet Recruiting1
DB00130L-Glutamine1Unknown Status1
DB00134L-Methionine1Completed2
DB12284LY-26082041Completed1
DB00367Levonorgestrel1Completed2
DB08882Linagliptin1Completed3
DB06655Liraglutide1Completed18
DB06655Liraglutide1Not Yet Recruiting1
DB06655Liraglutide1Recruiting2
DB00722Lisinopril1Completed2
DB09265Lixisenatide1Completed2
DB09265Lixisenatide1Recruiting1
DB09198Lobeglitazone1Completed5
DB09198Lobeglitazone1Not Yet Recruiting1
DB12044MK-08931Completed2
DB13024MK-82451Completed1
DB00742Mannitol1Active Not Recruiting1
DB05914Mesenchymal Stem Cells1Unknown Status1
DB00331Metformin1Active Not Recruiting2
DB00331Metformin1Completed43
DB00331Metformin1Not Yet Recruiting1
DB00331Metformin1Recruiting3
DB00331Metformin1Terminated2
DB00331Metformin1Unknown Status1
DB00331Metformin1Withdrawn1
DB00264Metoprolol1Completed2
DB00683Midazolam1Completed4
DB01252Mitiglinide1Completed1
DB00218Moxifloxacin1Completed3
DB00717Norethisterone1Completed2
DB00104Octreotide1Completed1
DB11992Omarigliptin1Completed3
DB11814PF-038828451Completed1
DB11765PF-049915321Completed5
DB12096PF-051751571Completed7
DB01132Pioglitazone1Completed4
DB01132Pioglitazone1Not Yet Recruiting1
DB01132Pioglitazone1Withdrawn1
DB01032Probenecid1Not Yet Recruiting1
DB00571Propranolol1Completed1
DB00243Ranolazine1Completed3
DB12935Remogliflozin etabonate1Completed2
DB00912Repaglinide1Completed2
DB02709Resveratrol1Completed1
DB01045Rifampicin1Not Yet Recruiting1
DB01045Rifampicin1Terminated1
DB01656Roflumilast1Completed1
DB00412Rosiglitazone1Completed4
DB01098Rosuvastatin1Completed1
DB12186SRT-21041Completed5
DB06335Saxagliptin1Active Not Recruiting1
DB06335Saxagliptin1Completed12
DB06335Saxagliptin1Recruiting1
DB06335Saxagliptin1Terminated1
DB06335Saxagliptin1Withdrawn1
DB00641Simvastatin1Completed7
DB00641Simvastatin1Recruiting1
DB01261Sitagliptin1Completed27
DB01261Sitagliptin1Recruiting1
DB01261Sitagliptin1Unknown Status1
DB09153Sodium Chloride1Completed2
DB12713Sotagliflozin1Completed2
DB12713Sotagliflozin1Not Yet Recruiting1
DB00820Tadalafil1Terminated1
DB11824Tofogliflozin1Completed3
DB00214Torasemide1Completed1
DB00177Valsartan1Completed2
DB00177Valsartan1Recruiting1
DB00661Verapamil1Not Yet Recruiting1
DB04876Vildagliptin1Completed5
DB11094Vitamin D1Completed1
DB00682Warfarin1Completed5
DB02381nor-NOHA1Completed1
DB09055Acipimox1 / 2Completed1
DB11906Acyline1 / 2Active Not Recruiting1
DB09026Aliskiren1 / 2Completed3
DB04115Berberine1 / 2Completed1
DB08907Canagliflozin1 / 2Completed1
DB01197Captopril1 / 2Active Not Recruiting1
DB11073Cetylpyridinium1 / 2Unknown Status1
DB01276Exenatide1 / 2Terminated1
DB06062Gevokizumab1 / 2Completed1
DB00030Insulin Human1 / 2Completed1
DB00046Insulin Lispro1 / 2Completed1
DB01006Letrozole1 / 2Active Not Recruiting1
DB00331Metformin1 / 2Completed5
DB01132Pioglitazone1 / 2Completed1
DB01261Sitagliptin1 / 2Completed1
DB00624Testosterone1 / 2Active Not Recruiting1
DB04876Vildagliptin1 / 2Terminated1
DB00284Acarbose2Completed2
DB00414Acetohexamide2Completed1
DB11704Adomeglivant2Completed3
DB11704Adomeglivant2Terminated1
DB05162Albiglutide2Completed1
DB09043Albiglutide2Completed4
DB08915Aleglitazar2Completed6
DB06203Alogliptin2Completed2
DB11863Alvelestat2Recruiting1
DB00915Amantadine2Completed1
DB01025Amlexanox2Active Not Recruiting1
DB01025Amlexanox2Completed1
DB12417Anagliptin2Completed2
DB00026Anakinra2Completed1
DB00026Anakinra2Unknown Status1
DB06158Arhalofenate2Terminated1
DB06543Astaxanthin2Completed1
DB12671Beloranib2Terminated1
DB11936Bempedoic acid2Completed1
DB09022Benfluorex2Unknown Status1
DB12236Bexagliflozin2Completed1
DB01393Bezafibrate2Completed1
DB12584Bimagrumab2Recruiting1
DB00559Bosentan2Completed1
DB08907Canagliflozin2Completed2
DB06168Canakinumab2Completed3
DB09061Cannabidiol2Completed1
DB12268Carmegliptin2Completed1
DB11758Cenicriviroc2Completed1
DB11121Chloroxylenol2Completed2
DB00672Chlorpropamide2Completed1
DB00169Cholecalciferol2Completed2
DB00169Cholecalciferol2Unknown Status1
DB00882Clomifene2Terminated1
DB00930Colesevelam2Completed2
DB09130Copper2Completed1
DB09131Cupric Chloride2Completed1
DB06292Dapagliflozin2Completed5
DB06292Dapagliflozin2Recruiting1
DB00514Dextromethorphan2Completed1
DB11994Diacerein2Completed3
DB11994Diacerein2Recruiting1
DB01119Diazoxide2Recruiting1
DB00861Diflunisal2Completed1
DB09045Dulaglutide2Active Not Recruiting1
DB09045Dulaglutide2Completed3
DB09045Dulaglutide2Recruiting1
DB05065Dutogliptin2Completed1
DB11723Dutogliptin2Terminated1
DB05187Elafibranor2Completed1
DB09038Empagliflozin2Completed9
DB09038Empagliflozin2Enrolling by Invitation1
DB09038Empagliflozin2Recruiting3
DB06735Enclomiphene2Completed1
DB12116Epigallocatechin Gallate2Withdrawn1
DB00153Ergocalciferol2Completed1
DB00153Ergocalciferol2Unknown Status1
DB11827Ertugliflozin2Completed2
DB00898Ethanol2Unknown Status1
DB12625Evogliptin2Recruiting1
DB01276Exenatide2Completed8
DB00973Ezetimibe2Completed1
DB12491Fasiglifam2Terminated1
DB12627GSK-12922632Completed2
DB11729GSK-23306722Completed2
DB06062Gevokizumab2Completed2
DB01120Gliclazide2Completed1
DB00222Glimepiride2Completed9
DB00222Glimepiride2Withdrawn1
DB01067Glipizide2Completed2
DB01016Glyburide2Completed3
DB01016Glyburide2Recruiting1
DB01016Glyburide2Terminated1
DB12934Granotapide2Completed1
DB05212HE32862Completed1
DB06205Hyaluronidase (Human Recombinant)2Completed2
DB00999Hydrochlorothiazide2Completed2
DB00999Hydrochlorothiazide2Terminated1
DB05506ISIS 1137152Completed2
DB05506ISIS 1137152Terminated1
DB05506ISIS 1137152Withdrawn1
DB12509Imeglimin2Completed1
DB01306Insulin Aspart2Completed1
DB09564Insulin Degludec2Completed1
DB00047Insulin Glargine2Completed10
DB00047Insulin Glargine2Terminated1
DB01309Insulin Glulisine2Completed1
DB00030Insulin Human2Completed6
DB00046Insulin Lispro2Completed3
DB00046Insulin Lispro2Terminated1
DB02325Isopropyl Alcohol2Unknown Status1
DB12632JNJ-414435322Completed1
DB06127KRP-1042Completed1
DB00149L-Leucine2Completed2
DB00134L-Methionine2Completed1
DB12284LY-26082042Withdrawn1
DB00451Levothyroxine2Terminated1
DB08882Linagliptin2Completed5
DB00166Lipoic Acid2Unknown Status1
DB06655Liraglutide2Completed17
DB06655Liraglutide2Recruiting3
DB06655Liraglutide2Terminated2
DB09265Lixisenatide2Completed3
DB09198Lobeglitazone2Completed1
DB11138Lutein2Completed1
DB05053MB-078032Completed1
DB12055MK-07672Terminated1
DB12044MK-08932Completed2
DB12044MK-08932Terminated1
DB01065Melatonin2Completed1
DB00331Metformin2Completed48
DB00331Metformin2Recruiting3
DB00331Metformin2Terminated9
DB00331Metformin2Unknown Status1
DB00264Metoprolol2Active Not Recruiting1
DB00834Mifepristone2Recruiting1
DB11721Mitoglitazone2Completed2
DB12445Nitroaspirin2Terminated1
DB05990Obeticholic acid2Completed1
DB11992Omarigliptin2Completed1
DB09539Omega-3-acid ethyl esters2Completed1
DB09568Omega-3-carboxylic acids2Completed1
DB00338Omeprazole2Not Yet Recruiting1
DB01083Orlistat2Completed1
DB11765PF-049915322Completed2
DB12096PF-051751572Terminated3
DB00910Paricalcitol2Completed1
DB01132Pioglitazone2Completed19
DB01132Pioglitazone2Terminated3
DB01278Pramlintide2Completed2
DB06815Pyrithione zinc2Completed1
DB00243Ranolazine2Completed1
DB00912Repaglinide2Completed1
DB02709Resveratrol2Recruiting1
DB02709Resveratrol2Unknown Status1
DB01656Roflumilast2Completed1
DB00412Rosiglitazone2Completed1
DB12186SRT-21042Completed2
DB06335Saxagliptin2Completed2
DB06335Saxagliptin2Recruiting1
DB00641Simvastatin2Completed1
DB01261Sitagliptin2Completed25
DB01261Sitagliptin2Recruiting1
DB01261Sitagliptin2Terminated1
DB01261Sitagliptin2Withdrawn1
DB09153Sodium Chloride2Completed1
DB09153Sodium Chloride2Recruiting1
DB00820Tadalafil2Recruiting1
DB11644Tafamidis2Completed1
DB04936Tagatose2Completed1
DB11950Teneligliptin2Completed2
DB08869Tesamorelin2Completed1
DB00624Testosterone2Completed1
DB00624Testosterone2Terminated1
DB11755Tetrahydrocannabivarin2Completed2
DB11824Tofogliflozin2Completed1
DB00839Tolazamide2Completed1
DB01124Tolbutamide2Completed1
DB00273Topiramate2Completed3
DB00620Triamcinolone2Completed1
DB00197Troglitazone2Completed1
DB09270Ubidecarenone2Completed1
DB01586Ursodeoxycholic acid2Completed1
DB12414Usistapide2Completed1
DB00862Vardenafil2Completed1
DB04876Vildagliptin2Completed2
DB00126Vitamin C2Completed1
DB11094Vitamin D2Completed1
DB11094Vitamin D2Unknown Status1
DB00163Vitamin E2Completed1
DB04878Voglibose2Completed2
DB01392Yohimbine2Completed1
DB11176Zeaxanthin2Completed1
DB01593Zinc2Completed1
DB06151Acetylcysteine2 / 3Completed1
DB09055Acipimox2 / 3Completed1
DB06203Alogliptin2 / 3Completed7
DB06158Arhalofenate2 / 3Completed1
DB08822Azilsartan medoxomil2 / 3Unknown Status1
DB12236Bexagliflozin2 / 3Completed1
DB10736Broussonetia papyrifera pollen2 / 3Completed1
DB06168Canakinumab2 / 3Terminated1
DB00169Cholecalciferol2 / 3Completed1
DB00930Colesevelam2 / 3Completed1
DB06292Dapagliflozin2 / 3Completed2
DB09045Dulaglutide2 / 3Completed1
DB12610Ebselen2 / 3Completed1
DB01276Exenatide2 / 3Completed1
DB01276Exenatide2 / 3Recruiting1
DB01039Fenofibrate2 / 3Terminated1
DB00222Glimepiride2 / 3Completed2
DB00030Insulin Human2 / 3Completed1
DB00125L-Arginine2 / 3Recruiting1
DB00331Metformin2 / 3Completed5
DB00331Metformin2 / 3Recruiting1
DB00331Metformin2 / 3Terminated2
DB00331Metformin2 / 3Unknown Status2
DB00731Nateglinide2 / 3Completed1
DB00213Pantoprazole2 / 3Completed1
DB01132Pioglitazone2 / 3Completed5
DB09200Rivoglitazone2 / 3Completed1
DB11829Ruboxistaurin2 / 3Completed1
DB01399Salsalate2 / 3Completed2
DB01261Sitagliptin2 / 3Completed2
DB00624Testosterone2 / 3Completed1
DB04876Vildagliptin2 / 3Completed2
DB00163Vitamin E2 / 3Completed1
DB04878Voglibose2 / 3Completed2
DB118982,4-thiazolidinedione3Completed4
DB00284Acarbose3Completed7
DB00284Acarbose3Recruiting1
DB00284Acarbose3Terminated1
DB08842Acetylcarnitine3Completed1
DB00945Acetylsalicylic acid3Recruiting1
DB05162Albiglutide3Active Not Recruiting1
DB09043Albiglutide3Active Not Recruiting1
DB09043Albiglutide3Completed7
DB09043Albiglutide3Recruiting1
DB05162Albiglutide3Withdrawn1
DB09043Albiglutide3Withdrawn2
DB08915Aleglitazar3Completed6
DB09026Aliskiren3Terminated1
DB00437Allopurinol3Recruiting1
DB06203Alogliptin3Completed6
DB06203Alogliptin3Recruiting1
DB00381Amlodipine3Completed1
DB12417Anagliptin3Completed2
DB12000Apabetalone3Recruiting1
DB01076Atorvastatin3Completed5
DB01076Atorvastatin3Recruiting2
DB01076Atorvastatin3Terminated1
DB08822Azilsartan medoxomil3Terminated2
DB12781Balaglitazone3Completed1
DB00542Benazepril3Completed1
DB04115Berberine3Completed1
DB12236Bexagliflozin3Active Not Recruiting1
DB12236Bexagliflozin3Completed1
DB12236Bexagliflozin3Not Yet Recruiting1
DB12236Bexagliflozin3Recruiting2
DB13100Biguanide3Completed2
DB00559Bosentan3Terminated1
DB01200Bromocriptine3Completed1
DB01200Bromocriptine3Terminated1
DB08907Canagliflozin3Active Not Recruiting1
DB08907Canagliflozin3Completed15
DB08907Canagliflozin3Recruiting2
DB00796Candesartan3Completed2
DB01136Carvedilol3Completed1
DB11121Chloroxylenol3Recruiting1
DB11121Chloroxylenol3Unknown Status1
DB00310Chlorthalidone3Completed1
DB00169Cholecalciferol3Active Not Recruiting1
DB00122Choline3Recruiting1
DB04660Choline alfoscerate3Recruiting1
DB00930Colesevelam3Completed8
DB06292Dapagliflozin3Active Not Recruiting3
DB06292Dapagliflozin3Completed26
DB06292Dapagliflozin3Not Yet Recruiting3
DB06292Dapagliflozin3Recruiting2
DB06292Dapagliflozin3Suspended1
DB11994Diacerein3Recruiting1
DB00343Diltiazem3Completed1
DB09045Dulaglutide3Active Not Recruiting2
DB09045Dulaglutide3Completed15
DB09045Dulaglutide3Recruiting2
DB11723Dutogliptin3Completed1
DB05065Dutogliptin3Terminated2
DB11723Dutogliptin3Terminated5
DB09038Empagliflozin3Active Not Recruiting2
DB09038Empagliflozin3Completed16
DB09038Empagliflozin3Recruiting3
DB09038Empagliflozin3Unknown Status1
DB09038Empagliflozin3Withdrawn1
DB00584Enalapril3Completed1
DB00700Eplerenone3Active Not Recruiting1
DB00153Ergocalciferol3Completed1
DB11827Ertugliflozin3Active Not Recruiting2
DB11827Ertugliflozin3Completed7
DB00736Esomeprazole3Completed1
DB12625Evogliptin3Completed2
DB09303Evolocumab3Completed1
DB01276Exenatide3Completed36
DB01276Exenatide3Recruiting4
DB00973Ezetimibe3Completed1
DB12491Fasiglifam3Completed1
DB12491Fasiglifam3Terminated1
DB12491Fasiglifam3Withdrawn1
DB01023Felodipine3Completed1
DB01039Fenofibrate3Completed3
DB01039Fenofibrate3Terminated1
DB08917Ferric Carboxymaltose3Recruiting1
DB00695Furosemide3Completed1
DB12412Gemigliptin3Completed2
DB12412Gemigliptin3Not Yet Recruiting1
DB01120Gliclazide3Completed4
DB00222Glimepiride3Active Not Recruiting3
DB00222Glimepiride3Completed51
DB00222Glimepiride3Not Yet Recruiting1
DB00222Glimepiride3Recruiting2
DB00222Glimepiride3Terminated11
DB00222Glimepiride3Withdrawn2
DB01067Glipizide3Completed11
DB00040Glucagon recombinant3Completed1
DB01016Glyburide3Completed4
DB01016Glyburide3Terminated2
DB12502Gosogliptin3Completed1
DB11939Henagliflozin3Not Yet Recruiting1
DB01275Hydralazine3Completed1
DB00999Hydrochlorothiazide3Completed1
DB00159Icosapent3Terminated1
DB08887Icosapent ethyl3Terminated1
DB11783Imidapril3Unknown Status1
DB01306Insulin Aspart3Active Not Recruiting1
DB01306Insulin Aspart3Completed19
DB01306Insulin Aspart3Recruiting1
DB01306Insulin Aspart3Terminated5
DB09564Insulin Degludec3Active Not Recruiting3
DB09564Insulin Degludec3Completed22
DB09564Insulin Degludec3Recruiting4
DB01307Insulin Detemir3Completed19
DB01307Insulin Detemir3Terminated1
DB00047Insulin Glargine3Active Not Recruiting7
DB00047Insulin Glargine3Completed83
DB00047Insulin Glargine3Recruiting11
DB00047Insulin Glargine3Terminated2
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DB00281LidocaineNot AvailableUnknown Status2
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DB00850PerphenazineNot AvailableCompleted1
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DB01100PimozideNot AvailableCompleted1
DB01132PioglitazoneNot AvailableCompleted22
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DB09311Polycarbophil calciumNot AvailableCompleted1
DB01345PotassiumNot AvailableCompleted2
DB01278PramlintideNot AvailableCompleted1
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DB00175PravastatinNot AvailableTerminated1
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DB01224QuetiapineNot AvailableCompleted1
DB00243RanolazineNot AvailableWithdrawn1
DB06213RegadenosonNot AvailableCompleted1
DB00912RepaglinideNot AvailableCompleted9
DB00912RepaglinideNot AvailableUnknown Status1
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DB00734RisperidoneNot AvailableCompleted2
DB00412RosiglitazoneNot AvailableCompleted13
DB00412RosiglitazoneNot AvailableTerminated2
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DB00641SimvastatinNot AvailableCompleted3
DB01261SitagliptinNot AvailableCompleted20
DB01261SitagliptinNot AvailableNot Yet Recruiting4
DB01261SitagliptinNot AvailableRecruiting5
DB01261SitagliptinNot AvailableTerminated2
DB01261SitagliptinNot AvailableUnknown Status4
DB01390Sodium bicarbonateNot AvailableCompleted1
DB00421SpironolactoneNot AvailableCompleted2
DB00857TerbinafineNot AvailableNot Yet Recruiting1
DB04844TetrabenazineNot AvailableCompleted1
DB01622ThioproperazineNot AvailableCompleted1
DB00679ThioridazineNot AvailableCompleted1
DB01623ThiothixeneNot AvailableCompleted1
DB02513ThymolNot AvailableRecruiting1
DB06273TocilizumabNot AvailableCompleted1
DB00839TolazamideNot AvailableCompleted3
DB01124TolbutamideNot AvailableCompleted3
DB00831TrifluoperazineNot AvailableCompleted1
DB00197TroglitazoneNot AvailableCompleted3
DB00177ValsartanNot AvailableActive Not Recruiting1
DB00661VerapamilNot AvailableCompleted1
DB04876VildagliptinNot AvailableCompleted3
DB04876VildagliptinNot AvailableNot Yet Recruiting1
DB04876VildagliptinNot AvailableRecruiting2
DB04876VildagliptinNot AvailableUnknown Status1
DB00126Vitamin CNot AvailableActive Not Recruiting1
DB00126Vitamin CNot AvailableCompleted1
DB11094Vitamin DNot AvailableCompleted1
DB11094Vitamin DNot AvailableRecruiting1
DB04878VogliboseNot AvailableCompleted3
DB00246ZiprasidoneNot AvailableCompleted2
DB01624ZuclopenthixolNot AvailableCompleted1
DB05875substance PNot AvailableCompleted1