Type 2 Diabetes Mellitus

Also known as: Diabetes Mellitus Non-insulin-dependent / Type-2 Diabetes Mellitus / Diabetes Mellitus Type 2 (T2DM) / Diabetes Mellitus Type-2 / Type 2 Diabetes (T2DM) / Diabetes, Type 2 / Diabetes Mellitus, Type 2 (T2DM) / Diabetes Mellitus,Type 2 / Diabetes Type II / Type-II Diabetes Mellitus / Diabetes Mellitus 2 Type / T2DM / Diabetes Mellitus Type II / Type II Diabetes / Diabetes Mellitus, Type 2 / Type 2 Diabetes Mellitus (T2DM) / Diabetes Type Two / Diabetes Mellitus - Type 2 / Diabetes, Type II / Non-Insulin-Dependent Diabetes Mellitus / Diabetes Mellitus. Type 2 / Diabetes Type 2 / Type 2 Diabetes Mellitus (T2D) / Type 2 Diabetes (T2D) / Type II; Diabetes / Type II Diabetes Mellitus / Diabetes Mellitus, Type II / NIDDM / Type-2 Diabetes / Type 2 Diabetes Mellitus(T2DM) / Type 2 Diabetes / Type 2-diabetes / Noninsulin Dependent Diabetes Mellitus, Type II / Diabetes Mellitus Type 2 / Type Two Diabetes Mellitus / T2DM (Type 2 Diabetes Mellitus) / Type-2-diabetes Mellitus / Diabetes mellitus -adult onset / Diabetes mellitus non insulin-dep / Maturity onset diabetes / Diabetes mellitus maturity onset

DrugDrug NameDrug Description
DB00284AcarboseAn inhibitor of alpha glucosidase that retards the digestion and absorption of carbohydrates in the small intestine and hence reduces the increase in blood-glucose concentrations after a carbohydrate load. It is given orally to non-insulin dependent diabetes mellitus patients where diet modification or oral hypoglycemic agents do not control their condition. (From Martindale The Extra Pharmacopoeia, 31st ed)
DB09043AlbiglutideAlbiglutide is a glucagon-like peptide-1 agonist (GLP-1) biologic drug indicated in the treatment of type 2 diabetes. It is marketed under the brands Eperzan and Tanzeum by GSK (GlaxoSmithKline). It is a dipeptidyl peptidase-4-resistant glucagon-like peptide-1 dimer fused to human albumin. Albiglutide was approved on April 15, 2014 by the FDA.
DB06203AlogliptinAlogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4). Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. FDA approved January 25, 2013.
DB01076AtorvastatinAtorvastatin (Lipitor) is a member of the drug class known as statins. It is used for lowering cholesterol. Atorvastatin is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-determining enzyme in cholesterol biosynthesis via the mevalonate pathway. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate. Atorvastatin acts primarily in the liver. Decreased hepatic cholesterol levels increases hepatic uptake of cholesterol and reduces plasma cholesterol levels.
DB01200BromocriptineBromocriptine mesylate is a semisynthetic ergot alkaloid derivative with potent dopaminergic activity. It is indicated for the management of signs and symptoms of Parkinsonian Syndrome. Bromocriptine also inhibits prolactin secretion and may be used to treat dysfunctions associated with hyperprolactinemia. It also causes sustained suppression of somatotropin (growth hormone) secretion in some patients with acromegaly. Bromocriptine has been associated with pulmonary fibrosis.
DB08907CanagliflozinCanagliflozin belongs to a new class of anti-diabetic drugs that works by inhibiting the sodium-glucose transport protein (SGLT2). This transport protein is found in the kidney and is responsible for reabsorbing glucose that has been filtered. FDA approved on March 29, 2013.
DB00672ChlorpropamideChlorpropamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination and binding site on their target pancreatic β cell receptor. Sulfonylureas also increase peripheral glucose utilization, decrease hepatic gluconeogenesis and may increase the number and sensitivity of insulin receptors. Sulfonylureas are associated with weight gain, though less so than insulin. Due to their mechanism of action, sulfonylureas may cause hypoglycemia and require consistent food intake to decrease this risk. The risk of hypoglycemia is increased in elderly, debilitated and malnourished individuals. Chlorpropamide is not recommended for the treatment of NIDDM as it increases blood pressure and the risk of retinopathy (UKPDS-33). Up to 80% of the single oral dose of chlorpropramide is metabolized, likely in the liver; 80-90% of the dose is excreted in urine as unchanged drug and metabolites. Renal and hepatic dysfunction may increase the risk of hypoglycemia.
DB00930ColesevelamColesevelam is a bile acid sequestrant. Colesevelam is used with exercise and diet changes (restriction of cholesterol and fat intake) to reduce the amount of cholesterol and certain fatty substances in the blood. It works by binding bile acids in the intestine. Bile acids are made when cholesterol is broken down in the body. Removing these bile acids helps to lower blood cholesterol.
DB06292DapagliflozinDapagliflozin is indicated for the management of diabetes mellitus type 2, and functions to improve glycemic control in adults when combined with diet and exercise. Dapagliflozin is a sodium-glucose cotransporter 2 inhibitor, which prevents glucose reabsorption in the kidney. Using dapagliflozin leads to heavy glycosuria (glucose excretion in the urine), which can lead to weight loss and tiredness. Dapagliflozin was approved by the FDA on Jan 08, 2014. Dapagliflozin is not recommended for patients with type 1 diabetes mellitus or for the treatment of diabetic ketoacidosis.
DB09045DulaglutideDulaglutide is a novel glucagon-like peptide-1 agonist (GLP-1) biologic drug consisting of a dipeptidyl peptidase-IV-protected GLP-1 analogue covalently linked to a human IgG4-Fc heavy chain by a small peptide linker. Dulaglutide is indicated in the treatment of type 2 diabetes and can be used once a week. It was approved by the FDA in September 2014. Dulaglutide is manufactured and marketed by Eli Lily under the brand Trulicity™. It is not known if dulaglutide can increase the risk of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2, and is thus not recommended for use in populations with a personal or family history of these conditions.
DB09038EmpagliflozinEmpagliflozin is a sodium glucose co-transporter-2 (SGLT-2) inhibitor indicated as an adjunct to diet and exercise to improve glycemic control in adult patients with type 2 diabetes. SGLT2 co-transporters are responsible for reabsorption of glucose from the glomerular filtrate in the kidney. The glucuretic effect resulting from SGLT2 inhibition reduces renal absorption and lowers the renal threshold for glucose, therefore resulting in increased glucose excretion. Additionally, it contributes to reduced hyperglycaemia and also assists weight loss and blood pressure reduction.
DB11827ErtugliflozinErtugliflozin belongs to the class of potent and selective inhibitors of the sodium-dependent glucose cotransporters (SGLT), more specifically the type 2 which is responsible for about 90% of the glucose reabsorption from glomerulus.[A31581] This drug was developed under the collaboration of Merck and Pfizer. It was FDA approved as monotherapy and in combination with sitagliptin or metformin hydrochloride on December 22, 2017.[L1132]
DB01276ExenatideExenatide, derived from a compound found in the saliva of the Gila monster, a large lizard native to the southwestern US, is a functional analog of Glucagon-Like Peptide-1 (GLP-1), a naturally occuring peptide.
DB01120GliclazideGliclazide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It has been classified differently according to its drug properties in which based on its chemical structure, gliclazide is considered a first-generation sulfonylurea due to the structural presence of a sulfonamide group able to release a proton and the presence of one aromatic group.[A39546] On the other hand, based on the pharmacological efficacy, gliclazide is considered a second-generation sulfonylurea which presents a higher potency and a shorter half-life.[T238, T360] Gliclazide belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination and binding site on their target pancreatic β cell receptor. Sulfonylureas also increase peripheral glucose utilization, decrease hepatic gluconeogenesis and may increase the number and sensitivity of insulin receptors. Sulfonylureas are associated with weight gain, though less so than insulin. Due to their mechanism of action, sulfonylureas may cause hypoglycemia and require consistent food intake to decrease this risk. The risk of hypoglycemia is increased in elderly, debilitated and malnourished individuals. Gliclazide has been shown to decrease fasting plasma glucose, postprandial blood glucose and glycosolated hemoglobin (HbA1c) levels (reflective of the last 8-10 weeks of glucose control). Gliclazide is extensively metabolized by the liver; its metabolites are excreted in both urine (60-70%) and feces (10-20%).
DB00222GlimepirideGlimepiride is the first III generation sulphonyl urea it is a very potent sulphonyl urea with long duration of action.
DB01067GlipizideAn oral hypoglycemic agent which is rapidly absorbed and completely metabolized.
DB01016GlyburideGlyburide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination and binding site on their target pancreatic β cell receptor. Sulfonylureas also increase peripheral glucose utilization, decrease hepatic gluconeogenesis and may increase the number and sensitivity of insulin receptors. Sulfonylureas are associated with weight gain, though less so than insulin. Due to their mechanism of action, sulfonylureas may cause hypoglycemia and require consistent food intake to decrease this risk. The risk of hypoglycemia is increased in elderly, debilitated and malnourished individuals. Glyburide has been shown to decrease fasting plasma glucose, postprandial blood glucose and glycosolated hemoglobin (HbA1c) levels (reflective of the last 8-10 weeks of glucose control). Glyburide appears to be completely metabolized, likely in the liver. Although its metabolites exert a small hypoglycemic effect, their contribution to glyburide's hypoglycemic effect is thought to be clinically unimportant. Glyburide metabolites are excreted in urine and feces in approximately equal proportions.
DB01306Insulin AspartInsulin aspart is a recombinant, biosynthetic, fast-acting insulin analogue. It has a single amino acid substitution at position B28 where proline is replaced with aspartic acid. This substitution decreases its propensity to form hexamers and gives it a higher rate of absorption following subcutaneous administration compared to native insulin. Insulin aspart is produced in a genetically modified strain of _Saccharomyces cerevisiae_ and harvested from a bioreactor.
DB09564Insulin DegludecInsulin Degludec is an ultra-long-acting insulin analogue used for glycemic control in Diabetes Mellitus. Insulin and its analogues lower blood glucose levels by stimulating peripheral glucose uptake and by preventing hepatic glucose production. Compared to endogenous insulin, this product has an added hexadecanedioic acid to lysine at the B29 position which allows for the formation of multi-hexamers. When injected subcutaneously, these multi-hexamers form a drug depot store from which monomers are slowly and continuously absorbed into the circulation. As a result, Insulin Degludec has a protracted time action profile due to the delayed absorption from subcutaneous tissue depots into the systemic circulation. Compared to available long-acting analogues such as insulin glargine and insulin detemir, which have a duration of action of 20-24 hours, insulin degludec provides a consistent level of basal insulin over 42 hours with a low peak:trough ratio. Limitations of shorter acting analogues include more frequent dosing and less stable pharmacokinetics, which may negatively impact patient adherence and glucose control, particularly nocturnal control. Insulin Degludec was approved by the FDA in September 2015 as the product Tresiba, for use in providing glycemic control to adults with diabetes mellitus.
DB01307Insulin DetemirInsulin detemir is a long-acting human insulin analogue used to maintain basal levels of insulin in diabetic individuals. It is produced using recombinant DNA technology in yeast cells. This insulin analogue has a 14-C fatty acid, myristic acid, bound to the lysine amino acid at position B29. The myristoyl side chain increases self-association and albumin binding. This along with slow systemic absorption from the injection site prolongs distribution of the hormone into tissues and results in a long duration of action. Novo Nordisk markets insulin detemir under the trade name Levemir.
DB00047Insulin GlargineInsulin glargine is produced by recombinant DNA technology using a non-pathogenic laboratory strain of Escherichia coli (K12) as the production organism. It is an analogue of human insulin made by replacing the asparagine residue at position A21 of the A-chain with glycine and adding two arginines to the C-terminus (positions B31 and 32) of the B-chain. The resulting protein is soluble at pH 4 and forms microprecipitates at physiological pH 7.4. Small amounts of insulin glargine are slowly released from microprecipitates giving the drug a long duration of action (up to 24 hours) and no pronounced peak concentration.
DB01309Insulin GlulisineInsulin glulisine is a biosynthetic, rapid-acting human insulin analogue produced in a non-pathogenic laboratory strain of _Escherichia coli_ (K12). This recombinant hormone differs from native human insulin in that the amino acid arginine at position B3 is replaced by lysine and the lysine at position B29 is replaced by glutamic acid. These structural modifications decrease hexamer formation, stabilize insulin glulisine monomers and increase the rate of absorption and onset of action compared to human insulin.
DB08882LinagliptinLinagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes [Wikipedia]. Two pharmacological characteristics that sets linagliptin apart from other DPP-4 inhibitors is that it has a non-linear pharmacokinetic profile and is not primarily eliminated by the renal system. FDA approved on May 2, 2011.
DB06655LiraglutideVictoza contains liraglutide, an analog of human GLP-1 and acts as a GLP-1 receptor agonist. The peptide precursor of liraglutide, produced by a process that includes expression of recombinant DNA in Saccharomyces cerevisiae, has been engineered to be 97% homologous to native human GLP-1 by substituting arginine for lysine at position 34. Liraglutide is made by attaching a C-16 fatty acid (palmitic acid) with a glutamic acid spacer on the remaining lysine residue at position 26 of the peptide precursor.
DB09265LixisenatideLixisenatide is a glucagon-like peptide-1 (GLP-1) receptor agonist used in the treatment of type 2 diabetes mellitus (T2DM). It is sold under the brand name Adlyxin by Sanofi-Aventis. Adlyxin recieved FDA approval July 28, 2016 [L763].
DB00331MetforminMetformin is a biguanide antihyperglycemic agent used for treating non-insulin-dependent diabetes mellitus (NIDDM). It improves glycemic control by decreasing hepatic glucose production, as well as decreasing glucose absorption and increasing insulin-mediated glucose uptake. Another well-known benefit of this drug is modest weight loss. Metformin is the drug of choice for obese NIDDM (non-insulin dependent diabetes mellitus) patients [A36559]. Metformin was approved in Canada initially in 1972 [A36552], the 1970s in Europe, and in 1995 in the USA [L4087].
DB00491MiglitolMiglitol is an oral anti-diabetic drug that acts by inhibiting the ability of the patient to breakdown complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the body. Miglitol inhibits glycoside hydrolase enzymes called alpha-glucosidases. Since miglitol works by preventing digestion of carbohydrates, it lowers the degree of postprandial hyperglycemia. It must be taken at the start of main meals to have maximal effect. Its effect will depend on the amount of non-monosaccharide carbohydrates in a person's diet. In contrast to acarbose (another alpha-glucosidase inhibitor), miglitol is systemically absorbed; however, it is not metabolized and is excreted by the kidneys.
DB00731NateglinideNateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that induces an early insulin response to meals decreasing postprandial blood glucose levels. It should only be taken with meals and meal-time doses should be skipped with any skipped meal. Approximately one month of therapy is required before a decrease in fasting blood glucose is seen. Meglitnides may have a neutral effect on weight or cause a slight increase in weight. The average weight gain caused by meglitinides appears to be lower than that caused by sulfonylureas and insulin and appears to occur only in those naïve to oral antidiabetic agents. Due to their mechanism of action, meglitinides may cause hypoglycemia although the risk is thought to be lower than that of sulfonylureas since their action is dependent on the presence of glucose. In addition to reducing postprandial and fasting blood glucose, meglitnides have been shown to decrease glycosylated hemoglobin (HbA1c) levels, which are reflective of the last 8-10 weeks of glucose control. Meglitinides appear to be more effective at lowering postprandial blood glucose than metformin, sulfonylureas and thiazolidinediones. Nateglinide is extensively metabolized in the liver and excreted in urine (83%) and feces (10%). The major metabolites possess less activity than the parent compound. One minor metabolite, the isoprene, has the same potency as its parent compound.
DB01132PioglitazonePioglitazone is a medication belonging to the thiazolidinedione class of drugs that are used as adjuncts to diet, exercise, and other diabetes medications to manage type 2 diabetes mellitus. The thiazolidinedione class of medications exerts its pharmacological effect primarily by promoting insulin sensitivity and the improved uptake of blood glucose. Following entry into fat cell nuclei, pioglitazone selectively binds to the Peroxisome Proliferator-Activated Receptor Gamma (PPARγ)[A19757]. PPARs are ligand-activated transcription factors that are involved in the expression of more than 100 genes, and affect numerous metabolic processes, notably lipid and glucose homeostasis [A19759]. PPARγ in particular is abundantly expressed in lipid cells (adipocytes), where it plays a central role in lipid production and regulation of lipid metabolism.
DB01278PramlintidePramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes.
DB00912RepaglinideRepaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response to meals decreasing postprandial blood glucose levels. It should only be taken with meals and meal-time doses should be skipped with any skipped meal. Approximately one month of therapy is required before a decrease in fasting blood glucose is seen. Meglitnides may have a neutral effect on weight or cause a slight increase in weight. The average weight gain caused by meglitinides appears to be lower than that caused by sulfonylureas and insulin and appears to occur only in those naïve to oral antidiabetic agents. Due to their mechanism of action, meglitinides may cause hypoglycemia although the risk is thought to be lower than that of sulfonylureas since their action is dependent on the presence of glucose. In addition to reducing postprandial and fasting blood glucose, meglitnides have been shown to decrease glycosylated hemoglobin (HbA1c) levels, which are reflective of the last 8-10 weeks of glucose control. Meglitinides appear to be more effective at lowering postprandial blood glucose than metformin, sulfonylureas and thiazolidinediones. Repaglinide is extensively metabolized in the liver and excreted in bile. Repaglinide metabolites do not possess appreciable hypoglycemic activity. Approximately 90% of a single orally administered dose is eliminated in feces and 8% in urine.
DB00412RosiglitazoneRosiglitazone is an anti-diabetic drug in the thiazolidinedione class of drugs. It is marketed by the pharmaceutical company GlaxoSmithKline as a stand-alone drug (Avandia) and in combination with metformin (Avandamet) or with glimepiride (Avandaryl). Like other thiazolidinediones, the mechanism of action of rosiglitazone is by activation of the intracellular receptor class of the peroxisome proliferator-activated receptors (PPARs), specifically PPARγ. Rosiglitazone is a selective ligand of PPARγ, and has no PPARα-binding action. Apart from its effect on insulin resistance, it appears to have an anti-inflammatory effect: nuclear factor kappa-B (NFκB) levels fall and inhibitor (IκB) levels increase in patients on rosiglitazone. Recent research has suggested that rosiglitazone may also be of benefit to a subset of patients with Alzheimer's disease not expressing the ApoE4 allele. This is the subject of a clinical trial currently underway.
DB06335SaxagliptinSaxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009.
DB13928SemaglutideSemaglutide is a once-daily glucagon-like peptide-1 analog that differs to others by the presence of an acyl group with a steric diacid at Lys26 and a large synthetic spacer and modified by the presence of a α-aminobutyric acid in position 8 which gives stability against the dipeptidylpeptidase-4.[A31421] The stability of semaglutide by the acylation permits a high-affinity albumin binding and gives it a long plasma half-life which allows the once-daily dosage. It was developed by the Danish pharmaceutical company Novo Nordisk and FDA approved on December 5, 2017.[L1067]
DB01261SitagliptinSitagliptin is a new oral hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. This enzyme-inhibiting drug is to be used either alone or in combination with metformin or a thiazolidinedione for control of type 2 diabetes mellitus. The drug works to competitively inhibit a protein/enzyme, dipeptidyl peptidase 4 (DPP-4), that results in an increased amount of active incretins (GLP-1 and GIP), reduced amount of release of glucagon (diminishes its release) and increased release of insulin.
DB00839TolazamideA sulphonylurea hypoglycemic agent with actions and uses similar to those of chlorpropamide.
DB01124TolbutamideTolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination and binding site on their target pancreatic β cell receptor. Sulfonylureas also increase peripheral glucose utilization, decrease hepatic gluconeogenesis and may increase the number and sensitivity of insulin receptors. Sulfonylureas are associated with weight gain, though less so than insulin. Due to their mechanism of action, sulfonylureas may cause hypoglycemia and require consistent food intake to decrease this risk. The risk of hypoglycemia is increased in elderly, debilitated and malnourished individuals. Tolbutamide appears to be metabolized in the liver. Tolbutamide and its metabolites are excreted in urine (75-85%) and feces.
DB04876VildagliptinVildagliptin, previously identified as LAF237, is a new oral anti-hyperglycemic agent (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. Vildagliptin inhibits the inactivation of GLP-1 and GIP by DPP-4, allowing GLP-1 and GIP to potentiate the secretion of insulin in the beta cells and suppress glucaon release by the alpha cells of the islets of Langerhans in the pancreas. It is currently in clinical trials in the U.S. and has been shown to reduce hyperglycemia in type 2 diabetes mellitus. While the drug is still not approved for use in the US, it was approved in Feb 2008 by European Medicines Agency for use within the EU and is listed on the Australian PBS with certain restrictions.
DrugDrug NameTargetType
DB00284AcarboseMaltase-glucoamylase, intestinaltarget
DB00284AcarboseLysosomal alpha-glucosidasetarget
DB00284AcarboseSucrase-isomaltase, intestinaltarget
DB00284AcarbosePancreatic alpha-amylasetarget
DB09043AlbiglutideGlucagon-like peptide 1 receptortarget
DB06203AlogliptinDipeptidyl peptidase 4target
DB06203AlogliptinCytochrome P450 3A4enzyme
DB06203AlogliptinCytochrome P450 2D6enzyme
DB01076Atorvastatin3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
DB01076AtorvastatinCytochrome P450 3A4enzyme
DB01076AtorvastatinDipeptidyl peptidase 4target
DB01076AtorvastatinCytochrome P450 2D6enzyme
DB01076AtorvastatinCytochrome P450 2C9enzyme
DB01076AtorvastatinCytochrome P450 2C19enzyme
DB01076AtorvastatinCytochrome P450 3A5enzyme
DB01076AtorvastatinCytochrome P450 3A7enzyme
DB01076AtorvastatinMultidrug resistance protein 1transporter
DB01076AtorvastatinSolute carrier organic anion transporter family member 1A2transporter
DB01076AtorvastatinSolute carrier organic anion transporter family member 1B1transporter
DB01076AtorvastatinMultidrug resistance-associated protein 4transporter
DB01076AtorvastatinMultidrug resistance-associated protein 5transporter
DB01076AtorvastatinMultidrug resistance-associated protein 1transporter
DB01076AtorvastatinCytochrome P450 2B6enzyme
DB01076AtorvastatinCytochrome P450 2C8enzyme
DB01076AtorvastatinAryl hydrocarbon receptortarget
DB01076AtorvastatinSolute carrier organic anion transporter family member 2B1transporter
DB01076AtorvastatinSolute carrier organic anion transporter family member 1B3transporter
DB01076AtorvastatinUDP-glucuronosyltransferase 1-1enzyme
DB01076AtorvastatinUDP-glucuronosyltransferase 1-3enzyme
DB01076AtorvastatinUDP-glucuronosyltransferase 2B7enzyme
DB01076AtorvastatinCanalicular multispecific organic anion transporter 1transporter
DB01076AtorvastatinBile salt export pumptransporter
DB01200BromocriptineD(2) dopamine receptortarget
DB01200BromocriptineCytochrome P450 3A4enzyme
DB01200Bromocriptine5-hydroxytryptamine receptor 1Dtarget
DB01200BromocriptineAlpha-2A adrenergic receptortarget
DB01200BromocriptineD(3) dopamine receptortarget
DB01200Bromocriptine5-hydroxytryptamine receptor 1Atarget
DB01200BromocriptineAlpha-2C adrenergic receptortarget
DB01200BromocriptineAlpha-2B adrenergic receptortarget
DB01200Bromocriptine5-hydroxytryptamine receptor 2Btarget
DB01200BromocriptineD(4) dopamine receptortarget
DB01200Bromocriptine5-hydroxytryptamine receptor 2Atarget
DB01200Bromocriptine5-hydroxytryptamine receptor 1Btarget
DB01200Bromocriptine5-hydroxytryptamine receptor 2Ctarget
DB01200BromocriptineD(1B) dopamine receptortarget
DB01200BromocriptineD(1A) dopamine receptortarget
DB01200BromocriptineAlpha-1A adrenergic receptortarget
DB01200BromocriptineAlpha-1B adrenergic receptortarget
DB01200BromocriptineAlpha-1D adrenergic receptortarget
DB01200Bromocriptine5-hydroxytryptamine receptor 7target
DB01200BromocriptineMultidrug resistance protein 1transporter
DB08907CanagliflozinUDP-glucuronosyltransferase 1-9enzyme
DB08907CanagliflozinUDP-glucuronosyltransferase 2B4enzyme
DB08907CanagliflozinCytochrome P450 3A4enzyme
DB08907CanagliflozinSerum albumincarrier
DB08907CanagliflozinSodium/glucose cotransporter 2target
DB08907CanagliflozinMultidrug resistance protein 1transporter
DB08907CanagliflozinCanalicular multispecific organic anion transporter 1transporter
DB08907CanagliflozinSodium/glucose cotransporter 1target
DB08907CanagliflozinAlpha-1-acid glycoprotein 1carrier
DB00672ChlorpropamideATP-binding cassette sub-family C member 8target
DB00672ChlorpropamideSolute carrier family 15 member 1transporter
DB00672ChlorpropamideSolute carrier family 15 member 2transporter
DB00672ChlorpropamideSolute carrier family 22 member 6transporter
DB00672ChlorpropamideCytochrome P450 2C9enzyme
DB00672ChlorpropamideCytochrome P450 2C19enzyme
DB00672ChlorpropamideProstaglandin G/H synthase 1enzyme
DB00930ColesevelamBile acidstarget
DB06292DapagliflozinSodium/glucose cotransporter 2target
DB06292DapagliflozinCytochrome P450 1A1enzyme
DB06292DapagliflozinCytochrome P450 1A2enzyme
DB06292DapagliflozinCytochrome P450 2A6enzyme
DB06292DapagliflozinCytochrome P450 2C9enzyme
DB06292DapagliflozinCytochrome P450 2D6enzyme
DB06292DapagliflozinCytochrome P450 3A4enzyme
DB06292DapagliflozinUDP-glucuronosyltransferase 1-9enzyme
DB06292DapagliflozinUDP-glucuronosyltransferase 2B4enzyme
DB06292DapagliflozinUDP-glucuronosyltransferase 2B7enzyme
DB06292DapagliflozinMultidrug resistance protein 1transporter
DB09045DulaglutideGlucagon-like peptide 1 receptortarget
DB09038EmpagliflozinSodium/glucose cotransporter 2target
DB11827ErtugliflozinUDP-glucuronosyltransferase 1-9enzyme
DB11827ErtugliflozinUDP-glucuronosyltransferase 2B7enzyme
DB11827ErtugliflozinSodium/glucose cotransporter 2target
DB11827ErtugliflozinMultidrug resistance protein 1transporter
DB11827ErtugliflozinATP-binding cassette sub-family G member 2transporter
DB11827ErtugliflozinSerum albumincarrier
DB11827ErtugliflozinUDP-glucuronosyltransferase 1-1enzyme
DB11827ErtugliflozinUDP-glucuronosyltransferase 1-4enzyme
DB01276ExenatideGlucagon-like peptide 1 receptortarget
DB01276ExenatideSerum albumincarrier
DB01120GliclazideATP-binding cassette sub-family C member 8target
DB01120GliclazideSerum albumincarrier
DB01120GliclazideVascular endothelial growth factor Atarget
DB01120GliclazideCytochrome P450 2C9enzyme
DB01120GliclazideCytochrome P450 2C19enzyme
DB00222GlimepirideATP-sensitive inward rectifier potassium channel 1target
DB00222GlimepirideATP-sensitive inward rectifier potassium channel 11target
DB00222GlimepirideCytochrome P450 2C9enzyme
DB00222GlimepirideATP-binding cassette sub-family C member 8target
DB00222GlimepirideBile salt export pumptransporter
DB01067GlipizideCytochrome P450 2C9enzyme
DB01067GlipizidePeroxisome proliferator-activated receptor gammatarget
DB01067GlipizideATP-binding cassette sub-family C member 8target
DB01067GlipizideCytochrome P450 3A4enzyme
DB01067GlipizideUDP-glucuronosyltransferase 1-1enzyme
DB01067GlipizideBile salt export pumptransporter
DB01016GlyburideATP-binding cassette sub-family C member 9target
DB01016GlyburideBile salt export pumptarget
DB01016GlyburideATP-binding cassette sub-family A member 1target
DB01016GlyburideCystic fibrosis transmembrane conductance regulatortarget
DB01016GlyburideSulfonylurea receptor 1, Kir6.2target
DB01016GlyburideG protein-activated inward rectifier potassium channel 4target
DB01016GlyburideCytochrome P450 2C9enzyme
DB01016GlyburideCanalicular multispecific organic anion transporter 2transporter
DB01016GlyburideBile salt export pumptransporter
DB01016GlyburideMultidrug resistance protein 1transporter
DB01016GlyburideMultidrug resistance-associated protein 1transporter
DB01016GlyburideSolute carrier family 15 member 1transporter
DB01016GlyburideSolute carrier organic anion transporter family member 1A2transporter
DB01016GlyburideSolute carrier family 15 member 2transporter
DB01016GlyburideSolute carrier family 22 member 6transporter
DB01016GlyburideCanalicular multispecific organic anion transporter 1transporter
DB01016GlyburideATP-binding cassette sub-family G member 2transporter
DB01016GlyburideSolute carrier family 22 member 7transporter
DB01016GlyburideSolute carrier organic anion transporter family member 2B1transporter
DB01016GlyburideCytochrome P450 2C19enzyme
DB01016GlyburideCytochrome P450 3A4enzyme
DB01016GlyburideSerum albumincarrier
DB01016GlyburideMitochondrial ATP-sensitive potassium channeltarget
DB01016GlyburideCarnitine O-palmitoyltransferase 1, liver isoformtarget
DB01306Insulin AspartInsulin receptortarget
DB09564Insulin DegludecInsulin receptortarget
DB01307Insulin DetemirInsulin receptortarget
DB01307Insulin DetemirSerum albumincarrier
DB00047Insulin GlargineInsulin receptortarget
DB00047Insulin GlargineInsulin-like growth factor 1 receptortarget
DB01309Insulin GlulisineInsulin receptortarget
DB08882LinagliptinDipeptidyl peptidase 4target
DB08882LinagliptinCytochrome P450 3A4enzyme
DB08882LinagliptinMultidrug resistance protein 1transporter
DB06655LiraglutideGlucagon-like peptide 1 receptortarget
DB06655LiraglutideDipeptidyl peptidase 4enzyme
DB06655LiraglutideNeprilysinenzyme
DB09265LixisenatideGlucagon-like peptide 1 receptortarget
DB00331Metformin5'-AMP-activated protein kinase subunit beta-1target
DB00331MetforminSolute carrier family 22 member 2transporter
DB00331MetforminSolute carrier family 22 member 1transporter
DB00331MetforminMultidrug and toxin extrusion protein 1transporter
DB00331MetforminEquilibrative nucleoside transporter 4transporter
DB00331MetforminSolute carrier family 22 member 3transporter
DB00331MetforminMultidrug and toxin extrusion protein 2transporter
DB00491MiglitolMaltase-glucoamylase, intestinaltarget
DB00491MiglitolPancreatic alpha-amylaseenzyme
DB00491MiglitolLysosomal alpha-glucosidasetarget
DB00491MiglitolNeutral alpha-glucosidase ABtarget
DB00491MiglitolNeutral alpha-glucosidase Ctarget
DB00731NateglinideATP-binding cassette sub-family C member 8target
DB00731NateglinideCytochrome P450 3A4enzyme
DB00731NateglinideCytochrome P450 2C9enzyme
DB00731NateglinidePeroxisome proliferator-activated receptor gammatarget
DB00731NateglinideCytochrome P450 3A5enzyme
DB00731NateglinideCytochrome P450 3A7enzyme
DB00731NateglinideSolute carrier family 15 member 1transporter
DB00731NateglinideSolute carrier family 15 member 2transporter
DB00731NateglinideSolute carrier family 22 member 6transporter
DB00731NateglinideMonocarboxylate transporter 1transporter
DB00731NateglinideProstaglandin G/H synthase 1enzyme
DB00731NateglinideUDP-glucuronosyltransferase 1-9enzyme
DB00731NateglinideCytochrome P450 2D6enzyme
DB00731NateglinideMultidrug resistance-associated protein 4transporter
DB00731NateglinideSerum albumincarrier
DB00731NateglinideAlpha-1-acid glycoprotein 1carrier
DB01132PioglitazonePeroxisome proliferator-activated receptor gammatarget
DB01132PioglitazoneCytochrome P450 2C8enzyme
DB01132PioglitazoneCytochrome P450 3A4enzyme
DB01132PioglitazoneSolute carrier organic anion transporter family member 1B3transporter
DB01132PioglitazoneSolute carrier organic anion transporter family member 1B1transporter
DB01132PioglitazoneProstaglandin G/H synthase 1enzyme
DB01132PioglitazoneCytochrome P450 2C9enzyme
DB01132PioglitazonePeroxisome proliferator-activated receptor deltatarget
DB01132PioglitazonePeroxisome proliferator-activated receptor alphatarget
DB01132PioglitazoneAmine oxidase [flavin-containing] Btarget
DB01278PramlintideReceptor activity-modifying protein 1target
DB01278PramlintideReceptor activity-modifying protein 2target
DB01278PramlintideReceptor activity-modifying protein 3target
DB01278PramlintideCalcitonin receptortarget
DB00912RepaglinideATP-binding cassette sub-family C member 8target
DB00912RepaglinideCytochrome P450 2C8enzyme
DB00912RepaglinidePeroxisome proliferator-activated receptor gammatarget
DB00912RepaglinideCytochrome P450 3A4enzyme
DB00912RepaglinideSerum albumincarrier
DB00912RepaglinideSolute carrier organic anion transporter family member 1B1transporter
DB00912RepaglinideBile salt export pumptransporter
DB00412RosiglitazonePeroxisome proliferator-activated receptor gammatarget
DB00412RosiglitazoneCytochrome P450 2C8enzyme
DB00412RosiglitazoneCytochrome P450 2C9enzyme
DB00412RosiglitazoneLong-chain-fatty-acid--CoA ligase 4target
DB00412RosiglitazoneSolute carrier organic anion transporter family member 1B1transporter
DB00412RosiglitazoneProstaglandin G/H synthase 1enzyme
DB00412RosiglitazoneCytochrome P450 1A2enzyme
DB00412RosiglitazoneCytochrome P450 2A6enzyme
DB00412RosiglitazoneCytochrome P450 2D6enzyme
DB00412RosiglitazoneSerum albumincarrier
DB00412RosiglitazonePeroxisome proliferator-activated receptor alphatarget
DB00412RosiglitazonePeroxisome proliferator-activated receptor deltatarget
DB00412RosiglitazoneRetinoic acid receptor RXR-alphatarget
DB00412RosiglitazoneRetinoic acid receptor RXR-betatarget
DB00412RosiglitazoneRetinoic acid receptor RXR-gammatarget
DB00412RosiglitazoneCytochrome P450 3A4enzyme
DB00412RosiglitazoneBile salt export pumptransporter
DB06335SaxagliptinDipeptidyl peptidase 4target
DB06335SaxagliptinCytochrome P450 3A4enzyme
DB06335SaxagliptinCytochrome P450 3A5enzyme
DB06335SaxagliptinMultidrug resistance-associated protein 1transporter
DB06335SaxagliptinSolute carrier organic anion transporter family member 4C1transporter
DB06335SaxagliptinSolute carrier family 22 member 8transporter
DB13928SemaglutideSerum albumincarrier
DB13928SemaglutideDipeptidyl peptidase 4enzyme
DB13928SemaglutideNeprilysinenzyme
DB13928SemaglutideGlucagon-like peptide 1 receptortarget
DB13928SemaglutideSolute carrier organic anion transporter family member 1B1transporter
DB13928SemaglutideSolute carrier organic anion transporter family member 1B3transporter
DB13928SemaglutideLipoprotein lipaseenzyme
DB13928SemaglutideAlpha-amylase 1enzyme
DB01261SitagliptinDipeptidyl peptidase 4target
DB01261SitagliptinCytochrome P450 3A4enzyme
DB01261SitagliptinCytochrome P450 2C8enzyme
DB01261SitagliptinMultidrug resistance protein 1transporter
DB01261SitagliptinSolute carrier family 22 member 8transporter
DB00839TolazamideSulfonylurea receptor 1, Kir6.2target
DB00839TolazamideCytochrome P450 2C9enzyme
DB01124TolbutamideATP-sensitive inward rectifier potassium channel 1target
DB01124TolbutamideCytochrome P450 2C19enzyme
DB01124TolbutamideCytochrome P450 2C9enzyme
DB01124TolbutamideCytochrome P450 2C8enzyme
DB01124TolbutamideATP-binding cassette sub-family C member 8target
DB01124TolbutamideSolute carrier family 15 member 1transporter
DB01124TolbutamideSolute carrier organic anion transporter family member 1A2transporter
DB01124TolbutamideSolute carrier family 15 member 2transporter
DB01124TolbutamideSolute carrier family 22 member 6transporter
DB01124TolbutamideSolute carrier organic anion transporter family member 2B1transporter
DB01124TolbutamideCytochrome P450 2C18enzyme
DB01124TolbutamideSerum albumincarrier
DB04876VildagliptinDipeptidyl peptidase 4target
DrugDrug NamePhaseStatusCount
DB00594Amiloride0Terminated1
DB00201Caffeine0Completed1
DB09303Evolocumab0Recruiting1
DB00999Hydrochlorothiazide0Terminated1
DB00331Metformin0Not Yet Recruiting1
DB01261Sitagliptin0Withdrawn1
DB09422Soybean oil0Not Yet Recruiting1
DB12084ADP-5971Completed2
DB12084ADP-5971Terminated1
DB00284Acarbose1Completed3
DB00316Acetaminophen1Completed1
DB11704Adomeglivant1Completed4
DB05162Albiglutide1Completed2
DB09043Albiglutide1Completed3
DB08915Aleglitazar1Completed1
DB06203Alogliptin1Completed2
DB00381Amlodipine1Completed1
DB12417Anagliptin1Completed1
DB05983Bardoxolone methyl1Terminated2
DB05983Bardoxolone methyl1Withdrawn1
DB01019Bethanechol1Completed1
DB12236Bexagliflozin1Completed2
DB12236Bexagliflozin1Withdrawn1
DB01200Bromocriptine1Completed1
DB00887Bumetanide1Completed1
DB01156Bupropion1Completed1
DB08907Canagliflozin1Completed8
DB08907Canagliflozin1Enrolling by Invitation1
DB00169Cholecalciferol1Completed1
DB11255Chromium picolinate1Terminated1
DB12815Crotedumab1Terminated1
DB00091Cyclosporine1Completed1
DB09102Daclatasvir1Completed1
DB06292Dapagliflozin1Active Not Recruiting2
DB06292Dapagliflozin1Completed18
DB06292Dapagliflozin1Terminated1
DB09341Dextrose, unspecified form1Completed2
DB00390Digoxin1Completed3
DB09045Dulaglutide1Completed10
DB09038Empagliflozin1Active Not Recruiting1
DB09038Empagliflozin1Completed7
DB09038Empagliflozin1Not Yet Recruiting1
DB00700Eplerenone1Not Yet Recruiting1
DB00153Ergocalciferol1Completed1
DB11827Ertugliflozin1Completed6
DB00783Estradiol1Not Yet Recruiting1
DB00898Ethanol1Terminated1
DB00977Ethinylestradiol1Completed4
DB12625Evogliptin1Completed1
DB12625Evogliptin1Unknown Status1
DB01276Exenatide1Completed8
DB00712Flurbiprofen1Completed1
DB00695Furosemide1Completed1
DB12627GSK-12922631Completed1
DB11729GSK-23306721Completed2
DB12654GSK-3765011Completed4
DB01241Gemfibrozil1Completed2
DB12412Gemigliptin1Active Not Recruiting1
DB12412Gemigliptin1Completed1
DB06062Gevokizumab1Completed1
DB11895Ghrelin1Active Not Recruiting1
DB00222Glimepiride1Completed5
DB00222Glimepiride1Terminated1
DB01067Glipizide1Active Not Recruiting1
DB01067Glipizide1Completed1
DB00040Glucagon recombinant1Completed5
DB01016Glyburide1Completed2
DB01016Glyburide1Unknown Status1
DB11939Henagliflozin1Completed4
DB11939Henagliflozin1Not Yet Recruiting1
DB11939Henagliflozin1Recruiting1
DB11939Henagliflozin1Unknown Status2
DB00999Hydrochlorothiazide1Completed3
DB05506ISIS 1137151Completed1
DB12509Imeglimin1Completed1
DB01306Insulin Aspart1Completed7
DB09564Insulin Degludec1Completed8
DB09564Insulin Degludec1Terminated1
DB01307Insulin Detemir1Completed4
DB00047Insulin Glargine1Active Not Recruiting1
DB00047Insulin Glargine1Completed14
DB01309Insulin Glulisine1Completed3
DB00030Insulin Human1Completed2
DB00030Insulin Human1Terminated1
DB00046Insulin Lispro1Completed8
DB00046Insulin Lispro1Withdrawn1
DB11567Insulin peglispro1Completed2
DB11568Insulin tregopil1Completed1
DB11698Ipragliflozin1Completed1
DB01026Ketoconazole1Completed2
DB00125L-Arginine1Not Yet Recruiting1
DB00130L-Glutamine1Unknown Status1
DB12284LY-26082041Completed1
DB11629Laropiprant1Completed1
DB00367Levonorgestrel1Completed2
DB08882Linagliptin1Completed3
DB06655Liraglutide1Completed21
DB06655Liraglutide1Recruiting1
DB00722Lisinopril1Completed2
DB09265Lixisenatide1Completed2
DB09265Lixisenatide1Recruiting1
DB09198Lobeglitazone1Completed5
DB09198Lobeglitazone1Not Yet Recruiting1
DB09198Lobeglitazone1Recruiting1
DB12044MK-08931Completed2
DB13024MK-82451Completed1
DB00742Mannitol1Active Not Recruiting1
DB05914Mesenchymal Stem Cells1Unknown Status1
DB00331Metformin1Active Not Recruiting2
DB00331Metformin1Completed46
DB00331Metformin1Recruiting2
DB00331Metformin1Terminated2
DB00331Metformin1Unknown Status1
DB00331Metformin1Withdrawn1
DB00134Methionine1Completed2
DB00264Metoprolol1Completed2
DB00683Midazolam1Completed4
DB01252Mitiglinide1Completed1
DB00218Moxifloxacin1Completed3
DB00717Norethisterone1Completed2
DB00104Octreotide1Completed1
DB09567Olive oil1Completed1
DB11992Omarigliptin1Completed3
DB11814PF-038828451Completed1
DB11765PF-049915321Completed5
DB12096PF-051751571Completed7
DB01132Pioglitazone1Completed4
DB01132Pioglitazone1Not Yet Recruiting1
DB01132Pioglitazone1Withdrawn1
DB01032Probenecid1Completed2
DB00571Propranolol1Completed1
DB00243Ranolazine1Completed3
DB12935Remogliflozin etabonate1Completed2
DB00912Repaglinide1Completed2
DB02709Resveratrol1Completed1
DB01045Rifampicin1Completed1
DB01045Rifampicin1Terminated1
DB01656Roflumilast1Completed1
DB00412Rosiglitazone1Completed4
DB01098Rosuvastatin1Completed1
DB12186SRT-21041Completed5
DB06335Saxagliptin1Active Not Recruiting1
DB06335Saxagliptin1Completed13
DB06335Saxagliptin1Terminated1
DB06335Saxagliptin1Withdrawn1
DB13928Semaglutide1Active Not Recruiting2
DB13928Semaglutide1Completed20
DB13928Semaglutide1Recruiting1
DB00641Simvastatin1Completed7
DB00641Simvastatin1Not Yet Recruiting1
DB00641Simvastatin1Recruiting1
DB01261Sitagliptin1Completed28
DB01261Sitagliptin1Recruiting1
DB01261Sitagliptin1Unknown Status1
DB09153Sodium Chloride1Completed5
DB09153Sodium Chloride1Not Yet Recruiting1
DB12713Sotagliflozin1Completed4
DB00820Tadalafil1Terminated1
DB14027Taspoglutide1Completed1
DB11824Tofogliflozin1Completed3
DB00214Torasemide1Completed1
DB00177Valsartan1Completed2
DB00177Valsartan1Recruiting1
DB00661Verapamil1Completed1
DB04876Vildagliptin1Completed5
DB11094Vitamin D1Completed1
DB00682Warfarin1Completed5
DB02381nor-NOHA1Completed1
DB09055Acipimox1 / 2Completed1
DB11906Acyline1 / 2Completed1
DB09026Aliskiren1 / 2Completed3
DB00345Aminohippuric acid1 / 2Recruiting2
DB04115Berberine1 / 2Completed1
DB08907Canagliflozin1 / 2Completed1
DB01197Captopril1 / 2Recruiting1
DB00482Celecoxib1 / 2Not Yet Recruiting1
DB11073Cetylpyridinium1 / 2Unknown Status1
DB01276Exenatide1 / 2Terminated1
DB06062Gevokizumab1 / 2Completed1
DB01611Hydroxychloroquine1 / 2Not Yet Recruiting1
DB00030Insulin Human1 / 2Completed1
DB00046Insulin Lispro1 / 2Completed1
DB01362Iohexol1 / 2Recruiting2
DB00161L-Valine1 / 2Not Yet Recruiting1
DB01006Letrozole1 / 2Completed1
DB05667Levoketoconazole1 / 2Completed1
DB00331Metformin1 / 2Completed5
DB00331Metformin1 / 2Not Yet Recruiting1
DB00331Metformin1 / 2Terminated1
DB01132Pioglitazone1 / 2Completed1
DB01261Sitagliptin1 / 2Completed1
DB00624Testosterone1 / 2Completed1
DB00177Valsartan1 / 2Not Yet Recruiting1
DB04876Vildagliptin1 / 2Terminated1
DB05631ALT-20742Completed1
DB00284Acarbose2Completed2
DB00414Acetohexamide2Completed1
DB11704Adomeglivant2Completed3
DB11704Adomeglivant2Terminated1
DB05162Albiglutide2Completed1
DB09043Albiglutide2Completed4
DB08915Aleglitazar2Completed6
DB00437Allopurinol2Not Yet Recruiting1
DB06203Alogliptin2Completed2
DB11863Alvelestat2Active Not Recruiting1
DB00915Amantadine2Completed1
DB01025Amlexanox2Active Not Recruiting2
DB12417Anagliptin2Completed2
DB00026Anakinra2Completed1
DB00026Anakinra2Unknown Status1
DB06158Arhalofenate2Terminated1
DB00126Ascorbic acid2Completed1
DB06543Astaxanthin2Completed1
DB05983Bardoxolone methyl2Completed3
DB05983Bardoxolone methyl2Terminated2
DB05983Bardoxolone methyl2Withdrawn2
DB12671Beloranib2Terminated1
DB11936Bempedoic acid2Completed1
DB09022Benfluorex2Unknown Status1
DB12236Bexagliflozin2Completed1
DB01393Bezafibrate2Completed1
DB12584Bimagrumab2Active Not Recruiting1
DB06127Bisegliptin2Completed1
DB00559Bosentan2Completed1
DB08907Canagliflozin2Completed2
DB06168Canakinumab2Completed3
DB09061Cannabidiol2Completed1
DB12268Carmegliptin2Completed1
DB11758Cenicriviroc2Completed1
DB06586Cetilistat2Completed1
DB11121Chloroxylenol2Completed2
DB00672Chlorpropamide2Completed1
DB00169Cholecalciferol2Completed2
DB00169Cholecalciferol2Unknown Status1
DB00882Clomifene2Terminated1
DB01394Colchicine2Recruiting1
DB00930Colesevelam2Completed2
DB11634Colestilan chloride2Completed1
DB09130Copper2Completed1
DB09131Cupric Chloride2Completed1
DB06292Dapagliflozin2Completed5
DB06292Dapagliflozin2Recruiting1
DB06643Denosumab2Not Yet Recruiting1
DB00514Dextromethorphan2Completed2
DB11994Diacerein2Completed3
DB11994Diacerein2Recruiting1
DB01119Diazoxide2Not Yet Recruiting1
DB01119Diazoxide2Recruiting3
DB00861Diflunisal2Completed1
DB09045Dulaglutide2Completed5
DB05065Dutogliptin2Completed1
DB11723Dutogliptin2Terminated1
DB05187Elafibranor2Completed1
DB09038Empagliflozin2Completed9
DB09038Empagliflozin2Enrolling by Invitation1
DB09038Empagliflozin2Recruiting5
DB06735Enclomiphene2Completed1
DB12116Epigallocatechin gallate2Withdrawn1
DB06405Eprodisate2Completed1
DB00153Ergocalciferol2Completed1
DB00153Ergocalciferol2Unknown Status1
DB11827Ertugliflozin2Completed2
DB11827Ertugliflozin2Not Yet Recruiting1
DB00898Ethanol2Unknown Status1
DB12625Evogliptin2Completed1
DB01276Exenatide2Completed8
DB00973Ezetimibe2Completed1
DB00973Ezetimibe2Recruiting1
DB12491Fasiglifam2Terminated1
DB13961Fish oil2Recruiting1
DB12627GSK-12922632Completed2
DB11729GSK-23306722Completed2
DB06062Gevokizumab2Completed2
DB01120Gliclazide2Completed1
DB00222Glimepiride2Completed9
DB00222Glimepiride2Withdrawn1
DB01067Glipizide2Completed2
DB01016Glyburide2Completed3
DB01016Glyburide2Recruiting1
DB01016Glyburide2Terminated1
DB12934Granotapide2Completed1
DB14307Green tea leaf2Completed1
DB05212HE32862Completed1
DB06205Hyaluronidase (Human Recombinant)2Completed2
DB00999Hydrochlorothiazide2Completed2
DB00999Hydrochlorothiazide2Terminated1
DB05506ISIS 1137152Completed2
DB05506ISIS 1137152Terminated1
DB05506ISIS 1137152Withdrawn1
DB12509Imeglimin2Completed1
DB01306Insulin Aspart2Completed1
DB09564Insulin Degludec2Completed1
DB00047Insulin Glargine2Completed10
DB00047Insulin Glargine2Terminated1
DB01309Insulin Glulisine2Completed1
DB00030Insulin Human2Completed6
DB00046Insulin Lispro2Completed3
DB00046Insulin Lispro2Terminated1
DB11567Insulin peglispro2Completed1
DB02325Isopropyl Alcohol2Unknown Status1
DB12632JNJ-414435322Completed1
DB00149L-Leucine2Completed2
DB12284LY-26082042Withdrawn1
DB05667Levoketoconazole2Terminated1
DB00451Levothyroxine2Terminated1
DB08882Linagliptin2Completed5
DB00166Lipoic Acid2Completed1
DB00166Lipoic Acid2Unknown Status1
DB06655Liraglutide2Active Not Recruiting1
DB06655Liraglutide2Completed18
DB06655Liraglutide2Recruiting2
DB06655Liraglutide2Terminated2
DB09265Lixisenatide2Completed3
DB09198Lobeglitazone2Completed1
DB11138Lutein2Completed1
DB05053MB-078032Completed1
DB12055MK-07672Terminated1
DB12044MK-08932Completed2
DB12044MK-08932Terminated1
DB05518Managlinat dialanetil2Completed1
DB01065Melatonin2Completed1
DB00331Metformin2Active Not Recruiting2
DB00331Metformin2Completed53
DB00331Metformin2Not Yet Recruiting2
DB00331Metformin2Terminated10
DB00331Metformin2Unknown Status1
DB00134Methionine2Completed1
DB00264Metoprolol2Active Not Recruiting1
DB00834Mifepristone2Recruiting1
DB11721Mitoglitazone2Completed2
DB14265Momordica charantia fruit2Withdrawn1
DB00627Niacin2Not Yet Recruiting1
DB00627Niacin2Recruiting1
DB12445Nitroaspirin2Terminated1
DB05990Obeticholic acid2Completed1
DB11992Omarigliptin2Completed1
DB09539Omega-3-acid ethyl esters2Completed1
DB09568Omega-3-carboxylic acids2Completed1
DB00338Omeprazole2Not Yet Recruiting1
DB01083Orlistat2Completed1
DB14016Ox bile extract2Completed1
DB11765PF-049915322Completed2
DB12096PF-051751572Terminated3
DB00910Paricalcitol2Completed1
DB01132Pioglitazone2Completed19
DB01132Pioglitazone2Terminated3
DB01278Pramlintide2Completed2
DB06815Pyrithione2Completed1
DB00178Ramipril2Recruiting1
DB00243Ranolazine2Completed1
DB00912Repaglinide2Completed1
DB02709Resveratrol2Completed1
DB02709Resveratrol2Terminated1
DB01656Roflumilast2Completed1
DB00412Rosiglitazone2Completed1
DB05678SLx-40902Completed2
DB12186SRT-21042Completed2
DB06335Saxagliptin2Active Not Recruiting1
DB06335Saxagliptin2Completed2
DB13928Semaglutide2Completed3
DB00641Simvastatin2Completed1
DB01261Sitagliptin2Completed26
DB01261Sitagliptin2Terminated1
DB01261Sitagliptin2Withdrawn1
DB09153Sodium Chloride2Completed1
DB09153Sodium Chloride2Recruiting2
DB00820Tadalafil2Recruiting1
DB11644Tafamidis2Completed1
DB04936Tagatose2Completed1
DB14027Taspoglutide2Completed2
DB11950Teneligliptin2Completed2
DB06536Tesaglitazar2Completed1
DB06536Tesaglitazar2Terminated3
DB08869Tesamorelin2Completed1
DB06156Tesofensine2Active Not Recruiting1
DB00624Testosterone2Completed1
DB00624Testosterone2Terminated1
DB11755Tetrahydrocannabivarin2Completed2
DB11824Tofogliflozin2Completed1
DB00839Tolazamide2Completed1
DB01124Tolbutamide2Completed1
DB00273Topiramate2Completed3
DB00620Triamcinolone2Completed1
DB00197Troglitazone2Completed1
DB09270Ubidecarenone2Completed1
DB01586Ursodeoxycholic acid2Completed1
DB12414Usistapide2Completed1
DB00862Vardenafil2Completed1
DB04876Vildagliptin2Completed2
DB11094Vitamin D2Completed1
DB11094Vitamin D2Unknown Status1
DB00163Vitamin E2Completed1
DB04878Voglibose2Completed2
DB01392Yohimbine2Completed1
DB11176Zeaxanthin2Completed1
DB01593Zinc2Completed1
DB06151Acetylcysteine2 / 3Completed1
DB09055Acipimox2 / 3Completed1
DB06203Alogliptin2 / 3Completed7
DB06158Arhalofenate2 / 3Completed1
DB08822Azilsartan medoxomil2 / 3Unknown Status1
DB12236Bexagliflozin2 / 3Completed1
DB10736Broussonetia papyrifera pollen2 / 3Completed1
DB06168Canakinumab2 / 3Terminated1
DB00169Cholecalciferol2 / 3Completed1
DB00930Colesevelam2 / 3Completed1
DB06292Dapagliflozin2 / 3Completed2
DB09045Dulaglutide2 / 3Completed1
DB12610Ebselen2 / 3Completed1
DB01276Exenatide2 / 3Completed1
DB01276Exenatide2 / 3Recruiting1
DB01039Fenofibrate2 / 3Terminated1
DB00222Glimepiride2 / 3Completed2
DB09564Insulin Degludec2 / 3Not Yet Recruiting1
DB00030Insulin Human2 / 3Completed1
DB00125L-Arginine2 / 3Recruiting1
DB05667Levoketoconazole2 / 3Terminated1
DB00331Metformin2 / 3Completed5
DB00331Metformin2 / 3Recruiting2
DB00331Metformin2 / 3Terminated2
DB00331Metformin2 / 3Unknown Status1
DB00916Metronidazole2 / 3Recruiting1
DB00731Nateglinide2 / 3Completed1
DB00213Pantoprazole2 / 3Completed1
DB01132Pioglitazone2 / 3Completed5
DB09200Rivoglitazone2 / 3Completed1
DB11829Ruboxistaurin2 / 3Completed1
DB01399Salsalate2 / 3Completed2
DB01261Sitagliptin2 / 3Completed2
DB09153Sodium Chloride2 / 3Completed1
DB00624Testosterone2 / 3Completed1
DB04876Vildagliptin2 / 3Completed2
DB00163Vitamin E2 / 3Completed1
DB04878Voglibose2 / 3Completed2
DB118982,4-thiazolidinedione3Completed4
DB00284Acarbose3Completed8
DB00284Acarbose3Recruiting1
DB00284Acarbose3Terminated1
DB08842Acetylcarnitine3Completed1
DB00945Acetylsalicylic acid3Completed1
DB00945Acetylsalicylic acid3Recruiting1
DB09043Albiglutide3Active Not Recruiting1
DB05162Albiglutide3Completed1
DB09043Albiglutide3Completed8
DB05162Albiglutide3Withdrawn1
DB09043Albiglutide3Withdrawn2
DB08915Aleglitazar3Completed6
DB09026Aliskiren3Terminated1
DB00437Allopurinol3Recruiting1
DB06203Alogliptin3Completed6
DB06203Alogliptin3Recruiting1
DB00381Amlodipine3Completed1
DB12417Anagliptin3Completed2
DB12000Apabetalone3Recruiting1
DB01076Atorvastatin3Completed5
DB01076Atorvastatin3Recruiting2
DB01076Atorvastatin3Terminated1
DB08822Azilsartan medoxomil3Terminated2
DB12781Balaglitazone3Completed1
DB05983Bardoxolone methyl3Terminated1
DB00542Benazepril3Completed1
DB04115Berberine3Completed1
DB12236Bexagliflozin3Active Not Recruiting2
DB12236Bexagliflozin3Completed3
DB13100Biguanide3Completed2
DB00559Bosentan3Terminated1
DB01200Bromocriptine3Completed1
DB01200Bromocriptine3Terminated1
DB08907Canagliflozin3Active Not Recruiting2
DB08907Canagliflozin3Completed16
DB08907Canagliflozin3Recruiting1
DB00796Candesartan cilexetil3Completed2
DB06774Capsaicin3Terminated1
DB01136Carvedilol3Completed1
DB11121Chloroxylenol3Recruiting1
DB11121Chloroxylenol3Unknown Status1
DB00310Chlorthalidone3Completed1
DB00169Cholecalciferol3Terminated1
DB00122Choline3Recruiting1
DB04660Choline alfoscerate3Recruiting1
DB00930Colesevelam3Completed8
DB06292Dapagliflozin3Completed30
DB06292Dapagliflozin3Not Yet Recruiting3
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DB06292Dapagliflozin3Suspended1
DB11994Diacerein3Completed1
DB00343Diltiazem3Completed1
DB09045Dulaglutide3Active Not Recruiting2
DB09045Dulaglutide3Completed17
DB09045Dulaglutide3Recruiting2
DB11723Dutogliptin3Completed1
DB05065Dutogliptin3Terminated2
DB11723Dutogliptin3Terminated5
DB09038Empagliflozin3Completed20
DB09038Empagliflozin3Recruiting4
DB09038Empagliflozin3Terminated1
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DB00584Enalapril3Completed1
DB00700Eplerenone3Active Not Recruiting1
DB00153Ergocalciferol3Completed1
DB11827Ertugliflozin3Active Not Recruiting1
DB11827Ertugliflozin3Completed8
DB00736Esomeprazole3Completed1
DB12625Evogliptin3Completed2
DB09303Evolocumab3Completed1
DB01276Exenatide3Active Not Recruiting1
DB01276Exenatide3Completed36
DB01276Exenatide3Recruiting4
DB00973Ezetimibe3Completed1
DB12491Fasiglifam3Completed1
DB12491Fasiglifam3Terminated1
DB12491Fasiglifam3Withdrawn1
DB01023Felodipine3Completed1
DB01039Fenofibrate3Completed3
DB01039Fenofibrate3Terminated1
DB08917Ferric Carboxymaltose3Active Not Recruiting1
DB00695Furosemide3Completed1
DB12412Gemigliptin3Completed4
DB01120Gliclazide3Completed4
DB00222Glimepiride3Active Not Recruiting2
DB00222Glimepiride3Completed53
DB00222Glimepiride3Not Yet Recruiting1
DB00222Glimepiride3Recruiting1
DB00222Glimepiride3Terminated12
DB00222Glimepiride3Withdrawn2
DB01067Glipizide3Completed11
DB00040Glucagon recombinant3Completed1
DB01016Glyburide3Completed4
DB01016Glyburide3Terminated2
DB12502Gosogliptin3Completed1
DB11939Henagliflozin3Not Yet Recruiting1
DB01275Hydralazine3Completed1
DB00999Hydrochlorothiazide3Completed1
DB00159Icosapent3Terminated1
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DB11783Imidapril3Unknown Status1
DB01306Insulin Aspart3Active Not Recruiting1
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DB01306Insulin Aspart3Recruiting1
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DB09564Insulin Degludec3Active Not Recruiting4
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DB09564Insulin Degludec3Recruiting1
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DB00047Insulin Glargine3Active Not Recruiting6
DB00047Insulin Glargine3Completed91
DB00047Insulin Glargine3Not Yet Recruiting1
DB00047Insulin Glargine3Recruiting8
DB00047Insulin Glargine3Terminated2
DB00047Insulin Glargine3Withdrawn1
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DB01309Insulin Glulisine3Recruiting1
DB00030Insulin Human3Completed6
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DB00046Insulin Lispro3Active Not Recruiting1
DB00046Insulin Lispro3Completed14
DB11567Insulin peglispro3Completed6
DB11567Insulin peglispro3Withdrawn1
DB11698Ipragliflozin3Completed6
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DB11698Ipragliflozin3Terminated1
DB01029Irbesartan3Completed1
DB00172L-Proline3Completed1
DB08882Linagliptin3Active Not Recruiting2
DB08882Linagliptin3Completed29
DB08882Linagliptin3Recruiting2
DB08882Linagliptin3Terminated2
DB06655Liraglutide3Active Not Recruiting4
DB06655Liraglutide3Completed35
DB06655Liraglutide3Not Yet Recruiting3
DB06655Liraglutide3Recruiting2
DB06655Liraglutide3Terminated2
DB00722Lisinopril3Completed1
DB00722Lisinopril3Terminated1
DB09265Lixisenatide3Active Not Recruiting3
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DB09265Lixisenatide3Recruiting2
DB09198Lobeglitazone3Completed2
DB00678Losartan3Completed1
DB00678Losartan3Terminated1
DB12055MK-07673Terminated7
DB00825Menthol3Terminated1
DB00331Metformin3Active Not Recruiting8
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DB00331Metformin3Not Yet Recruiting3
DB00331Metformin3Recruiting11
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DB00331Metformin3Unknown Status3
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DB00491Miglitol3Completed6
DB01252Mitiglinide3Completed3
DB06510Muraglitazar3Completed5
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DB00627Niacin3Terminated1
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DB11992Omarigliptin3Completed8
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DB01132Pioglitazone3Completed42
DB01132Pioglitazone3Terminated5
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DB01278Pramlintide3Completed1
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DB00206Reserpine3Completed1
DB06155Rimonabant3Completed3
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DB01098Rosuvastatin3Recruiting1
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DB06335Saxagliptin3Completed29
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DB06335Saxagliptin3Recruiting1
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DB00203Sildenafil3Completed1
DB00641Simvastatin3Completed4
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DB01261Sitagliptin3Completed89
DB01261Sitagliptin3Not Yet Recruiting1
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DB04936Tagatose3Completed1
DB06624Taranabant3Terminated1
DB14027Taspoglutide3Completed9
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DB11950Teneligliptin3Active Not Recruiting2
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DB06536Tesaglitazar3Terminated11
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DB00177Valsartan3Recruiting1
DB04876Vildagliptin3Completed65
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DB04878Voglibose3Completed2
DB00284Acarbose4Active Not Recruiting1
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DB00284Acarbose4Recruiting5
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DB06151Acetylcysteine4Terminated1
DB00945Acetylsalicylic acid4Active Not Recruiting1
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DB00945Acetylsalicylic acid4Recruiting2
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DB00051Adalimumab4Unknown Status1
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DB09026Aliskiren4Completed3
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DB00381Amlodipine4Completed4
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DB00381Amlodipine4Recruiting1
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DB01076Atorvastatin4Active Not Recruiting1
DB01076Atorvastatin4Completed8
DB01076Atorvastatin4Terminated1
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DB00626Bacitracin4Terminated1
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DB00559Bosentan4Completed2
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DB01200Bromocriptine4Completed1
DB01156Bupropion4Recruiting2
DB00201Caffeine4Recruiting1
DB08907Canagliflozin4Completed6
DB08907Canagliflozin4Recruiting8
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DB01136Carvedilol4Completed1
DB01136Carvedilol4Unknown Status1
DB00341Cetirizine4Enrolling by Invitation1
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DB00169Cholecalciferol4Completed1
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DB01166Cilostazol4Active Not Recruiting1
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DB00930Colesevelam4Recruiting2
DB11672Curcumin4Unknown Status2
DB00091Cyclosporine4Completed1
DB01914D-glucose4Not Yet Recruiting1
DB06292Dapagliflozin4Active Not Recruiting4
DB06292Dapagliflozin4Completed13
DB06292Dapagliflozin4Not Yet Recruiting7
DB06292Dapagliflozin4Recruiting20
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DB00514Dextromethorphan4Recruiting1
DB09341Dextrose, unspecified form4Completed1
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DB00254Doxycycline4Completed2
DB09045Dulaglutide4Active Not Recruiting1
DB09045Dulaglutide4Completed1
DB09045Dulaglutide4Not Yet Recruiting1
DB09045Dulaglutide4Recruiting1
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DB09038Empagliflozin4Not Yet Recruiting1
DB09038Empagliflozin4Recruiting6
DB09038Empagliflozin4Terminated1
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DB00700Eplerenone4Completed1
DB01240Epoprostenol4Completed1
DB11827Ertugliflozin4Not Yet Recruiting1
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DB01276Exenatide4Active Not Recruiting2
DB01276Exenatide4Completed23
DB01276Exenatide4Not Yet Recruiting1
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DB01276Exenatide4Terminated2
DB01276Exenatide4Unknown Status3
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DB00695Furosemide4Completed1
DB00996Gabapentin4Enrolling by Invitation1
DB12412Gemigliptin4Active Not Recruiting1
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DB12412Gemigliptin4Recruiting1
DB01120Gliclazide4Completed9
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DB01120Gliclazide4Recruiting1
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DB00222Glimepiride4Completed32
DB00222Glimepiride4Not Yet Recruiting1
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DB00222Glimepiride4Unknown Status5
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DB01016Glyburide4Completed9
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DB00999Hydrochlorothiazide4Not Yet Recruiting3
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DB01306Insulin Aspart4Completed33
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DB01307Insulin Detemir4Completed27
DB01307Insulin Detemir4Recruiting1
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DB01307Insulin Detemir4Unknown Status3
DB01307Insulin Detemir4Withdrawn1
DB00047Insulin Glargine4Completed90
DB00047Insulin Glargine4Not Yet Recruiting1
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DB01309Insulin Glulisine4Completed13
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DB00030Insulin Human4Completed20
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DB00046Insulin Lispro4Completed16
DB00046Insulin Lispro4Not Yet Recruiting1
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DB00046Insulin Lispro4Unknown Status1
DB00046Insulin Lispro4Withdrawn1
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DB11698Ipragliflozin4Active Not Recruiting1
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DB00160L-Alanine4Completed1
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DB09236Lacidipine4Completed1
DB08882Linagliptin4Active Not Recruiting1
DB08882Linagliptin4Completed12
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DB06655Liraglutide4Active Not Recruiting5
DB06655Liraglutide4Completed22
DB06655Liraglutide4Not Yet Recruiting1
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DB00722Lisinopril4Unknown Status1
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DB00331Metformin4Active Not Recruiting9
DB00331Metformin4Completed95
DB00331Metformin4Enrolling by Invitation1
DB00331Metformin4Not Yet Recruiting7
DB00331Metformin4Recruiting13
DB00331Metformin4Terminated5
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DB00134Methionine4Not Yet Recruiting1
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DB14158Microcrystalline cellulose4Completed1
DB00683Midazolam4Recruiting1
DB01252Mitiglinide4Active Not Recruiting1
DB01252Mitiglinide4Completed3
DB11675Mosapride4Completed1
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DB00704Naltrexone4Recruiting1
DB00731Nateglinide4Completed7
DB04861Nebivolol4Completed1
DB00627Niacin4Terminated1
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DB00334Olanzapine4Completed2
DB00275Olmesartan4Completed1
DB11992Omarigliptin4Completed1
DB11133Omega-3 fatty acids4Completed1
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DB01132Pioglitazone4Completed26
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DB01599Probucol4Completed1
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DB00243Ranolazine4Withdrawn1
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DB00912Repaglinide4Recruiting2
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DB01399Salsalate4Completed1
DB06335Saxagliptin4Active Not Recruiting3
DB06335Saxagliptin4Completed10
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DB01261Sitagliptin4Completed35
DB01261Sitagliptin4Enrolling by Invitation1
DB01261Sitagliptin4Recruiting13
DB01261Sitagliptin4Terminated8
DB01261Sitagliptin4Unknown Status8
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DB00864Tacrolimus4Completed1
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DB00862Vardenafil4Unknown Status1
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DB04878Voglibose4Completed4
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DB00551Acetohydroxamic AcidNot AvailableCompleted1
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DB11704AdomeglivantNot AvailableCompleted1
DB09026AliskirenNot AvailableCompleted1
DB06203AlogliptinNot AvailableCompleted4
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DB00026AnakinraNot AvailableCompleted1
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DB00673AprepitantNot AvailableRecruiting1
DB01238AripiprazoleNot AvailableCompleted1
DB00126Ascorbic acidNot AvailableCompleted2
DB01076AtorvastatinNot AvailableCompleted3
DB01076AtorvastatinNot AvailableWithdrawn1
DB11105BenzalkoniumNot AvailableUnknown Status2
DB12126BradykininNot AvailableCompleted1
DB04830BuforminNot AvailableCompleted3
DB00248CabergolineNot AvailableUnknown Status1
DB00136CalcitriolNot AvailableCompleted1
DB06724Calcium CarbonateNot AvailableNot Yet Recruiting1
DB08907CanagliflozinNot AvailableCompleted2
DB08907CanagliflozinNot AvailableNot Yet Recruiting2
DB08907CanagliflozinNot AvailableRecruiting1
DB11073CetylpyridiniumNot AvailableCompleted1
DB06777Chenodeoxycholic acidNot AvailableCompleted1
DB01178ChlormezanoneNot AvailableCompleted1
DB11121ChloroxylenolNot AvailableRecruiting1
DB00477ChlorpromazineNot AvailableCompleted1
DB00672ChlorpropamideNot AvailableCompleted3
DB01239ChlorprothixeneNot AvailableCompleted1
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DB00169CholecalciferolNot AvailableCompleted1
DB08862CholecystokininNot AvailableCompleted2
DB00363ClozapineNot AvailableCompleted1
DB00930ColesevelamNot AvailableCompleted3
DB06292DapagliflozinNot AvailableCompleted4
DB06292DapagliflozinNot AvailableNot Yet Recruiting1
DB06292DapagliflozinNot AvailableRecruiting3
DB06292DapagliflozinNot AvailableTerminated1
DB01234DexamethasoneNot AvailableCompleted1
DB09341Dextrose, unspecified formNot AvailableCompleted3
DB09038EmpagliflozinNot AvailableActive Not Recruiting5
DB09038EmpagliflozinNot AvailableCompleted3
DB09038EmpagliflozinNot AvailableNot Yet Recruiting1
DB09038EmpagliflozinNot AvailableRecruiting2
DB00584EnalaprilNot AvailableCompleted1
DB09477EnalaprilatNot AvailableCompleted1
DB01364EphedrineNot AvailableUnknown Status1
DB00876EprosartanNot AvailableCompleted1
DB00153ErgocalciferolNot AvailableActive Not Recruiting1
DB00153ErgocalciferolNot AvailableCompleted1
DB01175EscitalopramNot AvailableCompleted1
DB00736EsomeprazoleNot AvailableCompleted1
DB00898EthanolNot AvailableCompleted1
DB00898EthanolNot AvailableRecruiting1
DB03852EucalyptolNot AvailableRecruiting1
DB01276ExenatideNot AvailableCompleted18
DB01276ExenatideNot AvailableRecruiting3
DB01276ExenatideNot AvailableUnknown Status1
DB00973EzetimibeNot AvailableRecruiting1
DB01039FenofibrateNot AvailableCompleted2
DB13961Fish oilNot AvailableTerminated1
DB00875FlupentixolNot AvailableCompleted1
DB00623FluphenazineNot AvailableCompleted1
DB04842FluspirileneNot AvailableCompleted1
DB01095FluvastatinNot AvailableCompleted1
DB06717FosaprepitantNot AvailableRecruiting1
DB12412GemigliptinNot AvailableActive Not Recruiting1
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DB08962GlibornurideNot AvailableCompleted3
DB01120GliclazideNot AvailableCompleted5
DB01120GliclazideNot AvailableRecruiting2
DB01120GliclazideNot AvailableUnknown Status1
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DB00222GlimepirideNot AvailableNot Yet Recruiting2
DB01067GlipizideNot AvailableCompleted4
DB01251GliquidoneNot AvailableCompleted3
DB01289GlisoxepideNot AvailableCompleted3
DB12788Glucagon-like peptide IINot AvailableCompleted1
DB01016GlyburideNot AvailableCompleted8
DB01016GlyburideNot AvailableUnknown Status1
DB01382GlycodiazineNot AvailableCompleted3
DB00502HaloperidolNot AvailableCompleted1
DB00999HydrochlorothiazideNot AvailableCompleted2
DB01611HydroxychloroquineNot AvailableRecruiting1
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DB01088IloprostNot AvailableCompleted1
DB01306Insulin AspartNot AvailableCompleted33
DB01306Insulin AspartNot AvailableRecruiting2
DB01306Insulin AspartNot AvailableUnknown Status1
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DB09564Insulin DegludecNot AvailableActive Not Recruiting1
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DB09564Insulin DegludecNot AvailableNot Yet Recruiting1
DB01307Insulin DetemirNot AvailableActive Not Recruiting1
DB01307Insulin DetemirNot AvailableCompleted48
DB01307Insulin DetemirNot AvailableRecruiting1
DB01307Insulin DetemirNot AvailableUnknown Status1
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DB00047Insulin GlargineNot AvailableRecruiting2
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DB00030Insulin HumanNot AvailableCompleted8
DB00030Insulin HumanNot AvailableRecruiting1
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DB00046Insulin LisproNot AvailableCompleted1
DB11698IpragliflozinNot AvailableCompleted3
DB02325Isopropyl AlcoholNot AvailableCompleted1
DB01020Isosorbide MononitrateNot AvailableCompleted1
DB00125L-ArginineNot AvailableCompleted1
DB14566Lavender oilNot AvailableRecruiting1
DB00281LidocaineNot AvailableCompleted1
DB00281LidocaineNot AvailableUnknown Status2
DB08882LinagliptinNot AvailableActive Not Recruiting1
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DB08882LinagliptinNot AvailableTerminated1
DB06655LiraglutideNot AvailableCompleted22
DB06655LiraglutideNot AvailableNot Yet Recruiting1
DB06655LiraglutideNot AvailableRecruiting5
DB06655LiraglutideNot AvailableUnknown Status1
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DB00722LisinoprilNot AvailableTerminated1
DB09265LixisenatideNot AvailableRecruiting1
DB00678LosartanNot AvailableCompleted4
DB00227LovastatinNot AvailableCompleted1
DB00408LoxapineNot AvailableCompleted1
DB01046LubiprostoneNot AvailableTerminated1
DB12214LuseogliflozinNot AvailableCompleted1
DB00825MentholNot AvailableRecruiting1
DB00933MesoridazineNot AvailableCompleted1
DB00331MetforminNot AvailableActive Not Recruiting1
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DB00331MetforminNot AvailableRecruiting11
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DB09543Methyl salicylateNot AvailableRecruiting1
DB14158Microcrystalline celluloseNot AvailableRecruiting1
DB00491MiglitolNot AvailableCompleted3
DB08893MirabegronNot AvailableCompleted1
DB00731NateglinideNot AvailableCompleted3
DB04899NesiritideNot AvailableCompleted1
DB00325NitroprussideNot AvailableCompleted1
DB00334OlanzapineNot AvailableCompleted3
DB11992OmarigliptinNot AvailableCompleted1
DB11133Omega-3 fatty acidsNot AvailableActive Not Recruiting1
DB09539Omega-3-acid ethyl estersNot AvailableCompleted1
DB01267PaliperidoneNot AvailableCompleted1
DB00910ParicalcitolNot AvailableUnknown Status1
DB00556PerflutrenNot AvailableCompleted1
DB00850PerphenazineNot AvailableCompleted1
DB00914PhenforminNot AvailableCompleted3
DB01100PimozideNot AvailableCompleted1
DB01132PioglitazoneNot AvailableCompleted23
DB01132PioglitazoneNot AvailableRecruiting3
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DB01621PipotiazineNot AvailableCompleted1
DB09311PolycarbophilNot AvailableCompleted1
DB01345Potassium cationNot AvailableCompleted2
DB01278PramlintideNot AvailableCompleted1
DB01278PramlintideNot AvailableWithdrawn1
DB01708PrasteroneNot AvailableActive Not Recruiting1
DB00175PravastatinNot AvailableCompleted1
DB00175PravastatinNot AvailableTerminated1
DB01599ProbucolNot AvailableActive Not Recruiting1
DB01224QuetiapineNot AvailableCompleted1
DB00243RanolazineNot AvailableWithdrawn1
DB06213RegadenosonNot AvailableCompleted1
DB00912RepaglinideNot AvailableCompleted9
DB00912RepaglinideNot AvailableUnknown Status1
DB06155RimonabantNot AvailableCompleted1
DB00734RisperidoneNot AvailableCompleted2
DB00412RosiglitazoneNot AvailableCompleted14
DB00412RosiglitazoneNot AvailableTerminated2
DB01098RosuvastatinNot AvailableCompleted1
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DB06335SaxagliptinNot AvailableCompleted5
DB06335SaxagliptinNot AvailableRecruiting4
DB13928SemaglutideNot AvailableEnrolling by Invitation3
DB00658SevelamerNot AvailableCompleted1
DB00641SimvastatinNot AvailableCompleted3
DB01261SitagliptinNot AvailableCompleted21
DB01261SitagliptinNot AvailableNot Yet Recruiting4
DB01261SitagliptinNot AvailableRecruiting5
DB01261SitagliptinNot AvailableTerminated2
DB01261SitagliptinNot AvailableUnknown Status4
DB09153Sodium ChlorideNot AvailableCompleted6
DB01390Sodium bicarbonateNot AvailableCompleted1
DB09325Sodium fluorideNot AvailableCompleted1
DB09422Soybean oilNot AvailableCompleted1
DB00421SpironolactoneNot AvailableCompleted2
DB00857TerbinafineNot AvailableNot Yet Recruiting1
DB04844TetrabenazineNot AvailableCompleted1
DB01622ThioproperazineNot AvailableCompleted1
DB00679ThioridazineNot AvailableCompleted1
DB01623ThiothixeneNot AvailableCompleted1
DB02513ThymolNot AvailableRecruiting1
DB06273TocilizumabNot AvailableCompleted1
DB00839TolazamideNot AvailableCompleted3
DB01124TolbutamideNot AvailableCompleted3
DB00831TrifluoperazineNot AvailableCompleted1
DB00197TroglitazoneNot AvailableCompleted3
DB00177ValsartanNot AvailableActive Not Recruiting1
DB00661VerapamilNot AvailableCompleted1
DB04876VildagliptinNot AvailableCompleted3
DB04876VildagliptinNot AvailableNot Yet Recruiting2
DB04876VildagliptinNot AvailableRecruiting2
DB11094Vitamin DNot AvailableActive Not Recruiting1
DB11094Vitamin DNot AvailableCompleted1
DB04878VogliboseNot AvailableCompleted3
DB00246ZiprasidoneNot AvailableCompleted2
DB01624ZuclopenthixolNot AvailableCompleted1
DB05875substance PNot AvailableCompleted1