NAV

Efzofitimod

Identification

Generic Name
Efzofitimod
DrugBank Accession Number
DB16453
Background

Efzofitimod (ATYR1923) is a fusion protein comprised of the immuno-modulatory domain of histidyl tRNA synthetase fused to the FC region of a human antibody. It is a selective modulator of neuropilin-2 that downregulates the innate and adaptive immune response in inflammatory disease states.

Type
Biotech
Groups
Investigational
Biologic Classification
Protein Based Therapies
Fusion proteins
Protein Chemical Formula
Not Available
Protein Average Weight
Not Available
Sequences
Not Available
Synonyms
  • Human IgG1Fc- iMod domain (amino acids 2-60) of human HARS fusion protein
External IDs
  • ATYR 1923
  • ATYR-1923
  • ATYR1923
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Pharmacology

Indication

Not Available

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Pharmacodynamics

Not Available

Mechanism of action

ATYR1923 acts to reduce overall inflammation and fibrotic deposition in the lungs, stabilizing its function; it acts as a disease modifying therapy for people with interstitial lung disease (ILD). The mechanism behind this is that the drug selectively binds to and regulates NRP2, reducing its innate and adaptive immune response pathways associated with cytokine and chemokine production and T-cell activation.

TargetActionsOrganism
ANeuropilin-2
modulator
Humans
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
Not Available
Kingdom
Organic Compounds
Super Class
Organic Acids
Class
Carboxylic Acids and Derivatives
Sub Class
Amino Acids, Peptides, and Analogues
Direct Parent
Peptides
Alternative Parents
Not Available
Substituents
Not Available
Molecular Framework
Not Available
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
V5TNN0W368
CAS number
Not Available

References

General References
  1. External Link [Link]
  2. External Link [Link]
  3. External Link [Link]
Not Available

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3RecruitingTreatmentSarcoidosis, Pulmonary1
2CompletedTreatmentCoronavirus Disease 2019 (COVID‑19) / SARS-CoV-2 (COVID-19) Severe Pneumonia1
2RecruitingTreatmentInterstitial Lung Disease1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Targets

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Details1. Neuropilin-2
Kind
Protein
Organism
Humans
Pharmacological action
Yes
Actions
Modulator
General Function
High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.
Specific Function
Cytokine binding
Gene Name
NRP2
Uniprot ID
O60462
Uniprot Name
Neuropilin-2
Molecular Weight
104829.73 Da

Drug created at January 21, 2021 01:43 / Updated at September 17, 2023 04:15