Heparin Induced Thrombocytopenia (HIT)
Also known as: Heparin-induced Thrombocytopenia (HIT) / Heparin Induced Thrombocytopenia / Heparin-Induced Thrombocytopenia / Heparin-induced thrombocytopenia, unspecified / Heparin-induced thrombocytopenia NOS / Heparin-induced thrombocytopenia (disorder)
| Drug | Drug Name | Drug Description |
|---|---|---|
| DB00278 | Argatroban | A synthetic direct thrombin inhibitor used for the prevention and treatment of thrombosis related to heparin use. |
| DB00006 | Bivalirudin | A direct thrombin inhibitor used to treat heparin-induced thrombocytopenia and to prevent thrombosis during percutaneous coronary intervention. |
| DB06754 | Danaparoid | A heparinoid with anticoagulant and antithrombotic activities used for the treatment of acute episode of Heparin-Induced Thrombocytopenia (HIT), and for prophylaxis in patients with a history of HIT. |
| Drug | Drug Name | Target | Type |
|---|---|---|---|
| DB00278 | Argatroban | Prothrombin | target |
| DB00278 | Argatroban | Cytochrome P450 3A4 | enzyme |
| DB00278 | Argatroban | Cytochrome P450 3A5 | enzyme |
| DB00278 | Argatroban | Serum albumin | carrier |
| DB00278 | Argatroban | alpha1-acid glycoprotein | carrier |
| DB00006 | Bivalirudin | Prothrombin | target |
| DB00006 | Bivalirudin | Myeloperoxidase | enzyme |
| DB06754 | Danaparoid | Antithrombin-III | target |
| Drug | Drug Name | Phase | Status | Count |
|---|---|---|---|---|
| DB00278 | Argatroban | 1 | Completed | 1 |
| DB00569 | Fondaparinux | 1 | Completed | 1 |
| DB11728 | Fondaparinux | 1 | Completed | 1 |
| DB18307 | VLX-1005 | 1 | Completed | 1 |
| DB06605 | Apixaban | 2 | Terminated | 1 |
| DB00569 | Fondaparinux | 2 | Terminated | 1 |
| DB11728 | Fondaparinux | 2 | Terminated | 1 |
| DB18307 | VLX-1005 | 2 | Recruiting | 1 |
| DB00682 | Warfarin | 2 | Terminated | 1 |
| DB00278 | Argatroban | 3 | Completed | 1 |
| DB00278 | Argatroban | 3 | Terminated | 1 |
| DB00006 | Bivalirudin | 3 | Completed | 1 |
| DB06754 | Danaparoid | 3 | Terminated | 1 |
| DB06228 | Rivaroxaban | 3 | Terminated | 1 |
| DB00682 | Warfarin | 3 | Unknown Status | 1 |
| DB00278 | Argatroban | 4 | Terminated | 1 |
| DB00278 | Argatroban | 4 | Withdrawn | 1 |
| DB00006 | Bivalirudin | 4 | Withdrawn | 1 |
| DB09261 | Certoparin | 4 | Unknown Status | 1 |
| DB00569 | Fondaparinux | 4 | Withdrawn | 1 |
| DB11728 | Fondaparinux | 4 | Withdrawn | 1 |
| DB01109 | Heparin | 4 | Unknown Status | 1 |
| DB00001 | Lepirudin | 4 | Terminated | 1 |
| DB00001 | Lepirudin | 4 | Withdrawn | 1 |